Patent application number | Description | Published |
20100242082 | PROTECTING SENSITIVE INFORMATION FROM A SECURE DATA STORE - In embodiments of the present invention improved capabilities are described for the steps of receiving an indication that a computer facility has access to a secure data store, causing a security parameter of a storage medium local to the computer facility to be assessed, determining if the security parameter is compliant with a security policy relating to computer access of the remote secure data store, and in response to an indication that the security parameter is non-compliant, cause the computer facility to implement an action to prevent further dissemination of information, to disable access to network communications, to implement an action to prevent further dissemination of information, and the like. | 09-23-2010 |
20100333177 | SYSTEM AND METHOD FOR IDENTIFYING UNAUTHORIZED ENDPOINTS - In embodiments of the present invention improved capabilities are described for identifying unauthorized endpoints. The present invention includes computer implemented methods and systems for actively polling and monitoring network devices, such as network routers and switches, to obtain information on any or all of the endpoints on a network with which the router or switch may have communicated. Address information acquired through polling is compared with an authorized endpoint list, which is generated from information reported to the store by security agents on the authorized endpoints and which is stored in a security compliance store, in order to identify unauthorized endpoints. Methods and systems disclosed herein also include remediation measures to be taken on the unauthorized endpoints. Related user interfaces, applications, and computer program products are disclosed. | 12-30-2010 |
20110078497 | AUTOMATED RECOVERY FROM A SECURITY EVENT - In embodiments of the present invention improved capabilities are described for automated recovery from a security event. Automated recovery includes detecting a security event, using metadata to select a target backup for recovery, bringing the recovered environment online in a quarantine mode, initiating automated recovery of the environment, and running at least one of a generic remediation process and a specific remediation process in the quarantine mode prior to releasing the environment from quarantine mode. Related user interfaces, applications, and computer program products are disclosed. | 03-31-2011 |
Patent application number | Description | Published |
20080206763 | METHODS FOR ISOLATING AND CHARACTERIZING ENDOGENOUS mRNA-PROTEIN (mRNP) COMPLEXES - Cellular mRNA-protein (mRNP) complexes are partitioned in vivo by contacting a biological sample with at least one ligand that specifically binds at least one component of a mRNP complex. Suitable biological samples comprise at least one mRNA-protein (mRNP) complex and include cell cultures, cell extracts, and whole tissue, including tumor tissue. Ligands include antibodies that specifically bind RNA-binding or RNA-associated proteins present in the mRNP complex. The mRNP complex is separated by binding the ligand with a binding molecule specific for the ligand, where the binding molecule is attached to a solid support. The mRNP complex is collected by removing the mRNP complex from the solid support. After collecting the mRNP complex, the mRNA bound within the complex may be characterized and identified. Subsets of the total mRNA population of a cell may accordingly be characterized, and a gene expression profile of the cell obtained. | 08-28-2008 |
20080248479 | Methods for Isolating and Characterizing Endogenous mRNA-Protein (mRNP) Complexes - Cellular mRNA-protein (mRNP) complexes are partitioned in vivo by contacting a biological sample with at least one ligand that specifically binds at least one component of a mRNP complex. Suitable biological samples comprise at least one mRNA-protein (mRNP) complex and include cell cultures, cell extracts, and whole tissue, including tumor tissue. Ligands include antibodies that specifically bind RNA-binding or RNA-associated proteins present in the mRNP complex. The mRNP complex is separated by binding the ligand with a binding molecule specific for the ligand, where the binding molecule is attached to a solid support. The mRNP complex is collected by removing the mRNP complex from the solid support. After collecting the mRNP complex, the mRNA bound within the complex may be characterized and identified. Subsets of the total mRNA population of a cell may accordingly be characterized, and a gene expression profile of the cell obtained. | 10-09-2008 |
20080254461 | METHODS FOR ISOLATING AND CHARACTERIZING ENDOGENOUS mRNA-PROTEIN (mRNP) COMPLEXES - Cellular mRNA-protein (mRNP) complexes are partitioned in vivo by contacting a biological sample with at least one ligand that specifically binds at least one component of a mRNP complex. Suitable biological samples comprise at least one mRNA-protein (mRNP) complex and include cell cultures, cell extracts, and whole tissue, including tumor tissue. Ligands include antibodies that specifically bind RNA-binding or RNA-associated proteins present in the mRNP complex. The mRNP complex is separated by binding the ligand with a binding molecule specific for the ligand, where the binding molecule is attached to a solid support. The mRNP complex is collected by removing the mRNP complex from the solid support. After collecting the mRNP complex, the mRNA bound within the complex may be characterized and identified. Subsets of the total mRNA population of a cell may accordingly be characterized, and a gene expression profile of the cell obtained. | 10-16-2008 |
