| Patent application number | Description | Published |
|---|
| 20080221530 | Injection Device With A GearBox - An injection device for injection of set dose of liquid medicine from a cartridge has a piston rod ( | 09-11-2008 |
| 20080249384 | System and Method for Estimating the Glucose Concentration in Blood - This application relates to glucose monitoring systems for continuously measuring the glucose concentration in a patients blood. The system is adapted to communicate with one or more sensors ( | 10-09-2008 |
| 20080255440 | Method of Forming a Sterilized Sensor Package and a Sterilized Sensor Package - A sensor package is provided comprising an implantable sensor having an electrode area and an electric contact area, the package comprising a shielding packaging enclosing at least the electrode area of the sensor while exposing the electric contact area. The sensor package fascilitates handling of the implantable sensor and provides for the possibility of sterilising the electric contact area leaving the electrode area protected. | 10-16-2008 |
| 20090043264 | Injection Device - An injection device for injection of set doses of medicine from a cartridge has a nut ( | 02-12-2009 |
| 20090048499 | Sensor film for transcutaneous insertion and a method for making the sensor film - There is provided a thin film ( | 02-19-2009 |
| 20110204643 | APPARATUS FOR CONVERTING OCEAN WAVE ENERGY - The purpose of this invention is to present a device for utilisation of the horizontal component of wave motions in which there is no proportionality between the installed power and the initial costs of the device. According to the invention, this is obtained with a device which contains at least one oblong supporting structure and three or more independently movable resistance elements. | 08-25-2011 |
| 20120157932 | INJECTION DEVICE - An injection device for injection of set doses of medicine from a cartridge has a nut that is screwed up along a threaded piston rod during a dose setting operation. The nut is screwed along the piston rod by rotating a dose setting member. A rotational coupling mechanism includes an axially displaceable coupling member which is rotated as a function of axial displacement. During dose setting, the nut is allowed to rotate relative to the coupling member. During injection, the coupling member is rotationally locked to the nut. This provides a dose setting and injection mechanism wherein the nut member is both rotated during dose setting and during injection. | 06-21-2012 |
| 20120266997 | FLEXIBLE PIPE AND A METHOD OF PRODUCING A FLEXIBLE PIPE - The invention relates to a flexible pipe comprising an axis and a tubular innermost sealing sheath surrounding said axis, said innermost sealing sheath being surrounded by at least one outer armoring layer. The innermost sealing sheath has an inner side which is the side of the innermost sealing sheath comprising said axis. On the inner side of said innermost sealing sheath the flexible pipe comprises at least one carcass comprising a plurality of annular armoring members. | 10-25-2012 |
| 20130014849 | FLEXIBLE UNBONDED PIPE AND AN OFFSHORE SYSTEMAANM Glejbol; KristianAACI GlostrupAACO DKAAGP Glejbol; Kristian Glostrup DK - The invention provides a new family of flexible unbonded pipes. The flexible unbonded pipe of the invention comprises an internal sealing sheath, a carcass arranged inside the internal sealing sheath, and around the internal sealing sheath it comprises a first tensile armor layer comprising a plurality of helically wound elongate elements having a winding angle to the center axis of about 45 degrees or less. The flexible unbonded pipe further comprises at least one high pitch outer layer of one or more elongate elements wound with an angle to the center axis of at least about 80 degrees and arranged outside the internal sealing sheath. The weight of the high pitch outer layer in at least a length section (a low pressure armor section) of the flexible unbonded pipe is about half the weight of the carcass in the section or/and the low pressure armor section has a strength relative to the strength of the carcass such that the burst pressure (BP) of the flexible unbonded pipe is about 50% or less than the maximal crushing pressure (CP) of the flexible unbonded pipe determined when the flexible unbonded pipe is lying onshore on a flat horizontal surface and allowed freely to expand/contract as a consequence of an applied pressure during the test. | 01-17-2013 |
| 20130112307 | UNBONDED FLEXIBLE PIPE - The invention relates to a unbonded flexible pipe and a method for manufacturing such pipe. The unbonded flexible pipe has a length and a center axis along its length, and comprises an internal sealing sheath around its center axis, a carcass arranged inside the internal sealing sheath, and at least one armor arranged around the internal sealing sheath. The carcass comprises at least one helically wound elongate carcass reinforcement element providing a plurality of carcass reinforcement element windings along the length of the pipe wherein the carcass reinforcement element windings surround and/or are surrounded by a polymer structure, which polymer structure locks said carcass reinforcement element windings relative to each other. Accordingly the carcass reinforcement element windings need not be directly interlocked with each, but are mainly or totally locked to each other by the polymer structure. | 05-09-2013 |
| 20130112308 | UNBONDED FLEXIBLE PIPE - The invention concerns an unbonded flexible pipe with a length and a center axis along its length. The unbonded flexible pipe comprises an internal sealing sheath surrounding the center axis, and at least two tensile armor layers comprising cross wound elements surrounding the internal sealing sheath. The two tensile armor layers comprise a first tensile armoring layer comprising a plurality of first helically wound, elongate armoring elements, and a second tensile armoring layer comprising a plurality of second helically wound, elongate armoring elements. The first helically wound, elongate armoring elements consist of a first material or a first combination of materials and the second helically wound, elongate armoring elements consist of a second material or a second combination of materials, where the first material or the first combination of materials is different from the second material or the second combination of materials. The unbonded flexible pipe further comprises a galvanic barrier layer between the first and the second tensile armoring layer. | 05-09-2013 |
