Kiselev
Alexander Kiselev, Rochester Hills, MI US
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20110074179 | Composite Liftgate System - The present invention is a thermoplastic composite liftgate system with reinforcements in key areas to allow the system to meet performance requirements, while lowering the tooling investment, lowering the system mass, and improving the styling flexibility. The present invention includes an inner panel and at least one bracket or reinforcement member connected to the inner panel such that when a force is applied to the bracket, the force is distributed to the inner panel. | 03-31-2011 |
Anton Vladimirovich Kiselev, St. Petersburg RU
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20160116150 | LED LAMP - An LED lamp includes a base, the transition insulating element connected therewith which is made of dielectric plastic with the cavity inside. The power supply is located on a PCT with the heat-conducting metal base and attached on the radiator. The radiator is made as rod-shaped section profile having side faces pointed at different directions, on which the LED modules are placed, as well as ribs extending therefrom. The radiator is within the diffuser made of plastic. The radiator has longitudinally oriented ribs located on a portion of radiator height and extending from the surface of the radiator between faces for formation of heat removal surfaces. The diffuser has a cap made as longitudinally oriented segmented shells, each located in front of LED modules of one face and covers them, isolating these LED modules from the ones on the adjacent face. Longitudinally oriented ribs are located between segmented shells. | 04-28-2016 |
Denis Kiselev, Geneve CH
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20130301047 | MEASUREMENT DEVICE AND METHOD FOR DETECTION OF AIRBORNE PARTICLES - A measurement device and method for the detection of airborne particles. The device includes a nozzle designed to produce a laminar flow of air with a flow path beyond the nozzle, a first laser and a second laser being positioned for emitting time-amplitude modulated laser light with intersecting laser beams with a laser beam intersection region in a region of the air flow path, and two photodetectors positioned for the detection of laser light scattered in the laser beam intersection region by airborne particles contained in the laminar air flow. The lasers are designed for emission of time-amplitude modulated laser light of identical laser emission wavelength, and the photodetectors are positioned and designed each for the detection of scattered laser light from both lasers. | 11-14-2013 |
Dmitriy K. Kiselev, Tucson, AZ US
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20120265487 | Method and Apparatus of Analyzing Sample Surface Data - An improved apparatus and method for the analysis of surface data collected using a sub-micron scale metrology instrument which provides a persistent user experience by allocating set portions of the display to major functional regions thereby allowing a quick to learn and easy to user interface for the setup, analysis, and display of microscopic 3D surface data measurements and resulting analytic data with a variety of 3D surface scanners. | 10-18-2012 |
Evgeny A. Kiselev, West Lafayette, IN US
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20130143878 | SUBSTITUTED DIBENZONAPHTHYRIDINES, PHARMACEUTICAL USES THEREOF AND PROCESSES THERFOR - The invention described herein pertains to substituted dibenzonaphthyridine compounds, pharmaceutical compositions, and formulations comprising the dibenzonaphthyridine compounds, their synthesis, and methods for their use in the treatment and/or prevention of cancer. | 06-06-2013 |
20140018360 | AZAINDENOISOQUINOLINE TOPOISOMERASE I INHIBITORS - The invention described herein pertains to substituted azaindenoisoquinoline compounds, in particular 7-, 8-, 9-, and 10-azaindenoisoquinoline compounds, which are inhibitors of topoisomerase I, processes and intermediates for their syntheses, pharmaceutical compositions of the compounds, and methods of using them in the treatment of cancer. | 01-16-2014 |
20140187547 | AZAINDENOISOQUINOLINE TOPOISOMERASE I INHIBITORS - The invention described herein pertains to substituted azaindenoisoquinoline compounds, in particular 7-, 8-, 9-, and 10-azaindenoisoquinoline compounds, which are inhibitors of topoisomerase I, processes and intermediates for their syntheses, pharmaceutical compositions of the compounds, and methods of using them in the treatment of cancer. | 07-03-2014 |
Fedor L'Vovich Kiselev, Moscow RU
