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Lai, NJ

Chiajen Lai, Kendall Park, NJ US

Patent application numberDescriptionPublished
20090312549METHOD OF PREPARATION OF AZAINDOLE DERIVATIVES - A method of preparing azaindole compounds for antiviral use having the formula12-17-2009
20100076191PROCESS FOR PREPARING TRIAZOLE SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES AND NOVEL SALT FORMS PRODUCED THEREIN - A process is provided for preparing triazole substituted azaindoleoxoacetic piperazine derivative. Novel intermediates produced in the above process, and novel N-1 and amorphous forms of a 1,2,3-triazole substituted azaindoloxoacetic piperazine derivatives and processes for producing such novel forms are also provided.03-25-2010
20100292246FORMULATIONS OF 1-(4-BENZOYL-PIPERAZIN-1-YL)-2-[4-METHOXY-7-(3-METHYL-[1,2,4]TRIAZOL-1-YL- )-1H-PYRROLO[2,3-C]PYRIDIN-3-YL]-ETHANE-1,2-DIONE - The instant invention provides formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione; processes for the production of such formulations; and methods of treating HIV or AIDS with such crystalline materials or such formulations.11-18-2010

Patent applications by Chiajen Lai, Kendall Park, NJ US

Chiajen Lai, Princeton, NJ US

Patent application numberDescriptionPublished
20110172176CRYSTAL STRUCTURES OF SGLT2 INHIBITORS AND PROCESSES FOR PREPARING SAME - The present invention relates to physical crystal structures of a compound of the formula I:07-14-2011
20110201795Methods of Producing C-Aryl Glucoside SGLT2 Inhibitors - Method for the production of C-aryl glucoside SGLT2 inhibitors useful for the treatment of diabetes and related diseases. and intermediates thereof. The C-aryl glucosides may be complexed with amino acid complex forming reagents.08-18-2011
20130303467CRYSTAL STRUCTURES OF SGLT2 INHIBITORS AND PROCESSES FOR PREPARING SAME - The present invention relates to physical crystal structures of a compound of the formula I:11-14-2013
20140243517METHODS OF PRODUCING C-ARYL GLUCOSIDE SGLT2 INHIBITORS - Method for the production of C-aryl glucoside SGLT2 inhibitors useful for the treatment of diabetes and related diseases. and intermediates thereof. The C-aryl glucosides may be complexed with amino acid complex forming reagents.08-28-2014

Patent applications by Chiajen Lai, Princeton, NJ US

Ching-Yue Lai, Pennington, NJ US

Patent application numberDescriptionPublished
20100078046Apparatus and method for cleaning passageways such as endoscope channels using flow of liquid and gas - Apparatus and methods are disclosed for cleaning interiors of passageways in endoscopes or other luminal medical devices by flow of liquid and gas therethrough. The liquid flow may include rivulets, droplets or other liquid entities which move on the internal surfaces of the passageways, and may include a three-phase contact interface between liquid and dry solid and gas.04-01-2010
20100078047Method and composition for cleaning tubular systems employing moving three-phase contact lines - A method, composition and apparatus for cleaning an internal surface of a narrow diameter channel. The method includes: 04-01-2010
20120234357METHOD FOR COMPOSITION FOR CLEANING TUBULAR SYSTEMS EMPLOYING MOVING THREE-PHASE LINES - A method for cleaning an internal surface of a narrow diameter channel includes steps of flowing a liquid cleaning medium and a gas through the narrow diameter channel under a flow regime that creates surface flow entities in contact with and sliding along the internal surface of the narrow diameter channel, said surface flow entities having three-phase contact lines and associated menisci, said surface flow entities detaching contaminants with which they come in contact from the internal surface of the narrow diameter internal surface of the narrow diameter channel; and rinsing the internal surface of the narrow diameter channel to remove residual liquid cleaning medium and detached contaminants from the channel.09-20-2012
20120285488Apparatus and method for cleaning passageways such as endoscope channels using flow of liquid and gas - Apparatus and methods are disclosed for cleaning interiors of passageways in endoscopes or other luminal medical devices by flow of liquid and gas therethrough. The liquid flow may include rivulets, droplets or other liquid entities which move on the internal surfaces of the passageways, and may include a three-phase contact interface between liquid and dry solid and gas.11-15-2012

Chung-Yue Lai, Lawrenceville, NJ US

Chunze Lai, Kendall Park, NJ US

Patent application numberDescriptionPublished
20140158536Sensor Apparatus - In the present invention, the solid contacted ISE and the solid contacted reference are based on a conductive porous network with a solid contact and membrane disposed thereon. The porous networks are not only mechanically stable, but also provide pore structure for the solid contact and membrane to intercalate, which enhances the life time and stability of the sensors. The invention further incorporates a unique fluidic fitting sensor and sealing mechanism so that measurements can be taken at high pressures. The fitting design has many benefits, such as low cost and disposability, which allows them to be mass manufactured. These sensors can be produced for detection of many different kinds of ions by applying different types of ion selective membranes, including polyvinylchloride (PVC) based ion-selective membranes and fluorous matrixes based ion-selective membranes.06-12-2014

Eseng Lai, Short Hills, NJ US

Patent application numberDescriptionPublished
20100260841Method of Treating Atherosclerosis, Dyslipidemias and Related Conditions - A method of treating atherosclerosis, dyslipidemias and related conditions is disclosed wherein a therapeutic dose of nicotinic acid, approximately 1 gram, is administered to the patient once daily as a starting dose, and the dose is thereafter raised within a few days or weeks to 2 grams for the duration of therapy. The nicotinic acid may be administered in combination with a selective DP receptor antagonist. The selective DP receptor antagonist is administered to reduce, prevent or eliminate flushing that may otherwise occur.10-14-2010

Patent applications by Eseng Lai, Short Hills, NJ US

Frank Lai, Bridgewater, NJ US

Patent application numberDescriptionPublished
20110118520High activity small crystal ZSM-12 - A porous, crystalline material is described having the framework structure of ZSM-12 and a composition involving the molar relationship:05-19-2011

