Kuntz, US
Alan R. Kuntz, Webster, NY US
Patent application number | Description | Published |
---|---|---|
20090304400 | Apparatus and method for mounting an RF monitoring device onto a fuser roll - A replaceable unit monitor assembly includes a substrate member, multiple thermal insulating stand-off members, and a monitor device mounted on the substrate member. The stand-off members mount the substrate member to an end hub of a fuser roll of a printing machine while limiting conductive heat transfer to the monitor device. | 12-10-2009 |
20100221410 | PROCESS FOR COATING FLUOROELASTOMER FUSER MEMBER USING FLUORINATED SURFACTANT - A process for producing a fuser member coating including a) adding and reacting a fluoroelastomer, a crosslinking agent, a polar solvent, and a fluorinated copolymer surfactant to form a coating solution, and b) providing said coating solution on said fuser member to form a fuser member coating, wherein said fluorinated copolymer surfactant comprises a fluorinated acrylate copolymer having pendant fluorinated alkyl groups. | 09-02-2010 |
20100221444 | PROCESS FOR COATING FLUOROELASTOMER FUSER MEMBER USING FLUORINATED SURFACTANT - A process for producing a fuser member coating including a) adding and reacting a fluoroelastomer, a crosslinking agent, a polar solvent, and a fluorinated copolymer surfactant to form a coating solution, and b) providing said coating solution on said fuser member to form a fuser member coating, wherein said fluorinated copolymer surfactant comprises a fluorinated polyether copolymer comprising pendant trifluoroethoxy groups. | 09-02-2010 |
20110097588 | FUNCTIONAL SURFACES COMPRISED OF HYPER NANOCOMPOSITE (HNC) FOR MARKING SUBSYSTEM APPLICATIONS - Provided are hyper nanocomposite, hyper nanocomposite coatings, devices, and articles including s hyper nanocomposite coatings. An article can include a surface including at least one region and a hyper nanocomposite coating disposed over the one region, wherein the hyper nanocomposite coating can include a plurality of nanoparticles substantially uniformly dispersed in one or more cross-linked hyperbranched polymers selected from the group consisting of polycarbosilane, polycarbosilixane, and polycarbosilazene, polyfluorocarbon. | 04-28-2011 |
20110103854 | HYPER NANOCOMPOSITES (HNC) FOR FUSER MATERIALS - Provided are fuser members and printing apparatuses including fuser members. The fuser member can include a substrate and a top coat layer including a hyper nanocomposite disposed over the substrate, wherein the hyper nanocomposite can include a plurality of nanoparticles substantially uniformly dispersed in one or more cross-linked hyperbranched polymers selected from the group consisting of polycarbosilane, polycarbosilixane, polycarbosilazene, and polyfluorocarbon. | 05-05-2011 |
20130084426 | SURFACE COATING AND FUSER MEMBER - The present teachings disclose a coating that includes a inner layer having a first modulus and a first roughness; and a surface layer having a second modulus. The first modulus is greater than the second modulus. When the coating is subjected to a nip pressure the surface of the coating exhibits a surface roughness approximately equal to the first roughness. | 04-04-2013 |
Alan Richard Kuntz, Webster, NY US
Patent application number | Description | Published |
---|---|---|
20090110453 | FUSER MEMBER WITH NANO-SIZED FILLER - A fuser member suited to use in a fusing apparatus of an electrostatographic image rendering device includes a substrate and an outer layer over the substrate. The outer layer includes a matrix material and filler particles dispersed in the matrix material. an outer layer comprising a halopolymer and filler particles. The filler particles have a particle size of less than about 1 micrometer and a particle hardness of greater than about 3 on a Mohs hardness scale and form no more than about 3 percent by volume of the outer layer. The outer layer comprising filler particles nonetheless may provide improved wear of the fuser member. | 04-30-2009 |
20090130462 | FUSER MEMBER WITH INTERMEDIATE ADHESIVE LAYER - In accordance with the disclosure, a fusing member is provided comprising, in order, a base member, a cured liquid silicone rubber substrate layer, an amino silane, and an anhydrous solvent containing adhesive layer. The fusing member further comprises a fluoroelastomer fusing surface topcoat layer including poly (vinylidene fluoride-tetrafluoroethylene-hexafluoropropylene). | 05-21-2009 |
20110281036 | FUSER MEMBER WITH INTERMEDIATE ADHESIVE LAYER - In accordance with the disclosure, a fusing member is provided comprising, in order, a base member, a cured liquid silicone rubber substrate layer, an amino silane, and an anhydrous solvent containing adhesive layer. The fusing member further comprises a fluoroelastomer fusing surface topcoat layer including poly (vinylidene fluoride-tetrafluoroethylene-hexafluoropropylene). | 11-17-2011 |
20120094081 | VARIABLE GLOSS FUSER COATING MATERIAL COMPRISED OF A POLYMER MATRIX WITH THE ADDITION OF ALUMINA NANO FIBERS - Exemplary embodiments provide materials, methods, and systems for a fuser member used in electrophotographic devices and processes, wherein the fuser member can include a coating material containing a plurality of nanoceram fibers dispersed in a polymer matrix for providing a desired gloss level of fused toner images. | 04-19-2012 |
Ashley Lynn Kuntz, Cincinnati, OH US
Patent application number | Description | Published |
---|---|---|
20110189435 | FIBROUS STRUCTURES - Fibrous structures that exhibit a Dry Burst of greater than 100 g and a Cross-Machine Direction Flexural Rigidity (CD Flexural Rigidity) of greater than 56 mg*cm | 08-04-2011 |
20110189436 | FIBROUS STRUCTURES - Fibrous structures that exhibit a Tensile Ratio of greater than 0.5 as measured according to the Tensile Strength Test Method described herein and a Geometric Mean Flexural Rigidity (GM Flexural Rigidity or GM Flex) of less than 195 mg*cm | 08-04-2011 |
20110189442 | FIBROUS STRUCTURES - Fibrous structures that exhibit a Geometric Mean Modulus (GM Modulus) of less than 1070 g/cm as measured according to the Modulus Test Method described herein and a Geometric Mean Elongation (GM Elongation or GM Elong) of less than 15% measured according to the Elongation Test Method described herein are provided. | 08-04-2011 |
