Patent application number | Description | Published |
20100004207 | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto - The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation. | 01-07-2010 |
20110117073 | Protein Kinase Conjugates and Inhibitors - The invention relates to protein conjugates that contain a protein kinase containg a cysteine residue in the ATP binding site and an inhibitor that is covalently and irreversibly bonded to said cysteine residue, such that the activity of the protein kinase is irreversibly inhibited. The invention also relates to compounds that irreversibly inhibit protein kinases. | 05-19-2011 |
20110257207 | RAF INHIBITORS - The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are inhibitors or kinases such as Raf, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer. | 10-20-2011 |
20130217688 | HETEROARYL COMPOUNDS AND USES THEREOF - The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same. | 08-22-2013 |
20150328223 | HETEROARYL COMPOUNDS AND USES THEREOF - The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same. | 11-19-2015 |
Patent application number | Description | Published |
20100178304 | METHOD FOR SILK FIBROIN GELATION USING SONICATION - This invention provides for a process of rapidly forming silk fibroin gelation through ultrasonication. Under the appropriate conditions, gelation can be controlled to occur within two hours after the ultrasonication treatment. Biological materials, including viable cells, or therapeutic agents can be encapsulated in the hydrogels formed from the process and be used as delivery vehicles. | 07-15-2010 |
20130060008 | METHOD FOR SILK FIBROIN GELATION USING SONICATION - This invention provides for a process of rapidly forming silk fibroin gelation through ultrasonication. Under the appropriate conditions, gelation can be controlled to occur within two hours after the ultrasonication treatment. Biological materials, including viable cells, or therapeutic agents can be encapsulated in the hydrogels formed from the process and be used as delivery vehicles. | 03-07-2013 |
20140303346 | METHOD FOR SILK FIBROIN GELATION USING SONICATION - This invention provides for a process of rapidly forming silk fibroin gelation through ultrasonication. Under the appropriate conditions, gelation can be controlled to occur within two hours after the ultrasonication treatment. Biological materials, including viable cells, or therapeutic agents can be encapsulated in the hydrogels formed from the process and be used as delivery vehicles. | 10-09-2014 |
20150258199 | METHOD FOR SILK FIBROIN GELATION USING SONICATION - This invention provides for a process of rapidly forming silk fibroin gelation through ultrasonication. Under the appropriate conditions, gelation can be controlled to occur within two hours after the ultrasonication treatment. Biological materials, including viable cells, or therapeutic agents can be encapsulated in the hydrogels formed from the process and be used as delivery vehicles. | 09-17-2015 |
Patent application number | Description | Published |
20150183841 | HIGH MOLECULAR WEIGHT SILK FIBROIN AND USES THEREOF - Provided herein relates to high molecular weight silk-based materials, compositions comprising the same, and processes of preparing the same. The silk-based materials produced from high molecular weight silk can be used in various applications ranging from biomedical applications such as tissue engineering scaffolds to construction applications. In some embodiments, the high molecular weight silk can be used to produce high strength silk-based materials. In some embodiments, the high molecular weight silk can be used to produce silk-based materials that are mechanically strong with tunable degradation properties. | 07-02-2015 |
20160046679 | LOW MOLECULAR WEIGHT SILK COMPOSITIONS AND STABILIZING SILK COMPOSITIONS - The present disclosure provides certain silk-fibroin compositions with particular characteristics and/or properties. In some embodiments, the disclosure provides low molecular weight compositions. In some embodiments, the disclosure provides silk fibroin compositions that comprise an active (e.g., a biological) agent or component. In some embodiments, the disclosure provides low molecular weight silk fibroin compositions that comprise an active (e.g., a biological) agent or component. In some embodiments, an active agent is stabilized in a silk composition, e.g., for a period of time and/or against certain conditions or events. In some embodiments, a component present in a silk fibroin composition may be subject to analysis and/or characterization. In some embodiments, a component present in a silk fibroin composition may be recovered from the composition. | 02-18-2016 |
Patent application number | Description | Published |
20090108160 | Storage rack assembly - A wall-mounted storage rack assembly facilitates storage of articles such as bicycles, lawn care implements, tools, and the like by providing a pair of independently pivotally movable support arms, which are pivotally supported on an associated mounting bracket. The support arms are independently movable about respective pivot axes arranged in intersecting, angular relationship to each other, whereby in a lowered position of the support arms, they are arranged in a generally V-shaped, diverging orientation, while in a raised position of the support arms, they are positioned more closely together in a relatively compact configuration. By this compact configuration, efficient storage, shipment, and display for retail sales of the storage rack assembly is promoted. | 04-30-2009 |
20090199481 | Door mounting system for interior doors - A door-mounting system facilitates mounting of one or more closed doors in a fashion which facilitates substantially full-access to the closet. The mounting system includes upper and lower mounting plates which each define first and second guide tracks, with upper and lower pairs of guide members, operatively connecting the associated door to the guide tracks, mounting the door for generally arcuate movement with respect to the door opening. The system includes an arrangement by which the guide members can be selectively positioned to selectively vary the degree to which the door projects through and into the associated closet of the like, thus facilitating use of the present system in those applications which may include a relatively shallow closet or like enclosure. The present door mounting system includes an arrangement of one or more trim members which can be optionally employed to cover any gap between a side edge of the door and an associated side frame by facilitating fitment of one or more doors to door openings of varying widths. | 08-13-2009 |
