José Manuel
José Manuel Alguera, Aschaffenburg DE
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20110233002 | LUBRICATION SYSTEM WITH INTEGRATED ELECTRONICS - A lubrication system for a utility vehicle with a lubricating unit having a lubricant reservoir, a pump, and a distributor attached thereto to which supply lines to a plurality of lubrication points can be attached, and comprising a control module having at least two lubrication programs stored therein, wherein the pump initiates an ejection of grease in a cycle predetermined by the respective lubrication program. The object of the invention is to improve upon a lubrication system such that a change between lubrication programs and optionally the execution of an intermediate lubrication using an automatic lubrication system is possible during driving operations independent of the presence of a higher level on-board electronics system. The object is accomplished in that the lubricating unit is connected directly to an input and display device disposed in the vehicle or at other accessible places on the vehicle, the input and display device used to switch between lubrication programs and to initiate an intermediate lubrication. | 09-29-2011 |
José Manuel Algüera Gallego, Aschaffenburg DE
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20080250882 | Device For Detecting and Displaying the Position of Components of Vehicle Couplings - The invention relates to a device for detecting and for displaying the position of components of vehicle couplings comprising: a display device; having its own voltage source, and; sensor mechanisms. The displaying mechanisms can be attachable to or adjacent to the vehicle coupling. At least two sensor mechanisms are provided of which at least one mechanism is situated at a distance from the display mechanisms. | 10-16-2008 |
20110008992 | PLUG-IN SYSTEM FOR TRAILER VEHICLES - A plug-in system for trailer vehicles provided with an automatic coupling system of the supply lines, including a plug ( | 01-13-2011 |
20110025019 | VEHICLE COUPLING FOR PRODUCING A MECHANICAL CONNECTION BETWEEN A FIRST AND SECOND VEHICLE - A vehicle coupling for producing a mechanical connection between a first and a second vehicle including a coupling body ( | 02-03-2011 |
20110092080 | PLUG ELEMENT FOR CONNECTING SUPPLY LINES FOR VEHICLE PARTS - A plug element ( | 04-21-2011 |
20110118942 | THEFT SECURITY DEVICE FOR A VEHICLE COUPLING - An anti-theft security device for a vehicle coupling, in particular a fifth wheel coupling ( | 05-19-2011 |
20110127749 | AUTOMATIC BRAKE - A system for braking a trailer being coupled to a pulling vehicle by means of a coupling device, comprising a supply circuit on the pulling vehicle side, and a brake circuit on the trailer side, wherein the brake circuit is removably attached to the supply circuit by means of at least one plug-in coupling. The invention is based on the object of providing a system for braking a trailer, wherein the risk of an uncontrolled vehicle movement, at least of the trailer vehicle, is reduced. The problem is solved according to the invention by means of a system wherein disposed within the brake circuit is a ventilation valve that can be remotely controlled by the pulling vehicle. | 06-02-2011 |
20120032415 | METHOD AND CONTROL SYSTEM FOR A FIFTH WHEEL COUPLING SLIDING DEVICE HAVING A DISTANCE MEASUREMENT FOR DETECTING OBSTRUCTIONS - A method and to a system for controlling a sliding device for a fifth wheel coupling arranged on a towing vehicle, wherein the sliding device includes a substructure having at least one guide rail oriented in the driving direction, a movable slide, which supports the fifth wheel coupling and engages on the guide rail, and a control unit, to which a motorized drive unit for moving the slide and an actuator for fixing the slide relative to the guide rail are connected. The aim was to provide a method and a control system with which a sufficiently large gap width (W) can be set between the towing vehicle and the trailer in a timely manner. This is achieved, among other things, by a method in which a distance measurement is performed to detect an obstruction in front of the towing vehicle, the signal of the measurement is processed into a control signal in the control unit, and a start-up of the motorized drive unit and/or the actuator is initiated therewith. | 02-09-2012 |