20110189443 | FIBROUS STRUCTURES - Fibrous structures that exhibit a Geometric Mean Flexural Rigidity (GM Flexural Rigidity or GMFlex) as measured according to the Flexural Rigidity Test Method described herein to Dry Burst (DB) as measured according to the Dry Burst Test Method described herein ratio (GMFlex/DB ratio) of less than 0.26 and a Density of less than 0.10 g/cm | 08-04-2011 |
20110189451 | FIBROUS STRUCTURES - Fibrous structures that exhibit a Basis Weight of greater than 10 gsm as measured according to the Basis Weight Test Method described herein and/or a Geometric Mean Flexural Rigidity (GM Flexural Rigidity or GM Flex) of less than 57 mg*cm | 08-04-2011 |
20120261537 | MOUNTS FOR CONTAINERS - In one form of the present disclosure, a mount for a container is provided. The container comprises a recessed bottom surface at least partially surrounded by a wall extending therefrom. The wall comprises a projection extending therefrom in a direction transverse to a plane of a side of the wall. The mount comprises a base and a tab extending from the base. The tab is configured to be positioned at least partially intermediate the projection and the recessed bottom surface to retain the mount to the container. | 10-18-2012 |
20130071621 | FIBROUS STRUCTURES - Fibrous structures that exhibit a Geometric Mean Modulus (GM Modulus) of less than 1402.4 g/cm at 15 g/cm as measured according to the Modulus Test Method described herein and a Geometric Mean Elongation (GM Elongation or GM Elong) of less than 10.2% measured according to the Elongation Test Method described herein are provided. | 03-21-2013 |
20130071624 | FIBROUS STRUCTURES - Fibrous structures that exhibit a Tensile Ratio of less than 1.75 and/or less than 1.49 as measured according to the Tensile Strength Test Method described herein and a Geometric Mean Modulus (GM Modulus) of less than 1402.4 g/cm at 15 g/cm and/or a Machine Direction Modulus (MD Modulus) of less than 1253.4 g/cm at 15 g/cm and/or a Cross Machine Direction Modulus (CD Modulus) of less than 1569.2 g/cm at 15 g/cm, are provided. | 03-21-2013 |
20140000826 | FIBROUS STRUCTURES | 01-02-2014 |
20150049920 | METHOD FOR DETERMINING THE CLEANING EFFECTIVENESS OF TOILET PAPER - A method for determining the effective cleaning of bath tissue. The method can include providing at least one pair of worn underwear; optionally, cutting the pair of worn underwear and laying it flat with the inside surface exposed; scanning an image of the exposed, inside surface of the underwear, the image including at least a portion of the underwear likely to have fecal staining; capturing with the image at least one color standard; selecting image points in areas of the scanned image visually appearing clean and areas of the scanned image visually appearing stained with fecal staining; optionally, converting the Red, Green, Blue (RGB) color to L*a*b* color values; utilizing analysis software to characterize other areas of the scanned image corresponding to image points having similar color to the image points selected as clean or stained with fecal staining; classifying the entire image, pixel by pixel, into defined portions of the underwear that are clean or stained with fecal staining; and, calculating areas corresponding to portions of the underwear stained with fecal staining | 02-19-2015 |
Charles Kuntz, Cincinnati, OH US
Patent application number | Description | Published |
---|---|---|
20110106166 | REVISION CONNECTOR FOR SPINAL CONSTRUCTS - A revision connector is configured to couple a new spine fixation rod to a previously implanted spine fixation rod that is secured to a plurality of vertebrae. The new spine fixation rod can be implanted and secured to vertebrae that are caudal and/or cranial with respect to the previously secured vertebrae. | 05-05-2011 |
David J. Kuntz, Salt Lake City, UT US
Patent application number | Description | Published |
---|---|---|
20090159792 | Oral Detection Test for Cannabinoid Use - A method for confirming the active intake of marijuana and its active component Δ | 06-25-2009 |
20110020945 | ORAL DETECTION TEST FOR CANNABINOID USE - A method for confirming the active intake of marijuana and its active component Δ | 01-27-2011 |
David J. Kuntz, Olathe, KS US
David L. Kuntz, Richboro, PA US
Patent application number | Description | Published |
---|---|---|
20150058336 | PERSONALIZED CONTENT RECOMMENDATIONS - Methods, systems and computer program products for providing personalized educational content recommendations are disclosed. A computer-implemented method may include receiving information describing a body of content, receiving data describing an interaction of a user with one or more elements of the body of content, receiving a context that includes one or more criteria associated with the body of content, generating a list of modules from the body of content based on the data describing the interaction of the user with the one or more elements of the body of content in view of the context, and providing the generated list of modules to an interested party. | 02-26-2015 |
Dennis R. Kuntz, West Quincy & Taylor, MO US
Patent application number | Description | Published |
---|---|---|
20130257213 | DC Field Gradient Motor - A field gradient motor with a stator housing and first and second stator disks fixed to the stator housing for turning B-field flux lines 90 degrees toward a motor air gap of the field gradient motor. A shaft is rotatably retained by the housing, and a rotor has a hole and keyway for producing a nonferrous hole through the shaft. A plurality of tangentially magnetized triangular magnets are fixed to the rotor. In operation, the stator housing, the stator disks, the rotor, the permanent magnets, and the shaft cooperate with the coil produce an electromagnetic action of the motor. The stator housing can be an iron ring, and the first and second stator disks and the rotor can be steel. | 10-03-2013 |
