Patent application number | Description | Published |
20090156427 | Bio-Sensing Nanodevice - The invention provides a bio-sensing nanodevice comprising: a stabilized biologically-derived G-protein coupled receptor—the olfactory receptor—on a support, a real time receptor-ligand binding detection method, an odorant delivery system and an odorant recognition program. The biologically-derived G-protein coupled receptor can be stabilized on nanotechnology using surfactant peptide. The said nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized biologically-derived G-protein coupled receptor—the olfactory receptor—immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor. | 06-18-2009 |
20120108041 | Patterning of Nanostructures - A technique for forming nanostructures including a definition of a charge pattern on a substrate and introduction of charged molecular scale sized building blocks (MSSBBs) to a region proximate the charge pattern so that the MSSBBs adhere to the charge pattern to form the feature. | 05-03-2012 |
20130149724 | SYSTEMS, DEVICES AND METHODS FOR MICROFLUIDIC CULTURING, MANIPULATION AND ANALYSIS OF TISSUES AND CELLS - Microfluidic devices for dissociating tissue, culturing, separating, manipulating, and assaying cells and methods for using the device are disclosed. Individual modules for tissue dissociation, cell, protein and particle separation, cell adhesion to functionalized, permissive micro- and nano-substrates, cell culturing, cell manipulation, cell and extracellular component assaying via metabolic and therapeutic compounds, compound titration, cell transfection, and micro-ELISA are described. Specialized micro- and nano-substrates and their methods of fabrication are also described. An integrated device is also disclosed. The devices and methods can be used for diagnostic applications, monitoring of disease progression, analysis of disease recurrence, compound discovery, compound validation, drug efficacy screening, and cell-based assays. | 06-13-2013 |
20140099729 | Methods and Apparatus for Artificial Olfaction - In exemplary implementations of this invention, an electronic olfactor determines whether a scent being tested matches the scent of a positive control. The electronic olfactor can perform this scent matching even in a changing olfactory environment, and even if the positive control scent is a combination of hundreds or thousands of different odorants. No prior training is needed, and no attempt is made to identify a single odorant that is unambiguously responsible for a scent. Instead, a computer compares the total scent pattern of a positive control sample with the total scent pattern of a test sample, across a sweep of many permutations of electrical inputs to scent sensors, to try to find any condition under which the total scent patterns do not match. If such a condition cannot be found, then the computer declares a match between the test and target scents. | 04-10-2014 |
20150064791 | Microfluidic-based Gene Synthesis - A method for synthesizing long DNA constructs from oligonucleotide precursors directly within a microfluidic device uses several oligonucleotides at once. A precursor mix containing at least two oligonucleotide precursors with at least partial base complementarity is introduced into an input of a microfluidic chip and at least one cycle of at least one gene synthesis protocol is applied to fabricate a DNA construct containing the sequence of at least two oligonucleotide precursors. A method for the synthesis of a modified DNA construct includes electroporating at least one oligonucleotide encoding for at least one point mutation and having homology with at least one DNA region of a target cell into the target cell and incorporating the oligonucleotide into the target cell DNA through the action of recombination protein beta or a recombination protein beta functional homolog. | 03-05-2015 |
20150132928 | Patterning of Nanostructures - A technique for forming nanostructures including introducing a plurality of molecular-size scale and/or nanoscale building blocks to a region near a substrate and simultaneously scanning a pattern on the substrate with an energy beam, wherein the energy beam causes a change in at least one physical property of at least a portion of the building blocks, such that a probability of the portion of the building blocks adhering to the pattern scanned by the energy beam is increased, and wherein the building blocks adhere to the pattern to form the structure. The energy beam and at least a portion of the building blocks may interact by electrostatic interaction to form the structure. | 05-14-2015 |
