Patent application number | Description | Published |
20150143380 | SCHEDULING WORKLOADS AND MAKING PROVISION DECISIONS OF COMPUTER RESOURCES IN A COMPUTING ENVIRONMENT - Embodiments of the present invention disclose a computer-implemented method, computer program product, and system for workload scheduling and resource provisioning. In one embodiment, in accordance with the present invention, the computer implemented method includes the steps of scheduling a set of pending workloads for execution on computer resources in a computing environment; identifying a workload in the set of pending workloads that is scheduled to utilize hypothetic resources, wherein hypothetic resources are idle computer resources that are currently not available, but can be made available to execute workloads through provisioning actions; holding the identified workload from dispatch to hypothetic resources for a holding period, wherein the holding period is a customizable duration of time; provisioning the hypothetic resources corresponding to computer resource requirements of the identified workload; determining whether the provisioned hypothetic resources have become available during the holding period. | 05-21-2015 |
20150143382 | SCHEDULING WORKLOADS AND MAKING PROVISION DECISIONS OF COMPUTER RESOURCES IN A COMPUTING ENVIRONMENT - Embodiments of the present invention disclose a computer-implemented method, computer program product, and system for workload scheduling and resource provisioning. In one embodiment, in accordance with the present invention, the computer implemented method includes the steps of scheduling a set of pending workloads for execution on computer resources in a computing environment; identifying a workload in the set of pending workloads that is scheduled to utilize hypothetic resources, wherein hypothetic resources are idle computer resources that are currently not available, but can be made available to execute workloads through provisioning actions; holding the identified workload from dispatch to hypothetic resources for a holding period, wherein the holding period is a customizable duration of time; provisioning the hypothetic resources corresponding to computer resource requirements of the identified workload; determining whether the provisioned hypothetic resources have become available during the holding period. | 05-21-2015 |
Patent application number | Description | Published |
20100196388 | TARGETED BINDING AGENTS DIRECTED TO SONIC HEDGEHOG HOMOLOG AND USES THEREOF - The invention relates to targeted binding agents against human sonic hedgehog homolog (Shh) and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to Shh. The described targeted binding agents are useful in the treatment of diseases associated with the activity and/or overproduction of Shh and as diagnostics. | 08-05-2010 |
20110020360 | TARGETED BINDING AGENTS DIRECTED TO PDGRF-ALPHA AND USES THEREOF - Targeted binding agents directed to the antigen PDGFR-alpha and uses of such agents are disclosed herein. More specifically the invention relates to fully human monoclonal antibodies directed to the antigen PDGFR-alpha and uses of these antibodies. Aspects of the invention also relate to hybridomas or other cell lines expressing such antibodies. The described targeted binding agents and antibodies are useful as diagnostics and for the treatment of diseases associated with the activity and/or overexpression of PDGFR-alpha. | 01-27-2011 |
20120328625 | TARGETED BINDING AGENTS DIRECTED TO SONIC HEDGEHOG HOMOLOG AND USES THEREOF - The invention relates to targeted binding agents against human sonic hedgehog homolog (Shh) and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to Shh. The described targeted binding agents are useful in the treatment of diseases associated with the activity and/or overproduction of Shh and as diagnostics. | 12-27-2012 |
20130089544 | Antibodies Directed to ERBB2 - The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to ErbB2, preferably human ErbB2. In another embodiment, the antibodies or antigen-binding portions thereof inhibit ErbB2. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins or portions thereof derived from human anti-ErbB2 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-ErbB2 antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention | 04-11-2013 |
Patent application number | Description | Published |
20090258392 | SEQUENCE DIVERSITY GENERATION IN IMMUNOGLOBULINS - Compositions and methods are disclosed for generating immunoglobulin structural diversity in vitro, and in particular, for reducing biases in V region and J segment gene utilization, and for generating immunoglobulin V-D-J recombination events in a manner that does not require D-J recombination to precede V-DJ recombination. Selection of advantageous combinations of immunoglobulin gene elements, including introduction of artificial diversity (D) segment genes and optimization of recombination signal sequence (RSS) efficiency, are disclosed. | 10-15-2009 |
20100291088 | IL-18 BINDING PROTEINS - The present invention encompasses IL-18 binding proteins, particularly antibodies that bind human interleukin-18 (hIL-18). Specifically, the invention relates to antibodies that are entirely human antibodies. Preferred antibodies have high affinity for hIL-18 and/or that neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental. | 11-18-2010 |