20150214793 | DC Field Gradient Motor - A field gradient motor with a stator solenoid coil, a stator solenoid coil retained by a stator solenoid coil housing, a shaft rotatably retained in proximity to the stator solenoid coil, and a rotor retained relative to the shaft. The rotor comprises a plurality of iron disks retained by the shaft, and the stator solenoid coil, the plurality of iron disks, and the shaft cooperate to produce an axial closed toroidal B-field in a surrounding volume of air and an electromagnetic action of the motor. Radial notches with 45 degree equilateral triangular cross sections communicate radially on first and second faces of each disk. Where the notches are 360/N degrees wide, they can be 360/N degrees deep. | 07-30-2015 |
G. Ralph Kuntz, Denville, NJ US
Patent application number | Description | Published |
---|---|---|
20160110502 | Human and Machine Assisted Data Curation for Producing High Quality Data Sets from Medical Records - A method for building a Patient's Data Set from a Patient's Data File to provide robust patient care comprising the steps of obtaining a Patient's Data File, building a training set for machine learning through experts' selection of at least one desired feature from the Patient's Data File to create the Patient's Data Set, developing a data mining algorithm to automate extraction of at least one data feature from at least one other Patient's Data File using the training set, the algorithm automatically generating the Patient's Data Set from at least one other Patient's Data File, supplementing the Patient's Data Set with at least one patient input, and analyzing the Patient's Data Set to confirm patient course of treatment. | 04-21-2016 |
Heather J. Kuntz, Bradford, PA US
Patent application number | Description | Published |
---|---|---|
20160060498 | COMPOSITION COMPRISING SATURATED HYDROCARBON AND METHOD FOR DUST SUPPRESSION - A composition for suppressing dust particles includes from about 51% to about 100% by weight of saturated hydrocarbons, and from about 0 to about 49% by weight of unsaturated hydrocarbons. The composition has a content of wax in the range from about 5% to about 40% by weight of the total composition. A method of making and a method of using such a composition are also provided. | 03-03-2016 |
Jeffrey J. Kuntz, Grand Forks, ND US
Patent application number | Description | Published |
---|---|---|
20130197889 | MANAGEMENT TOOLS FOR QUANTIFICATION AND SIMULATION OF PERFORMANCE AND OUTCOME OF WINTER TRANSPORTATION INFRASTRUCTURE MAINTENANCE ACTIVITIES - An apparatus and system for evaluating winter transportation infrastructure maintenance operations includes a quantification component and a simulation component. Input data representative of collected winter transportation infrastructure maintenance data and observed transportation infrastructure data are modeled in a comprehensive data processing mechanism to measure and carry out effective and efficient winter maintenance planning and operations. | 08-01-2013 |
20130197977 | MANAGEMENT TOOLS FOR QUANTIFICATION OF PERFORMANCE AND OUTCOME OF WINTER TRANSPORTATION INFRASTRUCTURE MAINTENANCE ACTIVITIES - An apparatus and system for evaluating winter transportation infrastructure maintenance operations includes a quantification component and a simulation component. Input data representative of collected winter transportation infrastructure maintenance data and observed transportation infrastructure data are modeled in a comprehensive data processing mechanism to measure and carry out effective and efficient winter maintenance planning and operations. | 08-01-2013 |
20130198088 | MANAGEMENT TOOLS FOR SIMULATION OF PERFORMANCE AND OUTCOME OF WINTER TRANSPORTATION INFRASTRUCTURE MAINTENANCE ACTIVITIES - An apparatus and system for evaluating winter transportation infrastructure maintenance operations includes a quantification component and a simulation component. Input data representative of collected winter transportation infrastructure maintenance data and observed transportation infrastructure data are modeled in a comprehensive data processing mechanism to measure and carry out effective and efficient winter maintenance planning and operations. | 08-01-2013 |
20130346043 | LOCALIZED MOBILE DECISION SUPPORT METHOD AND SYSTEM FOR ANALYZING AND PERFORMING TRANSPORTATION INFRASTRUCTURE MAINTENANCE ACTIVITIES - Support for enabling maintenance decision-making activities within a transportation infrastructure network includes one or more methods, apparatuses and systems for localized assimilation, integration, and processing of both locally-generated and remotely-acquired road condition, treatment, and weather data within a mobile computing environment to improve the information available to manage maintenance decisions and performance. This maintenance decision-making support includes communication components and processing modules that integrate data from multiple external sources to locally simulate conditions on, and generate treatment recommendations for, local roadways and transportation network segments based on user-selected parameters. | 12-26-2013 |
John Charles Kuntz, Pittsburgh, PA US
Patent application number | Description | Published |
---|---|---|
20150074118 | SYSTEMS, METHODS AND COMPUTER-READABLE MEDIA FOR MANAGING AND INCENTIVIZING DATA ENTRY - Systems, methods and computer-readable storage media for managing and incentivizing data entry are described. A data management system may include a plurality of user profiles associated with system users capable of entering data entry records into the data management system. The data entry records may be scored to indicate a correlation between the data entry record and at least one data entry goal, such as timeliness, completeness and/or accuracy. The scores may be used to encourage, motivate or otherwise incentivize system users to enter data entry records that conform to the goals of the data management system. The scores may be ranked and made accessible by system users, for example, so that each user may be compared among his peers. In addition, the scores may be used as part of a reward/penalty system administered, for example, by an operator of the data management system. | 03-12-2015 |
Jonathan Kuntz, Johnsonburg, PA US
Patent application number | Description | Published |
---|---|---|
