Patent application number | Description | Published |
20090146017 | Aircraft Trailing Edge Devices, Including Devices With Non-Parallel Motion Paths, and Associated Methods - Aircraft trailing edge devices, including devices with non-parallel motion paths, and associated methods are disclosed. A device in accordance with one embodiment includes a wing and an inboard trailing edge device coupled to the wing and movable relative to the wing between a first stowed position and a first deployed position along a first motion path. An outboard trailing edge device can be coupled to the wing outboard of the inboard trailing edge device, and can be movable relative to the wing along a second motion path that is non-parallel to the first motion path. An intermediate trailing edge device can be coupled between the inboard and outboard trailing edge devices and can be movable along a third motion path that is non-parallel to both the first and second motion paths. Each of the trailing edge devices can open a gap relative to the wing when moved to their respective deployed positions. | 06-11-2009 |
20100170998 | AIRCRAFT TRAILING EDGE DEVICES, INCLUDING DEVICES HAVING FORWARDLY POSITIONED HINGE LINES, AND ASSOCIATED METHODS - Aircraft trailing edge devices, including devices having forwardly positioned hinge lines, and associated methods are disclosed. An aircraft system in accordance with one embodiment of the invention includes a wing and a trailing edge device coupled to the wing. The trailing edge device can be movable relative to the wing between a stowed position and a deployed position, with the trailing edge device having a leading edge, a trailing edge, an upper surface, and a lower surface. The upper surface can have an intersection point with the wing when the trailing edge device is in the stowed position. The motion of the trailing edge device relative to the wing can include rotational motion about a hinge line positioned forward of the intersection point, and a gap can be positioned between the trailing edge of the wing and the leading edge of the trailing edge device when the trailing edge device is in the deployed position. | 07-08-2010 |
20120018588 | Aircraft Trailing Edge Devices, Including Devices Having Forwardly Positioned Hinge Lines, and Associated Methods - Aircraft trailing edge devices, including devices having forwardly positioned hinge lines, and associated methods are disclosed. An aircraft system in accordance with one embodiment of the invention includes a wing and a trailing edge device coupled to the wing. The trailing edge device can be movable relative to the wing between a stowed position and a deployed position, with the trailing edge device having a leading edge, a trailing edge, an upper surface, and a lower surface. The upper surface can have an intersection point with the wing when the trailing edge device is in the stowed position. The motion of the trailing edge device relative to the wing can include rotational motion about a hinge line positioned forward of the intersection point, and a gap can be positioned between the trailing edge of the wing and the leading edge of the trailing edge device when the trailing edge device is in the deployed position. | 01-26-2012 |
Patent application number | Description | Published |
20120288494 | Anti-IL-12/IL-23 antibodies and uses thereof - The present invention provides antibodies, and antigen-binding portions thereof, that bind to epitopes comprising at least one amino acid residues from residues 1-197 of the p40 subunit of IL-12 and/or IL-23. The invention further provides nucleic acids encoding the antibodies, compositions, vectors and host cells comprising the antibodies, and methods of making and using the same. | 11-15-2012 |
20130330348 | ANTI-NGF ANTIBODIES AND THEIR USE - The present disclosure encompasses NGF binding proteins, specifically to antibodies that are chimeric, CDR grafted and canonized antibodies, and methods of making and uses thereof. The antibodies, or antibody portions, of the disclosure are useful for detecting NGF and for inhibiting NGF activity, e.g., in a mammal subject suffering from a disorder in which NGF activity is detrimental. | 12-12-2013 |
20140154270 | PURIFICATION OF NON-HUMAN ANTIBODIES USING KOSMOTROPIC SALT ENHANCED PROTEIN A AFFINITY CHROMATOGRAPHY - The present invention is directed to methods for purifying a non-human antibody, or antigen binding portion thereof, exhibiting weak binding strength and low binding capacity for Protein A chromatography media. In one aspect, a kosmotropic salt solution is employed to promote the hydrophobic interaction between the non-human antibody, or antigen binding portion thereof, and the Protein A ligand, thereby enhancing the binding of the non-human antibody, or antigen binding portion thereof, to the Protein A chromatography media. In another aspect, the concentration of the non-human antibody, or antigen binding portion thereof, in a sample comprising the antibody, or antigen binding portion thereof, exposed to a Protein A chromatography media is increased to enhance the binding of the non-human antibody, or antigen binding portion thereof, on the Protein A chromatography media. | 06-05-2014 |
