Patent application number | Description | Published |
20090115417 | Three dimensional RF coil structures for field profiling - In one illustrative embodiment, a radio frequency (RF) coil is disclosed. The RF coil may include a plurality of transmission line elements, wherein at least one of the plurality of transmission line elements may have at least one dimension different than a dimension of another one of the plurality of transmission line elements. In some cases, each of the transmission line elements may include a signal line conductor and a ground plane conductor separated by a dielectric. | 05-07-2009 |
20110182920 | IDENTIFICATION OF A NOVEL CYSTEINE-RICH CELL PENETRATING PEPTIDE - The present invention relates to a nucleic acid molecule encoding a peptide capable of being internalized into a cell, wherein said nucleic acid molecule consists of (a) a nucleic acid molecule encoding a peptide having the amino acid sequence of SEQ ID NO: 2; (b) a nucleic acid molecule having the DNA sequence of SEQ ID NO: 1, wherein T is U if the nucleic acid molecule is RNA; or (d) a nucleic acid molecule encoding a peptide having at least 80% sequence identity with that of SEQ ID NO: 2, wherein at least at two positions selected from the group consisting of positions 1, 7 and 8 of SEQ ID NO: 2 a cysteine is present and wherein at least at four positions selected from the groups consisting of position 2, 4, 6, 9 or 10 of SEQ ID NO: 2 an arginine or a lysine is present. The present invention also relates to a peptide encoded by the nucleic acid of the invention, a fusion molecule comprising the peptide of the invention and a composition comprising the peptide or the fusion molecule of the invention. Furthermore, the present invention relates to a method of detecting the internalization behaviour of a fusion molecule of the invention, the composition of the invention for treating and/or preventing a condition selected from cancer, enzyme deficiency diseases, infarcts, cerebral ischemia, diabetes, inflammatory diseases, infections such as bacterial, viral or fungal infections, autoimmune diseases such as systemic lupus erythematodes (SLE) or rheumatoid arthritis, diseases with amyloid-like fibrils such as Alzheimer's disease (AD) and Parkinson's disease (PD) or certain forms of myopathy. | 07-28-2011 |
20120056620 | MULTIPLICATIVE INCREASE IN MRI DATA ACQUISITION WITH MULTI-BAND RF EXCITATION PULSES IN A SIMULTANEOUS IMAGE REFOCUSING PULSE SEQUENCE - Disclosed are methods and systems for carrying out super-multiplexed magnetic resonance imaging that entwines techniques previously used individually and independently of each other in Simultaneous Echo (of Imaging) Refocusing (SER or SIR) and Multi-Band (MB) excitation, in a single pulse sequence that provides a multiplication rather than summation of desirable effects while suppressing undesirable effects of each of the techniques that previously were used independently. | 03-08-2012 |
20130342200 | Method for Reducing Power Deposition in Magnetic Resonance Imaging Using Multiband Pulses and Multichannel Transmission - A method is provided for substantially simultaneously manipulating spins in a plurality of slice locations using a magnetic resonance imaging [“MRI”) system that includes a radio frequency (“RF”) coil array composed of a plurality of RF coil dements, and in which power deposition, which may be measured as specific absorption rate (“SAR”), is reduce A plurality of slice locations to be substantially simultaneously manipulated with the MRI system are selected, and an RF transmission map (B | 12-26-2013 |
20130342206 | Method for Rapid Whole Brain Magnetic Resonance Imaging with Contrast Preparation - A method for acquiring image data from a plurality of slice locations in a subject with a magnetic resonance imaging (MRI) system is provided. The method includes directing the MRI system to perform a pulse sequence that includes performing a contrast preparation module configured to generate contrast-encoded longitudinal magnetization and an image encoding module configured to acquire image data from multiple slice locations substantially simultaneously. The contrast preparation module generally includes tipping longitudinal magnetization into the transverse plane to produce transverse magnetization, generating contrast-prepared transverse magnetization by establishing an image contrast in the transverse magnetization, and tipping the contrast-prepared magnetization back along the longitudinal axis to produce the contrast-encoded longitudinal magnetization. | 12-26-2013 |
20140218026 | System and Method For Iteratively Calibrated Reconstruction Kernel For Accelerated Magnetic Resonance Imaging - A method for iteratively calibrating a reconstruction kernel for use in accelerated magnetic resonance imaging (MRI) is provided. An MRI system is used to acquire k-space data from multiple slice locations following the application of a multiband radio frequency (RF) excitation pulse. An initial reconstruction kernel is generated from the acquired k-space data, and this initial reconstruction kernel is used to produce an initial image for each of the multiple slice locations by applying the initial reconstruction kernel to the acquired k-space data. The average phase of each slice location is then calculated from these images, and used to shift the phase values of the subsequently acquired k-space data. From the phase-shifted k-space data, an updated reconstruction kernel is then generated. This process is repeated iteratively until a stopping criterion is satisfied. | 08-07-2014 |
20140253120 | SYSTEM AND METHOD FOR REDUCING RADIO FREQUENCY PEAK VOLTAGE AND POWER REQUIREMENTS IN MAGNETIC RESONANCE IMAGING USING TIME-SHIFTED MULTIBAND RADIO FREQUENCY PULSES - A system and method for producing images depicting a plurality of slice locations in a subject using a magnetic resonance imaging (“MRI”} system is provided. In particular, the system and method utilize time-shifted multiband radio frequency (“RF”} pulses to lower peak voltage and peak power requirements when using conventional multiband RF pulses. A time-shifted multiband RF pulse includes at least two component RF pulses, which may be single-band or multiband pulses. The component RF pulses are designed such that they do not have temporal footprints that completely overlap; although, they may have temporal foot-prints that partially overlap or do not overlap at all. The MRI system is used to acquire magnetic resonance signals formed in response to a time-shifted multiband RF pulse and, from these acquired signals, images depicting each of the plurality of slice locations in the subject are reconstructed. | 09-11-2014 |
20150115958 | Multiband Slice Accelerated Imaging With Balanced Slice-Selective Gradients - A computer-implemented method for performing multi-band slice accelerated imaging includes performing a low-resolution fast multi-dimensional reference scan to obtain a coil sensitivity map. A multiband imaging scan is performed to acquire a plurality of k-space lines representative of an anatomical area of interest. A multi-band signal corresponding to the plurality of k-space lines is separated into a plurality of image slices using a parallel imaging reconstruction technique and the coil sensitivity map. | 04-30-2015 |