20120151745 | PLATE JOINT FOR A PARTS FIXTURE MADE OF CARBON FIBER COMPOSITE - A plate joint for joining two plates together includes a first plate and a second plate, with each of the first plate and second plate having a first edge and an opposite and generally parallel second edge. The first plate and second plate are connected together in a generally orthogonal orientation relative to each other with a finger joint defined by a notch in each plate which interlock with each other. The first edge of the first plate and the first edge of the second plate each have a groove therein which axially align with each other in and end-to-end manner. A locking pin is press fitted into the grooves in each of the first plate and the second plate. | 06-21-2012 |
Jonathan F. Kuntz, Venetia, PA US
Patent application number | Description | Published |
---|---|---|
20150218938 | Hard-Mounted EM Telemetry System for MWD Tool in Bottom Hole Assembly - An MWD apparatus has a bottomhole assembly for supporting a tool string and an antenna. The tool string has a sensor and an electromagnetic telemetry device. The tool string affixes in a muleshoe and carrier sub of the assembly using a stinger and fastener. An antenna disposes in an emitter sub of the assembly. The antenna is attached to extend from the tool string so the antenna is in electrical communication with the telemetry device. Finally, the portions of the assembly are connected together, and the antenna is affixed in the uphole portion of the assembly using a conductive landing and one or more fasteners. In this way, the tool string and the antenna are held in tension inside the assembly. The MWD apparatus can be used with an air drilling assembly having an air hammer and a motor coupled downhole of the apparatus. Non-magnetic and regular drill collars can couple uphole of the apparatus, along with a jet sub. | 08-06-2015 |
Judith D. Kuntz, Watertown, MA US
Patent application number | Description | Published |
---|---|---|
20140248240 | PIPERIDINE DERIVATIVES AND COMPOSITIONS FOR THE INHIBITION OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) - The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below: Formula (I) | 09-04-2014 |
Justin Kuntz, Pittsburgh, PA US
Patent application number | Description | Published |
---|---|---|
20090274395 | Container - An inflatable container includes a first body having an inner wall defining at least a portion of a receptacle and an outer wall. The inner wall is attached to the outer wall such that a cavity is defined between the inner wall and the outer wall. A first foam is positioned within the cavity. The first foam is of a type that expands when exposed to air. At least one first valve is attached to the first body. The one or more first valves are in communication with the cavity and are configured to adjust from a closed position to an open position. The at least one first valve permits air to pass through the at least one first valve and into the cavity when in the open position and prevents air from passing through the at least one first valve and into the cavity when in the closed position. | 11-05-2009 |
Kevin Kuntz, Woburn, MA US
Patent application number | Description | Published |
---|---|---|
20110230476 | PI3 KINASE INHIBITORS AND USES THEREOF - The present invention provides compounds, compositions thereof, and methods of using the same. | 09-22-2011 |
Kevin W. Kuntz, Woburn, MA US
Patent application number | Description | Published |
---|---|---|
20120071418 | Inhibitors of Human EZH2 and Methods of Use Thereof - The invention relates to inhibition of wild-type and certain mutant forms of human histone methyltransferase EZH2, the catalytic subunit of the PRC2 complex which catalyzes the mono- through tri-methylation of lysine 27 on histone H3 (H3-K27). In one embodiment the inhibition is selective for the mutant form of the EZH2, such that trimethylation of H3-K27, which is associated with certain cancers, is inhibited. The methods can be used to treat cancers including follicular lymphoma and diffuse large B-cell lymphoma (DLBCL). Also provided are methods for identifying small molecule selective inhibitors of the mutant forms of EZH2 and also methods for determining responsiveness to an EZH2 inhibitor in a subject. | 03-22-2012 |
20120142625 | Substituted Purine And 7-Deazapurine Compounds - The present invention relates to substituted purine and 7-deazapurine compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating disorders in which DOT1-mediated protein methylation plays a part, such as cancer and neurological disorders, by administering these compounds and pharmaceutical compositions to subjects in need thereof. | 06-07-2012 |
20120264734 | Aryl- or Heteroaryl-Substituted Benzene Compounds - The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes. | 10-18-2012 |
20130040906 | Inhibitors of Human EZH2, and Methods of Use Thereof - The invention relates to inhibition of wild-type and certain mutant forms of human histone methyltransferase EZH2, the catalytic subunit of the PRC2 complex which catalyzes the mono- through tri-methylation of lysine 27 on histone H3 (H3-K27). In one embodiment the inhibition is selective for the mutant form of the EZH2, such that trimethylation of H3-K27, which is associated with certain cancers, is inhibited. The methods can be used to treat cancers including follicular lymphoma and diffuse large B-cell lymphoma (DLBCL). Also provided are methods for identifying small molecule selective inhibitors of the mutant forms of EZH2 and also methods for determining responsiveness to an EZH2 inhibitor in a subject. | 02-14-2013 |
20130303555 | Inhibitors of Human EZH2 and Methods of Use Thereof - The invention relates to determining the presence of an EZH2 gene mutation in a sample from a subject and inhibition of wild-type and certain mutant forms of human histone methyltransferase EZH2, the catalytic subunit of the PRC2 complex which catalyzes the mono-through tri-methylation of lysine 27 on histone H3 (H3-K27). In one embodiment the inhibition is selective for the mutant form of the EZH2, such that trimethylation of H3-K27, which is associated with certain cancers, is inhibited. The methods can be used to treat cancers including follicular lymphoma and diffuse large B-cell lymphoma (DLBCL). Also provided are methods for identifying small molecule selective inhibitors of the mutant forms of EZH2 and also methods for determining responsiveness to an EZH2 inhibitor in a subject. | 11-14-2013 |