20140178332 | IL-12/p40 BINDING PROTEINS - The present invention encompasses IL-12p40 binding proteins, particularly antibodies that bind human interleukin-12 (hIL-12) and/or human IL-23 (hIL-23). Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-12 and/or hIL-23 and neutralize h IL-12 and/or hIL-23 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and/or hIL-23 and for inhibiting hIL-12 and/or hIL-23 activity, e.g., in a human subject suffering from a disorder in which hIL-12 and/or hIL-23 activity is detrimental. | 06-26-2014 |
20140178389 | IL-1 BINDING PROTEINS - The disclosure provides binding proteins that specifically bind to IL-1α and IL-1β. These binding proteins can be organized into DVD-Igs. These proteins can be used to modulate the activity of IL-1α and/or IL-1β and can be used for the treatment immunological diseases such as rheumatoid arthritis, osteoarthritis, psoriasis, multiple sclerosis, and other autoimmune diseases. In addition, their uses in the amelioration and/or treatment of pain in an individual suffering from a disease or disorder associated with IL-1 accumulation. | 06-26-2014 |
Patent application number | Description | Published |
20090124414 | Dual Core Golf Ball having Negative-Hardness-Gradient Thermoplastic Inner Core and Steep Negative-Hardness-Gradient Outer Core Layer - A golf ball comprising a thermoplastic inner core layer that has a geometric center hardness greater than its surface hardness to define a first “negative” hardness gradient. An outer core layer is disposed about the inner core and is formed from a substantially homogenous thermoset composition, typically rubber, and has an inner surface hardness greater than its outer surface hardness to also define a “negative” hardness gradient. An inner cover layer is disposed about the outer core layer and an outer cover layer is disposed about the inner cover layer. The “negative” hardness gradient of the inner core is typically −1 to −5 Shore C and the “negative” hardness gradient of the core layer is typically at least −7 Shore C. The difference between the inner core surface hardness and the outer core inner surface hardness, Δh, should be at least −3 Shore C. | 05-14-2009 |
20090124415 | Dual Core Golf Ball having Negative-Hardness-Gradient Thermoplastic Inner Core and Shallow Negative-Hardness-Gradient Outer Core Layer - A golf ball comprising a thermoplastic inner core layer that has a geometric center hardness greater than its surface hardness to define a first “negative” hardness gradient. An outer core layer is disposed about the inner core and is formed from a substantially homogenous thermoset composition, typically rubber, and has an inner surface hardness greater than its outer surface hardness to also define a “negative” hardness gradient. An inner cover layer is disposed about the outer core layer and an outer cover layer is disposed about the inner cover layer. The “negative” hardness gradient of the inner core is typically −1 to −5 Shore C and the “negative” hardness gradient of the core layer is typically at least −1 Shore C but less than −7 Shore C. The difference between the inner core surface hardness and the outer core inner surface hardness, Δh, should be at least −3 Shore C. | 05-14-2009 |
20090124416 | Dual Core Golf Ball having Negative-Hardness-Gradient Thermoplastic Inner Core and Steep Positive-Hardness-Gradient Thermoset Outer Core Layer - A golf ball comprising a thermoplastic inner core layer that has a geometric center hardness greater than its surface hardness to define a “negative” hardness gradient. An outer core layer is disposed about the inner core and is formed from a substantially homogenous thermoset composition, typically rubber, and has an inner surface hardness substantially less than its outer surface hardness to define a “positive” hardness gradient. An inner cover layer is disposed about the outer core layer and an outer cover layer is disposed about the inner cover layer. The “negative” hardness gradient of the inner core is typically −1 to −5 Shore C and the “positive” hardness gradient of the core layer is typically at least 25 Shore C. The difference between the inner core surface hardness and the outer core inner surface hardness, Δh, should be at least 25 Shore C. | 05-14-2009 |
20090124417 | Dual Core Golf Ball having Negative-Hardness-Gradient Thermoplastic Inner Core and Shallow Positive-Hardness-Gradient Thermoset Outer Core Layer - A golf ball comprising a thermoplastic inner core layer that has a geometric center hardness greater than its surface hardness to define a “negative” hardness gradient. An outer core layer is disposed about the inner core and is formed from a substantially homogenous thermoset composition, typically rubber, and has an inner surface hardness less than its outer surface hardness to define a “positive” hardness gradient. An inner cover layer is disposed about the outer core layer and an outer cover layer is disposed about the inner cover layer. The “negative” hardness gradient of the inner core is typically −1 to −5 Shore C and the “positive” hardness gradient of the core layer is less than 25 Shore C points. The difference between the inner core surface hardness and the outer core inner surface hardness, Δh, should be less than 25 Shore C points. | 05-14-2009 |
20090131203 | Marking of Golf Balls Using Luminescent and Optically-Stimulable Glasses - A golf ball comprising a core; a cover layer; and an additive comprising an optically-stimulable glass powder that is invisible to the naked eye without an external excitation source. | 05-21-2009 |
