Patent application number | Description | Published |
20110187477 | APPARATUS FOR FILTERING AN INPUT SIGNAL - A device is disclosed for filtering an input signal, by splitting the input signal into a plurality of signals. A plurality of first and second filters are arranged to filter one of the plurality of signals. The filtered plurality of signals are combined into a filtered output signal. Each one of the plurality of signals can be filtered by one of the plurality of first filter and one of the plurality of second filters. | 08-04-2011 |
20110215887 | WAVEGUIDE - A waveguide is provided that includes an elongate dielectric inner region, and an electrically conducting outer region spaced apart from the dielectric inner region. The dielectric inner region may be arranged to be flexible, and in some examples may be formed from powdered dielectric contained in a polymer tube or matrix, or in other examples may be formed from a plurality of segments. In some examples of the waveguide, each segment may be formed to have lenticular end faces, and may be formed from sintered BaTi | 09-08-2011 |
20110254641 | MULTI-BAND FILTER - A multi-band filter is disclosed which includes an input manifold; an output manifold; and a plurality of filters connected in parallel between the input manifold and output manifold. The filters have a first section proximal to the input manifold which is matched to the input manifold and a second section proximal to the output manifold which is matched to the output manifold. | 10-20-2011 |
20110256759 | CONNECTOR - A connector includes an outer connection element and an inner connection element. One of the outer connection element and inner connection element includes a plurality of fingers extending at an angle relative to a longitudinal axis of the connector. | 10-20-2011 |
Patent application number | Description | Published |
20080241883 | Recombinant expression vector elements (rEVEs) for enhancing expression of recombinant proteins in host cells - Compositions and methods comprising recombinant expression vector elements (rEVEs) to enhance the level of expression of recombinant proteins are described. Other compositions and methods for lowering, substantially suppressing, or essentially silencing expression of a recombinant protein are also described. | 10-02-2008 |
20110034368 | Multiple Gene Expression Including sORF Constructs and Methods with Polyproteins, Pro-Proteins and Proteolysis - Disclosed are useful constructs and methods for the expression of proteins using primary translation products that are processed within a recombinant host cell. Constructs comprising a single open reading frame (sORF) are described for protein expression including expression of multiple polypeptides. A primary translation product (a pro-protein or a polyprotein) contains polypeptides such as inteins or hedgehog family auto-processing domains, or variants thereof, inserted in frame between multiple protein subunits of interest. The primary product can also contain cleavage sequences such as other proteolytic cleavage or protease recognition sites, or signal peptides which contain recognition sequences for signal peptidases, separating at least two of the multiple protein subunits. The sequences of the inserted auto-processing polypeptides or cleavage sites can be manipulated to enhance the efficiency of expression of the separate multiple protein subunits. Also disclosed are independent aspects of conducting efficient expression, secretion, and/or multimeric assembly of proteins such as immunoglobulins. Where the polyprotein contains immunoglobulin heavy and light chain segments or fragments capable of antigen recognition, in an embodiment a selectable stoichiometric ratio is at least two copies of a light chain segment per heavy chain segment, with the result that the production of properly folded and assembled functional antibody is made. Modified signal peptides, including such from immunoglobulin light chains, are described. | 02-10-2011 |
20110150861 | SORF CONSTRUCTS AND MULTIPLE GENE EXPRESSION - Embodiments of the invention relate to vector constructs and methods for expression of polypeptides including multimeric products such as therapeutic antibodies. Particular constructs allow for the generation of expression products from a single open reading frame (sORF). An embodiment provides an isolated or purified expression vector for generating one or more recombinant protein products comprising a single open reading frame insert; said insert comprising a signal peptide nucleic acid sequence encoding a signal peptide; a first nucleic acid sequence encoding a first polypeptide; a first intervening nucleic acid sequence encoding a first protein cleavage site, wherein said first protein cleavage site is provided by an intein segment of a Ion protease gene of | 06-23-2011 |
20110201053 | Recombinant Expression Vector Elements (REVES) for Enhancing Expression of Recombinant Proteins in Host Cells - Compositions and methods comprising recombinant expression vector elements (rEVEs) to enhance the level of expression of recombinant proteins are described. Other compositions and methods for lowering, substantially suppressing, or essentially silencing expression of a recombinant protein are also described. | 08-18-2011 |
20130243789 | Multiple Gene Expression Including sORF Constructs and Methods with Polyproteins, Pro-Proteins and Proteolysis - Disclosed are useful constructs and methods for the expression of proteins using primary translation products that are processed within a recombinant host cell. Constructs comprising a single open reading frame (sORF) are described for protein expression including expression of multiple polypeptides. A primary translation product (a pro-protein or a polyprotein) contains polypeptides such as inteins or hedgehog family auto-processing domains, or variants thereof, inserted in frame between multiple protein subunits of interest. Also disclosed are independent aspects of conducting efficient expression, secretion, and/or multimeric assembly of proteins such as immunoglobulins. | 09-19-2013 |