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20130109861 | TELOMERASE INHIBITORS AND A METHOD FOR THE PREPARATION THEREOF | 05-02-2013 |
Igor Alekseevich Kiselev, Moscow RU
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20160060510 | POLYMER PROPPANT WITH INCREASED THERMAL RESISTANCE AND METHOD FOR PRODUCING SAME - The increased thermal strength polymer proppant and method for producing the same relate to the oil and gas production technology using materials of high-molecular compounds, especially to proppants of polymer materials with high requirements for the physical and mechanical characteristics, utilized as propping granules in the oil and gas production by a method of hydraulic fracturing. The proppant is made of a metathesis-radically cross-linked mixture of oligocyclopentadienes and methylcarboxy norbornene esters. The proppant represents microspheres having a roundness and sphericity of at least 0.9 for no less than 80% by weight, whose average size being in the range 0.25-1.1 mm and a bulk density being in the range of 0.5-0.7 g/cm | 03-03-2016 |
20160075938 | POLYMER PROPPANT MATERIAL AND METHOD FOR PRODUCING SAME - A polymer material for proppant in the form of a metathesis-radically cross-linked mixture of oligocyclopentadienes and methylcarboxy norbornene esters is obtained by mixing dicyclopentadiene with methacrylic esters and polymer stabilizers, heating the mixture to a temperature of 150-220° C., holding at said temperature for 15-360 minutes, and then cooling down to 20-50° C. A radical initiator and a catalyst are added successively to the resultant mixture of oligocyclopentadienes and methylcarboxy norbornene esters. The polymer matrix is heated to a temperature of 50-340° C., is held at this temperature for 1-360 minutes and then is cooled to room temperature. A technical result achieved by implementation of the present invention is an increase in thermal strength of the proppant material, providing a compressive strength of at least 150 MPa at a temperature of not less than 100° C. | 03-17-2016 |
Iouri Kiselev, Richmond Hill CA
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20100079489 | SYSTEM AND METHOD FOR EFFICIENT DIGITAL VIDEO COMPOSITION - An efficient method of compositing planes onto a target surface using a computing device with graphics processing capability is disclosed. The method includes partitioning the target surface, on which planes are composited, into partitions. Each one of the partitions contains connected pixels to be formed by compositing an identical subset of the planes to be composited. Each partition is associated with a corresponding subset of the planes. Each partition and its corresponding set of associated planes are then provided to a graphics processor for composition, using exemplary software components including an application programming interface, a library and device driver software. An image is formed on the target surface by compositing each partition. Using the disclosed method, a single pass through stages of the graphics pipeline for the graphics processor is sufficient to composite multiple planes to form an image on the target surface. | 04-01-2010 |
Ivan K. Kiselev, Deerfiled, IL US
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20130332193 | TECHNIQUES FOR MANAGIGN PATIENT CONSENT - A method includes displaying a first page and obtaining patient insurance eligibility data. Patient consent information is requested and received from the HIE. A second page is displayed and updated consent information is obtained. The updated consent information is transmitted to the HIE. | 12-12-2013 |
Maxim Kiselev, Broadlands, VA US
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20120108858 | METHOD AND DEVICE FOR MANUFACTURING OF RADIOPHARMACEUTICALS - The invention relates to a device for processing radioisotopes and production of radiopharmaceuticals, for example, 18F-2 Deoxy-2-Fluoro-D-Glucose (FDG), for Positron Emission Tomography (PET). Use of a tilting and rotating reactor with optimized geometry allows for decreased processing time and increased efficiency. Reagent vials are separated from the reactor module and placed in a separate enclosure allowing safe reloading of the system and production of multiple batches with minimal operator exposure to radiation. Reagent vials enclosure is protected from the environment and filled with purified air to reduce risk of contamination. Product and reagents pathways are sealed from the environment and are sterilized. | 05-03-2012 |
20130266105 | Device For Producing Radioisotopes - The invention relates to a device ( | 10-10-2013 |
Maxim Kiselev, Sterling, VA US
