Patent application number | Description | Published |
20110274696 | ANTIBODIES TO CCR2 - Provided are antibodies including human antibodies and antigen-binding portions thereof that specifically bind to CCR2, specifically human CCR2, and that may function to inhibit CCR2. Anti-CCR2 antibodies include those which bind to the first and/or second extracellular loops of CCR2. Also provided are human anti-CCR2 antibodies and antigen-binding portions thereof. Isolated heavy and light chain immunoglobulins derived from human anti-CCR2 antibodies and nucleic acid molecules encoding such immunoglobulins are provided. Methods of making human anti-CCR2 antibodies or antigen-binding portions, compositions comprising these antibodies or antigen-binding portions, methods of using the antibodies and antigen-binding portions, and compositions for diagnosis and treatment are provided. Also provided are gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-CCR2 antibodies or antigen binding portions thereof | 11-10-2011 |
20140271734 | BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF BARRETT'S ESOPHAGUS AND GASTROESOPHAGEAL REFLUX DISEASE - Provided herein are methods of treating or ameliorating Barrett's esophagus by administering to an individual in need thereof a therapeutically effective amount of an Apical Sodium-dependent Bile Acid Transporter Inhibitor (ASBTI) or a pharmaceutically acceptable salt thereof. Provided herein are methods of treating or ameliorating gastroesophageal reflux disease (GERD) by administering to an individual in need thereof a therapeutically effective amount of an ASBTI or a pharmaceutically acceptable salt thereof. Also provided are methods for treating or ameliorating symptoms or complications associated with Barrett's esophagus or GERD comprising administering to an individual in need thereof a therapeutically effective amount of ASBTI or a pharmaceutically acceptable salt thereof. | 09-18-2014 |
20140275090 | BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF PRIMARY SCLEROSING CHOLANGITIS AND INFLAMMATORY BOWEL DISEASE - Provided herein are methods of treating or ameliorating primary sclerosing cholangitis and inflammatory bowel disease by administering to an individual in need thereof a therapeutically effective amount of an Apical Sodium-dependent Bile Acid Transporter Inhibitor (ASBTI) or a pharmaceutically acceptable salt thereof. Also provided are methods for treating or ameliorating primary sclerosing cholangitis comprising administering to an individual in need thereof a therapeutically effective amount of ASBTI or a pharmaceutically acceptable salt thereof. | 09-18-2014 |
20140342450 | ANTIBODIES TO CCR2 - Provided are antibodies including human antibodies and antigen-binding portions thereof that specifically bind to CCR2, preferably human CCR2, and that may inhibit CCR2. The present antibodies may bind to the first and/or second extracellular loops of CCR2. Isolated heavy and light chains derived from the antibodies and nucleic acid molecules encoding the antibodies and chains are provided. Methods of making and using the anti-CCR2 antibodies or antigen-binding portions, and compositions comprising these antibodies or antigen-binding portions, including compositions for diagnosis and treatment, are provided. Also provided are gene therapy methods using nucleic acid molecules encoding the heavy and/or light chains that comprise the human anti-CCR2 antibodies or antigen-binding portions thereof. | 11-20-2014 |
Patent application number | Description | Published |
20100112525 | METHODS AND SYSTEMS FOR PROGRESSIVELY TREATING AND CONTROLLING ORAL PERIOPATHOGENS CAUSING SYSTEMIC INFLAMMATIONS - Methods and systems for treating and controlling oral periopathogens that have been found to be associated with systemic inflammation and/or disease in a periodontal pocket, inhibiting their entry into the host circulatory system, and decreasing the systemic effects. A bacterial community present in one or more oral treatment regions is determined. A periodontal medicament delivery tray is prepared for the patient with the delivery tray being configured with one or more application regions, each configured for applying a medicament to a different one of the oral treatment regions. The medicaments are applied to each oral treatment region, including placing each medicament into a different application region of the delivery tray. Each of the applied medicaments is applied as a function of a determined efficacy of the medicament against the bacterial community determined to be in the oral treatment region associated with the application region in which each medicament is applied. | 05-06-2010 |
20100112526 | ARTICLE AND METHOD FOR CONTROLLING ORAL-ORIGINATED SYSTEMIC DISEASE - Systems and methods for treating gingival tissue or oral biofilm includes applying to the gingival tissue (sulcus or periodontal pocket) a biofilm penetrating antimicrobial agent; removing the imbedded anaerobic bacteria from the gingival tissue following at least one applying of the antimicrobial agent to the gingival tissue; administering colloidal hydrogen peroxide gel to the gingival tissue following the removing of imbedded anaerobic bacteria; and cleaning the gingival tissue with a cleaning agent directly following the administering of the colloidal hydrogen peroxide gel for modifying the environment from anaerobic (diseased) to aerobic (healthy). | 05-06-2010 |
