Patent application number | Description | Published |
20090221811 | PROCESS FOR PREPARING GEMCITABINE AND ASSOCIATED INTERMEDIATES - The present invention provides processes for preparing intermediates useful in the preparation of gemcitabine and other nucleosides, and processes for preparing gemcitabine therewith. Exemplary intermediates include mixtures of D-erythro and D-threo isomers of 3-(hydroxy)-2,2-difluoro-3-(2,2-dimethyldioxolan-4-yl)-propionic acid salts. Also provided is a process for selectively isolating the D-erythro and D-threo isomers of D-erythro and D-threo isomers of 3-(hydroxy)-2,2-difluoro-3-(2,2-dimethyldioxolan-4-yl)-propionic acid salts, and processes for using such isomers in the preparation of nucleoside analogs such as, e.g., gemcitabine, intermediates thereof, and analogs thereof. | 09-03-2009 |
20100168431 | NOVEL ISOQUINOLINIUM COMPOUNDS USEFUL IN THE PREPARATION OF CISATRACURIUM AND ASSOCIATED INTERMEDIATES - The present invention provides novel isoquinolinium compounds, methods of producing the isoquinolinium compounds, and methods for converting them into cisatracurium, e.g., cisatracurium besylate. The isoquinolinium compounds of the present invention can be obtained in the form of solids, which can be purified using simple techniques and can be used to afford pure cisatracurium besylate without HPLC purification | 07-01-2010 |
20100184988 | PROCESS FOR PRODUCING CISATRACURIUM COMPOUNDS AND ASSOCIATED INTERMEDIATES - The present invention provides processes for producing isoquinolinium compounds, and for converting them into cisatracurium salts, e.g., cisatracurium besylate | 07-22-2010 |
20110185796 | CISATRACURIUM DERIVATIVES, PREPARATION AND USES THEREOF - The present invention provides compounds which are useful, e.g., as reference markers for analyzing the purity of cisatracurium and salts thereof, a test method for determining the said purity and processes for preparing reference markers. | 08-04-2011 |
20130041154 | PROCESS FOR PRODUCING CISATRACURIUM AND ASSOCIATED INTERMEDIATES - The present invention provides a process of producing cisatracurium compounds, e.g., cisatracurium besylate, from isoquinolinium salts of the structural formula (VIIA) wherein X | 02-14-2013 |
Patent application number | Description | Published |
20080279822 | Crystalline Polymorphs of a CXC-Chemokine Receptor Ligand - The present invention relates to four distinct crystalline polymorphs of a monohydrate of Compound A having the following chemical structure: | 11-13-2008 |
20090093496 | PREPARATION OF PHARMACEUTICAL SALTS OF PIPERAZINE COMPOUNDS - The present invention is generally directed to a process to directly prepare pharmaceutically acceptable salts enriched with respect to selected rotameric salts of a basic compound, by creative choice of an acid and a solvent medium. The process is particularly useful in preparing specific rotamers of pharmaceutically useful salts in desired preponderance of a rotamer. | 04-09-2009 |
20140356430 | PHARMACEUTICAL COMPOSITIONS OF 7-(6-(2-HYDROXYPROPAN-2-YL)PYRIDIN-3-YL)-1-((TRANS)-4-METHOXYCYCLOHEXYL)-- 3,4-DIHYDROPYRAZINO [2,3-B]PYRAZIN-2(1H)-ONE, A SOLID FORM THEREOF AND METHODS OF THEIR USE - Provided herein are compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, solid forms, isotopologues and metabolites thereof, and methods of their use for the treatment of a disease, disorder, or condition. | 12-04-2014 |
20150299208 | SOLID FORMS COMPRISING 7-(6-(2-HYDROXYPROPAN-2-YL)PYRIDIN-3-YL)-1-((TRANS)-4-METHOXYCYCLOHEXYL)-- 3,4-DIHYDROPYRAZINO[2,3-b]PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF - Provided herein are formulations, processes, solid forms and methods of use relating to 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one. | 10-22-2015 |
Patent application number | Description | Published |
20080197909 | Capacitative Proximity Switch, and Domestic Appliance Equipped With the Same - A capacitive proximity switch has an electrically conductive sensor surface, which is covered by an electrically non-conductive covering plate and which serves as a part of a capacitor with a capacitance that varies with proximity. A household appliance is equipped with a proximity switch of this type. The sensor surface has an active shielding, which is formed by a shielding surface to which a clock signal is applied at the same time as it is applied to the sensor surface. | 08-21-2008 |
20080224758 | Capacitive Proximity Switch, and Domestic Appliance Comprising the Same - A capacitive proximity switch includes an electrically conductive sensor area, which is covered by an electrically-insulating cover plate, as part of a capacitor having a capacitance which varies as a result of proximity. An associated evaluation circuit is provided, and an electrically-conducting body, via which the sensor area is connected to the evaluation circuit and which is arranged between the electrically-insulating cover plate and a mount disposed at a distance therefrom. A domestic appliance includes such a proximity switch. At least one electronic component of the evaluation circuit is arranged on the mount such that it protrudes into a cavity, which is surrounded by the electrically conductive body. | 09-18-2008 |
20080238444 | Capacitive Proximity Switch and Domestic Appliance Equipped Therewith - A capacitive proximity switch has an electrically conductive sensor surface, which is covered by an electrically non-conductive covering plate and which serves as a part of a capacitor having a capacitance that varies with proximity. The sensor surface is connected to a control input of a semiconductor switch that has a signal input with a clock signal and a signal output. A household appliance is equipped with the capacitive proximity switch. The signal output of the semiconductor switch has an output signal, which follows the clock signal and which has signal portions that are proportional to the capacitance of the capacitor formed with the sensor surface. | 10-02-2008 |
20080246494 | Capacitive Proximity Switch and Household Appliance Equipped Therewith - A capacitive proximity switch has an electrically conductive sensor surface, which is covered by an electrically non-conductive covering plate and which serves as a part of a capacitor with a capacitance that varies with proximity. The proximity switch includes a reference sensor surface for generating a reference signal for determining an actuation state of the proximity switch. Signal portions of the reference signal are proportional to the capacitance of a reference capacitor formed with the reference sensor surface, and the capacitance of the reference capacitor is determined by surrounding conditions of the sensor surface. | 10-09-2008 |