| 20130340877 | UNBONDED FLEXIBLE PIPE - The invention relates to an unbonded flexible pipe for sub sea transportation of fluids. The pipe has a length and comprises a tubular inner sealing sheath defining a bore and an axis of the pipe. In a pipe length section it comprises a second sealing sheath surrounding the inner sealing sheath and forming an annulus between the inner sealing sheath and the second sealing sheath. The annulus provides a primary maintaining passage along the length of the pipe length section with a first and a second end. The pipe comprises at least one secondary maintaining passage along the length of the pipe with a first and a second end. The secondary maintaining passage is arranged with an axial distance which is larger than the axial distance of the inner sealing sheath. The first end of one of the primary and the secondary maintaining passages is arranged as an input end for a maintaining fluid and the first end of the other of the primary and the secondary maintaining passages is arranged as an outflow end for the maintaining fluid, and the primary and the secondary maintaining passages are in fluidic connection with each other at their second ends to provide a pathway for the maintaining fluid. | 12-26-2013 |
| 20140014218 | FLEXIBLE ARMORED PIPE - The invention relates to a flexible armored pipe for transportation of fluids, comprising an inner sealing sheath and at least one displacement reduced armor layer comprising a plurality of elongate elements comprising at least a female type elongate element comprising at least one recess in each opposite side and a male type elongate element comprising at least one protruding tongue in each opposite side and wherein each of the female type and the male type elongate elements are substantially symmetrical in a symmetry line substantially normal to the inner sealing sheath when the pipe is in a non-bended state and where said protruding tongues of said male type elongate element windings are engaged in said recesses of adjacent female type elongate element windings. | 01-16-2014 |
| 20140076450 | FLEXIBLE UNBONDED PIPE - The invention relates to a flexible unbonded pipe for sub sea fluid transfer. The pipe comprises an inner sealing sheath defining a bore and a centre axis. Inside the inner sealing sheath the pipe comprises a carcass. The pipe further comprises a pair of reinforcement layers consisting essentially of helically wound elongate armoring elements of fiber reinforced polymer material. The elongate armoring elements of the innermost of the pair of reinforcement layers are wound in a first winding direction with an angle α to the centre axis, and the elongate armoring elements of the outermost of the pair of reinforcement layers are wound in a second winding direction with an angle β to the centre axis, wherein α≧βfπ/2, α is about 65° or less. The pipe preferably comprises an anti-creep layer placed between the inner sealing sheath and the innermost of the pair of reinforcement layers. | 03-20-2014 |
| 20140124078 | FLEXIBLE UNBONDED PIPE - The invention relates to an unbonded flexible pipe comprising an internal sealing sheath and at least one armoring layer comprising at least one helically wound fibre containing elongate armoring element, wherein the fibre containing elongate armoring element comprises polymer material, and at least about 10% by weight of basalt fibers. | 05-08-2014 |
| 20140196810 | ARMOURING ELEMENT FOR UNBONDED FLEXIBLE PIPE - The invention relates to an armouring element for an unbonded flexible pipe. The armouring element has a longitudinal axis and an elongated outer shape along said axis. The armouring element further has a longitudinal recess configured for fully or partly taking up a sensor element. The recess has a recess surface area and at least a surface area fixing part of the recess surface area has a surface finish comprising a surface roughness Ra. The invention further relates to an armouring element assembly and an unbonded flexible pipe comprising the armouring element, and a method of producing an armouring element assembly. | 07-17-2014 |
| 20140305532 | UNBONDED FLEXIBLE PIPE - The invention concerns an unbonded flexible pipe for subsea transportation of fluids, the pipe comprises from inside and outwards a carcass, an inner sealing sheath, a pressure armor, and a tensile armor. The pressure armor comprises at least one helically wound elongate and interlocked element in the form of a strip with a cross-sectional profile comprising a planar mid section and a first and a second interlocking edge configured to have an angle to the planar mid section and to protrude in a direction away from the inner sealing sheath to provide a channel between the first and the second interlocking edges, the pressure armor further comprises at least one helically wound elongate and non-interlocked elongate element where windings of the non-interlocked elongate element are placed at least partly in the channel such that displacement with respect to the helically wound elongate and interlocked element is limited by the first and the second interlocking edges. | 10-16-2014 |
| 20150027580 | REINFORCEMENT ELEMENT FOR AN UNBONDED FLEXIBLE PIPE - The invention relates to an elongate reinforcement element for reinforcing an unbonded flexible pipe, a method of producing the elongate reinforcement element and an unbonded flexible pipe comprising the elongate reinforcement element. The reinforcement element comprises a plurality of elongate armor strips and an elongate support element comprising a channel, wherein the plurality of elongate armor strips are arranged in the channel of the elongate support element. Preferably the elongate armor strips are arranged to be superimposed in the channel and the plurality of superimposed elongate armor strips are displaceable in relation to each other upon bending of the elongate reinforcement element. | 01-29-2015 |
| 20150059904 | UNBONDED FLEXIBLE PIPE WITH AN OPTICAL FIBER CONTAINING LAYER - A unbonded flexible pipe with a length and a longitudinal axis is described. The pipe comprises an innermost sealing sheath defining a bore, at least one armor layer surrounding the inner sealing sheath and at least one optical fiber containing layer, wherein the optical fiber containing layer comprises at least one tape and at least one optical fiber arranged with a length of at least about 3 times the length of the flexible pipe. In an embodiment the optical fiber is incorporated into the at least one tape of said optical fiber containing layer to provide an integrated fiber tape where advantageously the optical fiber is arranged with S-shaped folds. | 03-05-2015 |
