Patent application number | Description | Published |
20080232658 | Interactive Multiple Gene Expression Map System - Disclosed herein is a system and method for providing remotely accessible gene expression image data. The system and method allows for increased accuracy and semi-quantitative or fully quantitative data from images by enabling the remote user to select regions of interest on a compressed image, and then conducting quantitative analysis on original images at a central location. The subject invention relates to, in one embodiment, an BVIGEM (Interactive Multiple Gene Expression Maps) system: which provides internet based software tools for the extraction of functional information from gene expression images and also to act as a repository for gene expression image data. | 09-25-2008 |
20080233648 | BIASING OF CELLS TOWARD RETINAL, CORNEAL OR LENS DEVELOPMENT - Methods are described that bias cells, such as potent and multipotent stem cells, by transfection with a nucleic acid sequence, to differentiate to a desired end-stage cell or a cell having characteristics of a desired end-stage cell. In particular embodiments, human neural stem cells or mesenchymal stem cells are transfected with vectors comprising genes in the homeobox family of transcription factor developmental control genes, and this results in a greater percentage of resultant transformed cells, or their progeny, differentiating into a desired end-stage cell or a cell having characteristics of a desired end-stage cell. | 09-25-2008 |
20080288450 | USER ACCESSIBLE TISSUE SAMPLE IMAGE DATABASE SYSTEM AND METHOD - Disclosed herein is a user-accessible tissue image database system. The system is searchable using a query image provided by a user. The query image is matched with images in the database based on common visual features. Specifically exemplified is the matching of images based on the presence of a target molecule and/or internal anatomical structure. | 11-20-2008 |
20100077358 | System for Manipulation, Modification and Editing of Images Via Remote Device - Disclosed herein is a system and method for providing remotely accessible medical image data. The system and method allows for increased accuracy and semi-quantitative or fully quantitative data from images by enabling the remote user to select regions of interest on a compressed image, and then conducting quantitative analysis on original images at a central location. | 03-25-2010 |
20100196326 | METHOD AND SYSTEM FOR BIASING CELLULAR DEVELOPMENT - Compositions and methods comprising siRNA targeted to APP mRNA are advantageously used to transfect stem cells and bias the cells against differentiating into glial type neural cells. The siRNA of the invention causes RNAi-mediated silencing of the APP mRNA. The inventors have discovered that expression APP induces gliogenesis, i.e., promotes differentiation of potent cells into glial cells. The transfection of potent cells with the subject siRNA silences APP mRNA and thus increases probability of the cells to differentiate into non-glial neural cells. | 08-05-2010 |
20110046935 | VIRTUAL SURGICAL TABLE - Disclosed herein is a virtual surgical table that that comprises a virtual anatomical model that can be manipulated or simulated via contact by the user and/or replica surgical tools. The table embodiment is useful for presurgical simulation, simulation during the surgery, teaching and training purposes. It is also useful for virtual surgery and dissection of human and other organisms. | 02-24-2011 |
20110135740 | TISSUE SUBSTITUTES COMPRISING STEM CELLS AND REDUCED CERIA - A biocompatible composite includes a solid biocompatible material and a plurality of living human progenitor or living stem cells attached thereto. The composition resulting in accelerated repair to damaged bones and tissues. | 06-09-2011 |
20110159056 | METHODS AND MATERIALS FOR STIMULATING PROLIFERATION OF STEM CELLS - Disclosed herein are methods and materials for influencing proliferation of stem cells. Specifically exemplified herein are compositions comprising cerium oxide nanoparticles which can be used to stimulate proliferation of stem cells under common culture conditions, or which can be utilized to improve therapeutic outcomes. | 06-30-2011 |
20110190320 | Compositions for Treating or Delaying the Onset of Hair Loss - Disclosed herein are novel methods and compositions for treating and/or preventing hair loss in patients. Specifically exemplified herein are compositions containing a modified pyrimidine that are topically applied to a scalp of an patient. Typically, the patient has androgenic alopecia, alopecia greata, postpartum alopecia or telogen effluvium. | 08-04-2011 |