Gaifa Lai, Monmouth Junction, NJ US

Patent application numberDescriptionPublished
20080200445Heterocyclic aspartyl protease inhibitors - Disclosed are compounds of the formula I 08-21-2008
20090281075ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS - A chemical genus of purinones and 1H-imidazopyridinones, which are useful as PKCθ inhibitors, and their methods of use are disclosed. The genus is represented by the formula I:11-12-2009
200903060793,4-DI-SUBSTITUTED CYCLOBUTENE-1,2-DIONES AS CXC-CHEMOKINE RECEPTOR LIGANDS - There are disclosed compounds of the formula12-10-2009
20120231017HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS - Disclosed are compounds of the formula I09-13-2012
20120231018HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS - Disclosed are compounds of the formula I09-13-2012
20120276118HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS - Disclosed are compounds of the formula I11-01-2012

Patent applications by Gaifa Lai, Monmouth Junction, NJ US

Gaifa Lai, Edison, NJ US

Patent application numberDescriptionPublished
201102130293,4-Di-Substituted Cyclobutene-1,2-Diones as CXC-Chemokine Receptor Ligands - There are disclosed compounds of the formula09-01-2011

Henry Lai, West Windsor, NJ US

Patent application numberDescriptionPublished
20100205616APPLICATION WORKFLOW INTEGRATION SUBSYSTEM - A computer-implemented method, system and computer program product for integrating an application engine with processes depicted by a flow-chart created by a Business Process Management (BPM) engine are presented. Execution of a first application, which is generated by a first application engine, is initiated. The first application performs a first subtask that is depicted by a first component of a flow-chart that has been previously generated by the BPM engine. A Workflow Integration Subsystem (WIS), which provides an interface between the first application engine and the BPM engine, selects the flow-chart that contains the first subtask performed by the first application. The BPM engine calls other application engines to perform other subtasks that supplement the first subtask, such that the first subtask and the other subtasks combine to perform an entire task that is depicted by the flow-chart.08-12-2010

Jie Lai, Belle Mead, NJ US

Patent application numberDescriptionPublished
20090187805Turbo decoding module supporting state n metric value normalization operations - A baseband processing module for use within a Radio Frequency (RF) transceiver includes a downlink/uplink interface, TX processing components, a processor, memory, RX processing components, and a turbo decoding module. The RX processing components receive a baseband RX signal from the RF front end, produce a set of IR samples from the baseband RX signal, and transfer the set of IR samples to the memory. The turbo decoding module receives at least one set of IR samples from the memory, forms a turbo code word from the at least one set of IR samples, turbo decodes the turbo code word to produce inbound data, and outputs the inbound data to the downlink/uplink interface. The turbo decoding module performs metric normalization based upon a chosen metric performs error detection operations, and extracts information from a MAC packet that it produces.07-23-2009
20110002420METHOD AND SYSTEM FOR DECODING SINGLE ANTENNA INTERFERENCE CANCELLATION (SAIC) AND REDUNDANCY PROCESSING ADAPTATION USING BURST PROCESS - Aspects of a method and system for decoding single antenna interference cancellation (SAIC) and redundancy processing adaptation using burst process are provided. A wireless receiver may decode bit sequences based on a first decoding algorithm that may utilize redundancy in the data and that may impose physical constraints. The receiver may also decode a received bit sequence based on a second decoding algorithm that utilizes SAIC. Received data may be processed in a burst process portion in either decoding algorithm. Burst processed data from one of the decoding algorithms may be selected based on signal-to-noise ratio and/or received signal level measurements. The selected burst processed data may be communicated to a frame processing portion of the corresponding decoding algorithm.01-06-2011
20110069795Method and System For Decoding Single Antenna Interference Cancellation (SAIC) and Redundancy Processing Adaptation Using Frame Process - Aspects of a method and system for decoding single antenna interference cancellation (SAIC) and redundancy processing adaptation using frame process are provided. A receiver may decode video, voice, and/or speech bit sequences based on a first decoding algorithm that may utilize data redundancy and that may impose physical constraints. The receiver may also decode a bit sequence based on a second decoding algorithm that utilizes SAIC. The first and second decoding algorithms may be adapted to perform in parallel and a decoded received bit sequence may be selected based on a redundancy verification parameter. The first and second decoding algorithms may also be adapted to be performed sequentially where the subsequent decoding operation may be conditioned to the initial decoding operation. Moreover, either the first or the second decoding algorithm may be selected for decoding the received bit sequence. The selection may be based on noise and/or interference measurements.03-24-2011
20130010901Method and System for Decoding Single Antenna Interference Cancellation (SAIC) and Redundancy Processing Adaptation Using Burst Process - Aspects of a method and system for decoding single antenna interference cancellation (SAIC) and redundancy processing adaptation using burst process are provided. A wireless receiver may decode bit sequences based on a first decoding algorithm that may utilize redundancy in the data and that may impose physical constraints. The receiver may also decode a received bit sequence based on a second decoding algorithm that utilizes SAIC. Received data may be processed in a burst process portion in either decoding algorithm. Burst processed data from one of the decoding algorithms may be selected based on signal-to-noise ratio and/or received signal level measurements. The selected burst processed data may be communicated to a frame processing portion of the corresponding decoding algorithm.01-10-2013

Patent applications by Jie Lai, Belle Mead, NJ US

Katharine Lai, West Orange, NJ US

Patent application numberDescriptionPublished
20130115319Herbal composition for lowering likelihood of stroke and methods for healing stroke patients - Compositions and methods are provided for lowering blood pressure, lowering blood sugar, lowering cholesterol, prevent stroke, removing age spots, curing stroke, or enlarging blood vessels to remove the toxins from the blood. In one embodiment, the composition comprises the herbal extracts of liquorice root, self-heal, mulberry leaves, chrysanthemum, ginkgo nuts, mangosteen, maltose and dextrin. The composition is used as a nutraceutical treatment to lower likelihood of stroke.05-09-2013