20090081651 | METHODS FOR ISOLATING AND CHARACTERIZING ENDOGENOUS mRNA-PROTEIN (mRNP) COMPLEXES - Cellular mRNA-protein (mRNP) complexes are partitioned in vivo by contacting a biological sample with at least one ligand that specifically binds at least one component of a mRNP complex. Suitable biological samples comprise at least one mRNA-protein (mRNP) complex and include cell cultures, cell extracts, and whole tissue, including tumor tissue. Ligands include antibodies that specifically bind RNA-binding or RNA-associated proteins present in the mRNP complex. The mRNP complex is separated by binding the ligand with a binding molecule specific for the ligand, where the binding molecule is attached to a solid support. The mRNP complex is collected by removing the mRNP complex from the solid support. After collecting the mRNP complex, the mRNA bound within the complex may be characterized and identified. Subsets of the total mRNA population of a cell may accordingly be characterized, and a gene expression profile of the cell obtained. | 03-26-2009 |
20090263790 | Methods for Identifying Functionally Related Genes and Drug Targets - The identification and evaluation of mRNA and protein targets associated with mRNP complexes and implicated in the expression of proteins involved in common physiological pathways is described. Effective targets are useful for treating a disease, condition or disorder associated with the physiological pathway. | 10-22-2009 |
20100267573 | Methods for In Vivo Identification of Endogenous mRNA Targets of MicroRNAs - A method of generating a gene expression profile of noncoding regulatory RNA (ncRNA; e.g. a microRNA) in a cell in vivo, is carried out by: (a) partitioning from a cell at least one mRNA-protein (RNP) complex, the RNP complex comprising: (i) an RNA binding protein (RNABP) or RNA associated protein, (ii) at least one mRNA bound to or associated with said protein, and (iii) at least one ncRNA bound to or associated with said protein, and then (b) identifying at least one ncRNA in-at least one RNP complex, thereby to produce a gene expression profile comprising the identity of an ncRNA in an RNP complex. | 10-21-2010 |
Patent application number | Description | Published |
20130178147 | RIDGE VENT - A ridge vent comprising: (a) a first filter clothe layer extending along a predetermined width and a predetermined length; (b) a first entangled net layer extending along the predetermined width and the predetermined length; and, (c) a second entangled net layer operatively coupled to the first entangled net layer, the second entangled net layer extending along the predetermined length and a first portion and a second portion of the predetermined width so as to provide an air void in a widthwise direction within the second entangled net layer that extends along the predetermined length. | 07-11-2013 |
20130189506 | MASONRY WALL VENT - An insert for masonry walls comprising a first layer of a high loft material and a second layer of an entangled net material, where the first layer includes dimensions of a first length, a first width, and a first thickness, where the second layer includes dimensions of a second length, a second width, and a second thickness, where the first thickness is less than the first length and first width, where the second thickness is less than the second length and the second width, and where the first thickness is not greater than the second thickness. | 07-25-2013 |
Patent application number | Description | Published |
20090283658 | Spacer assembly for preventing an acoustic short circuit in a building - A spacer assembly adapted to prevent the formation of acoustical short circuits in a building ceiling, floor and/or wall assembly. The spacer assembly includes a support member and is adapted for spacing and supporting a finished interior building element in acoustic isolation with respect to a structural member. | 11-19-2009 |
20100229486 | NOISE CONTROL FLOORING SYSTEM - A noise control flooring system is presented herein for reducing noise transmission in a building structure that contains the system. The system comprises a solid substrate layer, a compressible layer overlying at least a portion of the substrate layer, and an entangled net layer that overlies at least a portion of the compressible layer, wherein the net layer is comprised of multiple polymer filaments and air, together forming a void space. A separation layer overlies at least a portion of the entangled net layer. The separation layer carries a floating solid substrate layer thereupon. This solid substrate layer provides loading for causing the compressible layer to compress into the overlying entangled net layer. | 09-16-2010 |