20120156640 | DEVICES AND METHODS FOR CREATING A POSITIVE PRESSURE ENVIRONMENT FOR TREATMENT OF ORAL BIOFILMS ASSOCIATED WITH PERIODONTAL DISEASE - A medicament delivery tray and method for treating periodontal disease include fitting of a tray about the teeth and gums wherein the tray includes a seal that creates a substantially airtight seal against the gumline and a substantially airtight treatment chamber about the enclosed teeth and gums, the tray further having a reinforcing skirt providing a biasing force to the seal wherein a positive pressure can be created in the treatment chamber for forcing a medicament into the gums about the enclosed teeth. | 06-21-2012 |
20130333707 | Article For Stabilizing Jaw Joint Relationships For Treatment Of Sleep Apnea - An oral appliance for treating sleep apnea of a patient including a monolithic body having an upper tray with an upper recess formed to conform to the maxillary teeth of the patient and a lower tray having a lower recess formed to conform to the mandibular teeth, the monolithic body defining a coupling of a rear portion of the upper tray to a rear portion of the lower tray at an angle forming a orifice between front mandibular teeth and front maxillary teeth, the upper tray including a raised upper seal surrounding the recess corresponding to the patient's upper gum line and the lower tray including a raised lower seal surrounding the recess corresponding to the patient's lower gum line each when the patient's teeth are disposed in the recesses. | 12-19-2013 |
20130334719 | Method Of Manufacturing An Oral Tray For Stabilizing Jaw Joint Relationships For Treatment Of Sleep Apnea - A method of manufacturing an oral appliance for treating sleep apnea of a patient that has a monolithic body with an upper tray with an upper recess formed to conform to the maxillary teeth of the patient and a lower tray with a lower recess formed to conform to the mandibular teeth, the monolithic body defining a coupling of a rear portion of the upper tray to a rear portion of the lower tray at an angle forming a orifice between front mandibular teeth and front maxillary teeth. | 12-19-2013 |
20140080089 | DEVICE AND METHOD OF MANUFACTURE THEREOF FOR CREATING A POSITIVE PRESSURE ENVIRONMENT FOR TREATMENT OF ORAL BIOFILMS ASSOCIATED WITH PERIODONTAL DISEASE - A medicament delivery tray and method for treating periodontal disease include fitting of a tray about the teeth and gums wherein the tray includes a seal that creates a substantially airtight seal against the gum line and a substantially airtight treatment chamber about the enclosed teeth and gums, the tray further having a reinforcing skirt providing a biasing force to the seal wherein a positive pressure can be created in the treatment chamber for forcing a medicament into the gums about the enclosed teeth. | 03-20-2014 |
20140271499 | ARTICLE AND METHOD OF INITIATING BONE REGROWTH AND RESTORATION OF GUM RECESSION WITH LOCALIZED SUBGINGIVAL DELIVERY OF MEDICATIONS - A system and method of initiating alveolar bone regrowth about a tooth of a patient suffering from bone loss due to periodontal disease that includes topically administering to a periodontal pocket about the tooth of the patient a hydrogen peroxide solution and topically administering to the periodontal pocket about the tooth a medicament that can help manage/control osteogenic activity. | 09-18-2014 |
Patent application number | Description | Published |
20090319116 | SYSTEMS AND METHOD FOR COLLECTING DATA IN A VEHICLE - A data collection system for a vehicle is provided. The data collection system includes a first data collection node configured to obtain data from a vehicle subsystem, and a processor communicatively coupled to the data collection node via a wiring system, wherein the wiring system includes a plurality of conductors and an overbraid surrounding said plurality of conductors, said overbraid comprising at least one fiber optic cable integrally woven therein and configured for the transmission of data related to an operational status of the vehicle subsystem. | 12-24-2009 |
20100017049 | Vehicle Health Management Systems and Methods - Systems and methods for managing the exchange of vehicle information between software modules with different safety importance. In one embodiment, a vehicle health management system includes a mission critical software module, a flight critical software module and a gatekeeper. The mission critical software module receives vehicle state information and provides it to the flight critical software module if the gatekeeper confirms the validity of the vehicle information. | 01-21-2010 |