20150362469 | Methods and Apparatus for Artificial Olfaction - In exemplary implementations of this invention, an electronic olfactor determines whether a scent being tested matches the scent of a positive control. The electronic olfactor can perform this scent matching even in a changing olfactory environment, and even if the positive control scent is a combination of hundreds or thousands of different odorants. No prior training is needed, and no attempt is made to identify a single odorant that is unambiguously responsible for a scent. Instead, a computer compares the total scent pattern of a positive control sample with the total scent pattern of a test sample, across a sweep of many permutations of electrical inputs to scent sensors, to try to find any condition under which the total scent patterns do not match. If such a condition cannot be found, then the computer declares a match between the test and target scents. | 12-17-2015 |
20160079060 | Patterning of Nanostructures - A technique for forming nanostructures including introducing a plurality of molecular-size scale and/or nanoscale building blocks to a region near a substrate and simultaneously scanning a pattern on the substrate with an energy beam, wherein the energy beam causes a change in at least one physical property of at least a portion of the building blocks, such that a probability of the portion of the building blocks adhering to the pattern scanned by the energy beam is increased, and wherein the building blocks adhere to the pattern to form the structure. The energy beam and at least a portion of the building blocks may interact by electrostatic interaction to form the structure. | 03-17-2016 |
Patent application number | Description | Published |
20100075384 | Helicase-dependent amplification of circular nucleic acids - A helicase-mediated amplification method for circular DNA templates and target DNA sequences within the templates is provided. The method combines a DNA polymerase and a helicase preparation to amplify a target sequence as well as the entire circular DNA template. | 03-25-2010 |
20110229887 | DETECTION OF NUCLEIC ACID AMPLIFICATION PRODUCTS IN THE PRESENCE OF AN INTERNAL CONTROL SEQUENCE ON AN IMMUNOCHROMATOGRAPHIC STRIP - Compositions and methods useful in nucleic acid assays are provided. The invention permits detection of test and control nucleic acids. Test nucleic acids can be immobilized at multiple locations, such that amplification of either a test nucleic acid or a control nucleic acid provides a captured nucleic acid in a control capture zone. | 09-22-2011 |
20120040359 | Endonuclease-Enhanced Helicase-Dependent Amplification - The invention provides methods and compositions for enhancing the speed and sensitivity of helicase-dependent amplification through the use of an endonuclease. | 02-16-2012 |
20130203057 | STEP-WISE DETECTION OF MULTIPLE TARGET SEQUENCES IN ISOTHERMAL NUCLEIC ACID AMPLIFICATION REACTIONS - Compositions and methods useful in nucleic acid assays are provided. The invention permits detection of multiple target sequences and control nucleic acids using isothermal nucleic acid amplification methods and subsequent detection of amplification products at different temperature steps by at least two probes with different annealing temperatures. This method can be used in isothermal nucleic acid amplification reactions to detect multiple targets of interest. In a particular example, cycling hybridization probes with different spectral and hybridization temperatures are used to detect different target sequences. Probes become fluorescent when they are cleaved by a thermostable ribonuclease, which only acts when the probes are hybridized to their respective templates. | 08-08-2013 |
20140186847 | ENDONUCLEASE-ENHANCED HELICASE-DEPENDENT AMPLIFICATION - The invention provides methods and compositions for enhancing the speed and sensitivity of helicase-dependent amplification through the use of an endonuclease. | 07-03-2014 |
Patent application number | Description | Published |