20110107700 | SOUND CONTROL MAT - The disclosed invention relates to a sound control mat, comprising: a resilient layer of extruded polymer monofilaments, and a fiberglass scrim adhered to the resilient layer. A floor assembly employing the foregoing sound control mat is disclosed. | 05-12-2011 |
20120183744 | DRAINAGE MAT - A drainage mat for use in building structures, particularly in exterior walls and roofing, to improve drainage and ventilation within such structures. The drainage mat includes a web of extruded polymer monofilaments that are heat welded at junctions to form a matrix of tangled monofilaments. The web includes on its front face an alternating array of ridges and planar regions, each ridge having a substantially trapezoidal shape with a top surface and a base, the width of the top surface being less than the width of the base. | 07-19-2012 |
20120183746 | DRAINAGE MAT - A drainage mat for use in building structures, particularly in exterior walls and roofing, to improve drainage and ventilation within such structures. The drainage mat includes a web of extruded polymer monofilaments that are heat welded at junctions to form a matrix of tangled monofilaments. The web has a uniform thickness and includes alternating rows of high filament density and low filament density. | 07-19-2012 |
20120279153 | MORTAR AND DEBRIS COLLECTION SYSTEM FOR MASONRY CAVITY WALLS - A mortar and debris collection device for use in a masonry wall assembly includes a water permeable body made of an open-space defining array of polymer filaments that twist and turn between filament intersections where adjacent filaments are bonded to each other. The water permeable body comprises a shell having a hollow interior and includes an elongated base and extensions upwardly projecting from the base. | 11-08-2012 |
20150068838 | NOISE CONTROL DEVICE - A noise control flooring system includes a resilient layer of extruded polymer monofilaments and a porous separation layer overlying at least a portion of the resilient layer. The porous separation layer carries a floating solid substrate layer thereupon and enhances the speed of drying of the floating solid substrate layer. | 03-12-2015 |
Patent application number | Description | Published |
20120172662 | Snare with Retractable Engaging Members - A snare for retrieving foreign objects within the body of a patient including a hollow elongate tubular member comprising an inner surface and an outer surface and a lumen defined by the inner surface, a proximal end and a distal end, the hollow elongate tubular member forms a loop at the distal end, the loop having an open position and a closed position, the loop comprising at least one opening and a wire slidably disposed in the lumen of the elongate tubular member, the wire comprising at least one engaging member for engaging tissue, the at least one engaging member extends through the at least one opening in the hollow elongate tubular member when the wire is in a first position and the at least one engaging member retracts into the lumen of the elongate tubular member when the wire moved to a in a second position. | 07-05-2012 |
20130018384 | Medical Retrieval and Capture Device and Related Methods of Use - A medical device and related methods of use are provided for capture and removal of tissue from body lumens. The device includes an end-effector unit configured to capture tissue, having a distal end and a proximal end. The distal end and the proximal end form a substantially closed structure, and the distal end is more flexible than the proximal end. The device also includes a control member at the proximal end for holding and controlling the severing device. | 01-17-2013 |
20130018385 | Polypectomy Snare Device - Medical devices are disclosed including polypectomy snare devices. An example polypectomy snare device may include an elongated sheath having a distal end. A hollow shaft may extend through and be movable relative to the sheath. A distal portion of the shaft may have a slit formed therein. The shaft may be shiftable between a first configuration wherein the distal portion is substantially straight and a second configuration wherein the distal portion includes a bend. A snare wire may be disposed within the shaft. A distal section of the snare wire may extend through the slit when the shaft is in the second configuration. | 01-17-2013 |
Patent application number | Description | Published |
20120181013 | MODULAR SKID SYSTEM FOR MANIFOLDS - The disclosure provides an adjustable modular skid system with a plurality of skid modules having a frame to support oil field fluid components, such as manifolds, mixing blocks, collection blocks, fracturing pumps, piping and connections, and other devices used to transport water, sand slurries, gas, oil, or other fluids in oil field applications. The modules can be arranged in multiple configuration to fit a particular well site. The modules can include supply modules, transition modules, and distribution modules. The skid modules can be coupled together through piping and relevant connections at the well site. If appropriate, the skid modules can be supported on pilings or other foundational supports. The system can be assembled remotely, started and tested, partially disassembled into the skid modules, and then installed at the well site with minimal additional effort by generally providing lines and connections between the modules. | 07-19-2012 |