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20120305789 | METHOD AND DEVICE FOR QUALITY CONTROL OF RADIOPHARMACEUTICALS - A method and a device are provided for evaluating quality of radiopharmaceutical preparations. | 12-06-2012 |
Oleg Kiselev, Palo Alto, CA US
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20080320261 | Coordinated Storage Management Operations In Replication Environment - A method, system, computer system, and computer-readable medium for maintaining up-to-date, consistent copies of primary data without the need to replicate modified data when the data were modified as a result of an operation that is not an application-driven write operation captured during replication. Selected storage management operations are performed on the primary and secondary data stores at points in time when the data are the same to ensure that the data stored within the data stores remain consistent. These selected storage management operations include operations that produce modified data stored in the primary data store, where a portion of the modified data are not replicated to a secondary node. Other types of storage management operations are selected to be performed on both the primary and secondary data stores, where the operations do not directly change data in the primary data store, but may affect data stored in the primary data store. | 12-25-2008 |
20090006494 | Resource Management for Scalable File System Recovery - A system and method for storing data. In one embodiment, a file system stores data including associated metadata. In response to detecting that a file system error has occurred, the file system identifies a container including data in which the error occurred and performs a consistency check of the data included in the container. If a bidirectional link exists between the container and another container and if an error is found in the bidirectional link, the file system performs a consistency check of data included in the other container and determines if another bidirectional link exists between the other container and a third container. If another bidirectional link exists between the other container and a third container and if an error is found in the other bidirectional link, the file system performs a consistency check of data included in the third container. | 01-01-2009 |
20090089612 | SYSTEM AND METHOD OF REDUNDANTLY STORING AND RETRIEVING DATA WITH COOPERATING STORAGE DEVICES - A system and method for data storage in an array. A system includes a client coupled to a storage subsystem. The storage subsystem comprises data storage locations addressable as rows and columns in an array. Each column comprises a separate storage device. Each row includes redundant data. For a given row, a coordinating storage device receives data from the client, coordinates computation and storage of redundant data, and forwards data to other storage devices. In response to receiving data targeted for storage in a given storage location, a non-volatile, temporary storage device that is associated with the separate storage device that includes the given storage location buffers the received data. The coordinating storage device conveys a write completion message to the client in response to detecting that the data has been buffered in the non-volatile, temporary storage devices. At least two storage devices are coordinating storage devices in separate rows. | 04-02-2009 |
20150074168 | DECENTRALIZED DISTRIBUTED COMPUTING SYSTEM - A distributed system includes a plurality of nodes connected over a network. Each node has a unique node identifier which identifies the node in the distributed system. Tasks are launched from any node in the distributed system and include one or more node identifiers. If a node receives a task including its node identifier, the node executes the task. Each node may store each task in a log. If a node fails, after recovering from the failure, the node queries the distributed system for tasks which were not received and tasks which were not completed due to the failure. | 03-12-2015 |
20150088882 | LOCATING FILE DATA FROM A MAPPING FILE - In some examples, a distributed system may include a plurality of nodes with a file stored in a file system across the plurality of nodes. One of the nodes may receive a request for location data corresponding to a part of the file. For instance, the location data may be included in a mapping file, and the request may specify an offset of the mapping file. The mapping file may include locations of nodes storing parts of the file in the file system across the plurality of nodes, and the mapping file may have a plurality of parts corresponding to the parts of the file. In response to the request, the node may access the mapping file and send location data corresponding to the offset of the mapping file. The location data may indicate at least one of the nodes storing the part of the file. | 03-26-2015 |
