Kazantsev
Aleksey G. Kazantsev, Brookline, MA US
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20090259044 | COMPOSITIONS AND METHODS FOR MODULATING SIRTUIN ACTIVITY - The present invention is based, in part, on our discovery of compounds that inhibit an activity of a sirtuin (e.g., compounds that inhibit or preferentially inhibit an activity of SIRT2) and are therefore believed useful in the treatment or prevention of diseases associated with sirtuin activity. These diseases include, but are not limited to, neurological disorders such as Parkinson's Disease (PD). | 10-15-2009 |
20100069372 | COMPOSITIONS AND METHODS FOR MODULATING POLY(ADP-RIBOSE) POLYMERASE ACTIVITY - The present invention is based, in part, on assays we conducted that revealed compounds that modulate (e.g., inhibit) PARP-1 and are therefore useful in treating or preventing diseases characterized by abnormal PARP-1 activity (e.g., undesirable PARP-1 activity). | 03-18-2010 |
20130203733 | COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES - The present invention is based, in part, on assays we conducted that revealed compounds that may be used to treat or prevent diseases characterized by an abnormal or undesirable association of one protein with another. | 08-08-2013 |
20140336178 | COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES - The present invention is based, in part, on assays we conducted that revealed compounds that may be used to treat or prevent diseases characterized by an abnormal or undesirable association of one protein with another. | 11-13-2014 |
Aleksey G. Kazantsev, Boston, MA US
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20090069559 | Compositions and methods for modulating sirtuin activity - The present invention is based, in part, on our discovery of compounds that inhibit an activity of a sirtuin (e.g., compounds that inhibit or preferentially inhibit an activity of SIRT2) and are therefore believed useful in the treatment or prevention of diseases associated with sirtuin activity. These diseases include, but are not limited to, neurological disorders such as Parkinson's Disease (PD). | 03-12-2009 |
20150025235 | Benzamide Compounds and Related Methods of Use - Benzamide compounds and derivatives thereof, as can be used for selective inhibition of the SIRT2 enzyme and/or therapeutic use in the treatment of Huntington's disease. | 01-22-2015 |
Aleksey G. Kazantsev, Brighton, MA US
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20160101098 | SMALL MOLECULE ACTIVATORS OF NRF2 PATHWAY - This disclosure relates to compounds that act as activators of the NRF2/KEAP1/ARE pathway. Specifically, the compounds provided herein can act as high affinity reversible bindings for the NRF2 inhibitor, KEAP1. In some cases, NRF2/KEAP1/ARE pathway activation compounds are capable of repressing expression of inflammatory markers and/or reducing levels of TNFa to provide neuroprotective anti-inflammatory effects in the CNS. Such compounds are useful in the treatment of a variety of diseases including Huntington's disease, Parkinson's disease, Alzheimer's disease, inflammation, and cancer. | 04-14-2016 |
Alexei Kazantsev, Boulder, CO US
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20130243878 | BIOMATERIALS FOR DELIVERY OF BLOOD EXTRACTS AND METHODS OF USING SAME - The disclosure provides biomaterials including scaffolds that include blood products including blood fractions and products including platelets for administration to subjects in need thereof. More specifically, the scaffolds based on step growth polymers are enriched with blood extracts that contain platelet rich plasma (PRP) and/or extracts of platelets. Compositions comprising a biomaterial or precursor thereof and a blood extract are provided, as are methods of making and using the biopolymers or precursors thereof. Kits and articles of manufacture comprising the biopolymers or precursors thereof are also described. | 09-19-2013 |
20140273153 | COVALENT MODIFICATION OF BIOLOGICAL MACROMOLECULES - The present disclosure provides a method of covalently modifying a biological macromolecule, the method comprising subjecting a reaction mixture comprising: (a) a biological macromolecule comprising one or more thiol groups; and (b) a molecule comprising one or more olefin or alkyne moieties to a radical reaction under conditions sufficient to produce the covalently modified biological macromolecule. The present disclosure also provides a method of covalently modifying a biological macromolecule, the method comprising subjecting a reaction mixture comprising: (a) a molecule comprising one or more thiol groups; and (b) a biological macromolecule comprising one or more olefin or alkyne moieties to a radical reaction under conditions sufficient to produce the covalently modified biological macromolecule. The present disclosure further provides a covalently modified biological macromolecule prepared by any of the disclosed methods. The covalently modified biological macromolecules may be further crosslinked to form a scaffold. | 09-18-2014 |
Andrey Kazantsev, St. Petersburg RU
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20150104292 | Aero-hydroelectric power station - The invention relations to hydroelectric power industry and can be used for capturing the energy stored within atmospheric moisture at any locations worldwide. The device comprises a tail race ( | 04-16-2015 |
Andrey Nikolaevich Kazantsev US
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20150104292 | Aero-hydroelectric power station - The invention relations to hydroelectric power industry and can be used for capturing the energy stored within atmospheric moisture at any locations worldwide. The device comprises a tail race ( | 04-16-2015 |
Ilya Kazantsev, Whitehouse Station, NJ US
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20150244814 | ADAPTIVE CO-BROWSING - Embodiments of the invention provide systems and methods for adaptively and dynamically providing image-capture screen sharing or co-browsing within a screen sharing session. More specifically, screen sharing systems and methods described herein combine both HTML co-browsing and image-capture screen sharing technologies within a single screen sharing session, that is, without having to terminate the current screen sharing session to switch from one screen sharing technology to another screen sharing technology. As used herein, “screen sharing” encompasses both image-capture screen sharing and HTML co-browsing, and “a screen sharing session” can refer to either an image-capture screen sharing session or a HTML co-browsing session. | 08-27-2015 |
Kirill Kazantsev, Yurlobo RU
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20150139039 | Communication system and method for making telephone calls over the internet - A system and related method are disclosed for sending SMS messages and phone calls via a Voice over Internet Protocol network. Disclosed embodiments permit the insertion of user identification data into the calls or SMS messages such that the recipient's phone displays that data as caller identification. Additional embodiments include geographical data such as GPS coordinates in the caller identification data to permit the immediate location of emergency calls. | 05-21-2015 |
Sergei Kazantsev, Ontario CA
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20080263607 | Downloading and Transfer of Audio or Video Data from Video Broadcasts - A method for purchasing, downloading, and transferring audio and/or video data files through video broadcasts is disclosed. The user signals the set-top box of his video viewing system that he is interested in downloading the audio/video data file being offered. The box records the time, the channel being viewed, and, where applicable, the user ID. The box then sends this information to the controlling server when it next reports in. The server transmits the requested data, either over the Internet or by broadcasting it back to the set-top box, where it can be downloaded to a desired format. | 10-23-2008 |
Yury Nikolaevich Kazantsev, Moscow RU
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20090025973 | ELECTROMAGNETIC SCREEN - The device according to an exemplary embodiment of the present invention relates to an area of wireless communication and can be used for shielding from electromagnetic radiation. The electromagnetic screen with the big surface impedance contains a flat metal reflector substrate and two lattices of capacitor type that are shifted from each other on a share of the period in parallel and located above the reflector substrate. At least one of lateral edges of the lattices has an electric connection with an edge of the reflector substrate. | 01-29-2009 |