20120200064 | SYSTEM FOR AUTOMATIC ADJUSTMENT OF THE GAP BETWEEN A TRACTOR VEHICLE AND AN ATTACHED TRAILER - A system is specified for the automatic adjustment of a gap between a tractor vehicle and an attached trailer, with a length-adjustable hitch with a tension tube, at the end of which is arranged a tension lug, while the tension lug can travel in the vehicle's lengthwise axis relative to the tension tube by an actuator along a predetermined travel path, as well as a control unit. The basic problem of the invention was to provide a system with which the gap between tractor vehicle and trailer can be changed automatically in driving operation and depending on the speed, both for articulated and unarticulated trailers. The problem is solved according to the invention with a system in which the control unit is an electronic controller, which is hooked up to a speed pickup for the processing of a speed signal and connected to the actuator. | 08-09-2012 |
20120242108 | AIR-CONDUCTING SYSTEM - An air-conducting system for a tractor and/or trailer is described, wherein at least one of the vehicles has a wind deflector. The problem addressed by the invention was to improve the aerodynamic drag of tractors and/or trailers. The problem is solved according to the invention by an air-conducting system in which the wind deflector is arranged at the rear of the trailer and/or at the rear and/or in the front region of the tractor and can be adjusted depending on the driving speed. | 09-27-2012 |
José Manuel Allard Serrano, Santiago CL
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20120110746 | COMPACT CUTLERY KIT WHICH MANIFESTS ITS PREVIOUS USE THROUGH RELEASE OF ITS PARTS - A cutlery kit configured from a laminar sheet which manifests its previous use through the detachment of its parts. The kit is comprised of two or more daily, known utensils selected from a spoon, a fork and a knife, which are jointly located in a single plane and are separated by thin, continuous dotted or cut lines. The utensils fit into each other in a complementary form, counter-form way and remain joined together by the presence of continuities in the surface where these continuities interrupt the dotted lines. Each of these cutlery utensils is detached from the others through breaking, done by the user, of these continuities on the surface. | 05-10-2012 |
José Manuel Baeyens-Cabrera, Granada ES
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20090042898 | USE OF COMPOUNDS ACTIVE ON THE SIGMA RECEPTOR FOR THE TREATMENT OF MECANICAL ALLODYNIA - The present invention refert to the use of compounds active on the sigma receptor for the treatment of mechanical allodynia. | 02-12-2009 |
20110052723 | USE OF COMPOUNDS BINDING TO THE SIGMA RECEPTOR LIGANDS FOR THE TREATMENT OF NEUROPATHIC PAIN DEVELOPING AS A CONSEQUENCE OF CHEMOTHERAPY - The present invention refers to the use of compounds binding to the sigma receptor for the treatment or prevention of neuropathic pain resulting from chemotherapy. | 03-03-2011 |
José Manuel Baeyens-Cabrera, Granada ES
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20110052723 | USE OF COMPOUNDS BINDING TO THE SIGMA RECEPTOR LIGANDS FOR THE TREATMENT OF NEUROPATHIC PAIN DEVELOPING AS A CONSEQUENCE OF CHEMOTHERAPY - The present invention refers to the use of compounds binding to the sigma receptor for the treatment or prevention of neuropathic pain resulting from chemotherapy. | 03-03-2011 |
20120141606 | SIGMA LIGANDS FOR THE PREVENTION OR TREATMENT OF PAIN INDUCED BY CHEMOTHERAPY - The invention refers to the use of a sigma ligand of formula (I) to prevent or treat pain induced by a chemotherapeutic agent, especially pain induced by taxanes, vinca alkaloids or platinum-containing chemotherapeutic drugs. | 06-07-2012 |
José Manuel Bartolome-Nebreda, Toledo ES
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20110294858 | SUBSTITUTED 6-METHYLNICOTINAMIDES AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS - In one aspect, the invention relates to substituted 6-methylnicotinamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 12-01-2011 |
20120295913 | BICYCLIC PYRAZOLE COMPOUNDS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS - In one aspect, the invention relates to bicyclic pyrazole compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 11-22-2012 |
José Manuel Bartolomé-Nebreda, Toledo, ES