20100171630 | VEHICLE HEALTH MANAGEMENT SYSTEM - A method, apparatus, and computer program product for processing health management data for a vehicle. A plurality of modulated signals is received on a bus system in the vehicle. The plurality of modulated signals contains health management data from a plurality of data acquisition units. Each modulated signal has a different frequency from another modulated signal in the plurality of modulated signals to form a plurality of frequencies. The plurality of frequencies is selected to avoid interference with other data transmitted over the bus system by a plurality of data processing systems in the vehicle. The plurality of modulated signals is processed based on the plurality of frequencies used to transmit the plurality of modulated signals. | 07-08-2010 |
20110033153 | APPARATUS AND METHOD FOR ESTABLISHING AN OPTICAL PATH SPANNING A DISCONTINUITY IN AN OPTICAL CHANNEL - An apparatus for establishing an optical circuit path spanning a discontinuity in an optical channel supported by a first cable oriented about a first axis on a first side of the discontinuity and supported by a second cable section oriented about a second axis on a second side of the discontinuity includes: (a) a first coupling member coupled with the optical channel on the first side; (b) a first supporting member fixed with the first coupling member in an installed orientation in a clamping relation with the first cable section; (c) a second coupling member coupled with the optical channel on the second side; (d) a second supporting member fixed with the second coupling member in an installed orientation clamped with the second cable section; and (e) a connecting member optically coupling the first coupling member with the second coupling member to establish the optical circuit path. | 02-10-2011 |
Patent application number | Description | Published |
20090276276 | Method For Analyzing Maintenance Operations And Assessing The Readiness Of Repairable Systems - An automated method for assessing the readiness of a plurality of repairable systems, such as a fleet of aircraft, is provided. In addition to identifying the repairable systems that will be operational, the relative state of readiness of the repairable systems is determined such that the repairable systems that are most likely to successfully complete the designated task can be selected. Additionally, an automated method of analyzing the maintenance operations performed upon a plurality of repairable systems, such as a fleet of aircraft, is provided. In this regard, the relative states of readiness of the repairable systems are determined and maintenance resources are allocated based upon the respective measures of the relative states of readiness of the repairable systems. As such, maintenance operations scheduled for the aircraft that will have the greatest state of readiness upon completion of the maintenance operations can be prioritized. | 11-05-2009 |
20090299789 | Method, System And Computer Program Product For Analyzing Maintenance Operations And Assessing The Readiness Of Repairable Systems - An automated method, system and computer program product for assessing the readiness of a plurality of repairable systems, such as a fleet of aircraft, are provided. In addition to identifying the repairable systems that will be operational, the relative state of readiness of the repairable systems is determined such that the repairable systems that are most likely to successfully complete the designated task can be selected. Additionally, an automated method of analyzing the maintenance operations performed upon a plurality of repairable systems, such as a fleet of aircraft, is provided. In this regard, the relative states of readiness of the repairable systems are determined and maintenance resources are allocated based upon the respective measures of the relative states of readiness of the repairable systems. As such, maintenance operations scheduled for the aircraft that will have the greatest state of readiness upon completion of the maintenance operations can be prioritized. | 12-03-2009 |
20140067695 | METHOD, SYSTEM AND COMPUTER PROGRAM PRODUCT FOR ANALYZING MAINTENANCE OPERATIONS AND ASSESSING THE READINESS OF REPAIRABLE SYSTEMS - An automated method, system and computer program product for assessing the readiness of a plurality of repairable systems, such as a fleet of aircraft, are provided. In addition to identifying the repairable systems that will be operational, the relative state of readiness of the repairable systems is determined such that the repairable systems that are most likely to successfully complete the designated task can be selected. Additionally, an automated method of analyzing the maintenance operations performed upon a plurality of repairable systems, such as a fleet of aircraft, is provided. In this regard, the relative states of readiness of the repairable systems are determined and maintenance resources are allocated based upon the respective measures of the relative states of readiness of the repairable systems. As such, maintenance operations scheduled for the aircraft that will have the greatest state of readiness upon completion of the maintenance operations can be prioritized. | 03-06-2014 |