20150089504 | CONFIGURING A VIRTUAL MACHINE - In some examples, a node in a distributed system may receive one or more IP addresses for use with one or more virtual machines. For example, at least one of the received IP addresses may be encoded into a respective MAC address. Further, a hypervisor implemented on the node may configure a virtual machine on the node. For instance, configuring the virtual machine may include passing the encoded MAC address to the virtual machine through the hypervisor. The virtual machine may be configured to decode the IP address from the encoded MAC address, and the IP address is assigned to the virtual machine. | 03-26-2015 |
20150121131 | INDEPENDENT DATA INTEGRITY AND REDUNDANCY RECOVERY IN A STORAGE SYSTEM - A storage system includes a plurality of nodes connected to a network. Each node is capable of performing its own recovery of partially written data and maintaining consistency of the data stored on the storage system. The nodes may independently calculate the location of the data across the nodes and independently balance the data, maintain consistency based on a redundancy policy of the storage system, and migrate data according to a location change. If a node determines that the stored data thereon is incomplete or damaged, the node may reconstruct its respective data from replica data on other nodes. During migration of data between the nodes, I/O processing from a host is not interrupted in some examples. | 04-30-2015 |
20150143066 | DATA CONFIGURATION AND MIGRATION IN A CLUSTER SYSTEM - A cluster system includes a plurality of computing nodes connected to a network. Each node is configured to access its own storage device, and to send and receive input/output (I/O) operations associated with its own storage device. Further, each node of the plurality of nodes may be configured to have a function of acting as a first node, which sends a first message to other nodes of the plurality of nodes. The first message may include configuration information indicative of a data placement of data on the plurality of nodes in the cluster system according to an event. Following receipt of the first message from the first node, each of the other nodes may be configured to determine, based at least in part on the configuration information, whether data stored on its own storage device is affected by the event. | 05-21-2015 |
20150149423 | DATA REDUNDANCY IN A CLUSTER SYSTEM - A cluster system includes a plurality of computing nodes connected to a network, each node including one or more storage devices. The cluster system stores data and at least one of data replicas or erasure-coded segments across the plurality of nodes based on a redundancy policy. Further, configuration information, which may be indicative of a data placement of the data and the data replicas or erasure-coded segments on the plurality of nodes, is provided to each of the plurality of nodes. Additionally, each of the nodes may act as a first node which is configured to determine, upon a change of the redundancy policy, updated configuration information based on the change of the redundancy policy and to send a message including information indicating the change of the redundancy policy to the other nodes of the plurality of nodes. | 05-28-2015 |
Oleg Kiselev, St. Petersburg RU
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20120164175 | NOVEL INFLUENZA VIRUS - The present invention provides a novel influenza virus wherein both the NS and the PB1 gene segments are modified and wherein the PB1-F2 open reading frame is modified by introduction of at least one stop codon. Specifically, the influenza virus is lacking functional NS1 and PB1-F2 proteins. | 06-28-2012 |
Oleg Ivanovich Kiselev, Saint-Petersburg RU
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20150374814 | Polyvalent Fusion Protein Vaccine Against Influenza - The problem to be solved: absence of safe efficient universal vaccine against influenza. The solution: The vaccine based on the fusion protein consisting of antigenic determinants of haemagglutinins of influenza A and B viruses and flagellin fragments functioning as safe adjuvant (SEQ ID NO:1) joined via flexible hinges is given which can be used for prophylaxis of influenza caused by existing influenza A and B strains as well as by possible reassortants. Safety, efficacy, polyvalence and preventive effect have been demonstrated. Usage of the present vaccine will allow to provide a universal protection against influenza. | 12-31-2015 |