20110313229 | Therapy Targeting Cancer Stem Cells - Disclosed herein are new immunotherapy methods that involve the isolation of cancer stem cells from tumor tissue and use of the cells either directly or indirectly through proteins or other factors associated with the cells to activate antigen presenting cells. The activated antigen presenting cells are useful as a therapy against the tumor. Also disclosed herein are novel methods of isolating and characterizing cancer stem cells and producing individual cancer stem cell lines. Dendritic cell lines are also disclosed herein. | 12-22-2011 |
20120156226 | Marker Differentially Expressed in Cancer Stem Cells and Methods of Using Same - The present invention pertains to methods and agents that target nanog expression or activity for treating or preventing cancer. Alternative methods involve diagnosing cancer stage or type by identifying presence of cancer cells expressing nanog. Other embodiments relate to methods of identifying agents that modulate nanog. | 06-21-2012 |
20120156785 | METHODS AND PRODUCTS FOR BIASING CELLULAR DEVELOPMENT - Methods are described that bias cells, such as potent and multipotent stem cells, by transfection with a nucleic acid sequence, to differentiate to a desired end-stage cell or a cell having characteristics of a desired end-stage cell. In particular embodiments, human neural stem cells are transfected with vectors comprising genes in the homeobox family of transcription factor developmental control genes, and this results in a greater percentage of resultant transformed cells, or their progeny, differentiating into a desired end-stage cell or a cell having characteristics of a desired end-stage cell. | 06-21-2012 |
20120238015 | METHODS AND MATERIALS FOR INCREASING POTENCY OF CELLS - Disclosed herein are methods and materials for producing a more developmentally potent cell from a less developmentally potent cell. Specifically exemplified herein are methods that comprise introducing an expressible dedifferentiating polynucleotide sequence into a less developmentally potent cell, wherein the transfected less developmentally potent cell becomes a more developmentally potent cell capable of differentiating to a less developmentally potent cell of its lineage of origin or a different lineage. | 09-20-2012 |
20120301440 | METHODS AND MATERIALS FOR INCREASING POTENCY OF CELLS - Disclosed herein are methods and materials for producing a more developmentally potent cell from a less developmentally potent cell. Specifically exemplified herein are methods that comprise introducing an expressible dedifferentiating polynucleotide sequence into a less developmentally potent cell, wherein the transfected less developmentally potent cell becomes a more developmentally potent cell capable of differentiating to a less developmentally potent cell of its lineage of origin or a different lineage. | 11-29-2012 |
20130116268 | USE OF MODIFIED PYRIMIDINE COMPOUNDS TO PROMOTE STEM CELL MIGRATION AND PROLIFERATION - Disclosed herein are methods and materials for improving vision. Particularly exemplified herein are pyrimidine compounds that serve to proliferate retinal stem cells. | 05-09-2013 |
20140037589 | NOVEL MAMMALIAN MULTIPOTENT STEM CELLS AND COMPOSITIONS, METHODS OF PREPARATION AND METHODS OF ADMINISTRATION THEREOF - This invention provides methods for preparing novel mammalian multipotent stem cells (MSCs), compositions thereof, and methods of preparing and administering the cells. | 02-06-2014 |
20150051558 | COMPOSITION AND METHOD FOR CORNEAL PROLIFERATION - Disclosed herein in exemplary embodiments are methods and compositions for repairing or treating a defected cornea in a patient in need. The methods and compositions including, for example, administering a dose of a composition to the patient, wherein the composition comprises may be administered to an intraocular area of the patient via a container having a spout for ophthalmic delivery. The methods and compositions promote progenitor cell migration and increase cellular proliferation in the cornea of the patient. | 02-19-2015 |
20150056704 | METHODS AND PRODUCTS FOR BIASING CELLULAR DEVELOPMENT - Methods are described that bias cells, such as potent and multipotent stem cells, by transfection with a nucleic acid sequence, to differentiate to a desired end-stage cell or a cell having characteristics of a desired end-stage cell. In particular embodiments, human neural stem cells are transfected with vectors comprising genes in the homeobox family of transcription factor developmental control genes, and this results in a greater percentage of resultant transformed cells, or their progeny, differentiating into a desired end-stage cell or a cell having characteristics of a desired end-stage cell. | 02-26-2015 |