20120181015 | UNI-BORE DUMP LINE FOR FRACTURING MANIFOLD - The disclosure provides one or more manifolds having manifold portions primarily of fluid conduit and flow components mounted to the manifold portions, such as valves and fluid fittings. The manifold is formed with a uniform bore, so that the manifold portions are the same size along the flow path of the manifold, and the valves and fluid fittings have a bore the same size of the bore of the manifold portions. The uni-bore manifold creates a less turbulent flow path and allows draining of the manifold through one or more valves coupled to an end of the manifold that otherwise can to become restricted or plugged with particles entrained in fluids in the manifold. | 07-19-2012 |
20120181016 | COLLECTION BLOCK WITH MULTI-DIRECTIONAL FLOW INLETS IN OILFIELD APPLICATIONS - The disclosure provides a collection block that aggregates multiple incoming flow lines and provides a consolidated outgoing flow path. The collection block can be remote from a given well that is being fractured to minimize safety risk in operations around the well. The collection block has dual capabilities of being connected to individual incoming flow lines as well as to manifold systems for distributing the out flowing fluids. The one or more inlets can be formed in the collection block at an offset to a centerline of a longitudinal bore through the collection block. In some to embodiments, frac trucks can connect along an extended connection zone that provides the fluids from the truck to the collection block. | 07-19-2012 |
20120181030 | GOAT HEAD TYPE INJECTION BLOCK FOR FRACTURING TREES IN OILFIELD APPLICATIONS - The disclosure provides a goat head, as a mixing block, for multiple fluids in oilfield applications, the goat head having a reversing directional flow, mixing portion, wear reduction surfaces, and restricted outlet bore. The goat head provides an underneath approach for piping, reducing the overall height, and mixes the fluids dynamically within the goat head from angled flow paths. The goat head then reverses at least a component of the fluid flow direction that enters the wellbore below the goat head and exits the goat head into the well therebelow. The goat head to contains hardened wear surfaces, including surfaces in specific zones, to resist erosion caused by the reversing directional flow. A restricted outlet bore has a cross-sectional area that is less than the sum of cross-sectional areas of the inlets to assist in creating higher velocity and streamlined flow as the fluid exits the goat head. | 07-19-2012 |
20120181046 | ADJUSTABLE SUPPORT SYSTEM FOR MANIFOLD TO MINIMIZE VIBRATION - The disclosure provides an adjustable modular skid system with a plurality of skid modules to support oil field fluid components, such as manifolds, mixing blocks, collection blocks, fracturing pumps, piping and connections, and other devices used to transport water, sand slurries, gas, oil, or other fluids in oil field applications. The skid system has vibration adjusting features. The skid modules can be coupled together through piping and relevant connections at the well site. If appropriate, the skid modules can be supported on pilings or other foundational supports. The system can be assembled remotely, started and tested, partially disassembled into the skid modules, and then installed at the well site with minimal additional effort by generally providing lines and connections between the modules. Excessive vibrations in the system can be reduced by adjusting an overall stiffness of the system to change a natural frequency of the system. | 07-19-2012 |
Patent application number | Description | Published |
20100320695 | ANNULAR SEAL - A seal assembly capable of low temperature service is disclosed. It features upper and lower metallic backup rings that are specially shaped to act as a spring to keep the sidewalls of such rings in contact with the inside and outside surfaces to be sealed to prevent extrusion of the seal material even in low temperature situations. Inner and outer grooves are provided. O-ring seals, used for the ID of the seal, are manufactured to have a slightly greater diameter than the groove into which they will be installed. The greater length provides stored energy to promote sealing functionality in cold temperature situations. The O-rings used for the OD of the seal are manufactured to have a slightly smaller diameter than the groove into which they will be installed. The shorter length provides stored energy to promote sealing functionality in cold temperature situations. | 12-23-2010 |
20130038021 | ANNULAR SEAL - A seal assembly capable of low temperature service is disclosed. It features upper and lower metallic backup rings that are specially shaped to act as a spring to keep the sidewalls of such rings in contact with the inside and outside surfaces to be sealed to prevent extrusion of the seal material even in low temperature situations. Inner and outer grooves are provided. O-ring seals, used for the ID of the seal, are manufactured to have a slightly greater diameter than the groove into which they will be installed. The greater length provides stored energy to promote sealing functionality in cold temperature situations. The O-rings used for the OD of the seal are manufactured to have a slightly smaller diameter than the groove into which they will be installed. The shorter length provides stored energy to promote sealing functionality in cold temperature situations. | 02-14-2013 |