| 20150060589 | METHOD OF PRODUCING AN UNBONDED FLEXIBLE PIPE AND AN UNBONDED FLEXIBLE PIPE - The invention relates to a method of producing an unbonded flexible pipe and an unbonded flexible pipe. The method comprises providing an innermost sealing sheath defining a bore and a longitudinal axis, and a pressure armor layer surrounding the innermost sealing sheath. The pressure armor layer comprises at least one helically wound elongate armor element with at least one helical armor element gap between windings thereof, and the method comprises providing a foundation layer for the pressure armor layer. The foundation layer is provided with at least one helically shaped groove, and the elongate armor element is applied in the helically shaped groove, preferably such that the foundation layer at least partly fills the helical armor element gap, the foundation layer is preferably a fluid permeable foundation layer. | 03-05-2015 |
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| 20100100047 | MEDICATION DELIVERY DEVICE WITH PRE-SET BOLUS PUMP - The present invention relates to a handheld medication delivery device comprising first and second mutually displaceable housing parts ( | 04-22-2010 |
| 20100137830 | MEDICATION DELIVERY DEVICE COMPRISING A PLURALITY OF RESERVOIRS - The present invention relates to a medication delivery device for delivering a set dose of medicament, the medication delivery device comprising pump means having first and second pump chambers. The first pump chamber is adapted to transfer medicament from a first collapsible reservoir to an outlet arrangement, said outlet arrangement being in fluidic communication with an associated hypodermic needle. The second pump chamber is adapted to transfer substance from a second reservoir to the outlet arrangement, wherein the first pump chamber is adapted to deliver the set dose of medicament during one or more pump strokes, the stroke volume(s) of said one or more pump strokes being variable. | 06-03-2010 |
| 20110034878 | DEVICE FOR INJECTING APPORTIONED DOSES OF LIQUID DRUG - A mechanical injection device ( | 02-10-2011 |
| 20110046565 | DEVICE FOR INJECTING APPORTIONED DOSES OF LIQUID DRUG - A mechanical injection device ( | 02-24-2011 |
| 20110067776 | METHOD OF MANUFACTURING A REINFORCEMENT ELEMENT FOR A FLEXIBLE PIPELINE - For use in the manufacture of reinforcement layers for flexible pipes which are capable of absorbing compressive or tensile forces, and which are used for the transport of oil and gas, a thermoplastic material is applied to a strength-imparting layer. | 03-24-2011 |
| 20110264033 | MEDICAL DEVICE WITH VALUE SENSOR - A RFID comprising a value sensor such as a pressure sensor is integrated with a liquid drug container to enable wireless pressure or other drug relevant parameter value monitoring and code-matching of drug container to a medical delivery device. | 10-27-2011 |
| 20120016315 | NEEDLE MAGAZINE - A needle magazine for holding a plurality of injection needles ( | 01-19-2012 |
| 20120022461 | TILTABLE SAFETY NEEDLE - A shielded needle assembly for a drug delivery device in which a needle cannula ( | 01-26-2012 |
| 20120226235 | METHOD AND ARRANGEMENT FOR REDUCING AIR BUBBLES IN FLUIDIC SYSTEM - The invention provides a fluidic system ( | 09-06-2012 |
| 20120261019 | UNBONDED, FLEXIBLE PIPE - The invention relates to an unbonded, flexible pipe having a length and comprising a tubular inner sealing sheath, at least one metal armor layer and an outer sealing sheath. The unbonded, flexible pipe comprises at least one insulated length section comprising a fluid permeable thermally insulating cover surrounding the outer sealing sheath in the insulated length section. The thermally insulating cover is further surrounded by a liquid permeable jacket, and preferably the thermally insulating cover is liquid permeable. | 10-18-2012 |
| 20120273080 | FLEXIBLE PIPE AND A METHOD OF PRODUCING A FLEXIBLE PIPE - The invention relates to a flexible pipe. Such flexible pipe has a length and comprises a tubular inner sealing sheath surrounding an axis and defining a bore; at least one pressure armor and at least one tensile armor comprising one or more layers. The pressure armor and the tensile armor are non-bonded relative to each other. In the flexible pipe of the invention, the pressure armor comprises a sandwich structure comprising a polymer structure and a first and a second strength imparting layer arranged on either side of said polymer structure and locked or bonded to the polymer structure. | 11-01-2012 |
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| 20130181746 | CONTINUOUS TIME CROSS-CORRELATOR - There is provided a continuous time cross-correlator comprising: a quantizer for quantizing the incoming signal into discrete levels; a delay line comprising one or more delay units separating a plurality of delay line taps; for each of said delay line taps, a comparator for comparing the signal level of the delay line tap with a correlation value; a continuous time counter for taking the outputs of the plurality of comparators as its inputs, counting the results of the comparisons and outputting the results of the comparisons; and an output comparator for comparing the counter output with a threshold value. The cross-correlator provides for high speed continuous time cross-correlation with low power consumption and a small chip area. Methods of continuous time cross correlation are also provided. | 07-18-2013 |
| 20130285728 | PULSE GENERATOR - A pulse generator comprising: an input for receiving a trigger; an output node for outputting a signal; a delay line comprising one or more delay units and a plurality of taps; one or more pull-up devices each connected to the output node for increasing the output voltage on the output node; and/or one or more pull-down devices each connected to the output node for decreasing the output voltage on the output node; wherein the taps of the delay line are operably connected to the pull-up and/or pull-down devices such that a trigger passing along the delay line activates one or more of the pull-up and/or one or more of the pull-down devices more than once. Re-use of the pull-up and/or pull-down devices enables longer and more complex pulse shapes, such as high-order Gaussian pulse shapes to be produced while keeping the number of components low, thus reducing chip area, power requirements and parasitic capacitance. | 10-31-2013 |
| 20130287151 | CONTINUOUS TIME COUNTER - A continuous time counter and method of counting are provided, comprising a sequence of adding stages which build up the output based on the inputs by progressively adding new values to opposite ends of an output stack. The counter provides for fast and reliable continuous time counting operations. | 10-31-2013 |