20100021708 | Large-Area Single- and Few-Layer Graphene on Arbitrary Substrates - A film of single-layer to few-layer graphene is formed by depositing a graphene film via chemical vapor deposition on a surface of a growth substrate. The surface on which the graphene is deposited can be a polycrystalline nickel film, which is deposited by evaporation on a SiO | 01-28-2010 |
20100086604 | ABSORBANT SUPERHYDROPHOBIC MATERIALS, AND METHODS OF PREPARATION AND USE THEREOF - The present invention relates to coated, absorbent, freestanding assemblies comprising inorganic nanowires, articles of manufacture comprising the same, processes of producing the same and methods of use thereof. The assemblies of this invention are useful in various applications, including removal of organics or hydrophobic materials, and waterproofing applications. | 04-08-2010 |
20110135835 | METHOD FOR DEPOSITING A CARBON NANOTUBE THIN FILM COATING ON AN ARBITRARY SUBSTRATE DIRECTLY FROM CHEMICAL VAPOR DEPOSITION SYNTHESIS - A method includes generating an aerosol comprising a plurality of catalyst particles from a precursor solution comprising a carbon source and a catalyst, transmitting the plurality of catalyst particles through a reaction zone extending along a temperature profile including at least one temperature sufficient to induce in each of the plurality of catalyst particles growth of a plurality of carbon nanotubes, and positioning at least one substrate along the temperature profile and at least partially outside of the reaction zone at a position to collect a portion of the plurality of carbon nanotubes on a surface of the at least one substrate. | 06-09-2011 |
20110256386 | Fabrication of Large-Area Hexagonal Boron Nitride Thin Films - A hexagonal boron nitride thin film is grown on a metal surface of a growth substrate and then annealed. The hexagonal boron nitride thin film is coated with a protective support layer and released from the metal surface. The boron nitride thin film together with the protective support layer can then be transferred to any of a variety of arbitrary substrates. | 10-20-2011 |
20120241069 | Direct Synthesis of Patterned Graphene by Deposition - A graphene pattern is fabricated by forming a pattern of passivation material on a growth substrate. The pattern of passivation material defines an inverse pattern of exposed surface on the growth substrate. A carbon-containing gas is supplied to the inverse pattern of the exposed surface of the growth substrate, and patterned graphene is formed from the carbon. The passivation material does not facilitate graphene growth, and the inverse pattern of exposed surface of the growth substrate facilitates graphene growth on the exposed surface of the growth substrate. | 09-27-2012 |
20130202890 | AEROGELS AND METHODS OF MAKING SAME - Provided in one embodiment is a method of making an aerogel, comprising: (A) increasing a concentration of a suspension comprising a gel precursor under a condition that promotes formation of a gel, wherein the gel precursor comprises particulates having an asymmetric geometry; and (B) removing a liquid from the gel to form the aerogel, wherein the aerogel and the gel have substantially the same geometry. An aerogel comprising desirable properties are also provided. | 08-08-2013 |
20130320302 | DEVICES COMPRISING GRAPHENE AND A CONDUCTIVE POLYMER AND RELATED SYSTEMS AND METHODS - The present invention generally relates to devices comprising graphene and a conductive polymer (e.g., poly(3,4-ethylenedioxythiophene) (PEDOT)), and related systems and methods. In some embodiments, the conductive polymer is formed by oxidative chemical vapor deposition. | 12-05-2013 |
20130340533 | STRAIN GAUGE USING TWO-DIMENSIONAL MATERIALS - Strain gauge. The gauge includes a substrate and a thin film of overlapping, two-dimensional flakes deposited on the substrate. Structure responsive to conductance across the film is provided whereby a strain induced change in overlap area between neighboring flakes results in a change in conductance across the film. In a preferred embodiment, the two-dimensional flakes are graphene. | 12-26-2013 |