Ming-Yee Lai, Short Hills, NJ US

Patent application numberDescriptionPublished
20090279483METHOD AND SYSTEM TO MANAGE WIRELESS COMMUNICATIONS OF HIGH-OCCUPANCY VEHICLES - A system and method for managing wireless communications for a plurality of devices in a high occupancy vehicle is presented. The method comprises steps of creating a global bandwidth usage map across all vehicles, routes, and passengers, transmitting the global bandwidth usage map to a vehicle controller, interpreting the global bandwidth usage map and creating a local usage map, and commanding a wireless concentrator to manage the wireless communications for the devices in accordance with the local usage map. Further, the global map can be created by gathering ticket and route information, obtaining customer productivity data from a network, and parsing obtained data into canonical form. A step of inputting the ticketing information by one of the user, and a ticketing agent can be included. A step of displaying messages using a wireless access application residing on the device can be included.11-12-2009
20120296968System and Method for Group Communications in 3GPP Machine-to-Machine Networks - An inventive system and method for group communication among devices in M2M networks comprises associating one or more of the devices with a gateway having a unique identifier, initiating registration of the devices at an M2M network using the unique identifier of the gateway, providing from the network a temporary identifier to the gateway and associating, in the network, the temporary identifier with the gateway, attaching the devices to the network using the temporary identifier, and communicating information between the network and the device through the gateway. In one aspect, the devices can be classified into sub-groups and each sub-group has a sub-group head that can be attached to the gateway so that the devices can communicate with the network through the sub-group head instead of the gateway. Each sub-group can be associated with a unique temporary identifier, in addition to the temporary identifier associated with the gateway.11-22-2012
20130094444AUTOMATIC PROVISIONING OF AN M2M DEVICE HAVING A WIFI INTERFACE - A method for automatically provisioning a WiFi-equipped machine-to-machine (M2M) device is disclosed. A WiFi M2M gateway identifies a WiFi network identifier broadcast by a powered-on M2M device in WiFi ad hoc mode through a scanning procedure and joins the ad hoc network defined by the M2M device. The WiFi M2M gateway obtains device information (e.g., MAC address) of the M2M device. The WiFi M2M gateway transmits a command to the M2M device to switch from ad hoc mode to infrastructure mode. The WiFi M2M gateway registers the M2M device with an M2M server associated with a service provider based on the device information of the M2M device. The WiFi M2M gateway receives a fully qualified domain name (FQDN) associated with the M2M device from the M2M server.04-18-2013

Patent applications by Ming-Yee Lai, Short Hills, NJ US

Nan-Ming Lai, Weehawken, NJ US

Patent application numberDescriptionPublished
20130242314LASER RANGEFINDER SENSOR - The specification discloses a pulsed time-of-flight laser range finding system used to obtain vehicle classification information. The sensor determines a distance range to portions of a vehicle traveling within a sensing zone of the sensor. A scanning mechanism made of a four facet cube, having reflective surfaces, is used to collimate and direct the laser toward traveling vehicles. A processing system processes the respective distance range data and angle range data for determining the three-dimensional shape of the vehicle.09-19-2013
20140313518Laser Rangefinder Sensor - The specification discloses a pulsed time-of-flight laser range finding system used to obtain vehicle classification information. The sensor determines a distance range to portions of a vehicle traveling within a sensing zone of the sensor. A scanning mechanism made of a four facet cube, having reflective surfaces, is used to collimate and direct the laser toward traveling vehicles. A processing system processes the respective distance range data and angle range data for determining the three-dimensional shape of the vehicle.10-23-2014

Pamela M. Lai, Parsippany, NJ US

Patent application numberDescriptionPublished
20090036821Iontophoretic Transdermal Delivery of Nicotine Salts - The present invention relates to iontophoretic transdermal delivery of nicotine salts useful for nicotine replacement therapy for an individual in need thereof. The present invention further relates to the iontophoretic transdermal delivery of nicotine maleate and nicotine citrate. Methods of reducing skin irritation generally caused by transdermal nicotine delivery by iontophoretic transdermal delivery of nicotine salts are also disclosed.02-05-2009

Polin Lai, Plainsboro, NJ US

Patent application numberDescriptionPublished
20090129465METHODS AND APPARATUS FOR ADAPTIVE REFERENCE FILTERING (ARF) OF BI-PREDICTIVE PICTURES IN MULTI-VIEW CODED VIDEO - There are provided methods and apparatus for adaptive reference filtering of bi-predictive pictures in multi-view coded video. An apparatus includes an encoder (05-21-2009
20110286530Frame packing for video coding - Implementations are provided that relate, for example, to view tiling in video encoding and decoding. A particular implementation accesses a video picture that includes multiple pictures combined into a single picture, and accesses additional information indicating how the multiple pictures in the accessed video picture are combined. The accessed information includes spatial interleaving information and sampling information. Another implementation encodes a video picture that includes multiple pictures combined into a single picture, and generates information indicating how the multiple pictures in the accessed video picture are combined. The generated information includes spatial interleaving information and sampling information. A bitstream is formed that includes the encoded video picture and the generated information. Another implementation provides a data structure for transmitting the generated information.11-24-2011

Po-Lin Lai, Princeton, NJ US

Patent application numberDescriptionPublished
20110292043Depth Map Coding to Reduce Rendered Distortion - Several implementations relate to depth map coding. In one implementation, a depth coding rate, that results from coding one or more portions of a depth map using a particular coding mode, is determined. The depth map can be used to render video for a different view than that of the depth map. A depth map distortion, that results from coding the one or more portions of the depth map using the particular coding mode, is determined. A value of distortion for the rendered video, based on the depth map distortion and on a particular relationship between the depth map distortion and values of distortion for the rendered video, is determined. It is determined whether to use the particular coding mode to code the one or more portions of the depth map, and the determination is based on the value of distortion for the rendered video and the depth coding rate.12-01-2011
20120140819DEPTH MAP CODING - Various implementations relate to depth map coding. In one method, a depth coding rate and depth distortion are determined for a coding mode. Based on the value of depth distortion, a correlation coefficient is determined between at least a portion of a video picture and a translated version of the video picture. The video picture is one or more of a video picture corresponding to the depth being coded, or a rendered video picture for a different view. A video distortion is determined based on the correlation coefficient, and is used to evaluate the coding mode. Another implementation determines a multiplier, to be used in a rate-distortion cost, based on pixel values from one or more of a video picture from a particular view or a rendered video picture for a different view.06-07-2012