20140175750 | ANNULAR SEAL - A seal assembly capable of low temperature service is disclosed. It features upper and lower metallic backup rings that are specially shaped to act as a spring to keep the sidewalls of such rings in contact with the inside and outside surfaces to be sealed to prevent extrusion of the seal material even in low temperature situations. Inner and outer grooves are provided. O-ring seals, used for the ID of the seal, are manufactured to have a slightly greater diameter than the groove into which they will be installed. The greater length provides stored energy to promote sealing functionality in cold temperature situations. The O-rings used for the OD of the seal are manufactured to have a slightly smaller diameter than the groove into which they will be installed. The shorter length provides stored energy to promote sealing functionality in cold temperature situations. | 06-26-2014 |
Patent application number | Description | Published |
20080236243 | Pressure Monitor Optimization of Fluid Path Utilization - A device comprising a pressure monitor and a control means that receives a signal representing measured pressure at the pressure monitor and controls the controllable elements of a fluid system is utilized to monitor a fluid system for error conditions, to optimize operations and to diagnose the fluid system. By following a testing protocol that selectively enables parts of the system, the control means narrows the list of possible failing components. Comparing the measured pressure against normal pressures allows the device to identify error conditions. Determining the volume of fluid being transported and controlling the duration of the flow optimizes operation of the fluid system. | 10-02-2008 |
20080290309 | Pin Valve Assembly - A pin valve assembly and a method of controlling the flow of fluids comprising a pin block housing pin valves, a fluid plate with a fluid channel for fluidically communicating with the pin valves, and a fitting block housing fittings for fluidic communication with the fluid plate and for fluidic communication with fluidic components. The fluid flow through the channels of the fluid plate are controlled by the fluidic components and the pin valves. | 11-27-2008 |
20120216602 | Pressure Monitor Optimization Of Fluid Path Utilization - A device comprising a pressure monitor and a control means that receives a signal representing measured pressure at the pressure monitor and controls the controllable elements of a fluid system is utilized to monitor a fluid system for error conditions, to optimize operations and to diagnose the fluid system. By following a testing protocol that selectively enables parts of the system, the control means narrows the list of possible failing components. Comparing the measured pressure against normal pressures allows the device to identify error conditions. Determining the volume of fluid being transported and controlling the duration of the flow optimizes operation of the fluid system. | 08-30-2012 |
20130340503 | Pressure Monitor Optimizaiton Of Fluid Path Utilization - A device comprising a pressure monitor and a control means that receives a signal representing measured pressure at the pressure monitor and controls the controllable elements of a fluid system is utilized to monitor a fluid system for error conditions, to optimize operations and to diagnose the fluid system. By following a testing protocol that selectively enables parts of the system, the control means narrows the list of possible failing components. Comparing the measured pressure against normal pressures allows the device to identify error conditions. Determining the volume of fluid being transported and controlling the duration of the flow optimizes operation of the fluid system. | 12-26-2013 |
20130340509 | Flow Through Isolation Valve For High Pressure Fluids - A flow through isolation valve having a stationary member; a movable member, with a surface of the stationary member interfacing with a surface of the movable member; and at least one pin isolation valve. The pin isolation valve has a flow through internal conduit and is movable so that the internal conduit can fluidically communicate with at least one blank opening in the movable member and with a flow through internal conduit in the movable member. Movement is by rotation, linear or curvilinear translation. At least one pin isolation valve is fluidically coupled typically to a sample loop of a face seal valve, or to a pump supplying high pressure liquid to or to a column discharging liquid from a face seal valve of a high pressure liquid chromatography (HPLC) system or directly to the face seal valve. | 12-26-2013 |
Patent application number | Description | Published |