20140245946 | Synthesis and Transfer of Transition Metal Disulfide Layers on Diverse Surfaces - Aromatic molecules are seeded on a surface of a growth substrate; and a layer (e.g., a monolayer) of a metal dichalcogenide is grown via chemical vapor deposition on the growth substrate surface seeded with aromatic molecules. The seeded aromatic molecules are contacted with a solvent that releases the metal dichalcogenide layer from the growth substrate. The metal dichalcogenide layer can be released with an adhered transfer medium and can be deposited on a target substrate. | 09-04-2014 |
20150064471 | Seed for Metal Dichalcogenide Growth by Chemical Vapor Deposition - A metal dichalcogenide layer is produced on a transfer substrate by seeding F | 03-05-2015 |
20150068974 | IN-SITU AEROGELS AND METHODS OF MAKING SAME - Provided in one embodiment is a method of making an aerogel, comprising: (A) subjecting a suspension or a solution comprising a concentration of at least one chemical reactant to at least one of a hydrothermal and a solvothermal process for at least a reaction time to form an in-situ hydrogel, wherein the hydrogel comprises particulates having an asymmetric geometry, and (B) removing a liquid from the hydrogel to form an aerogel. | 03-12-2015 |
20150311363 | NANOWIRE-MODIFIED GRAPHENE AND METHODS OF MAKING AND USING SAME - A transparent electrode can include a graphene sheet on a substrate, a layer including a conductive polymer disposed over the graphene sheet, and a plurality of semiconducting nanowires, such as ZnO nanowires, disposed over the layer including the conductive polymer. | 10-29-2015 |
Patent application number | Description | Published |
20080243024 | Detection and classification of neuromuscular late wave activity for the assessment of neuromuscular function - A method for the assessment of neuromuscular function by the detection and classification of late wave activity, comprising: (i) pre-processing an ensemble of traces so as to attenuate noise, PFI and baseline disturbances; (ii) identifying time segments of late wave activity in the ensemble of traces; (iii) classifying the time segments of late wave activity into F-wave, A-wave and Repeater segments by exploiting the variable morphology of F-waves across the traces and the fixed morphology of A-waves and Repeater waves across the traces; and (iv) searching the traces in the vicinity of the F-wave trace segments on a trace-by-trace basis so as to identify the F-wave onset latency. | 10-02-2008 |
20090024051 | Estimation of F-wave times of arrival (TOA) for use in the assessment of neuromuscular function - A method and apparatus for the assessment of neuromuscular function by estimating motor unit F-wave component time of arrival (TOA), comprising: (i) determining and comparing F-wave component features so as to accurately identify individual F-wave components; (ii) repeatedly searching the individual F-wave components and extracting additional individual F-wavelets where possible so as to build a complete F-wave TOA profile; and (iii) computing and reporting TOA results for the assessment of neuromuscular function. | 01-22-2009 |
20090299214 | METHOD AND APPARATUS FOR QUANTITATIVE NERVE LOCALIZATION - A method for localizing a needle to a nerve, the method comprising:
| 12-03-2009 |
20100249643 | Apparatus and method for performing nerve conduction studies with localization of evoked responses - An apparatus and method for detecting physiological function, for example, nerve conduction, is described. In one embodiment the apparatus includes a housing including a stimulator shaped to fit a first anatomical site and a detector shaped to fit a second anatomical site. The housing automatically positions the detector substantially adjacent to the second anatomical site when the stimulator is positioned substantially adjacent to the first anatomical site. The detector contains a plurality of individual detection elements, whereby the response evoked by stimulation at the first anatomical site is measured using one or more of these detection elements at the second anatomical location. | 09-30-2010 |
20110071421 | Method for automated detection of A-waves - In one form of the present invention, there is provided a method for detecting an A-wave, the method comprising:
| 03-24-2011 |