Po-Lin Lai, Plainsboro, NJ US

Patent application numberDescriptionPublished
20110292044DEPTH MAP CODING USING VIDEO INFORMATION - Several implementations relate to depth map coding. In one implementation, it is determined that differences between collocated video blocks are small enough to be interchanged. Based on that determination, a depth block corresponding to a first of the video blocks is coded using an indicator that instructs a decoder to use a collocated depth block, corresponding to a second of the video blocks, in place of the depth block. In another implementation, a video signal includes a coding of at least a single indicator that instructs a decoder to decode both a depth block and a corresponding video block using collocated blocks, from other pictures, in place of the depth block and the corresponding video block. In another implementation, the depth block and the corresponding video block are decoded, based on the single indicator, using the collocated blocks in place of the depth block and the corresponding video block.12-01-2011
201102988953D VIDEO FORMATS - Several implementations relate to 3D video formats. One or more implementations provide adaptations to MVC and SVC to allow 3D video formats to be used. According to a general aspect, a set of images including video and depth is encoded. The set of images is related according to a particular 3D video format, and are encoded in a manner that exploits redundancy between the set of images. The encoded images are arranged in a bitstream in a particular order, based on the particular 3D video format that relates to the images. The particular order is indicated in the bitstream using signaling information. According to another general aspect, a bitstream is accessed that includes the encoded set of images. The signaling information is also accessed. The set of images is decoded using the signaling information.12-08-2011

Song Lai, Cherry Hill, NJ US

Patent application numberDescriptionPublished
20110260726PHASE LABELING USING SENSITIVITY ENCODING: DATA ACQUISITION AND IMAGE RECONSTRUCTION FOR GEOMETRIC DISTORTION CORRECTION IN EPI - A phase labeling using sensitivity encoding system and method for correcting geometric distortion caused by magnetic field inhomogeneity in echo planar imaging (EPI) uses local phase shifts derived directly from the EPI measurement itself, without the need for extra field map scans or coil sensitivity maps. The system and method employs parallel imaging and k-space trajectory modification to produce multiple images from a single acquisition. The EPI measurement is also used to derive sensitivity maps for parallel imaging reconstruction. The derived phase shifts are retrospectively applied to the EPI measurement for correction of geometric distortion in the measurement itself.10-27-2011

Wai Sum Lai, Matawan, NJ US

Patent application numberDescriptionPublished
20100061255Reliability Metrics in an IP Network - Embodiments of the present invention are directed to characterizing reliability associated with a network. To characterize the reliability, an edge-pair reliability metric is determined for service edge point pairs. An end-to-end reliability metric is computed based on a distribution of the edge-pair reliability metric for the service edge point pairs and a threshold value.03-11-2010
20110075585RELIABILITY METRICS IN AN IP NETWORK - Embodiments of the present invention are directed to characterizing reliability associated with a network. To characterize the reliability, an edge-pair reliability metric is determined for service edge point pairs. An end-to-end reliability metric is computed based on a distribution of the edge-pair reliability metric for the service edge point pairs and a threshold value.03-31-2011
20120087377METHODS AND APPARATUS FOR HIERARCHICAL ROUTING IN COMMUNICATION NETWORKS - Methods and apparatus for hierarchical routing in communication networks are disclosed. An example hierarchical routing method for a communication network disclosed herein comprises determining a plurality of constrained weighted paths to connect pairs of border nodes of a cluster in the communication network, each constrained weighted path having a respective bandwidth and a respective weight, a constrained weighted path for a pair of border nodes of the cluster being selected, based on a bandwidth threshold, from a set of possible paths capable of connecting the pair of border nodes, and advertising the plurality of constrained weighted paths determined for the cluster.04-12-2012

Patent applications by Wai Sum Lai, Matawan, NJ US

Wang Lin Lai, Princeton, NJ US

Patent application numberDescriptionPublished
201200443223D VIDEO CODING FORMATS - Several implementations relate to 3D video (3DV) coding formats. One implementation encodes multiple pictures that describe different three-dimensional (3D) information for a given view at a given time. Syntax elements are generated that indicate, for the encoded multiple pictures, how the encoded picture fits into a structure that supports 3D processing. The structure defines content types for the multiple pictures. A bitstream is generated that includes the encoded multiple pictures and the syntax elements. The inclusion of the syntax elements provides, at a coded-bitstream level, indications of relationships between the encoded multiple pictures in the structure. The syntax elements also enable efficient inter-layer coding of the 3DV content, thereby reducing the bandwidth used to transmit the 3DV content. Corresponding decoding implementations are also provided. Extraction methods are also provided from extracting pictures of interest from such a 3DV multiple pictures and the syntax elements, the video stream characterized by such a 3D structure.02-23-2012
20120056981INTER-LAYER DEPENDENCY INFORMATION FOR 3DV - Various implementations are directed to providing inter-layer dependency information. In one implementation, syntax elements are generated that indicate an inter-layer dependency structure among three-dimensional video (3DV) layers. Based on the inter-layer dependency structure, an inter-layer reference is identified for a picture from a layer of the 3DV layers. The picture is encoded based, at least in part, on the inter-layer reference. Corresponding decoding implementations are also provided. Additionally, in another implementation, a transmission priority and an indication of network congestion are used to determine whether to transmit data for a particular 3DV layer. The transmission priority is based on an inter-layer dependency structure among multiple 3DV layers. Another implementation is directed to a network abstraction layer unit that can explicitly identify and convey inter-layer references and corresponding dependencies.03-08-2012

Warren Yiu-Cho Lai, Chatham Township, NJ US

Patent application numberDescriptionPublished
20090075424Process for making microelectronic element chips - Apparatus including a chip substrate having a first chip surface facing away from a second chip surface; an array of microelectronic elements on the first chip surface; and an array of conductors each in communication with one of the microelectronic elements, the conductors passing through the chip substrate and fully spanning a distance between the first and second chip surfaces. Process including: providing an apparatus including a chip substrate having a first chip surface facing away from a second chip surface, an array of microelectronic elements being on the first chip surface, an array of conductors each being in communication with one of the microelectronic elements and partially spanning an average distance between the first and second chip surfaces; bonding a temporary support carrier onto the array of microelectronic elements; removing a portion of the chip substrate, thereby reducing the average distance between the first and second chip surfaces; and forming an under bump metallization pad at the second chip surface in electrical communication with a conductor.03-19-2009