| 20130293275 | PROGRAMMABLE DELAY UNIT - A tunable delay unit and methods of tuning are provided, comprising a plurality of first delay elements and a plurality of first delay element taps between the first delay elements, wherein the first delay element taps are inputs to a first multiplexer and wherein the output of the first multiplexer is selected from among the inputs according to a first tap select input, further comprising a plurality of second delay elements connected in series to the output of the first multiplexer and a plurality of second delay element taps between the second delay elements, wherein the second delay element taps are inputs to a second multiplexer and wherein the output of the second multiplexer is selected from among the inputs according to a second tap select input, the output of the second multiplexer forming the output of the programmable delay unit. The programmable delay unit provides for highly accurate calibration of timed circuits, in particular delay lines. | 11-07-2013 |
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| 20090289591 | PROGRAMMABLE ROBOT AND USER INTERFACE - The invention relates to a programmable robot system comprising a robot provided with a number of individual arm sections, where adjacent sections are interconnected by a joint, the system furthermore comprising controllable drive means provided in at least some of said joints and a control system for controlling said drive means. The robot system is furthermore provided with user interface means comprising means for programming the robot system, said user interface means being either provided externally to the robot, as an integral part of the robot or as a combination hereof and storage means co-operating with said user interface means and said control system for storing information related to the movement and further operations of the robot and optionally for storing information relating to the surroundings. | 11-26-2009 |
| 20120210817 | Programmable Robot and User Interface - A programmable robot system includes a robot provided with a number of individual arm sections, where adjacent sections are interconnected by a joint. The system furthermore includes a controllable drive mechanism provided in at least some of the joints and a control system for controlling the drive. The robot system is furthermore provided with user a interface mechanism including a mechanism for programming the robot system, the user interface mechanism being either provided externally to the robot, as an integral part of the robot or as a combination hereof, and a storage mechanism co-operating with the user interface mechanism and the control system for storing information related to the movement and further operations of the robot and optionally for storing information relating to the surroundings. | 08-23-2012 |
| 20130255426 | PROGRAMMABLE ROBOT AND USER INTERFACE - A programmable robot system includes a robot provided with a number of individual arm sections, where adjacent sections are interconnected by a joint. The system furthermore includes a controllable drive mechanism provided in at least some of the joints and a control system for controlling the drive. The robot system is furthermore provided with user a interface mechanism including a mechanism for programming the robot system, the user interface mechanism being either provided externally to the robot, as an integral part of the robot or as a combination hereof, and a storage mechanism co-operating with the user interface mechanism and the control system for storing information related to the movement and further operations of the robot and optionally for storing information relating to the surroundings. | 10-03-2013 |
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| 20080305117 | Kir-Binding Agents and Methods of Use Thereof - The present invention relates to agents and methods that are capable of augmenting NK-mediated killing of target cells by reducing inhibitory KIR signalling without reducing the binding of KIR to HLA-C. As described herein, transduction of negative signaling via KIR, 5 upon binding of KIR to its HLA class I ligand, can involve a ligand-binding induced, conformational reorientation of the KIR molecules allowing interactions to form between adjacent KIRs in specific domains, leading to accelerated clustering. Methods and agents such as mono-clonal antibodies for reducing KIR-mediated inhibition of NK cell cytotoxicity without reducing or blocking HLA-binding by, e.g., reducing or blocking dimerization of KIR, are provided. | 12-11-2008 |
| 20080305516 | Method of Producing Antibodies - Methods for producing immunoglobulin molecules or immunologically functional immunoglobulin fragments, the fragments comprising at least functional portions of the variable domains of immunoglobulin heavy and light chains, are described. The methods comprise producing the heavy and the light chains in two separate host cells and refolding the immunoglobulin molecule or fragment ex vivo. | 12-11-2008 |
| 20090075340 | Kir-Binding Agents and Methods of Use Thereof - The present invention relates to agents and methods that are capable of augmenting NK-mediated killing of target cells by reducing inhibitory KIR signalling without reducing the binding of KIR to HLA-C. As described herein, transduction of negative signaling via KIR, upon binding of KIR to its HLA class I ligand, can involve a ligand-binding induced, conformational reorientation of the KIR molecules allowing interactions to form between adjacent KIRs in specific domains, leading to accelerated clustering. Methods and agents such as monoclonal antibodies for reducing KIR-mediated inhibition of NK cell cytotoxicity without reducing or blocking HLA-binding by, e.g., reducing or blocking dimerization of KIR, are provided. | 03-19-2009 |
| 20090081240 | Human Anti-Kir Antibodies - Compositions and methods for regulating an immune response in a subject are described. More particularly, described are human antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties similar to those of human monoclonal antibody 1-7F9 or 1-4F1. Described also are also fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly for use in therapy, to increase NK cell activity or cytotoxicity in subjects. | 03-26-2009 |
| 20090182127 | Production of Bispecific Antibodies - Bispecific antibodies comprising (a) a first light-heavy chain pair having specificity for a first target and a sufficient number of substitutions in its heavy chain constant domain with respect to a corresponding wild-type antibody of the same isotype to significantly reduce the formation of first heavy chain-first heavy chain dimers and (b) a second light-heavy chain pair comprising a heavy chain having a sequence that is complementary to the sequence of the first pair heavy chain sequence with respect to the formation of intramolecular ionic interactions, wherein the first pair or second pair comprises a substitution in the light chain and complementary substitution in the heavy chain that reduces the ability of the light chain to interact with the heavy chain of the other light chain-heavy chain pair are provided. Methods of producing such antibodies in one or more cells also are provided. | 07-16-2009 |