20130338173 | Carbocycle-Substituted Purine And 7-Deazapurine Compounds - The present invention relates to carbocycle-substituted purine and 7-deazapurine compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating disorders in which DOT1-mediated protein methylation plays a part, such as cancer and neurological disorders, by administering these compounds and pharmaceutical compositions to subjects in need thereof. | 12-19-2013 |
20140051654 | Substituted Purine and 7-Deazapurine Compounds - The present invention relates to substituted purine and 7-deazapurine compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating disorders in which DOT1-mediated protein methylation plays a part, such as cancer and neurological disorders, by administering these compounds and pharmaceutical compositions to subjects in need thereof. | 02-20-2014 |
20150141362 | Inhibitors of Human EZH2, and Methods of Use Thereof - The invention relates to inhibition of wild-type and certain mutant forms of human histone methyltransferase EZH2, the catalytic subunit of the PRC2 complex which catalyzes the mono- through tri-methylation of lysine 27 on histone H3 (H3-K27). In one embodiment the inhibition is selective for the mutant form of the EZH2, such that trimethylation of H3-K27, which is associated with certain cancers, is inhibited. The methods can be used to treat cancers including follicular lymphoma and diffuse large B-cell lymphoma (DLBCL). Also provided are methods for identifying small molecule selective inhibitors of the mutant forms of EZH2 and also methods for determining responsiveness to an EZH2 inhibitor in a subject. | 05-21-2015 |
20150216890 | METHOD OF TREATING LEUKEMIA - The present invention relates to methods of treating disorders in which DOT1L-mediated protein methylation plays a part, such as cancer, by administering DOT1L inhibitor compounds and pharmaceutical compositions to subjects in need thereof. | 08-06-2015 |
20150344427 | 1,4-PYRIDONE COMPOUNDS - The present invention relates to 1,4-pyridone compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes. | 12-03-2015 |
20150344459 | 1,4-PYRIDONE BICYCLIC HETEROARYL COMPOUNDS - The present invention relates to 1,4-pyridone bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes. | 12-03-2015 |
Kevin Wayne Kuntz, Woburn, MA US
Patent application number | Description | Published |
---|---|---|
20130123234 | Aryl- or Heteroaryl-Substituted Benzene Compounds - The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes. | 05-16-2013 |
20130310333 | Modulators of Histone Methyltransferase, and Methods of Use Thereof - Disclosed are compounds, pharmaceutical compositions containing the compounds, and the uses of the compounds and compositions as modulators of histone methyltransferases, and for treating diseases influenced by modulation of histone methyltransferase activity. | 11-21-2013 |
20130310334 | 7-Deazapurine Modulators of Histone Methyltransferase, and Methods of Use Thereof - Disclosed are compounds, pharmaceutical compositions containing the compounds, uses of the compounds and compositions as modulators of histone methyltransferases, and methods for treating diseases influenced by modulation of histone methyltransferase activity. | 11-21-2013 |
20130317026 | SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS - The present invention relates to substituted 6,5-fused bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. | 11-28-2013 |
20140057891 | Substituted 6,5-Fused Bicyclic Heteroaryl Compounds - The present invention relates to substituted 6,5-fused bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. | 02-27-2014 |
20140073597 | 7-Deazapurine Modulators of Histone Methyltransferase, and Methods of Use Thereof - Disclosed are compounds, pharmaceutical compositions containing the compounds, uses of the compounds and compositions as modulators of histone methyltransferases, and methods for treating diseases influenced by modulation of histone methyltransferase activity. | 03-13-2014 |
20140107122 | Substituted Benzene Compounds - The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes. | 04-17-2014 |
20140142083 | Substituted Benzene Compounds - The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes. | 05-22-2014 |
20140275081 | INHIBITORS OF HUMAN EZH2, AND METHODS OF USE THEREOF - The invention relates to inhibition of wild-type and certain mutant forms of human histone methyltransferase EZH2, the catalytic subunit of the PRC2 complex which catalyzes the mono- through tri-methylation of lysine 27 on histone H3 (H3-K27). In one embodiment the inhibition is selective for the mutant form of the EZH2, such that trimethylation of H3-K27, which is associated with certain cancers, is inhibited. The methods can be used to treat cancers including follicular lymphoma and diffuse large B-cell lymphoma (DLBCL). Also provided are methods for identifying small molecule selective inhibitors of the mutant forms of EZH2 and also methods for determining responsiveness to an EZH2 inhibitor in a subject. | 09-18-2014 |
20140288041 | Aryl- or Heteroaryl-Substituted Benzene Compounds - The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes. | 09-25-2014 |
20140288124 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF - Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting arginine methyltransferase activity. Methods of using the compounds for treating arginine methyltransferase-mediated disorders are also described. | 09-25-2014 |
20140288129 | PRMT1 INHIBITORS AND USES THEREOF - Described herein are compounds of Formula (I-a) and (I-b), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT1 activity. Methods of using the compounds for treating PRMT1-mediated disorders are also described. | 09-25-2014 |
20140288141 | PRMT1 INHIBITORS AND USES THEREOF - Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting PRMT1 activity. Methods of using the compounds for treating PRMT1-mediated disorders are also described. | 09-25-2014 |
20140296283 | Substituted 6,5-Fused Bicyclic Heteroaryl Compounds - The present invention relates to azole bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes. | 10-02-2014 |