20110021373 | ANTIBODY CATEGORIZATION BASED ON BINDING CHARACTERISTICS - Methods for categorizing antibodies based on their epitope binding characteristics are described. Methods and systems for determining the epitope recognition properties of different antibodies are provided. Also provided are data analysis processes for clustering antibodies on the basis of their epitope recognition properties and for identifying antibodies having distinct epitope binding characteristics. | 01-27-2011 |
20120107324 | TARGETED BINDING AGENTS DIRECTED TO a5 1 AND USES THEREOF - The invention relates to targeted binding agents against α5β1 and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to α5β1. The described targeted binding agents are useful in the treatment of diseases associated with the activity and/or overproduction of α5β1 and as diagnostics. | 05-03-2012 |
20120114667 | TARGETED BINDING AGENTS DIRECTED TO a5BETA1 AND USES THEREOF - The invention relates to targeted binding agents against α5β1 and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to α5β1. The described targeted binding agents are useful in the treatment of diseases associated with the activity and/or overproduction of α5β1 and as diagnostics. | 05-10-2012 |
20120258495 | SEQUENCE DIVERSITY GENERATION IN IMMUNOGLOBULINS - Compositions and methods are disclosed for generating immunoglobulin structural diversity in vitro, and in particular, for reducing biases in V region and J segment gene utilization, and for generating immunoglobulin V-D-J recombination events in a manner that does not require D-J recombination to precede V-DJ recombination. Selection of advantageous combinations of immunoglobulin gene elements, including introduction of artificial diversity (D) segment genes and optimization of recombination signal sequence (RSS) efficiency, are disclosed. | 10-11-2012 |
20130034559 | Targeted Binding Agents Against B7-H1 - Human monoclonal antibodies directed against B7-H1 and uses of these antibodies in diagnostics and for the treatment of diseases associated with the activity and/or expression of B7-H1 are disclosed. Additionally, hybridomas or other cell lines expressing such antibodies are disclosed | 02-07-2013 |
20130085074 | Antibody Categorization Based on Binding Characteristics - Methods for categorizing antibodies based on their epitope binding characteristics are described. Methods and systems for determining the epitope recognition properties of different antibodies are provided. Also provided are data analysis processes for clustering antibodies on the basis of their epitope recognition properties and for identifying antibodies having distinct epitope binding characteristics. | 04-04-2013 |
20130236931 | SEQUENCE DIVERSITY GENERATION IN IMMUNOGLOBULINS AND OTHER PROTEINS - An in vitro system for generating sequence, and thus structural, diversity in proteins is described. The system can be constructed using appropriately selected nucleic acid molecules that encode regions of a selected protein or proteins and recombination signal sequences (RSS). The selected protein(s) can be, for example, immunoglobulin (Ig) V, D, J and/or C regions, regions of a non-immunoglobulin (non-Ig) protein, or a combination of Ig regions and non-Ig regions. Assembly of such appropriately selected components and their introduction into suitable recombination-competent host cells allows for recombination between the RSS sequences and introduction of sequence and structural diversity into the protein(s). | 09-12-2013 |
20140088296 | IL-18 BINDING PROTEINS - The present invention encompasses IL-18 binding proteins, particularly antibodies that bind human interleukin-18 (hIL-18). Specifically, the invention relates to antibodies that are entirely human antibodies. Preferred antibodies have high affinity for hIL-18 and/or that neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-1 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental. | 03-27-2014 |
20140314784 | ANTI-CXCR4 ANTIBODIES AND METHODS OF USE - The disclosure relates to antibodies or antigen binding fragments that specifically bind to CXCR4 and inhibit the biological activity of CXCR4 and uses of such agents. More specifically the disclosure relates to fully human antibodies or antigen binding fragments directed to CXCR4 that specifically bind to CXCR4 and uses of these antibodies. Aspects of the disclosure also relate to hybridomas or other cell lines expressing such antibodies. The disclosed antibodies (including antigen binding fragments) are useful as diagnostics and for the treatment of diseases associated with the activity and/or expression of CXCR4. | 10-23-2014 |
20140356353 | TARGETED BINDING AGENTS AGAINST B7-H1 - Human monoclonal antibodies directed against B7-H1 and uses of these antibodies in diagnostics and for the treatment of diseases associated with the activity and/or expression of B7-H1 are disclosed. Additionally, hybridomas or other cell lines expressing such antibodies are disclosed. | 12-04-2014 |
Patent application number | Description | Published |