Oleg Ivanovich Kiselev, St. Petersburg RU
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20150299257 | BIOACTIVE PEPTIDE COMPLEXES - The present invention refers to proteins and bioactive peptides with immunomodulating and antiviral activity. Present peptide complexes have three-dimensional structure and are described by the following structural formula (SEQ ID NO: 23): | 10-22-2015 |
Oleg Mikhailovich Kiselev, Essen DE
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20090272115 | Method of Utilization of Gas Expansion Energy and Utilization Power Installation for Implementation of this Method - A method and installation are provided for reduction of natural gas from high pressure, such as in a borehole or in a main pipeline down to the pressure valve required for the consumer. | 11-05-2009 |
20160034568 | Computer-Based Method of Processing of Machine-Readable Information - The invention relates to processing of machine-readable data. The invention can be used for processing of data specially intended for a wide range of specific functions. The invention can be used in computers, for composing of computer programs, as well as for building systems of processing of information. Particular cases of using the invention include information search, processing of information in databases, data selection and its statistics. The invention can be used for receiving a visualized representation of data being processed, including data in the form of electronic documents. A computer-based method of processing of machine-readable data comprises: calling for a set of electronic documents; defining a search query; matching of search attributes to a search query; determining of matching of search attributes of electronic documents to specified search queries; attributing of electronic documents relevant to specified search queries to corresponding subject subsets of electronic documents. | 02-04-2016 |
Roman Kiselev, Daejeon Metropolitan City KR
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20100012930 | ORGANIC TRANSISTOR USING THIAZOLOTHIAZOLE DERIVATIVES AND METHOD FOR FABRICATING THE SAME - The present invention relates to an organic transistor that includes an organic semiconductor layer containing a thiazolothiazole derivative and an insulating organic material having a band gap of 3 eV or more or no portion having four pairs or more of double bonds and single bonds continuously connected. | 01-21-2010 |
20100084637 | ORGANIC TRANSISTOR AND METHOD FOR FABRICATING THE SAME - The present invention provides an organic transistor that includes an organic semiconductor layer containing a material having conductive particles and an organic semiconductor polymer chemically bonded to each other and a method of producing the same. | 04-08-2010 |
20100236631 | Thiazolothiazole derivatives and organic electronic device using the same - The present invention relates to novel thiazolothiazole derivatives and an organic electronic device such as an organic light emitting device, an organic transistor, and an organic solar cell using the same. In the compound of the invention, various substituents are introduced to the core structure, so as to satisfy the requirements such as suitable energy levels, and electrochemical and thermal stability, and also have amorphous or crystalline property depending on the kind of the substituents, so as to satisfy the characteristics individually required for each of the devices. Further, an organic semiconductor of p-type or n-type can be fabricated by introducing various substituents to the core structure having a property of n-type. Therefore, the compound of the present invention can provide a device having higher stability. | 09-23-2010 |
Sergej L'Vovich Kiselev, Moscow RU
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20140341870 | BIOCOMPOSITE FOR REGENERATION OF INJURED TISSUE AND ORGANS, A KIT FOR MAKING THE BIOCOMPOSITE, A METHOD OF MAKING THE BIOCOMPOSITE AND A METHOD OF TREATING INJURIES - Provided is a biocomposite including cells, a genetic construction, and a scaffold and a method for repairing tissue and organs in mammalians with the biocomposite. The interaction of the components of the biocomposite provides a complex effect on reparative regeneration processes. Also provided is a method for administration of gene-cellular therapeutic constructions to a recipient which can be used in medicine and veterinary to provide reparative processes. After administering the biocomposite to a recipient, the scaffold structure releases the nucleic acids which enter into the cells of a recipient bed and cells of the transplanted product. The nucleic acids are expressed, which results in the increased concentration of a target product responsible for reparative processes. | 11-20-2014 |