20140315945 | Substituted Benzene Compounds - The present invention relates to azole compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes. | 10-23-2014 |
20150051163 | COMBINATION THERAPY FOR TREATING CANCER - The present invention relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and one or more other therapeutic agents, particularly anticancer agents such as prednisone, and methods of combination therapy for administering to subjects in need thereof for the treatment of cancer. | 02-19-2015 |
20150065483 | Substituted 6,5-Fused Bicyclic Heteroaryl Compounds - The present invention relates to substituted 6,5-fused bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. | 03-05-2015 |
20150065503 | SALT FORM OF A HUMAN HISTONE METHYLTRANSFERASE EZH2 INHIBITOR - Provided herein is N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4′-(morpholinomethyl)-[1,1′-biphenyl]-3-carboxamide hydrobromide. Also provided herein is a particular polymorph form of this compound. | 03-05-2015 |
20150174136 | SUBSTITUTED BENZENE COMPOUNDS - The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes. | 06-25-2015 |
20150246916 | Substituted 6, 5-Fused Bicyclic Heteroaryl Compounds - The present invention relates to azole bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes. | 09-03-2015 |
20150266854 | Substituted 6,5-Fused Bicyclic Heteroaryl Compounds - The present invention relates to substituted 6,5-fused bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. | 09-24-2015 |
20150284334 | PRMT1 INHIBITORS AND USES THEREOF - Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting PRMT1 activity. Methods of using the compounds for treating PRMT1-mediated disorders are also described. | 10-08-2015 |
20150284370 | SUBSTITUTED BENZENE COMPOUNDS - The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes. | 10-08-2015 |
20150352119 | SUBSTITUTED BENZENE COMPOUNDS - The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes. | 12-10-2015 |
20150353494 | ARYL- OR HETEROARYL-SUBSTITUTED BENZENE COMPOUNDS - The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes. | 12-10-2015 |
20150366893 | SUBSTITUTED PURINE AND 7-DEAZAPURINE COMPOUNDS - The present invention relates to substituted purine and 7-deazapurine compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating disorders in which DOT1-mediated protein methylation plays a part, such as cancer and neurological disorders, by administering these compounds and pharmaceutical compositions to subjects in need thereof. | 12-24-2015 |
20160022693 | ARYL- OR HETEROARYL-SUBSTITUTED BENZENE COMPOUNDS - The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes. | 01-28-2016 |
20160024017 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF - Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting arginine methyltransferase activity. Methods of using the compounds for treating arginine methyltransferase-mediated disorders are also described. | 01-28-2016 |
20160024081 | Substituted 6,5-Fused Bicyclic Heteroaryl Compounds - The present invention relates to azole bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes. | 01-28-2016 |
20160031907 | Substituted Benzene Compounds - The present invention relates to compounds of Formula (I), wherein the variables are as defined herein. Pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof are disclosed. | 02-04-2016 |
20160068559 | Modulators of Histone Methyltransferase, and Methods of Use Thereof - Disclosed are compounds, pharmaceutical compositions containing the compounds, and the uses of the compounds and compositions as modulators of histone methyltransferases, and for treating diseases influenced by modulation of histone methyltransferase activity. | 03-10-2016 |
Kyle Kuntz, Malvern, PA US
Patent application number | Description | Published |
---|---|---|
20130041377 | ARTICULATED CAVITY CREATOR - Disclosed herein are devices for use through a cannula to create cavities within interior body regions. When deployed, the distal end of several such devices extend beyond the distal end of the catheter and can then be selectively curved into a shaped compression surface that, when articulated, creates a void within the interior body. This compression surface may then be withdrawn back into the cannula for removal and to make way for bone cement that, in certain instances, may be introduced through the same cannula. | 02-14-2013 |
20150366566 | ARTICULATED CAVITY CREATOR - Disclosed herein are devices for use through a cannula to create cavities within interior body regions. When deployed, the distal end of several such devices extend beyond the distal end of the catheter and can then be selectively curved into a shaped compression surface that, when articulated, creates a void within the interior body. This compression surface may then be withdrawn back into the cannula for removal and to make way for bone cement that, in certain instances, may be introduced through the same cannula. | 12-24-2015 |
Kyle Kuntz, West Chester, PA US
Patent application number | Description | Published |
---|---|---|
20100131016 | LESS INVASIVE SURGICAL SYSTEM AND METHODS - A system for performing a less invasive surgical procedure and, in particular, devices and methods for spinal fixation. The system comprises dilation tool(s), at least one working/insertion cannula, a plurality of screws, at least one fixation rod for connecting the screws, and a rod inserter. The dilation tool(s) may be used to dilate an incision made in a patient to form an opening. Thereafter, a drill may be used to form holes in the vertebrae. An insertion cannula may be attached to a screw and inserted into the opening. The screws may be polyaxial screws and may be inserted into the vertebrae using a screwdriver. An operator may then move the insertion cannula to manipulate a head portions of the screws such that the head portions may be aligned to receive a fixation rod. A rod inserter may be used to insert a fixation rod into the head portions. After the fixation rod is in place, it may be locked to the screws, thereby fixing the system in place on the spine. | 05-27-2010 |
20100305625 | SURGICAL INSTRUMENT FOR FIXING A CLAMP TO A BONE FIXATION DEVICE - A surgical instrument for moving a clamp relative to a bone anchor to properly position and secure the clamp to the bone anchor. The surgical instrument including a housing, a socket assembly, a manipulating assembly, a gripping assembly and a reduction assembly. | 12-02-2010 |