| 20100113747 | Coupling of Antibody Polypeptides at the C-Terminus - The present invention relates to a process for dimerization of antibody fragments, antibody fragment dimers, pharmaceutical compositions comprising antibody fragment dimers as well as their use in medicaments for therapeutic applications. The methods described can advantageously be used for producing bispecific antibodies and/or bispecific fragments thereof. | 05-06-2010 |
| 20120208237 | HUMAN ANTI-KIR ANTIBODIES - Compositions and methods for regulating an immune response in a subject are described. More particularly, described are human antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties similar to those of human monoclonal antibody 1-7F9 or 1-4F1. Described also are also fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly for use in therapy, to increase NK cell activity or cytotoxicity in subjects. | 08-16-2012 |
| 20130004514 | THERAPEUTIC ANTIBODIES - The present invention concerns human antibodies recognising the human C5a receptor. By binding to C5aR the antibodies inhibit C5a signalling, whereby the pro-inflammatory signal is inhibited. Based on the role of C5a and its receptor in stimulation of inflammation the invention further relates to therapeutic use of said human anti-C5aR antibodies and in particular in relation to treatment of immunological disorders. | 01-03-2013 |
| 20130040889 | Factor VIII Fusion Protein - The present invention relates to modified coagulation factors. In particular, the present invention relates to conjugated Factor VIII molecules fused to a polypeptide such as e.g. an antibody binding protein or a Fc domain. | 02-14-2013 |
| 20130143269 | KIR-Binding Agents and Methods of Use Thereof - The present invention relates to agents and methods that are capable of augmenting NK-mediated killing of target cells by reducing inhibitory KIR signalling without reducing the binding of KIR to HLA-C. As described herein, transduction of negative signaling via KIR, upon binding of KIR to its HLA class I ligand, can involve a ligand-binding induced, conformational reorientation of the KIR molecules allowing interactions to form between adjacent KIRs in specific domains, leading to accelerated clustering. Methods and agents such as monoclonal antibodies for reducing KIR-mediated inhibition of NK cell cytotoxicity without reducing or blocking HLA-binding by, e.g., reducing or blocking dimerization of KIR, are provided. | 06-06-2013 |
| 20130295116 | THERAPEUTIC ANTIBODIES - The present invention concerns human antibodies recognising the human C5a receptor. By binding to C5aR the antibodies inhibit C5a signalling, whereby the pro-inflammatory signal is inhibited. Based on the role of C5a and its receptor in stimulation of inflammation the invention further relates to therapeutic use of said human anti-C5aR antibodies and in particular in relation to treatment of immunological disorders. | 11-07-2013 |
| 20130330360 | ANTAGONISTIC DR3 LIGANDS - The present disclosure relates to treatment of inflammatory diseases. In particular, the present disclosure relates to antagonistic DR | 12-12-2013 |
| 20130336984 | ANTAGONISTIC DR3 LIGANDS - The present invention relates to treatment of inflammatory diseases. In particular, the present invention relates to antagonistic DR3 ligands useful for treating inflammatory diseases. | 12-19-2013 |
| 20140294853 | ANTAGONISTIC DR3 LIGANDS - The present invention relates to treatment of inflammatory diseases. In particular, the present invention relates to antagonistic DR3 ligands useful for treating inflammatory diseases. | 10-02-2014 |
| 20150044231 | Therapeutic Antibodies - The present invention concerns human antibodies recognising the human C5a receptor. By binding to C5aR the antibodies inhibit C5a signalling, whereby the pro-inflammatory signal is inhibited. Based on the role of C5a and its receptor in stimulation of inflammation the invention further relates to therapeutic use of said human anti-C5aR antibodies and in particular in relation to treatment of immunological disorders. | 02-12-2015 |
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| 20090246219 | NOVEL SURFACE EXPOSED HAEMOPHILUS INFLUENZAE PROTEIN (PROTEIN E; pE) - The present invention relates to a surface exposed protein (protein E; pE), a virulence factor, which can be detected in | 10-01-2009 |
| 20100062027 | INTERACTION OF MORAXELLA CATARRHALIS WITH EPITHELIAL CELLS, EXTRACELLULAR MATRIX PROTEINS AND THE COMPLEMENT SYSTEM - The present invention relates to surface proteins of | 03-11-2010 |
| 20100098729 | NOVEL SURFACE EXPOSED IMMUNOGLOBULIN D-BINDING PROTEIN FROM FORAXELLA CATARRHALIS - The present invention relates to a surface exposed protein, which can be detected in | 04-22-2010 |
| 20110280910 | NOVEL SURFACE EXPOSED IMMUNOGLOBULIN D-BINDING PROTEIN FROM MORAXELLA CATARRHALIS - The present invention relates to a surface exposed protein, which can be detected in | 11-17-2011 |
| 20120017288 | Anticoagulant Fusion Protein Anchored to Cell Membrane - The invention relates to the inhibition of blood coagulation, especially during organ rejection, and in particular the inhibition of delayed vascular rejection. The invention provides anticoagulant proteins which are anchored to cell membranes. The anticoagulant function is preferably provided by heparin, antithrombin, hirudin, TFPI, tick anticoagulant peptide, or a snake venom factor. These anticoagulant proteins are preferably prevented from being constitutively expressed at the cell surface. In particular, expression at the cell surface is regulated according to cell activation, for instance by targeting the protein to a suitable secretory granule. Expression of these proteins renders cells, tissues and organs less vulnerable to rejection after transplantation (e.g. after xenotransplantation). | 01-19-2012 |
| 20120148614 | Interaction of Moraxella Catarrhalis with Epithelial Cells, Extracellular Matrix Proteins and the Complement System - The present disclosure relates to surface proteins of | 06-14-2012 |
| 20130129763 | INTERACTION OF MORAXELLA CATARRHALIS WITH EPITHELIAL CELLS, EXTRACELLULAR MATRIX PROTEINS AND THE COMPLEMENT SYSTEM - The present disclosure relates to surface proteins of | 05-23-2013 |
| 20140286977 | Protein F - A Novel Haemophilus Influenzae Adhesin with Laminin and Vitronectin binding Properties - A vaccine composition comprising a protein, which can be detected in | 09-25-2014 |