Wenyih F. Lai, Bridgewater, NJ US

Patent application numberDescriptionPublished
20090215612Aromatic hydrogenation catalysts - An MCM-41 catalyst having a crystalline framework containing SiO08-27-2009
20100147741High activity MTT framework type molecular sieves - A process is described of producing an MTT framework type molecular sieve by crystallizing a mixture capable of forming said molecular sieve, wherein the mixture comprises sources of alkali or alkaline earth metal (M), an oxide of trivalent element (X), an oxide of tetravalent element (Y), water and a directing agent (R) of the formula (CH06-17-2010
20100147747Dewaxing catalysts and processes - A process for dewaxing a waxy component-containing hydrocarbon feedstock comprises contacting the feedstock under dewaxing conditions with a catalyst system comprising ZSM-48 and a molecular sieve of the MTT framework type.06-17-2010
20100187155Integrated hydrocracking and dewaxing of hydrocarbons - An integrated process for producing naphtha fuel, diesel fuel and/or lubricant base oils from feedstocks under sour conditions is provided. The ability to process feedstocks under higher sulfur and/or nitrogen conditions allows for reduced cost processing and increases the flexibility in selecting a suitable feedstock. The sour feed can be delivered to a catalytic dewaxing step without any separation of sulfur and nitrogen contaminants, or a high pressure separation can be used to partially eliminate contaminants. The integrated process includes an initial hydrotreatment, hydrocracking, catalytic dewaxing of the hydrocracking effluent, and an option final hydrotreatment.07-29-2010
20100187156Sour service hydroprocessing for lubricant base oil production - An integrated process for producing lubricant base oils from feedstocks under sour conditions is provided. The ability to process feedstocks under higher sulfur conditions allows for reduced cost processing and increases the flexibility in selecting a suitable feedstock. The sour feed can be delivered to a catalytic dewaxing step without any separation of sulfur and nitrogen contaminants, or a high pressure separation can be used to partially eliminate contaminants.07-29-2010
20100280290"METHOD OF MAKING M41S FAMILY MOLECULAR SIEVE" - This disclosure relates to a novel method of making and recovering M41S family molecular sieve materials using synthesis mixtures having high solids-content and without a purification step. The solids-content, for example, is in a range from about 20 wt. % to 50 wt. %. The method also includes the step of mixing at least a portion of the M41S made with another material to form a composition, wherein the amount of said material to be mixed with said M41S product is such that said composition having less than 10 wt. % free fluid. The material mixed with the M41S made includes metal oxides, metal nitrides, metal carbides and mixtures thereof, as well as absorptive material capable of absorbing mother liquor and selected from the group consisting of carbon silica, alumina, titania, zirconia and mixtures thereof. The amount of the wastewater generated by this novel method is reduced by at least 50% to as much as 100% as comparing with conventional method of making M41S materials. By reducing and/or eliminating at least a portion of the wastewater generated in the synthesis product, the new method reduces cost of making of M41S materials and provides a more environmentally-friendly synthesis product.11-04-2010
20110174684Sweet or Sour Service Catalytic Dewaxing in Block Mode Configuration - Sweet and sour lubricant feeds are block and continuous processed to produce lubricant basestocks. Total liquid product yields at a desired pour point are maintained for catalytic dewaxing of both sweet and sour conditions. The desired pour point is achieved for both the sweet and sour feeds by varying the catalytic dewaxing reaction temperature as a function of sulfur content entering the reactor.07-21-2011
20110192766DEWAXING CATALYSTS - A supported catalyst comprises a zeolite having a silica to alumina molar ratio of 500 or less, a first metal oxide binder having a crystallite size greater than 200 Å and a second metal oxide binder having a crystallite size less than 100 Å, wherein the second metal oxide binder is present in an amount less than 08-11-2011
20110315596INTEGRATED HYDROCRACKING AND DEWAXING OF HYDROCARBONS - An integrated process for producing naphtha fuel, diesel fuel and/or lubricant base oils from feedstocks under sour conditions is provided. The ability to process feedstocks under higher sulfur and/or nitrogen conditions allows for reduced cost processing and increases the flexibility in selecting a suitable feedstock. The sour feed can be delivered to a catalytic dewaxing step without any separation of sulfur and nitrogen contaminants. The integrated process includes an initial dewaxing of a feed under sour conditions, optional hydrocracking of the dewaxed feed, and a separation to form a first diesel product and a bottoms fraction. The bottoms fraction is then exposed to additional hydrocracking and dewaxing to form a second diesel product and optionally a lubricant base oil product. Alternatively, a feedstock can be hydrotreated, fractionated, dewaxed, and then hydrocracked to form a diesel fuel and a dewaxed, hydrocracked bottoms fraction that is optionally suitable for use as a lubricant base oil.12-29-2011
20110315599INTEGRATED HYDROCRACKING AND DEWAXING OF HYDROCARBONS - An integrated process for producing naphtha fuel, diesel fuel and/or lubricant base oils from feedstocks under sour conditions is provided. The ability to process feedstocks under higher sulfur and/or nitrogen conditions allows for reduced cost processing and increases the flexibility in selecting a suitable feedstock. The sour feed can be delivered to a catalytic dewaxing step without any separation of sulfur and nitrogen contaminants, or with only a high pressure separation so that the dewaxing still occurs under sour conditions. Various combinations of hydrotreating, catalytic dewaxing, hydrocracking, and hydrofinishing can be used to produce fuel products and lubricant base oil products.12-29-2011
20120316365Dehydrogenation Process - In a process for the dehydrogenation of cyclohexanone to produce phenol, a feed comprising cyclohexanone is contacted with a catalyst comprising an inorganic, crystalline, mesoporous support material and a hydrogenation-dehydrogenation component under dehydrogenation conditions effective to convert at least part of the cyclohexanone in the feed into phenol and hydrogen.12-13-2012
20130172514"PROCESS FOR PRODUCING CYCLOALKYLAROMATIC COMPOUNDS" - In a process for producing a cycloalkylaromatic compound, an aromatic compound, hydrogen and at least one diluent are supplied to a hydroalkylation reaction zone, such that the weight ratio of the diluent to the aromatic compound supplied to the hydroalkylation reaction zone is at least 1:100. The aromatic compound, hydrogen and the at least one diluent are then contacted under hydroalkylation conditions with a hydroalkylation catalyst in the hydroalkylation reaction zone to produce an effluent comprising a cycloalkylaromatic compound.07-04-2013
20130251627High Throughput Process for Manufacturing Molecular Sieves - A method of crystallizing a crystalline molecular sieve having a pore size in the range of from about 2 to about 19 Å, said method comprising the steps of (a) providing a mixture comprising at least one source of ions of tetravalent element (Y), at least one hydroxide source (OH09-26-2013
20140171293Xylene Isomerization Process and Catalyst Therefor - The invention concerns a xylenes isomerization process for the production of equilibrium or near-equilibrium xylenes. The process utilizes a catalyst comprising HZSM-5 or MCM-49 and process conditions including a temperature of less than 295° C. and a pressure sufficient to maintain the xylenes in liquid phase. In embodiments, the process can be operated in a continuous mode with ppm levels of dissolved H06-19-2014
20140194653High Throughput Process for Manufacturing Molecular Sieves of MFI Framework Type - A process for converting hydrocarbons comprising the step of contacting said hydrocarbons under conversion conditions with a crystalline molecular sieve having a pore size in the range of from about 2 to about 19 Å, said molecular sieve made by a method comprising the steps of (a) providing a mixture comprising at least one source of ions of tetravalent element (Y), at least one trivalent element hydroxide source (OH07-10-2014

