Patent application number | Description | Published |
20080200451 | Tetrahydroquinolines for Use as Modulators of the Mitotic Motor Protein Eg5 - Compounds of the formula (I), in which W, R, R | 08-21-2008 |
20080221118 | Tetrahydroquinoline Derivatives - Compounds of the formula I, in which s, k, I, W, R | 09-11-2008 |
20080234299 | Quinazolinones - Compounds of the formula (I), in which R, R | 09-25-2008 |
20090030028 | Tetrahydroquinolines - Disclosed are compounds of formula (I), wherein W, R, R | 01-29-2009 |
20090054459 | Substituted indoles - Substituted indoles of the formula (I) and physiologically acceptable derivatives and salts thereof, in which R | 02-26-2009 |
20090118267 | INDANES - Compounds of the formula (I), in which R | 05-07-2009 |
20090176820 | POLYMORPHIC FORMS AND PROCESS - The invention relates to a process for the manufacture of enantiomerically enriched or pure compounds of formula I | 07-09-2009 |
20090247584 | PHENOXY-PIPERIDINES FOR THE TREATMENT OF DISEASES SUCH AS SCHIZOPHRENIA AND DEPRESSION - Compounds of the formula (I), in which R | 10-01-2009 |
20090291963 | SUBSTITUTED INDOLES - Substituted indoles of the formula (I) and physiologically acceptable derivatives and salts thereof, in which R | 11-26-2009 |
20100022530 | TETRAHYDROBENZOISOXAZOLE AND TETRAHYDROINDAZOLE DERIVATIVES AS MODULATORS OF THE MITOTIC MOTOR PROTEIN - Compounds of the formula (I) in which A | 01-28-2010 |
20100022579 | SUBSTITUTED TETRAHYDROQUINOLINES - Compounds of the formula (I), in which R | 01-28-2010 |
20100076012 | TETRAHYDROQUINOLINE DERIVATIVES AND THE USE THEREOF FOR THE TREATMENT OF CANCER - Compounds of the formula (I), in which E, R | 03-25-2010 |
20100240676 | THIAZOLE DERIVATIVES - Compounds of the formula (I), in which R | 09-23-2010 |
20100249132 | IMIDAZOLE DERIVATIVES - Compounds of the formula (I), in which R | 09-30-2010 |
20100311976 | PROCESS FOR PREPARING TETRAHYDROQUINOLINE DERIVATIVES - The invention relates to a novel process for preparing enantiomerically enriched or pure tetrahydroquinoline derivatives by reacting a chiral dihydropyran-methylamine C with a aldehyde B and an aniline A in a multicomponent one pot synthesis in the presence of a protonic acid or Lewis acid with a suitable solvent. A, B, C have the meaning as described in the specification. | 12-09-2010 |
20110230471 | BENZONAPHTYRIDINE COMPOUNDS AS INHIBITORS OF AUTOTAXIN - Compounds of the formula (I), in which R | 09-22-2011 |
20110237583 | 2, 5-DIAMINO-SUBSTITUTED PYRIDO [4, 3-D] PYRIMIDINES AS AUTOTAXIN INHIBITORS AGAINST CANCER - The present invention relates to pyridopyrimidine derivatives according to formula (I) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers. | 09-29-2011 |
20110281859 | NOVEL HETEROCYCLIC COMPOUNDS AS METAP-2 INHIBITORS - Compounds of the formula I, in which D, X, Y, Z, R and R | 11-17-2011 |
20120015959 | HETEROCYCLIC COMPOUNDS AS AUTOTAXIN INHIBITORS - Compounds of the formula (I), in which Het, R, X, Y, R | 01-19-2012 |
20120015976 | AUTOTAXIN INHIBITORS - The present invention relates to compounds according to formula (I) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers. | 01-19-2012 |
20120059016 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS - The present invention relates to piperidine and pyrazine derivatives according to formulae (Ia), (Ib) and (II) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers. | 03-08-2012 |
20120115852 | HETEROCYCLIC COMPOUNDS AS AUTOTAXIN INHIBITORS - Compounds of the formula (I), in which R, R | 05-10-2012 |
20120202827 | SULFOXIDE DERIVATIVES FOR THE TREATMENT OF TUMORS - Sulfoxide derivatives of the formula Ia to Im as described, and pharmaceutically usable salts, solvates, enantiomers, tautomers and stereoisomers thereof, including mixtures thereof in all ratios, for the treatment of tumours. | 08-09-2012 |
20120316162 | PIPERIDINE AND PIPERAZINE DERIVATIVES - Compounds of the formula (I), in which R | 12-13-2012 |
20130012505 | BENZONAPHTHYRIDINAMINES AS AUTOTAXIN INHIBITORS - The present invention relates to benzonaphthyridinamines of the formula (I) as autotaxin inhibitors and to the use thereof in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions in which the inhibition, regulation and/or modulation of phosphodiesterase or lysophospholipase autotaxin plays a role, in particular of various types of cancer and autoimmune and inflammatory diseases. | 01-10-2013 |
20130165478 | PYRAZOLOPYRIDINONE DERIVATIVES AS LPA RECEPTOR ANTAGONISTS - The present invention relates to novel pyrazolopyridinone derivatives according to formula (I) and a process of manufacturing thereof. These pyrazolopyridinone derivatives can be used as LPA receptor antagonists for the treatment of various herein disclosed diseases. | 06-27-2013 |
20140343075 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS - The present invention relates to piperidine and pyrazine derivatives according to formulae (Ia), (Ib) and (II) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers. | 11-20-2014 |
20140350046 | PYRAZOLOPYRIDINONE DERIVATIVES AS LPA RECEPTOR ANTAGONISTS - The present invention relates to novel pyrazolopyridinone derivatives according to formula (I) and a process of manufacturing thereof. These pyrazolopyridinone derivatives can be used as LPA receptor antagonists for the treatment of various herein disclosed diseases. | 11-27-2014 |
20140378431 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES - Compounds of the formula I | 12-25-2014 |
20150011557 | Benzyl Piperidine Compounds as Lysophosphatidic Acid (LPA) Receptor Antagonist - The invention provides novel substituted benzyl piperidine compounds according to Formula (I) as lysophosphatidic acid (LPA) receptor antagonists, their manufacture and use for the treatment of proliferative or inflammatory diseases, such as cancer, fibrosis or arthritis. | 01-08-2015 |
20150051202 | TRIAZOLOPYRAZINE DERIVATIVES - Compounds of the formula I | 02-19-2015 |