| 20140350220 | NOVEL SURFACE EXPOSED HAEMOPHILUS INFLUENZAE PROTEIN (PROTEIN; pE) - The present invention relates to a surface exposed protein (protein E; pE), a virulence factor, which can be detected in | 11-27-2014 |
| 20150071956 | NOVEL SURFACE EXPOSED HAEMOPHILUS INFLUENZAE PROTEIN (PROTEIN E; pE) - The present invention relates to a surface exposed protein (protein E, pE), a virnlence factor, which can be detected in | 03-12-2015 |
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| 20080241838 | METHODS AND SYSTEMS FOR DETECTING NUCLEIC ACIDS - Methods and kits for detecting a target nucleic acid in a sample are described. In some embodiments, the sample to be analyzed includes a primer which hybridizes to at least a portion of the target nucleic acid, a probe having a first region which hybridizes to at least a portion of the target nucleic acid and a second region having a detectable label, a polymerase which extends the hybridized primer and an enzyme comprising nuclease activity that can cleave the hybridized hybridization probe to thereby release a labeled probe fragment. In some embodiments, the sample can then be contacted with a solid support comprising surface bound capture probes which can hybridize to the labeled probe fragment(s). These capture probes more readily bind to the probe fragment(s) than to the intact hybridization probe. The label can then be detected on the support surface. In this manner, improved discrimination between the probe fragments and the intact hybridization probes can be achieved. | 10-02-2008 |
| 20110014617 | Methods and Systems for Detecting Nucleic Acids - Methods and kits for detecting a target nucleic acid in a sample are described. In some embodiments, the sample to be analyzed includes a primer which hybridizes to at least a portion of the target nucleic acid, a probe having a first region which hybridizes to at least a portion of the target nucleic acid and a second region having a detectable label, a polymerase which extends the hybridized primer and an enzyme comprising nuclease activity that can cleave the hybridized hybridization probe to thereby release a labeled probe fragment. In some embodiments, the sample can then be contacted with a solid support comprising surface bound capture probes which can hybridize to the labeled probe fragment(s). These capture probes more readily bind to the probe fragment(s) than to the intact hybridization probe. The label can then be detected on the support surface. In this manner, improved discrimination between the probe fragments and the intact hybridization probes can be achieved. | 01-20-2011 |
| 20130164748 | Detection of nucleic acid amplification - Methods for detecting a target polynucleotide sequences are provided that utilize a probe having a target-complementary segment and a detectable tag. By cleaving the detectable tab and associating the tag with a tag complement coupled to an electrode, an electrochemical signal can be detected that is related to the presence of the tag:tag complement complex. | 06-27-2013 |
| 20140287945 | SURFACE OXIDATION FOR SEQUESTERING BIOMOLECULES AND RELATED METHODS - Solid supports comprising polymers covalently bound to a solid substrate are provided. The polymers find utility in any number of applications including immobilizing analyte molecules to solid supports for high throughput assays. | 09-25-2014 |
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| 20090191899 | System for Providing Location-Based Services in a Wireless Network, Such as Locating Sets of Desired Locations - A system and associated method receives a command from a user's mobile device to locate points of interest near the mobile device's location. The points of interest are associated with different, user-identified, point of interest categories. Based at least in part on the mobile device's location, the system substantially simultaneously provides a list of points of interest for at least some of the point of interest categories. | 07-30-2009 |
| 20100279711 | System For Providing Location-Based Services In A Wireless Network, Such As Locating Sets Of Desired Locations - A system and associated method receives a command from a user's mobile device to locate points of interest near the mobile device's location. The points of interest are associated with different, user-identified, point of interest categories. Based at least in part on the mobile device's location, the system substantially simultaneously provides a list of points of interest for at least some of the point of interest categories. | 11-04-2010 |
| 20110099153 | METHOD AND APPARATUS FOR GENERATING A POLYMORPHIC NOTE - An approach is provided for generating a polymorphic note. A polymorphic note manager receives a request, from a device, to generate a polymorphic note, wherein the polymorphic note includes information of a plurality of application types that is developed over a period of time. The polymorphic note manager then generates the polymorphic note in response to the request and stores the polymorphic note for access by the device. | 04-28-2011 |
| 20110099189 | METHOD AND APPARATUS FOR EXPLORING CONNECTIONS OF A POLYMORPHIC NOTE - An approach is provided for exploring connections of a polymorphic note. A polymorphic note manager receives a request to display one or more polymorphic notes connected to a selected polymorphic note. In response to the request, the polymorphic note manager determining the one or more connected polymorphic notes and causes, at least in part, actions that result in display of the selected polymorphic note, the one or more connected polymorphic notes, corresponding connections between the selected polymorphic note and the one or more connection polymorphic notes, or a combination thereof. | 04-28-2011 |
| 20110099490 | METHOD AND APPARATUS FOR PRESENTING POLYMORPHIC NOTES IN A GRAPHICAL USER INTERFACE - An approach is provided for presenting polymorphic notes in a graphical user interface. A polymorphic note manager receives a request to display a plurality of polymorphic notes on a graphical user interface of a device. In response to the request, the polymorphic note manager determines an order of the plurality of polymorphic notes according to either an associated date or, if there is no associated date, a creation date corresponding to each of the plurality of polymorphic notes. The polymorphic note manager then causes, at least in part, actions that result in display of the plurality of polymorphic notes in the graphical user interface according to the determined order | 04-28-2011 |