20140172000 | DEVICE TO AID IN THE DEPLOYMENT OF A SHAPE MEMORY INSTRUMENT - A system is configured to create or enlarge a cavity in a tissue body and generally includes a cannula, a friction reduction covering, and a cavity creation member. The cavity creation member includes an end portion that is configured to transition between a first shape and a second shape that is different from the first shape. In operation, retracting the friction reduction covering relative to end portion causes the end portion to change shape from the first shape to the second shape such that the cavity creation member is configured to create or enlarge a cavity in the tissue body as the second end portion exits the friction reduction member. | 06-19-2014 |
Matthew Kuntz, Wellesley Hills, MA US
Patent application number | Description | Published |
---|---|---|
20140222707 | DISTRIBUTED COMMERCE SYSTEM - A networked system for managing commercial interactions is providing. In some embodiments, the system includes: a bundle-passing interface between a plurality of networked users including distribution logic including a distribution control input responsive to machine-readable information in the bundles; and a statistics collection engine including a control input responsive to machine-readable information in the bundles. | 08-07-2014 |
Matthew Kuntz, Wellesley, MA US
Patent application number | Description | Published |
---|---|---|
20120110053 | ELECTRONIC COMMERCE INFRASTRUCTURE SYSTEM - A networked commercial interaction management method assembles information into bundles that include a data element reference and meta data describing the data element. The method distributes the meta data and the data element reference from the bundles through the network, and distributes copies of the data elements in the bundles from the network node of their respective data owners to the network nodes of accessors using the meta data and the data element reference distributed through the network. In at least one embodiment, the method periodically issues bundle version identifying signals to different nodes of the network. The bundle version identifying signals indicate changes to the data elements to the network nodes of accessors. | 05-03-2012 |
20130138476 | DISTRIBUTED COMMERCE SYSTEM - A networked system for managing commercial interactions is providing. In some embodiments, the system includes: a bundle-passing interface between a plurality of networked users including distribution logic including a distribution control input responsive to machine-readable information in the bundles; and a statistics collection engine including a control input responsive to machine-readable information in the bundles. | 05-30-2013 |
Matthew John Kuntz, Helena, MT US
Patent application number | Description | Published |
---|---|---|
20140213417 | GYROSCOPIC EXERCISE DEVICE - A gyroscopic exercise apparatus combining the principles of simulation and virtual reality for exercising the body and for developing balance training skills in sports such as river boarding, sledding and other sport where it is necessary for the body to be in a prone position on a board while engaged in that sport. The movement of the apparatus on its axis depends and is guided by the pressure exerted by the chest of the user on the upper section of the wobbling support board of the device. The user of the apparatus interacts with the games and video's displayed on a head mount or a computer monitor by pressing the appropriate buttons on the handles on the upper section of the wobbling support board of the device or by kicking their feet against the pressure sensitive foam mats incorporated at the bottom of the lower section of the board. | 07-31-2014 |
Matthew K. Kuntz, Tequesta, FL US
Patent application number | Description | Published |
---|---|---|
20090255941 | BEVERAGE INSULATOR INCLUDING INTEGRATED OPENER - A beverage insulator comprising a top thermally insulating portion for receiving a beverage container therein, a bottom supportive portion attached to the thermally insulating portion, and at least one beverage container opener integrated in the bottom supportive portion, wherein the at least one opener is recessed from a bottom surface of the supportive portion. | 10-15-2009 |
Michael R. Kuntz, Grand Forks, ND US
Patent application number | Description | Published |
---|---|---|
20140190100 | RINK DIVIDER RAISING AND LOWERING SYSTEM - A rink divider raising and lowering system is configured to raise and lower a rink divider utilizing a plurality supports secured to existing trusses that supports a roof of an ice rink. The rink divider system includes a plurality of cables have a first end attached to the rink divider and a second end that engages a hoisting mechanism. Each of the plurality of supports has a pulley attached thereto wherein one of the plurality of cables engages the one of the pulleys such that the rink divider can be moved in a substantially vertical plane from a raised position to a lowered position utilizing the hoisting mechanism. | 07-10-2014 |
Richard Kuntz, Minneapolis, MN US
Patent application number | Description | Published |
---|---|---|
20130024125 | STATISTICAL ANALYSIS OF MEDICAL THERAPY OUTCOMES - A method for evaluating a medical therapy with a computing device comprises accessing a data storage system to obtain baseline characteristics for a population of patients who each receive a medical therapy, accessing baseline characteristics and one or more post-therapy outcomes for a subset of the population, and accessing an association between the baseline characteristics and the post-therapy outcomes in the subset. The method further includes modeling the distribution of the post-therapy outcomes in the population based on the distribution of the post-therapy outcomes in the subset and further based on a comparison of the distribution of the of the baseline characteristics in the subset with the distribution of the baseline characteristics in the population, and storing an indication of the modeled distribution of the post-therapy outcomes in the population of patients on the data storage system. | 01-24-2013 |
