Kloxin
April M. Kloxin, Newark, DE US
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20140031285 | PHOTODEGRADABLE GROUPS FOR TUNABLE POLYMERIC MATERIALS - Here, we present a photodegradable microparticle system that can be employed to entrap and deliver bioactive proteins to cells during culture. By using a photosensitive delivery system, experimenters can achieve a wide variety of spatiotemporally regulated release profiles with a single microparticle formulation, thereby enabling one to probe many questions as to how protein presentation can be manipulated to regulate cell function. Photodegradable microparticles were synthesized via inverse suspension polymerization with a mean diameter of 22 μm, and degradation was demonstrated upon exposure to several irradiation conditions. The protein-loaded depots were incorporated into cell cultures and release of bioactive protein was quantified during the photodegradation process. This phototriggered release allowed for the delivery of TGF-β1 to stimulate PE25 cells and for the delivery of fluorescently labeled Annexin V to assay apoptotic 3T3 fibroblasts during culture. By incorporating these photoresponsive protein delivery depots into cell culture, new types of experiments are now possible to test hypotheses about how individual or multiple soluble factors might affect cell function when presented in a uniform, temporally varying, or gradient manner. | 01-30-2014 |
Christopher Kloxin, Boulder, CO US
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20120160828 | Radio Frequency Magnetic Field Responsive Polymer Composites - The invention includes a composite material comprising magnetic field responsive particles distributed in a reversibly crosslinked polymer, wherein the reversibly crosslinked polymer includes thermally reversible bonds. In one embodiment, exposing the composite material to an electromagnetic field allows for crack-healing, remolding and/or bonding of the material. | 06-28-2012 |
Christopher Kloxin, Newark, DE US
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20120202917 | Stress Relief for Crosslinked Polymers - The invention provides methods for inducing reversible chain cleavage of polymer chains in a crosslinked polymeric material or during polymerization of a polymeric material. Reversible cleavage of the polymer backbone is capable of relieving stress in the polymeric material as the bonds reform in a less stressed state. The invention also provides mixtures for making crosslinked polymeric materials, methods for making polymeric materials capable of reversible chain cleavage, materials made by the methods of the invention, and linear monomers containing reversible chain cleavage groups which are useful in the materials and methods of the invention. The mixtures of the invention may be dental restorative compositions used for forming dental restorative materials. | 08-09-2012 |
Christopher J. Kloxin, Newark, DE US
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20120295227 | DISULFIDE MONOMERS COMPRISING ETHYLENICALLY UNSATURATED NORBORNYL GROUPS SUITABLE FOR DENTAL COMPOSITIONS - Dental compositions and disulfide monomers described. The disulfide monomer comprises a disulfide backbone group wherein each of the sulfur atoms are bonded to a group terminating with an ethylenically unsaturated norbornyl group; and at least one other monomer comprising at least two ethylenically unsaturated groups. | 11-22-2012 |
20120295228 | DISULFIDE MONOMERS COMPRISING ETHYLENICALLY UNSATURATED GROUPS SUITABLE FOR DENTAL COMPOSITIONS - Dental compositions and disulfide monomers are described. The disulfide monomer comprise a disulfide backbone group wherein each of the sulfur atoms are bonded to an ethylenically unsaturated group via a divalent linking group and the linking group comprises at least one heteroatom; and at least one other monomer ethylenically unsaturated monomer. | 11-22-2012 |
20130244179 | Novel Thermoreversible Network Scaffolds and Methods of Preparing Same - The invention includes a novel light-activated polymerizable composition, wherein reversible crosslinks may be converted into irreversible crosslinks using a fully controllable physical and/or chemical process. The invention further includes methods of photofixing a light sensitive material or patterning an article comprising a light sensitive material. | 09-19-2013 |
20150057187 | Click Nucleic Acids - Click nucleic acid monomers and polymers containing such monomers are disclosed. The click nucleic acid monomers include an optionally protected thiol moiety, an optionally protected thiol-click acceptor moiety, and an optionally protected nucleobase (NB), which in some examples is an A, G, T, U, or C nucleobase. In some examples, the click nucleic acid monomer includes a N-vinyl thiol acetamide (VTA) backbone. In other examples the click nucleic acid monomer includes a N-vinyl thiol ethylamine (VTE) backbone. Methods of using such polymers, for example in place of naturally occurring nucleic acid polymer applications, such as DNA or RNA, and synthetic nucleic acid polymer applications, such as PNA or morpholino nucleic acids, are also disclosed. | 02-26-2015 |
Christopher J. Kloxin, Boulder, CO US
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20130323642 | Photoinduced Alkyne-Azide Click Reactions - The present invention includes a composition comprising an alkyne-based substrate, an azide-based substrate, a Cu(II) salt and a photoinducible reducing agent. The present invention further includes a method of immobilizing a chemical structure in a given pattern onto a section of the surface of a solid substrate, using the photoinducible Cu(I)-catalyzed azide-alkyne cycloaddition Click reaction. | 12-05-2013 |