20100107718 | Necking die with redraw surface and method of die necking - The invention provides a die set comprising an annular necking die and a knockout punch for necking-in a metal container, and a method of necking. In the method, in at least one necking-in step, the metal container is both reduced in diameter and the container wall is redrawn to minimize circumferential irregularities of wall thickness and/or circumferential rippling of the container wall caused by the reduction of diameter. The die of the die set is provided with a redraw surface to achieve this redrawing effect. | 05-06-2010 |
20100159266 | Clad can body stock - The invention relates to can body stock having opposed surfaces. The can body stock has a core layer, a cladding layer at a first surface (intended to form an exterior surface of an eventual container body), and optionally a cladding layer at a second surface (intended to form an interior surface of an eventual container body). The cladding layer at the first surface is made of alloy AA3104 or AA3004 (or a modified version of AA3004 or AA3104 containing more iron and optionally more silicon), and the core layer is an aluminum alloy having yield strength less than that of the aluminum alloy of the cladding layer at the first surface. The can body stock may be used to produce a container body by a method involving drawing and ironing, as well as die necking to reduce the diameter of the open end of the container body. | 06-24-2010 |
20100159275 | Clad can stock - Exemplary embodiments of the invention relate to a sheet article having opposed first and second surfaces, and having a core layer, a cladding layer at the first surface of the sheet article, and optionally a cladding layer at the second surface of the sheet article. The cladding layer at the first surface is made of an aluminum alloy selected from alloys AA3104, AA3004 and modified versions of alloys AA3104 and AA3004 additionally containing 1.0 to 2.0 wt % Fe and optionally up to 1 wt % Si. The core layer is an aluminum alloy having a yield strength and/or ductility greater than the yield strength and/or ductility of the alloy of the cladding layer at the first surface. The sheet article may be used as can body stock, can end stock and tab stock. | 06-24-2010 |
Patent application number | Description | Published |
20100231603 | ARTIFACT MITIGATION METHOD AND APPARATUS FOR IMAGES GENERATED USING THREE DIMENSIONAL COLOR SYNTHESIS - Embodiments of the invention relate generally to generating images, and more particularly, to systems, apparatuses, integrated circuits, computer-readable media, and methods to facilitate the use of three dimensional color synthesis techniques to reproduce colors properly using, for example, two sub-pixel mosaics, at a boundary between two colors. A method can include receiving into a color element a first colored illuminant and a second colored illuminant. The method also can include determining that the color element is configured to generate a color that has one or more color characteristics for a portion of the reproduced image. Further, the method can include modifying at least one of the first colored illuminant and the second colored illuminant to adjust the one or more color characteristics into a range of values associated with a portion of an image that corresponds to the portion of the reproduced image. | 09-16-2010 |
20120038693 | High Dynamic Range Projection System - Embodiments relate generally to computer-based image processing, and more particularly, to systems, computer-readable media, methods, integrated circuits, and apparatuses to facilitate operation of a projection system with relatively high dynamic range output by, among other things, providing subsets of light patterns along an optical path during respective first and second temporal fields associated with respective first and second illuminants. The projection system can synthesize color for projectable images by combining or otherwise using the subsets of light patterns with an array of color elements to produce projectable images with color in at least the visible spectrum. | 02-16-2012 |
20120092360 | Dual Modulation Using Concurrent Portions of Luminance Patterns in Temporal Fields - Embodiments of the invention facilitate high-dynamic-range (HDR) imaging by generating portions of spatial and/or temporal luminance patterns with different spectral power distributions substantially concurrent with, for example, the modulation of the light intensity associated with the portions of luminance patterns. The method can include predicting luminance patterns associated with multiple spectral power distributions. The method also can include distributing portions of the luminance patterns in one or more temporal fields. In some embodiments, distributing the portions of the luminance patterns can include interlacing those portions. Further, the method can include modulating light intensities of the luminance patterns to produce an age with other spectral power distributions. In some embodiments, the distribution of the luminance pattern portions can be substantially synchronous with modulating the light intensity of the luminance patterns. | 04-19-2012 |