| 20110239158 | METHOD AND APPARATUS FOR PROVIDING SOFT REMINDERS - An approach is provided for presenting soft reminders (e.g., reminders for notes with no triggering criteria). A reminder manager receives an input, from a user, for specifying a note. The note is not associated with triggering criteria. In response to the request, the reminder manager retrieves contextual information from a device associated with the user, and causes, at least in part, presentation of a reminder of the note based, at least in part, on the contextual information. | 09-29-2011 |
| 20120009946 | System For Providing Location-Based Services In A Wireless Network, Such As Locating Sets Of Desired Locations - A system and associated method receives a command from a user's mobile device to locate points of interest near the mobile device's location. The points of interest are associated with different, user-identified, point of interest categories. Based at least in part on the mobile device's location, the system substantially simultaneously provides a list of points of interest for at least some of the point of interest categories. | 01-12-2012 |
| 20130165149 | System For Providing Location-Based Services In A Wireless Network, Such As Locating Sets Of Desired Locations - A system and associated method receives a command from a user's mobile device to locate points of interest near the mobile device's location. The points of interest are associated with different, user-identified, point of interest categories. Based at least in part on the mobile device's location, the system substantially simultaneously provides a list of points of interest for at least some of the point of interest categories. | 06-27-2013 |
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| 20120244246 | INJECTION MOLDING TOOLS WITH MICRO/NANO-METER PATTERN - The present invention relates to methods for embedded a micrometer and/or nanometer pattern into an injection molding tool. In a first main aspect, a micro/nanometer structured imprinting device is applied in, or on, an active surface so as to transfer the micro/nanometer patterned structure to the tool while the imprinting device is, at least partly, within a cavity of the injection molding tool. In a second main aspect, a base plate with a micro/nanometer structured pattern positioned on an upper part is positioned on the active surface within the tool, the lower part of the base plate facing the tool, the active surface receiving the base plate being non-planar on a macroscopic scale. Both aspects enable a simple and effective way of transferring the pattern, and the pattern may be transferred on the active working site of tool immediately prior to molding without the need for extensive preparations or remounting of the tool before performing the molding process. | 09-27-2012 |
| 20120292820 | METHOD AND DEVICE FOR NANOIMPRINT LITHOGRAPHY - The invention relates to an imprinting device for imprinting nano/micro structures. The imprinting device comprises a second expandable cavity constituted in part by a membrane of the stamp. The membrane is flexible and formed in such a way so that when fluid is pumped into the expandable cavity then the membrane expands towards the imprintable substrate and imprints the substrate. The imprinting device is further provided with a force provider, alternatively a first expandable cavity, for forcing a contact part of the substrate to make contact with a matching contact part of the stamp. | 11-22-2012 |
| 20150026952 | METHOD FOR MANUFACTURING A TOOL PART FOR AN INJECTION MOLDING PROCESS, A HOT EMBOSSING PROCESS, A NANO-IMPRINT PROCESS, OR AN EXTRUSION PROCESS - The present invention relates to a method for manufacturing a tool part for an injection molding process, a hot embossing process, nano-imprint process or an extrusion process. First, there is provided a master structure ( | 01-29-2015 |
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| 20100243269 | Well Tools Utilizing Swellable Materials Activated on Demand - A well tool includes a generally tubular mandrel with a flow passage extending longitudinally through the mandrel, and a flow controller which initially prevents a fluid from contacting a swellable material, but which permits the fluid to contact the material in response to manipulation of pressure in the flow passage. Another well tool includes a swellable material, a generally tubular mandrel, and a conduit wrapped circumferentially about the mandrel, the conduit containing a fluid which, upon contact with the swellable material, causes the material to swell. A method of actuating a well tool in a well includes manipulating pressure in a flow passage extending through a tubular string, thereby opening at least one flow control device of the well tool which selectively permits fluid communication between a reservoir of the well tool and a swellable material of the well tool, whereby a fluid in the reservoir contacts the swellable material. | 09-30-2010 |
| 20110315405 | WELL TOOLS UTILIZING SWELLABLE MATERIALS ACTIVATED ON DEMAND - A well tool includes a generally tubular mandrel with a flow passage extending longitudinally through the mandrel, and a flow controller which initially prevents a fluid from contacting a swellable material, but which permits the fluid to contact the material in response to manipulation of pressure in the flow passage. Another well tool includes a swellable material, a generally tubular mandrel, and a conduit wrapped circumferentially about the mandrel, the conduit containing a fluid which, upon contact with the swellable material, causes the material to swell. A method of actuating a well tool in a well includes manipulating pressure in a flow passage extending through a tubular string, thereby opening at least one flow control device of the well tool which selectively permits fluid communication between a reservoir of the well tool and a swellable material of the well tool, whereby a fluid in the reservoir contacts the swellable material. | 12-29-2011 |
| 20120067565 | SWELLABLE PACKER WITH ENHANCED SEALING CAPABILITY - A swellable packer with enhanced sealing capability. A packer assembly includes multiple seal elements, each seal element being swellable downhole, each seal element having at least one face inclined relative to a longitudinal axis of the assembly, and the inclined faces of adjacent seal elements contacting each other. A method of constructing a packer assembly having a desired differential pressure sealing capability includes: providing a base pipe and multiple seal elements, each seal element being swellable in a downhole environment, and each seal element having a predetermined differential pressure sealing capability less than the desired sealing capability; and after the desired sealing capability is determined, installing a selected number of the seal elements on the base pipe, so that the combined predetermined differential pressure sealing capabilities of the installed seal elements is at least as great as the desired sealing capability. | 03-22-2012 |