20110014998 | DUAL CORE GOLF BALL HAVING NEGATIVE-HARDNESS-GRADIENT THERMOPLASTIC INNER CORE AND STEEP POSITIVE-HARDNESS-GRADIENT THERMOSET OUTER CORE LAYER - A golf ball comprising a thermoplastic inner core layer that has a geometric center hardness greater than its surface hardness to define a “negative” hardness gradient. An outer core layer is disposed about the inner core and is formed from a substantially homogenous thermoset composition, typically rubber, and has an inner surface hardness substantially less than its outer surface hardness to define a “positive” hardness gradient. An inner cover layer is disposed about the outer core layer and an outer cover layer is disposed about the inner cover layer. | 01-20-2011 |
20110159996 | DUAL CORE GOLF BALL HAVING NEGATIVE-HARDNESS-GRADIENT THERMOPLASTIC INNER CORE AND SHALLOW POSITIVE-HARDNESS-GRADIENT THERMOSET OUTER CORE LAYER - A golf ball including a thermoplastic inner core and a thermoset outer core layer is described. The inner core has a surface hardness of 43 to about 65 Shore D and a center hardness of about 30 to 43 Shore D that is less than the surface hardness to define a positive hardness gradient. A cover includes an inner and outer cover layer. The thermoplastic inner core is formed from a highly-neutralized ionomer comprising a copolymer of ethylene and an α,β-unsaturated carboxylic acid, an organic acid or salt thereof, and sufficient cation source to fully-neutralize the acid groups of the copolymer by 80% or greater. The outer core layer includes a polybutadiene rubber and has a surface hardness greater than an interior hardness by about 6 to 11 Shore D points to define a shallow positive hardness gradient. | 06-30-2011 |
20110159997 | DUAL CORE GOLF BALL HAVING NEGATIVE-HARDNESS-GRADIENT THERMOPLASTIC INNER CORE AND STEEP POSITIVE-HARDNESS-GRADIENT THERMOSET OUTER CORE LAYER - A golf ball includes an inner core layer formed from a thermoplastic material comprising a highly-neutralized ionomer comprising a copolymer of ethylene and an α,β-unsaturated carboxylic acid, an organic acid or salt thereof, and sufficient cation source to fully-neutralize the acid groups of the copolymer by 80% or greater. The inner core has a geometric center hardness less than its surface hardness to define a positive hardness gradient. An outer core layer is formed over the inner core and is formed from a substantially homogenous thermoset composition. The outer core layer has an interior hardness substantially less than an outer surface hardness to define a steep positive hardness gradient. An inner cover layer and an outer cover layer are formed over the outer core layer. | 06-30-2011 |
20110237351 | DUAL CORE GOLF BALL HAVING NEGATIVE-HARDNESS-GRADIENT THERMOPLASTIC INNER CORE AND SHALLOW POSITIVE-HARDNESS-GRADIENT THERMOSET OUTER CORE LAYER - A golf ball includes an inner core layer formed from a thermoplastic material. The inner core has a hardness at the center that is greater than the hardness at the surface to define a negative hardness gradient. An outer core layer is disposed about the inner core. The outer core has a surface hardness that is greater than the surface hardness of the inner core to define a positive hardness gradient. An inner cover layer and an outer core layer are formed over the outer core layer. The negative hardness gradient of the inner core is about −1 to −5 Shore C, the positive hardness gradient of the outer core layer is less than 25 Shore C, the surface hardness of the outer core layer is about 45 Shore D to about 70 Shore D, and the surface hardness of the inner core is about 20 Shore D to about 60 Shore D. | 09-29-2011 |
20120322583 | DUAL CORE GOLF BALL HAVING NEGATIVE-HARDNESS-GRADIENT THERMOPLASTIC INNER CORE AND SHALLOW POSITIVE-HARDNESS-GRADIENT THERMOSET OUTER CORE LAYER - A golf ball includes an inner core layer formed from a thermoplastic material. The inner core has a center hardness at the center that is greater than the surface hardness at the surface to define a negative hardness gradient. An outer core layer is disposed about the inner core. The outer core has a surface hardness that is greater than the surface hardness of the inner core to define a positive hardness gradient. An inner cover layer and an outer core layer are formed over the outer core layer. The negative hardness gradient of the inner core is about −1 to −5 Shore C, the positive hardness gradient of the outer core layer is less than 25 Shore C, the surface hardness of the outer core layer is about 45 Shore D to about 70 Shore D, and the surface hardness of the inner core is about 20 Shore D to about 60 Shore D. | 12-20-2012 |
20140256471 | DUAL CORE GOLF BALL HAVING NEGATIVE-HARDNESS-GRADIENT THERMOPLASTIC INNER CORE AND SHALLOW POSITIVE-HARDNESS-GRADIENT THERMOSET OUTER CORE LAYER - A golf ball includes a core including a thermoplastic inner core and a thermoset outer core layer. The inner core has a surface hardness of about 40 to 80 Shore C and a center hardness of about 30 to 75 Shore C. The center hardness is less than the surface hardness to define a positive hardness gradient. A cover is formed over the core and includes an inner cover layer and an outer cover layer. The thermoplastic inner core includes a highly-neutralized ionomer formed from a copolymer of ethylene and an α,β-unsaturated carboxylic acid, an organic acid or salt thereof, and sufficient cation source to neutralize the acid groups of the copolymer by 80% or greater. The outer core layer comprises a polybutadiene rubber and has a positive hardness gradient of less than 25 Shore C. | 09-11-2014 |