Patent applications by Wenyih F. Lai, Bridgewater, NJ US

Wenyih Frank Lai, Bridgewater, NJ US

Patent application numberDescriptionPublished
20090076317Synthesis of high activity ZSM-48 - A process for producing ZSM-48 comprises crystallizing an aqueous reaction mixture comprising at least one source of silica, at least one source of alumina, at least one source of hydroxyl ions, at least one source of diquaternary alkylammonium, R03-19-2009
20090206004Aromatic hydrogenation process - An MCM-41 catalyst having a crystalline framework containing SiO08-20-2009
20100298598Method of Preparing a Molecular Sieve Composition - This disclosure provides a method of preparing a crystalline molecular sieve comprising: (a) providing a reaction mixture comprising at least one source of ions of tetravalent element Y, at least one source of alkali metal hydroxide, water, optionally at least one seed crystal, and optionally at least one source of ions of trivalent element X, the reaction mixture having the following molar composition: 11-25-2010
20110021855Process for Manufacturing MCM-22 Family Molecular Sieves - A method of manufacturing a molecular sieve of the MCM-22 family, said method comprising the steps of (a) providing a mixture comprising at least one source of ions of tetravalent element, at least one source of alkali metal hydroxide, at least one directing-agent (R), water, and optionally at least one source of ions of trivalent element, said mixture having the following mole composition: 01-27-2011
20110021856Method of Preparing a Molecular Sieve Composition - A method of preparing a crystalline molecular sieve is provided, which method comprises 01-27-2011
20110034749Synthesis and use of ZSM-12 - A process is described for synthesizing a porous, crystalline material having the framework structure of ZSM-12 of the formula:02-10-2011
20110038789MCM-22 Family Molecular Sieve Composition - An MCM-22 family molecular sieve having an X-ray diffraction pattern of the as-synthesized MCM-22 family molecular sieve including d-spacing maxima at 12.4±0.25, 3.57±0.07 and 3.42±0.07 Angstroms and at least one peak between 26.6° and 29° (2θ). The peak between 26.6° to 29° (2θ) has a two theta (2θ) of about 26.9°. A method of manufacturing an MCM-22 family molecular sieve, said method comprising the steps of (a) combining at least one silicon source, at least one source of alkali metal hydroxide, at least one directing-agent (R), water, and optionally one aluminum source, to form a mixture having the following mole composition: 02-17-2011
20110263918Xylene Isomerization Process and Catalyst Therefor - The invention concerns a xylenes isomerization process for the production of equilibrium or near-equilibrium xylenes. The process utilizes a catalyst comprising HZSM-5 or MCM-49 and process conditions including a temperature of less than 295° C. and a pressure sufficient to maintain the xylenes in liquid phase. In embodiments, the process can be operated in a continuous mode with ppm levels of dissolved H10-27-2011
20130026070Hydrocracking Catalysts Containing Stabilized Aggregates of Small Crystallites of Zeolite Y Associated Hydrocarbon Conversion Processes - This invention relates to hydrocracking catalysts utilizing stabilized aggregates of small primary crystallites of zeolite Y that are clustered into larger secondary particles. At least 80% of the secondary particles may comprise at least 5 primary crystallites. The size of the primary crystallites may be at most about 0.5 micron, or at most about 0.3 micron, and the size of the secondary particles may be at least about 0.8 micron, or at least about 1.0 μm. The silica to alumina ratio of the resulting stabilized aggregated Y zeolite may be 4:1 or more. This invention also relates to the use of such catalysts in hydrocracking processes for the conversion of heavy oils into lighter fuel products. The invention is particularly suited for the selective production of diesel range products from gas oil range feedstock materials under hydrocracking conditions.01-31-2013
20130029832STABILIZED AGGREGATES OF SMALL CRYSTALLITES OF ZEOLITE Y - This invention relates to stabilized aggregates of small primary crystallites of zeolite Y that are clustered into larger secondary particles. At least 80% of the secondary particles may comprise at least 5 primary crystallites. The size of the primary crystallites may be at most about 0.5 micron, or at most about 0.3 micron, and the size of the secondary particles may be at least about 0.8 micron, or at least about 1.0 μm. The silica to alumina ratio of the resulting stabilized aggregated Y zeolite may be 4:1 or more.01-31-2013
20130029833AGGREGATES OF SMALL CRYSTALLITES OF ZEOLITE Y - This invention relates to aggregates of small primary crystallites of zeolite Y that are clustered into larger secondary particles. At least 80% of the secondary particles may comprise at least 5 primary crystallites. The size of the primary crystallites may be at most about 0.5 micron, or at most about 0.3 micron, and the size of the secondary particles may be at least about 0.8 micron, or at least about 1.0 μm. The silica to alumina ratio of the resulting stabilized aggregated Y zeolite may be 4:1 or more.01-31-2013
20130096358PROCESS FOR PRODUCING PHOSPHORUS MODIFIED ZEOLITE CATALYSTS - In a process for producing a phosphorus-modified zeolite catalyst, an aqueous reaction mixture comprising a source of silica and a source of an organic directing agent effective to direct the synthesis of a desired zeolite is heated at a temperature and for a time sufficient to produce crystals of the desired zeolite. Wet zeolite crystals can then be separated from the reaction mixture and, without removing all the water from the wet zeolite crystals, the zeolite can be converted into the ammonium form by ion exchange, and the crystals can be treated with a phosphorus compound. The phosphorus-treated, ammonium-exchanged zeolite can then be formed into a catalyst to be heated in one or more stages to remove the water and organic directing agent from the zeolite crystals and to convert the zeolite to the hydrogen form.04-18-2013
20130144100SYNTHESIS OF HIGH ACTIVITY LARGE CRYSTAL ZSM-5 - In a process for preparing a high activity, large crystal ZSM-5 type zeolite in the absence of a template, a reaction mixture can be prepared comprising water, a silica source having a surface area less than 150 m06-06-2013
20130157840Molecular Sieve Composition From Pre-Formed Extrudates and Process of Use - This disclosure provides a molecular sieve composition having a first and second crystalline molecular sieve, made by the method comprising: (a) providing a reaction mixture comprising at least one source of ions of tetravalent element Y, at least one source of alkali metal hydroxide, water, optionally at least one seed crystal, and optionally at least one source of ions of trivalent element X, the reaction mixture having the following molar composition:06-20-2013
20130324760Hydrocarbon Conversion Process Using a High Throughpout Process for Manufacturing Molecular Sieves - A method of crystallizing a crystalline molecular sieve having a pore size in the range of from about 2 to about 19 Å, said method comprising the steps of (a) providing a mixture comprising at least one source of ions of tetravalent element (Y), at least one hydroxide source (OH12-05-2013
20140024523Process for Producing Molecular Sieve Materials - In a process for producing a molecular sieve material, water, at least one source of an oxide of a tetravalent and/or a trivalent element and at least one structure directing agent is mixed in a reactor equipped with a mixer having a Froude number of at least 1, to produce a molecular sieve synthesis mixture having a solids content of at least about 20 wt %. The molecular sieve synthesis mixture is heated in the reactor while agitating the mixture with said mixer to form crystals of said molecular sieve material and the molecular sieve crystals are subsequently recovered from the reactor.01-23-2014
20140024868Synthesis and Use of M41S Family Molecular Sieves - A process is described for producing an M41S family molecular sieve. The process comprises preparing a synthesis mixture capable of forming said molecular sieve in a reactor, which is equipped with a mixer having a Froude number of at least 1, said synthesis mixture having a solids content of at least 20 wt %. The synthesis mixture is heated in the reactor while agitating the mixture with said mixer to form a product mixture comprising water and crystals of said molecular sieve material. Thereafter at least part of the water is removed from the product mixture in the reactor so as to decrease the water content of the product mixture inside the reactor by at least 5 wt %.01-23-2014
20140162866FIBER REINFORCED ZEOLITE EXTRUDATES WITH ENHANCED PHYSICAL PROPERTIES - The invention relates to a method of making a reinforced catalytic microporous and/or mesoporous bound composition comprising the steps of: providing a pre-formed catalytic crystalline material; mixing the catalytic crystalline material with water, a metal oxide binder, and a reinforcing glass fiber to form an extrudable composition; extruding the extrudable slurry under conditions sufficient to form the reinforced catalytic bound extrudate; and calcining the reinforced catalytic bound extrudate at a temperature and for a time sufficient to form a calcined reinforced catalytic bound catalyst. Advantageously, the reinforcing glass fiber can have a diameter from 5-100 microns and a length-to-diameter ratio from 300:1-3000:1 and can be present in an amount from about 1-50 parts, based on about 1000 parts combined of catalytic crystalline material and metal oxide binder.06-12-2014
20140162867SYNTHESIS OF ZSM-5 CRYSTALS WITH IMPROVED MORPHOLOGY - Methods are provided for synthesizing crystals having a ZSM-5 framework structure from synthesis mixtures suitable for synthesis of ZSM-12 framework structure crystals in the absence of seed crystals with a ZSM-5 framework structure, such as in the absence of any seed crystals. For synthesis mixtures with a sufficiently high XO06-12-2014