20100258692 | Shelf support bracket and wall standard - A shelf support system is provided for supporting one or more shelves at selected elevations on a vertical surface. The system includes at least one standard having a rear wall, a first mounting wall extending from the rear wall, and a second mounting wall extending from the rear wall. The first and second mounting walls define between them a channel open to the front of the standard. At least one of the first and second walls defines notches which are not visible from the front of the standard, and the notches are adapted to receive a retention member on a bracket or shelf support which can be disposed within the channel of the standard. The shelf support can be tilted to an orientation that permits it be moved up or down within the standard to a different position, or to be removed from the standard altogether, or to be reinserted into the standard. | 10-14-2010 |
20120006957 | SHELF SUPPORT BRACKET AND WALL STANDARD - A standard and shelf support are provided for supporting one or more shelves at selected elevations from a vertical surface. The standard has a rear wall, and first and second mounting walls being spaced apart and extending from the rear wall. The first and second mounting walls define a channel that is open to the front of the standard. At least one of the first and second mounting walls defines a plurality of spaced apart notches which are not visible from the front of the standard, and the notches are adapted to receive a retention member on a shelf support. | 01-12-2012 |
Patent application number | Description | Published |
20110056201 | METHOD AND APPARATUS FOR CONTROLLING MOISTURE SEPARATOR REHEATERS - A system and a method are provided that may be used to control the temperature of steam being reheated by a moisture separator reheater (MSR). The temperature of a steam being reheated by a MSR may be sensed, and controller embodiments may use the sensed temperature to control the transfer of heat from various MSR components into the reheated steam. By using such control embodiments, the MSR may provide optimally heated steam to other power plant components, thus increasing the performance, efficiency, and safety of a power plant. | 03-10-2011 |
20120151918 | METHOD FOR OPERATING A TURBOMACHINE DURING A LOADING PROCESS - A method for increasing the operational flexibility of a turbomachine is provided. The turbomachine may include a first section, a second section, and a rotor disposed within the first section and the second section. The method may determine an allowable range of a physical parameter associated with the first section and/or the second section. The method may modulate a first valve and/or a second valve to allow steam flow into the first section and the second section respectively, wherein the modulation is based on the allowable range of the physical parameter. In addition, the physical parameter allows the method to independently apportion steam flow between the first section and the second section of the turbomachine, during the loading process. | 06-21-2012 |
20120151921 | METHOD FOR STARTING A TURBOMACHINE - A method for increasing the operational flexibility of a turbomachine during a startup phase is provided. The turbomachine may include a first section, a second section, and a rotor disposed within the first section and the second section. The method may determine an allowable range of a physical parameter associated with the first section and/or the second section. The method may modulate a first valve and/or a second valve to allow steam flow into the first section and the second section respectively, wherein the modulation is based on the allowable range of the physical parameter. In addition, the physical parameter allows the method to independently apportion steam flow between the first section and the second section of the turbomachine, during the startup phase. | 06-21-2012 |
20120151925 | METHOD AND SYSTEM FOR CONTROLLING A VALVE OF A TURBOMACHINE - A method and a system for limiting steam flow entering a steam turbine are provided. The method and system may intentionally unbalance the steam flow apportioned between sections of the steam turbine. The steam turbine comprises at least: a first section, a second section, and a rotor disposed within each section. The method may receive a speed/load command, or the like, which provides reference strokes for a first valve, associated with the first section; and a second valve, associated with the second section. The method may also determine an operational parameter that may limit the reference strokes relative to the speed/load command. The operational parameter may determine the allowable steam flow for each section of steam turbine, independent of the speed/load command. | 06-21-2012 |
20120156004 | METHOD FOR SHUTTING DOWN A TURBOMACHINE - A method for increasing the operational flexibility of a turbomachine during a shutdown phase is provided. The turbomachine may include a first section, a second section, and a rotor disposed within the first section and the second section. The method may determine an allowable range of a physical parameter associated with the first section and/or the second section. The method may modulate a first valve and/or a second valve to allow steam flow into the first section and the second section respectively, wherein the modulation is based on the allowable range of the physical parameter. In addition, the physical parameter allows the method to independently apportion steam flow between the first section and the second section of the turbomachine, during the shutdown phase. | 06-21-2012 |
20120249090 | SYSTEM AND METHOD FOR CONTROLLING A TEMPERATURE OF A GENERATOR - According to one aspect of the invention, a system for controlling a temperature of a generator is provided, wherein the system includes a fluid supply in fluid communication with the generator and a heat exchange apparatus in fluid communication with the fluid supply, the generator and a cooling fluid source. The system also includes a first sensor configured to determine a first temperature of a fluid flowing from the heat exchange apparatus to the generator, a second sensor configured to determine a second temperature of the fluid flowing from the generator to the fluid supply and a controller configured to determine an operating limit temperature for the fluid based on the determined first and second temperatures. | 10-04-2012 |
20130333386 | METHOD AND APPARATUS FOR CONTROLLING MOISTURE SEPARATOR REHEATER - A system and a method are provided that may be used to control the temperature of steam being reheated by a moisture separator reheater (MSR). One embodiment provides a system including a steam turbine, a moisture separator reheater coupled to the steam turbine, and a controller programmed to control a temperature of steam leaving the moisture separator reheater based at least in part on sensor feedback. The controller is programmed to facilitate substantially smooth linear temperature ramping. | 12-19-2013 |