20120189426 | BLADE OUTER AIR SEAL ASSEMBLY AND SUPPORT - An example blade outer air seal support assembly includes a main support member configured to support a blade outer air seal. The main support member extends generally axially between a leading edge portion and a trailing edge portion. The leading edge portion is configured to be slidably received within a groove established by the blade outer air seal. A support tab extends radially from the support member toward the blade outer air seal. The support tab is configured to contact an extension of the blade outer air seal to limit relative axial movement of the blade outer air seal. A gusset spans between the support tab and the support member. An example blade outer air seal assembly includes a blade outer air seal assembly having an inwardly facing surface. A blade path portion of the inwardly facing surface is axially aligned with a tip of a rotating blade. A peripheral portion of the inwardly facing surface is located axially in front of the blade path portion, axially behind the blade path portion, or both. The blade outer air seal assembly establishes cooling paths that terminate at a plurality of apertures established within the inwardly facing surface. The plurality of apertures are locate exclusively within the blade path portion. | 07-26-2012 |
20130323033 | BLADE OUTER AIR SEAL WITH CORED PASSAGES - A blade outer air seal for a gas turbine engine includes a wall, a forward hook, and an aft hook. The wall extends between the forward hook and the aft hook, which are adapted to mount the blade outer air seal to a casing of the gas turbine engine. The wall includes a cored passage extending along at least a portion of the wall. The cored passage extends radially and axially through a portion of the aft hook to communicate with one or more apertures along a trailing edge of the aft hook. | 12-05-2013 |
20140064969 | BLADE OUTER AIR SEAL - An example blade outer air seal assembly for a gas turbine engine includes a main body portion extending along an axis. The main body portion has a radially inward facing surface and at least one radially outward facing surface. A passage is provided in the main body portion between the at least one radially inward facing surface and the at least one radially outward facing surface. The passage has a first portion and a second portion transverse to the first portion, and at least one rib disposed along the axis radially outward of the second portion. | 03-06-2014 |
20140127006 | BLADE OUTER AIR SEAL - A blade outer air seal for a gas turbine engine includes a first side surface, a second side surface, and a wall. The wall extends between the first side surface and the second side surface and has one or more holes formed therein. The holes are spaced from the first side surface and/or the second side surface and have areas between about 0.005% and 0.450% of a surface area of the blade outer air seal. | 05-08-2014 |
20150016954 | BLADE OUTER AIR SEAL ASSEMBLY AND SUPPORT - An blade outer air seal support assembly includes a main support member configured to support a blade outer air seal. The main support member extends generally axially between a leading edge portion and a trailing edge portion. The leading edge portion is configured to be slidably received within a groove established by the blade outer air seal. A support tab extends radially inward from the main support member toward the blade outer air seal. The support tab configured to contact an extension of the blade outer air seal to limit relative axial movement of the blade outer air seal. A gusset spans between the support tab and the main support member. | 01-15-2015 |
Patent application number | Description | Published |
20090050212 | METHOD AND APPARATUS FOR SAMPLE INJECTION IN LIQUID CHROMATOGRAPHY - The present invention provides a method and apparatus for substantially eliminating destructive transients of pressure or flow rate which can degrade the efficiency and useful lifetime of chromatography columns. The present invention enables a substantially constant flow of mobile phase liquid to be maintained through the chromatography system by eliminating the flow blockage interval associated with the actuation of sample injection valves. The present invention further provides a method to reduce the pressure and flow rate transients associated with pressurization of the sample loop contents when the sample loop is introduced to chromatography system delivery pressure. | 02-26-2009 |
20120024399 | Electrospray Interface To A Microfluidic Substrate - A liquid-chromatography module includes a microfluidic cartridge housing a microfluidic substrate with a channel for transporting fluid. The microfluidic substrate has fluidic apertures through which fluid is supplied to the channel. One side of the cartridge has nozzle openings, each aligning with a fluidic aperture in the microfluidic substrate and receiving a fluidic nozzle. A clamping assembly has a plunger that is movable into a clamped position and an end housing that defines a chamber. One wall of the end housing has a fluidic block with fluidic nozzles extending into the chamber. A second wall has a slot through which the cartridge enters the chamber. When moved into the clamped position while the cartridge is in the chamber, the plunger urges the cartridge against the fluidic block such that each fluidic nozzle enters one nozzle opening and establishes fluidic communication with one fluidic aperture in the microfluidic substrate. | 02-02-2012 |