Patent applications by Wenyih Frank Lai, Bridgewater, NJ US

Xinzhong Lai, Edison, NJ US

Patent application numberDescriptionPublished
20110207154METHOD FOR DETERMINATION OF MARINOBUFAGENIN LEVELS AND COMPOUNDS EMPLOYABLE IN SUCH METHOD - The present invention is directed toward a method for determination of marinobufagenin concentration in a body specimen through conjugation of marinobufagenin to a suitable protein, thereby creating a conjugate which will trigger an antibody response in a host. The conjugated marinobufagenin is immunogenic. The antibodies so produced may be employed in an ELISA test to ascertain the concentration of marinobufagenin in a body specimen. A number of unique compounds are created in the process and are disclosed. An ELISA assay may be employed.08-25-2011

Yhean-Sen Lai, Somerset County, NJ US

Patent application numberDescriptionPublished
20100253400Phase-Locked Loop (PLL) Having Extended Tracking Range - A method for extending a tracking range of a PLL includes the steps of: establishing an initial tracking window of the PLL, the tracking window having a first width associated therewith; and dynamically adjusting the tracking window of the PLL within an extended tracking range when a frequency of an input signal supplied to the PLL is outside of the tracking window, the extended tracking range having a second width associated therewith which is greater than the first width.10-07-2010