20150335711 | PHARMACEUTICAL COMPOSITION FOR STIMULATION OF ANGIOGENESIS - Provided is a pharmaceutical composition for growth induction in blood vessel tissue which contains purified plasmid DNA encoding a vascular endothelial growth factor (VEGF) and pharmaceutically acceptable excipients that include a cryoprotectant as a vehicle and/or a pH stabilizer for stabilizing the pH in the range of 7.0 to 9.0, in effective quantities. Also provided is a storage method of plasmid DNA which encodes a VEGF comprising mixing the purified plasmid DNA with a solution of at least one cryoprotectant having properties of a vehicle and/or a pH stabilizer in the pH range of 7.0-9.0. The solution is lyophilized and stored at +2 to +8° C. Supercoiled DNA pCMV-VEGF165 may be used which is produced by culturing | 11-26-2015 |
Sergey Kiselev, Moscow RU
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20080310055 | REPEATABLE SHORTING AND UNSHORTING OF MICRO-ELECTRICAL CIRCUITS - The present invention provides methods and systems for repeatably creating and severing a short circuit to protect an electronic component from ESD. A short circuit may be formed between read sensor pads of a read sensor by depositing a shorting material on a magnetic head using a Laser Induced Forward Transfer (LIFT) process. The short circuit may be unshorted using a laser scan configured to sever the shorting material. In one embodiment, a shorting station may be provided to prevent spreading of the shorting material to undesired areas of the electronic component. | 12-18-2008 |
Sergey L. Kiselev, Moscow RU
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20120129256 | METHOD OF PREPARING PLURIPOTENT STEM CELLS - The invention relates to biotechnology, and particularly to the preparation of pluripotent stem cells. The method involves introduction into umbilical cord and placental stem cells of RNA with at least one sequence which ensures the transition of cells to the pluripotent state. The method enables to effectively prepare pluripotent stem cells from the cells of mammalian placenta and umbilical cord which have not yet acquired somatic mutations, which reduces the risk of oncogenesis and other adverse effects of reprogramming. | 05-24-2012 |
Valerij Kiselev, Freiburg DE
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20110275929 | Device and method for measuring contrast agent - A tomography device ( | 11-10-2011 |
20130102884 | NMR measurement of contrast medium concentrations - A method for measuring the cerebral perfusion of a living organism ( | 04-25-2013 |
20160042508 | SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR OBTAINING AND/OR DETERMINING MESOSCOPIC STRUCTURE AND ORIENTATION WITH FIBER TRACKING - Exemplary systems, methods, and computer-accessible mediums can be provided that can generate resultant data regarding fiber tract(s) and anatomical structure(s). For example, first information related to imaging data of the anatomical structure(s) can be received. Second information related to a predictive model of further fiber tract(s) can be received. The resultant data can be generated based on the first information, the second information and a fiber cost procedure. | 02-11-2016 |
Valeriy Kiselev, Pasadena, CA US
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20090257775 | Pin driver - The present invention also includes a method of remanufacturing a printer cartridge, the printer cartridge comprising printer cartridge components fastened together by a pin, the method comprising the steps of providing a device, the device comprising a shaft configured to apply pressure to the pin; a drive means for driving the shaft against the pin; and applying pressure to the pin using the device. | 10-15-2009 |
Vsevolod Ivanovich Kiselev, Moscow RU
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20080267982 | Methods Kits and Compositions for the Developement and Use of Monoclonal Antibodies Specific to Anbtigens of Low Immunogenicity - The invention relates to the development and use of monoclonal antibodies specific to antigens traditionally of low immunogenicity. The present invention provides methods of producing monoclonal antibodies by chemically conjugating the antigen of interest to a carrier molecule that enables the immune system to respond to immunization with the conjugated antigen. The invention also provides particular compositions of conjugated antigens as well as of monoclonal antibodies specific for those conjugated antigens. The present invention also provides kits for use in detecting disease conditions using the monoclonal antibodies. | 10-30-2008 |