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20100069394 | FAST-DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS - The present invention relates to 4-aryl-6-piperazin-1-yl-3-substituted-pyridazines that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects. | 03-18-2010 |
20100076187 | FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS - The present invention relates to 6-(piperidin-4-ylamino)pyridazin-3-carbonitriles that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects. | 03-25-2010 |
20100120860 | THIA(DIA)ZOLES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS - The present invention relates to [1-(benzyl)-piperidin-4-yl]-([1,3,4]thiadiazol-2-yl)-amine and [1-(benzyl)-piperidin-4-yl]-(thiazol-2-yl)-amine derivatives of formula (I) that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects. | 05-13-2010 |
20100137368 | PYRIDINE DERIVATIVES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS - The present invention relates to (1-benzyl-piperidin-4-yl)-(pyridin-2-yl)-amines that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects. | 06-03-2010 |
20110112107 | SUBSTITUTED 6-(1-PIPERAZINYL)-PYRIDAZINES AS 5-HT6 RECEPTOR ANTAGONISTS - The present invention is concerned with novel substituted 6-(1-piperazinyl)-pyridazines of Formula (I) | 05-12-2011 |
20110183980 | O-BENZYL NICOTINAMIDE ANALOGS AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS - In one aspect, the invention relates to O-benzyl nicotinamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 07-28-2011 |
20110269752 | IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS - The present invention relates to novel imidazo[1,2- | 11-03-2011 |
20120172391 | NAPHTHYRIDINONE ANALOGS AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS - In one aspect, the invention relates to naphthyridinone analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 07-05-2012 |
20120178776 | DIHYDRONAPHTHYRIDINYL(ORGANO)METHANONE ANALOGS AS POSITIVE ALLOSTERIC MGLUR5 MODULATORS - In one aspect, the invention relates to dihydronaphthyridinyl(organo)methanone analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 07-12-2012 |
20120220581 | IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS - The present invention relates to novel imidazo[1,2-b]pyridazine derivatives which are inhibitors of the phosphodiesterase 10 enzyme (PDE10) and which are useful for the treatment or prevention of neurological, psychiatric and metabolic disorders in which the PDE10 enzyme is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, to the use of such compounds or pharmaceutical compositions for the prevention or treatment of neurological, psychiatric and metabolic disorders and diseases. | 08-30-2012 |
20120225844 | BICYCLIC TRIAZOLE AND PYRAZOLE LACTAMS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS - In one aspect, the invention relates to bicyclic triazole and pyrazole lactams, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 09-06-2012 |
20120258955 | BICYCLIC THIAZOLES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS - The present invention relates to novel bicyclic thiazoles which are positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (“mGluR5”) and which are useful for the treatment or prevention of disorders associated with glutamate dysfunction and diseases in which the mGluR5 subtype of receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which mGluR5 is involved. | 10-11-2012 |
20120329792 | IMIDAZO[1,2-a]PYRAZINE DERIVATIVES AND THEIR USE FOR THE PREVENTION OR TREATMENT OF NEUROLOGICAL, PSYCHIATRIC AND METABOLIC DISORDERS AND DISEASES - The present invention relates to novel imidazo[1,2-a]pyrazine derivatives which are inhibitors of the phosphodiesterase 10 enzyme (PDE10) and which are useful for the treatment or prevention of neurological, psychiatric and metabolic disorders in which the PDE10 enzyme is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, to the use of such compounds or pharmaceutical compositions for the prevention or treatment of neurological, psychiatric and metabolic disorders and diseases. | 12-27-2012 |
20130245043 | SUBSTITUTED IMIDAZOPYRIMIDIN-5(6H)-ONES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS - In one aspect, the invention relates to imidazopyrimidin-5(6H)-one analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 09-19-2013 |
José Manuel Bartolomé-Nebreda, Toledo ES