20120037724 | Electrospray Interface To A Microfluidic Substrate - An apparatus for chemical separations includes a microfluidic substrate having an outlet aperture for outputting an eluent of a sample, a spray unit having an inlet to receive the eluent and an outlet to emit a spray of the eluent, and a force-applying unit. The spray unit has a deformable portion defining the inlet and having an elastic modulus that is lower than an elastic modulus of the microfluidic substrate. The force-applying unit, such as a spring, is disposed to urge the deformable portion in contact with the substrate to form a substantially fluid-tight seal. | 02-16-2012 |
20130056084 | Method And Apparatus For Sample Injection In Liquid Chromatography - The present invention provides a method and apparatus for substantially eliminating destructive transients of pressure or flow rate which can degrade the efficiency and useful lifetime of chromatography columns. The present invention enables a substantially constant flow of mobile phase liquid to be maintained through the chromatography system by eliminating the flow blockage interval associated with the actuation of sample injection valves. The present invention further provides a method to reduce the pressure and flow rate transients associated with pressurization of the sample loop contents when the sample loop is introduced to chromatography system delivery pressure. | 03-07-2013 |
20140174160 | MICROFLUIDIC DEVICE WITH DRIED BLOOD SPOTS (DBS) CARD INTERFACE - An apparatus for use in a chromatography system includes a first microfluidic substrate having a first fluidic channel. One end of the first fluidic channel terminates at a first fluidic port on a first side of the first microfluidic substrate and an opposite end of the first fluidic channel terminates at a second fluidic port on a second side of the first microfluidic substrate. A second microfluidic substrate has a second fluidic channel. One end of the second fluidic channel terminates at a first fluidic port on a first side of the second microfluidic substrate. The first side of the second microfluidic substrate abuts the second side of the first microfluidic substrate such that the fluidic port of the second microfluidic substrate aligns with one of the fluidic ports of the first microfluidic substrate and the alignment produces a fluidic path comprised of the first and second fluidic channels. | 06-26-2014 |
20140319042 | ELECTROSPRAY INTERFACE TO A MICROFLUIDIC SUBSTRATE - An apparatus for chemical separations includes a microfluidic substrate having an outlet aperture for outputting an eluent of a sample, a spray unit having an inlet to receive the eluent and an outlet to emit a spray of the eluent, and a force-applying unit. The spray unit has a deformable portion defining the inlet and having an elastic modulus that is lower than an elastic modulus of the microfluidic substrate. The force-applying unit, such as a spring, is disposed to urge the deformable portion in contact with the substrate to form a substantially fluid-tight seal. | 10-30-2014 |
20150047730 | METHOD AND APPARATUS FOR SAMPLE INJECTION IN LIQUID CHROMATOGRAPHY - The present invention provides a method and apparatus for substantially eliminating destructive transients of pressure or flow rate which can degrade the efficiency and useful lifetime of chromatography columns. The present invention enables a substantially constant flow of mobile phase liquid to be maintained through the chromatography system by eliminating the flow blockage interval associated with the actuation of sample injection valves. The present invention further provides a method to reduce the pressure and flow rate transients associated with pressurization of the sample loop contents when the sample loop is introduced to chromatography system delivery pressure. | 02-19-2015 |
Patent application number | Description | Published |
20090252799 | MATERIALS AND METHODS FOR WOUND TREATMENT - The subject invention pertains to materials and methods for stopping or decreasing the blood flow from an open wound or medical or surgical procedure. Compositions of the invention comprise a salt form of a cross-linked polyacrylic acid. In one embodiment, the composition comprises a sodium salt of a polyacrylic acid. Compositions of the invention can also optionally comprise one or more different salt ferrates, and/or a cationic exchanger resins, and/or a silver compound. In an exemplified embodiment, a composition of the invention comprises sodium polyacrylate provided in a dry powdered form. Polyacrylate compositions of the invention can be applied directly to a wound or treatment site, or they can be incorporated into a wound dressing, such as a bandage. The clot or scab formed at a wound or treatment site treated with the present invention is extremely elastic and exhibits considerable tensile strength when stretched to the breaking point. The subject invention also concerns wound and surgical site dressings and coverings, and methods of using a composition of the invention to stop blood flow from an open wound or treatment site. | 10-08-2009 |