20130039979 | MEDICATION ON THE BASIS OF 3,3'-DIINDOLYLMETHANE (DIM) WITH HIGH-BIOAVAILABILITY AND ITS USE IN TREATMENT OF HUMAN HYPERPLASTIC AND INFLAMMATORY DISEASES - The invention relates to medicine and chemico-pharmaceutical industry. A medication for treating human hyperplastic and inflammatory diseases containing 3,3′-diindolylmethane as an active agent and a carrier containing a mixture of cod-liver oil and at least one polysorbate at the following proportions of the components in mass %: | 02-14-2013 |
20130065933 | PHARMACEUTICAL COMPOSITION FOR PERORAL ADMINISTRATION OF DIINDOLYLMETHANE - The invention relates to pharmacy. It comprises block copolymer pharmaceutical compositions containing 3,3′-diindolylmethane (DIM). The pharmaceutical composition for peroral administration comprises 3,3′-diindolylmethane as an active component and a target additive, the target additive being a block copolymer of oxyethylene and oxypropylene, in which the content of the hydrophobic block is less than 50 mass % and the molecular mass of the hydrophilic block is equal to 2,250 Da or more, at a ratio of the active component to the selected block copolymer varying between 10:1 and 2:1. | 03-14-2013 |
20140235708 | PHARMACEUTICAL COMPOSITION ON THE BASIS OF NANOMICELLES CONTAINING EPIGALLOCATECHIN GALLATE AND A METHOD OF ADMINISTRATION THEREOF TO TREAT ATOPIC DERMATITIS, CROHN'S DISEASE, ADENOMYOSIS, AND HYPERPLASTIC DISEASES OF THE PROSTATE GLAND - The invention relates to pharmacy. It is an object of the present invention to produce nanomicellar structures containing EGCG and achieving a positive result consisting in increasing bioavailability in peroral administration. The object of this invention is achieved by a new pharmaceutical composition for peroral administration containing epigallocatechin-3-gallate as the active component and a target additive that is a block copolymer of oxyethylene and oxypropylene, in which the content of the hydrophobic block is less than 50% by mass and the hydrophilic block has a molecular weight of 2,250 daltons or more at a ratio of the block copolymer to the active component ranging from 1:1 to 10:1. The composition improves absorption of the active compound by the blood flow when delivered perorally. | 08-21-2014 |
20140303225 | PHARMACEUTICAL COMPOSITION FOR PERORAL ADMINISTRATION OF 3,3'-DIINDOLYLMETHANE - Block copolymer pharmaceutical compositions containing 3,3′-diindolylmethane (DIM). The pharmaceutical composition for peroral administration comprises 3,3′-diindolylmethane as an active component and a target additive, the target additive being a block copolymer of oxyethylene and oxypropylene, in which the content of the hydrophobic oxypropylene block is less than 50 mass % and the molecular mass of the hydrophilic oxyethylene block is equal to 2,250 Da or more, at a ratio of the active component to the selected block copolymer varying between 1:2 and 1:10. The composition improves absorption of the active compound by the bloodstream upon peroral delivery. | 10-09-2014 |
20150265575 | PHARMACEUTICAL COMPOSITION ON THE BASIS OF PHYTO-NUTRIENTS WITH INCREASED BIOAVAILABILITY, HAVING ANTI-TUMOR ACTIVITY, AND METHOD FOR PRODUCING SAID COMPOSITION (ALTERNATIVES) - A pharmaceutical composition for peroral delivery of phyto-nutrients includes at least one phyto-nutrient from the following series: epigallocatechin-3-gallate, diindolylmethane, genestein, resveratrol, curcumine, and a solubilizer—a polyvinylcaprolactam/polyvinylacetate/polyethyleneglycol graft copolymer with an average molecular mass of 90000-140000 g/mol at a mass ratio of at least one phyto-nutrient and solubilizer of 1/5 to 1/1. The composition can additionally include a pharmaceutically acceptable carrier. The composition may be produced by dissolving the solubilizer in an organic solvent, dissolving at least one phyto-nutrient in the same organic solvent, mixing the resulting solutions, and distilling off the solvent in vacuo. The resulting mixture is heated to 45-50° C. with constant stirring and, after distillation, the product is dried in vacuo. Ethanol, acetone, or isopropanol can be used as the organic solvent. Alternatively, the composition may be produced by dry mixing the powders of the solubilizer and of at least one phyto-nutrient. | 09-24-2015 |