20130024207 | USE OF PATIENT-CENTRIC RECORDS TO FACILITATE ANALYSIS OF OUTCOMES OF MEDICAL THERAPIES - Data is received from multiple data sources. The data received from the data sources provides information about patients in a population who have received one or more therapies. Patient-centric records are generated. Each of the patient-centric records stores patient data regarding a different patient in the population. The patient data stored in the patient-centric records is based on the data received from the data sources. | 01-24-2013 |
Richard E. Kuntz, Minneapolis, MN US
Patent application number | Description | Published |
---|---|---|
20130231944 | Evaluation of Medical Therapy Design Assumptions Based on Trial Outcomes - A computing system receives design assumption data prior to a trial of a medical therapy. The design assumption data indicate design assumptions regarding clinical outcomes that are potentially associated with the medical therapy. In addition, the computing system receives trial outcome data that indicate clinical outcomes experienced by participants in the trial of the medical therapy. The computing system generates data that associate the design assumptions with the clinical outcomes experienced by the participants. | 09-05-2013 |
Steven K. Kuntz, Ewing, NJ US
Patent application number | Description | Published |
---|---|---|
20150302470 | EMBEDDABLE CONTENT - Computer readable media, methods, and systems for interactive web advertisements that allow in-place electronic transactions related to an advertisement without disturbing or navigating away from a web page containing the advertisement are described, including a computer system for automatically generating the computer instructions for such advertisements and a computer system for remotely administering such advertisements. | 10-22-2015 |
Susan Kuntz, Rochester, MN US
Patent application number | Description | Published |
---|---|---|
20090215084 | B7-H1 AND B7-H4 IN CANCER - Methods of determining prognosis of a subject with cancer or determining risk of cancer progression by assessing expression of B7-H4, or B7-H1 and B7-H4 in combination. | 08-27-2009 |
20100015642 | B7-H1 AND SURVIVIN IN CANCER - Methods of determining prognosis of a subject with cancer by assessing expression of B7-H1 and survivin in combination. | 01-21-2010 |
20100203035 | B7-H3 IN CANCER - Methods of determining the prognosis of a subject with cancer and determining risk of cancer progression by assessing expression of B7-H3. Methods of reducing B7-H3 levels and/or activity. | 08-12-2010 |
Suzanne D. Kuntz, Ithaca, NY US
Patent application number | Description | Published |
---|---|---|
20130089852 | Methods of Teaching and Learning Using Movement - Methods of teaching and learning use a multi-sensory approach where students physically move as they practice and learn the relationships of words, numbers, or any abstract concept. In some embodiments, methods include physical activity and imagination when practicing. In some embodiments, activity mats allow students to physically move as they learn the relationships of abstract concepts thus using more learning modalities (visual, auditory, motor, and kinesthetic) when practicing. Methods result in enthusiasm for the task of learning and practicing the abstract concept. Enthusiasm for the task leads to greater willingness to practice over and over again, thus leading to competence in learning, often at a younger age than conventionally expected. In some embodiments, the instructions are provided to the student by an automated device. In some embodiments, a GPS device provides the student with instructions associated with a specific display that the student has found. | 04-11-2013 |
Thomas L. Kuntz, Portland, OR US
Patent application number | Description | Published |
---|---|---|
20090073951 | System and Method for Using CDMA PN Offset to Maintain Instrument Timing Reference - A system and method is provided enabling identification of different PN offsets values for CDMA signals without access to a GPS signal, such as when making measurements within indoor environments. When a timing reference, such as that provided by a GPS signal, is lost, the frame boundary timestamp of the CDMA signal itself is used. The parameters of the strongest available PN offset are used. The timing error is determined and the new timing reference timestamp is estimated. The strongest PN is used as the time reference and tau is corrected for. In further embodiments, a user may be able to provide identifying information allowing the estimated timing reference timestamp to be determined even when a GPS signal was never established for providing an initial timing reference. | 03-19-2009 |
20130039406 | TWO STAGE ADAPTIVE EQUALIZER FOR A BATCH RECEIVER - A two stage adaptive filter for use in a batch receiver includes an equalizer filter having as inputs an acquired signal representing a batch of data points and an equalizer filter value. The filtered signal is batch processed to produce reference and data symbols, which symbols are input to a residual filter to generate iteratively over the batch an error value. The error value is convolved with the equalizer filter value to produce a new equalizer filter value for use by the equalizer filter when a next batch of data points is processed. | 02-14-2013 |
20140172339 | AUTOMATIC CENTER FREQUENCY AND SPAN SETTING IN A TEST AND MEASUREMENT INSTRUMENT - A test and measurement instrument having initial display center frequency and span settings and configured to process an input signal is disclosed. The test and measurement instrument includes a processor configured to digitize the input signal and locate a primary peak and determine a primary peak center frequency of the input signal. The processor is configured to adjust the initial display center frequency setting based on the primary peak center frequency. The processor is configured to perform a bandwidth comparison by comparing a bandwidth of the primary peak at a peak bandwidth test level to a peak bandwidth threshold. The processor is configured adjust the initial span setting based on the bandwidth comparison and generate a processed waveform signal using the adjusted display center frequency and span settings. | 06-19-2014 |