Yhean-Sen Lai, Warren, NJ US

Patent application numberDescriptionPublished
20080267326Multi-channel receiver with improved AGC - An improved multi-channel receiver for satellite broadcast applications or the like. In an exemplary embodiment, an AGC loop, under the control of an AGC processor, controls the gain of an analog sub-receiver adapted to simultaneously receive multiple signals to achieve a desired AGC setpoint signal intensity from the sub-receiver. Multiple digital demodulators, coupled to the sub-receiver by an analog-to-digital converter (ADC), demodulate the multiple received signals. The AGC controller, based upon which of the received signals are being demodulated, selects the desired AGC setpoint from a table of setpoints. The AGC controller may also provide selective power control to circuitry in the receiver and select the resolution of the ADC. The controller updates the AGC loop with step values selected from a group of values by an AGC control algorithm. Different groups of step values may be used by the controller depending on whether the signals are fading or not.10-30-2008
20080268798Multi-channel receiver with improved AGC - An improved multi-channel receiver for satellite broadcast applications or the like. In an exemplary embodiment, an AGC loop, under the control of an AGC processor, controls the gain of an analog sub-receiver adapted to simultaneously receive multiple signals to achieve a desired AGC setpoint signal intensity from the sub-receiver. Multiple digital demodulators, coupled to the sub-receiver by an analog-to-digital converter (ADC), demodulate the multiple received signals. The AGC controller, based upon which of the received signals are being demodulated, selects the desired AGC setpoint from a table of setpoints. The AGC controller may also provide selective power control to circuitry in the receiver and select the resolution of the ADC. The controller updates the AGC loop with step values selected from a group of values by an AGC control algorithm. Different groups of step values may be used by the controller depending on whether the signals are fading or not.10-30-2008
20090110047DEMODULATOR WITH CONFIGURABLE ADAPTIVE EQUALIZER - An improved multi-channel receiver for satellite broadcast applications or the like. In an exemplary embodiment, the receiver has an adaptive equalizer configurable to operate with QPSK or 8PSK modulated signals. In the equalizer, a slicer table memory responsive to an 8-level quantizer (slicer) and a select signal is configured to map the output of the quantizer into QPSK or 8PSK symbol coordinates depending on whether the QPSK or the 8PSK signal is being received. The slicer table memory may be loaded with the symbol coordinates calculated from data in the 8PSK signal. A pattern matcher determines if the 8PSK or the QPSK signal is being received and asserts the select signal to configure the slicer table memory accordingly.04-30-2009
20090154613TIMING-FREQUENCY OFFSET AND CARRIER-FREQUENCY OFFSET ESTIMATIONS FOR MULTI-CARRIER MODULATED SIGNALS USING PILOT TONES - In one embodiment, a demodulator demodulates a multi-carrier modulated signal having two pilot tones. The demodulator calculates a first phase angle for the first pilot tone and a second phase angle for the second pilot tone based on the time-domain multi-carrier modulated signal. A timing-frequency offset estimate is calculated using the first and second phase angles. Further, a fine carrier-frequency offset estimate is calculated for each pilot tone based on the corresponding phase angle and the timing-frequency offset estimate. Each fine carrier-frequency offset estimate is combined with a coarse estimate and weighted. The weighted estimates are then combined. In further embodiments, the timing-frequency offset estimate is weighted and combined with a weighted timing-frequency offset estimate generated using a cyclic prefix. In yet further embodiments, the weighted carrier-frequency offset estimates are combined with a weighted carrier-frequency offset estimate generated using a cyclic prefix.06-18-2009
20110188489MULTI-CHANNEL RECEIVER WITH IMPROVED AGC - An improved multi-channel receiver for satellite broadcast applications or the like. In an exemplary embodiment, a primary AGC loop controls an analog sub-receiver adapted to simultaneously receive multiple signals. Multiple digital demodulators, coupled to the sub-receiver, demodulate the multiple received signals. Multiple secondary AGC loops, one for each received signal, compensate for variations in demodulated signal strengths caused by the primary AGC loop. A feed-forward AGC compensation technique generates scalar control values for scaling the demodulated signals before the demodulated signals are processed by the secondary AGC loops. This at least partially compensates for gain variations caused by the primary AGC, reducing received signal drop-outs before the secondary AGC loops can compensate for the gain variations. Because of systemic delays in the sub-receiver and the demodulators, the scalar control values are independently timed to be coincident with the variations in the demodulated signal strengths caused by the primary AGC loop.08-04-2011

Patent applications by Yhean-Sen Lai, Warren, NJ US

Zhichang Lai, Bridgewater, NJ US

Patent application numberDescriptionPublished
20110305307NETWORK NODE, COMMUNICATION SYSTEM, AND METHOD FOR TRANSMITTING CLOCK PACKET THROUGH TUNNEL - A network node, a communication system, and a method for transmitting a clock packet through a tunnel are disclosed. The method includes: encapsulating a tunnel ingress clock packet received at an ingress of a tunnel in an encapsulation mode corresponding to the tunnel, and performing clock correction for the encapsulated clock packet; and sending the corrected clock packet to an egress of the tunnel. The network node for processing a clock packet includes an encapsulating module and a sending module. The communication system includes the network node for processing a clock packet, and further includes an intra-tunnel network node and a tunnel egress network node. According to the present invention, a clock packet is re-encapsulated and transmitted through a tunnel. In the subsequent process of transmitting the clock packet transparently, the node itself serves as a clock reference point, and all network nodes do not need to synchronize time absolutely.12-15-2011

Zhong Lai, Rahway, NJ US

Patent application numberDescriptionPublished
20140088124IMIDAZOLE DERIVATIVES - Described herein are compounds of formula (I), The compounds of formula I act as DGAT1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperlipidemia, diabetes mellitus and obesity.03-27-2014

Zhong Lai, East Brunswick, NJ US

Patent application numberDescriptionPublished
20140199263HETEROCYCLIC-SUBSTITUTED BENZOFURAN DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES - The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.07-17-2014
20140213571TETRACYCLIC HETEROCYCLE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES - The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.07-31-2014

Zhong Lai, Scotch Plains, NJ US

Patent application numberDescriptionPublished
20100184799OXADIAZOLE BETA CARBOLINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS - Beta-carboline derivatives of structural formula I are selective antagonists of the somatostatin subtype receptor 3 (SSTR3) and are useful for the treatment of Type 2 diabetes mellitus and of conditions that are often associated with this disease, including hyperglycemia, insulin resistance, obesity, lipid disorders, and hypertension. The compounds are also useful for the treatment of depression and anxiety.07-22-2010
20120264777OXADIAZOLE BETA CARBOLINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS - Beta-carboline derivatives of structural formula I are selective antagonists of the somatostatin sub-type receptor 3 (SSTR3) and are useful for the treatment of Type 2 diabetes mellitus and of conditions that are often associated with this disease, including hyperglycemia, insulin resistance, obesity, lipid disorders, and hypertension. The compounds are also useful for the treatment of depression and anxiety.10-18-2012
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