20100129427 | Hemostatic Wound Dressings - Hemostatic wound dressings for substantially arresting the flow of severe, life threatening bleeding from a wound by rapidly adhering to the wound site, absorbing and concentrating and thickening the blood at the dressing blood interface and accelerating the natural clot formation beneath the dressing and finally, forming a strong seal that will substantially prohibits further flow of blood out of the wound site. These hemostatic wound dressings are formed of unique combinations of hemostatic dressing aspects which achieve wound seal strengths that are significantly higher than the sum of seal strengths expected from the individual aspects alone. Some embodiments also achieve these synergistic seal strengths by combining one hemostatic dressing with a non-hemostatic device. | 05-27-2010 |
20100226873 | Hemostatic Composition with Magnetite - A composition and method of arresting the flow of blood from a bleeding wound. The composition preferably includes an anhydrous salt ferrate compound preferably combined with an effective amount of an insoluble cation exchange material and an effective amount of anhydrous Magnetite mixed uniformly together. Povidone iodine may be added for enhanced antimicrobial properties. In the method, a quantity of the composition is magnetically attached to a surface of a magnet, after which the powderous mixture is applied to the wound by pressing the surface covered with the powderous compound against the wound for a time sufficient to clot the blood to arrest substantial further blood flow from the wound. | 09-09-2010 |
20110020425 | Materials and methods for wound treament - The subject invention pertains to methods and compositions for wound treatment. The methods and compositions provide for promoting and accelerating wound healing; provide for inhibition of microbial infection; provide for a protective scab-like covering on a wound; and/or for arresting the flow of blood or body fluids from an open wound. The methods and compositions can be used to increase granulation and epithelialization in a wound. In one embodiment, a substantially anhydrous compound of a salt ferrate and a cation exchange material is provided. Compositions of the invention can also include silver compounds. In use, compositions of the invention are preferably applied as a dry dressing to an exuding chronic wound site. If the chronic wound site is dry, the wound site may be wetted with a suitable liquid or aqueous media prior to applying the dressing in dry form. | 01-27-2011 |
20110245868 | Vascular Access Wound Sealing System and Method - A wound sealing system and method for closing a vascular access site. The method invisions suturing a single continuous Z-stitch into a skin area around a wound and wound tract while the catheter remains within the vessel; covering the wound and suture holes with a hemostatic powder; tightening and knotting the ends of the suture together in an X configuration, applying finger pressure against the hemostatic powder as the catheter is removed; and twisting the suture ends together to tension the Z-stitch, pulling the skin area into inversion. The wound sealing system includes a powder containment device (PCD) which surrounds wound and catheter and a suture twisting member configured with the PCD to tension the Z-stitch closing the wound and arresting blood flow. The hole in the PCD holds a quantity of the hemostatic agent sufficient to cover the wound and suture holes. | 10-06-2011 |
20120087887 | Composition and Method for Arresting Blood Flow and for Forming a Persistent Microbial Barrier - A composition and method useful in promoting healing of a bleeding wound site. The composition preferably includes a substantially anhydrous acid form of a cation exchange resin, which when applied over blood, provides an antimicrobial against planktonic microorganisms and biofilms in the wound. The resin is also capable, when applied in sufficient quantities, of providing a continuing and persistent antimicrobial against planktonic microorganisms and biofilms through dehydration and ion exchange with cations present in the blood and other body fluids. When the resin has a concentration of at least 26 mg/ml, it provides a >3 log reduction in biological activity of MRSA, MRSE and Pseudomonas aeruginosa. | 04-12-2012 |
20140120052 | COMPOSITION AND METHOD FOR ARRESTING BLOOD FLOW AND FOR FORMING A PERSISTENT MICROBIAL BARRIER - A composition and method useful in promoting healing of a bleeding wound site. The composition preferably includes a substantially anhydrous acid form of a cation exchange resin, which when applied over blood, provides an antimicrobial against planktonic microorganisms and biofilms in the wound. The resin is also capable, when applied in sufficient quantities, of providing a continuing and persistent antimicrobial against planktonic microorganisms and biofilms through dehydration and ion exchange with cations present in the blood and other body fluids. When the resin has a concentration of at least 26 mg/ml, it provides a >3 log reduction in biological activity of MRSA, MRSE and Pseudomonas aeruginosa. | 05-01-2014 |