20120101358 | APPARATUS AND METHOD FOR THE AUTOMATED MEASUREMENT OF SURAL NERVE CONDUCTION VELOCITY AND AMPLITUDE - Apparatus comprising a housing; stimulation means mounted to the housing; a biosensor releasably mounted to the housing, the biosensor comprising a plurality of electrodes for detecting a sural nerve response evoked by the stimulation means; acquisition means mounted to the housing and electrically connected to the biosensor for acquiring the sural nerve response; processing means mounted to the housing and electrically connected to the acquisition means for digitizing, processing and storing the acquired sural nerve response; calculation means mounted to the housing and electrically connected to the processing means for calculating the conduction velocity and amplitude of the processed sural nerve response; and display means mounted to the housing for displaying the sural nerve conduction velocity and amplitude; wherein the stimulation means and the biosensor are designed to be placed on a patient's anatomy, in the vicinity of a sural nerve, by manipulating the housing. | 04-26-2012 |
20130158627 | APPARATUS AND METHOD FOR RELIEVING PAIN USING TRANSCUTANEOUS ELECTRICAL NERVE STIMULATION - Apparatus for transcutaneous electrical nerve stimulation in humans, comprising a housing; stimulation means mounted within the housing for electrically stimulating nerves; an electrode array releasably mounted to the housing, connectable to the stimulation means, and comprising electrodes for electrical stimulation of nerves; control means mounted to the housing and electrically connected to the stimulation means for controlling the stimulation means; monitoring means mounted to the housing and electrically connected to the stimulation means for monitoring the stimulation means; user interface means mounted to the housing and electrically connected to the control means for controlling the stimulation means; display means mounted to the housing and electrically connected to the control means and the monitoring means for displaying the status of the stimulations means; and a strap attached to the housing and configured to hold the housing, stimulation means and electrode array at a specific anatomical location to treat pain. | 06-20-2013 |
20140296934 | DETECTING CUTANEOUS ELECTRODE PEELING USING ELECTRODE-SKIN IMPEDANCE - Apparatus for transcutaneous electrical nerve stimulation in a user, the apparatus comprising:
| 10-02-2014 |
20140296935 | TRANSCUTANEOUS ELECTRICAL NERVE STIMULATOR WITH USER GESTURE DETECTOR AND ELECTRODE-SKIN CONTACT DETECTOR, WITH TRANSIENT MOTION DETECTOR FOR INCREASING THE ACCURACY OF THE SAME - Apparatus for transcutaneous electrical nerve stimulation in a user, the apparatus comprising:
| 10-02-2014 |
20140309709 | TRANSCUTANEOUS ELECTRICAL NERVE STIMULATOR WITH AUTOMATIC DETECTION OF USER SLEEP-WAKE STATE - Apparatus for transcutaneous electrical nerve stimulation in a user, the apparatus comprising:
| 10-16-2014 |
20150038873 | APPARATUS AND METHOD FOR STIMULATOR ON-SKIN SHORT DETECTION - A device for measuring sural nerve conduction velocity and amplitude, the device comprising:
| 02-05-2015 |
20150148865 | APPARATUS AND METHOD FOR RELIEVING PAIN USING TRANSCUTANEOUS ELECTRICAL NERVE STIMULATION - Apparatus for transcutaneous electrical nerve stimulation in humans, the apparatus comprising:
| 05-28-2015 |
20150306387 | MEASURING THE "ON-SKIN" TIME OF A TRANSCUTANEOUS ELECTRICAL NERVE STIMULATOR (TENS) DEVICE IN ORDER TO MINIMIZE SKIN IRRITATION DUE TO EXCESSIVE UNINTERRUPTED WEARING OF THE SAME - Apparatus for providing transcutaneous electrical nerve stimulation (TENS) therapy to a user, the apparatus comprising: a stimulation unit for electrically stimulating at least one nerve of the user; an electrode array connectable to the stimulation unit, the electrode array comprising a plurality of electrodes for electrical stimulation of the at least one nerve of the user; a monitoring unit electrically connected to the stimulation unit for monitoring the on-skin status of the electrode array; an analysis unit for analyzing the on-skin status of the electrode array to determine the effective on-skin time of the electrode array; and a feedback unit for alerting the user when the analysis unit determine that the effective on-skin time exceeds a threshold. | 10-29-2015 |
20160120425 | APPARATUS AND METHOD FOR THE AUTOMATED MEASUREMENT OF SURAL NERVE CONDUCTION VELOCITY AND AMPLITUDE - Apparatus for measuring sural nerve conduction velocity and amplitude, the apparatus comprising:
| 05-05-2016 |