| 20150075817 | SWELLABLE PACKER WITH ENHANCED ANCHORING AND/OR SEALING CAPABILITY - A swellable packer for use with a subterranean well can include a swellable seal having a circumferentially extending recess formed on a surface of the seal. Another swellable packer can include a swellable seal having a helically extending recess formed in the seal. A method of constructing a swellable packer can include forming a circumferentially extending recess on a surface of a swellable seal. | 03-19-2015 |
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| 20110178022 | MODIFIED PEPTIDES AS POTENT INHIBITORS OF THE PSD-95/NMDA RECEPTOR INTERACTION - The present invention is directed to the provision of small molecule inhibitors of the PSD-95/NMDA receptor interaction, employing an undecapeptide corresponding to the C-terminal of the NMDA as a template for finding lead candidates. A compound (NMDAR/PSD-95 inhibitor) of the invention includes a peptide or peptide analogue comprising at least four peptide bonded residues having the sequence YTXV or YSXV, wherein Y is selected from among E, Q, and A, or an analogue thereof and X is selected from among A, Q, D, N, N-Me-A, N-Me-Q, N-Me-D, and N-Me-N or an analogue thereof, wherein an amino-terminal residue of the peptide is N-alkylated. Alternatively the compound of the invention comprises a first peptide or peptide analogue linked to a second peptide or peptide analogue by a linker, where the first and second peptide or peptide analogue each comprise at least four peptide bonded residues having the sequence YTXV or YSXV, wherein Y is selected from among E, Q, and A, or an analogue thereof, and X is selected from among A, Q, D, N, N-Me-A, N-Me-Q, N-Me-D, and N-Me-N or an analogue thereof. | 07-21-2011 |
| 20140094415 | HIGH-AFFINITY, DIMERIC INHIBITORS OF PSD-95 AS EFFICIENT NEUROPROTECTANTS AGAINST ISCHEMIC BRAIN DAMAGE AND FOR TREATMENT OF PAIN - The invention provides novel potent inhibitors of the ternary protein complex of nNOS, PSD-95, and the NMDA receptor and pharmaceutical compositions comprising the inhibitors for prophylaxis and/or treatment of excitotoxic-related disease and chronic pain conditions in a subject. The inhibitors are dimeric PSD-95 inhibitors comprising a first peptide or peptide analogue linked to a second peptide or peptide analogue by a linker, wherein the first and the second peptide or peptide analogue comprise at least four amide-bonded residues having a sequence YTXV or YSXV, wherein a. Y is selected from among E, Q, and A, or an analogue thereof, and b. X is selected from among A, Q, D, N,N-Me-A, N-Me-Q, N-Me-D, and N-Me-N or an analogue thereof, and wherein a Cell Penetrating Peptide (CPP) is linked to the linker or to an amino acid side chain of the first and second peptide or peptide analogue. The linker can be a PEG or NPEG linker. | 04-03-2014 |
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| 20100258288 | Heat Exchanger - A plate for the use in a heat exchanger cassette, where the plate comprises a corrugated pattern having a plurality of ridges ( | 10-14-2010 |
| 20150030837 | NOVEL BRAZING CONCEPT - The present invention relates to an intermediate product for joining and coating by brazing comprising a base metal and a blend of boron and silicon, said base metal having a solidus temperature above 1040° C., and the intermediate product has at least partly a surface layer of the blend on the base metal, wherein the boron in the blend is selected from a boron source, and the silicon in the blend is selected from a silicon source, and wherein the blend comprises boron and silicon in a ratio of boron to silicon within a range from about 3:100 wt/wt to about 100:3 wt/wt. The present invention relates also to a stacked intermediate product, to an assembled intermediate product, to a method of brazing, to a brazed product, to a use of an intermediate product, to a pre-brazed product, to a blend and to paint. | 01-29-2015 |
| 20150034286 | PLATE HEAT EXCHANGER - Disclosed is a method for producing a permanently joined plate heat exchanger comprising a plurality of metal heat exchanger plates having a solidus temperature above 1100° C., provided beside each other and forming a plate package with first plate interspaces for a first medium and second plate interspaces for a second medium, wherein the first and second plate interspaces are provided in an alternating order in the plate package. Each heat exchanger plate comprises a heat transfer area and an edge area which extend around the heat transfer area. The heat transfer area comprises a corrugation of elevations and depressions, wherein said corrugation of the plates are provided by pressing the plates. Also disclosed is a plate heat exchanger produced by the method. | 02-05-2015 |
| 20150044501 | METHOD FOR JOINING METAL PARTS - A method for joining a first metal part ( | 02-12-2015 |
| 20150060030 | PLATE HEAT EXCHANGER - Disclosed is a method for producing a permanently joined plate heat exchanger comprising a plurality of metal heat exchanger plates having a solidus temperature above 1100° C., provided beside each other and forming a plate package with first plate interspaces for a first medium and second plate interspaces for a second medium, wherein the first and second plate interspaces are provided in an alternating order in the plate package, wherein each heat exchanger plate comprises a heat transfer area and an edge area comprising bent edges which extend around the heat transfer area, wherein a first surface of the plates forms a convex shape and a second surface of the plates forms a concave shape, wherein the heat transfer area comprises a corrugation of elevations and depressions, wherein said corrugation of the plates and the bent edges are provided by pressing the plates. Also disclosed is a plate heat exchanger produced by the method. | 03-05-2015 |
| 20150086776 | NOVEL BRAZING CONCEPT - The present invention relates to a blend of at least one boron source and at least one silicon source, wherein the blend comprises boron and silicon in a weight ratio boron to silicon within a range from about 5:100 to about 2:1, wherein silicon and boron are present in the blend in at least 25 wt %, and wherein the at least one boron source and the at least one silicon source are oxygen free except for inevitable amounts of contaminating oxygen, and wherein the blend is a mechanical blend of powders, and wherein particles in the powders have an average particle size less than 250 μm. The present invention relates further to a composition comprising the blend a substrate applied with the blend, a method for providing a brazed product, and uses. | 03-26-2015 |