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20100063058 | 4-ALKOXYPYRIDAZINE DERIVATIVES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS - The present invention relates to (1-benzyl-piperidin-4-yl)-(4-alkoxy-pyridazin-3-y1)-amines that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects. | 03-11-2010 |
20100069394 | FAST-DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS - The present invention relates to 4-aryl-6-piperazin-1-yl-3-substituted-pyridazines that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects. | 03-18-2010 |
20100076187 | FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS - The present invention relates to 6-(piperidin-4-ylamino)pyridazin-3-carbonitriles that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects. | 03-25-2010 |
20100120860 | THIA(DIA)ZOLES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS - The present invention relates to [1-(benzyl)-piperidin-4-yl]-([1,3,4]thiadiazol-2-yl)-amine and [1-(benzyl)-piperidin-4-yl]-(thiazol-2-yl)-amine derivatives of formula (I) that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects. | 05-13-2010 |
20100137368 | PYRIDINE DERIVATIVES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS - The present invention relates to (1-benzyl-piperidin-4-yl)-(pyridin-2-yl)-amines that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects. | 06-03-2010 |
20110112107 | SUBSTITUTED 6-(1-PIPERAZINYL)-PYRIDAZINES AS 5-HT6 RECEPTOR ANTAGONISTS - The present invention is concerned with novel substituted 6-(1-piperazinyl)-pyridazines of Formula (I) | 05-12-2011 |
20120329792 | IMIDAZO[1,2-a]PYRAZINE DERIVATIVES AND THEIR USE FOR THE PREVENTION OR TREATMENT OF NEUROLOGICAL, PSYCHIATRIC AND METABOLIC DISORDERS AND DISEASES - The present invention relates to novel imidazo[1,2-a]pyrazine derivatives which are inhibitors of the phosphodiesterase 10 enzyme (PDE10) and which are useful for the treatment or prevention of neurological, psychiatric and metabolic disorders in which the PDE10 enzyme is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, to the use of such compounds or pharmaceutical compositions for the prevention or treatment of neurological, psychiatric and metabolic disorders and diseases. | 12-27-2012 |
20130245043 | SUBSTITUTED IMIDAZOPYRIMIDIN-5(6H)-ONES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS - In one aspect, the invention relates to imidazopyrimidin-5(6H)-one analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 09-19-2013 |
20130252943 | BICYCLIC OXAZOLE LACTAMS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS - In one aspect, the invention relates to substituted bicyclic oxazole lactam analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 09-26-2013 |
20130261107 | BICYCLIC OXAZOLE AND THIAZOLE COMPOUNDS AND THEIR USE AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS - In one aspect, the invention relates to novel bicyclic oxazole and thiazole compounds which are positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (“mGluR5”); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions; and methods for the treatment or prevention of disorders associated with glutamate dysfunction and diseases in which the mGluR5 subtype of receptors is involved. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 10-03-2013 |
20130345203 | SUBSTITUTED BICYCLIC ALKOXY PYRAZOLE ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS - In one aspect, the invention relates to substituted bicyclic alkoxy pyrazole analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 12-26-2013 |
20130345204 | SUBSTITUTED BICYCLIC CYCLOALKYL PYRAZOLE LACTAM ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS - In one aspect, the invention relates to substituted bicyclic cycloalkyl pyrazole lactam analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 12-26-2013 |
20130345205 | SUBSTITUTED BICYCLIC ARALKYL PYRAZOLE LACTAM ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS - In one aspect, the invention relates to substituted bicyclic aralkyl pyrazole lactam analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 12-26-2013 |
20130345206 | SUBSTITUTED BICYCLIC ALKOXY PYRAZOLE ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS - In one aspect, the invention relates to substituted bicyclic alkoxy pyrazole analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 12-26-2013 |
20140057870 | BICYCLIC TRIAZOLE AND PYRAZOLE LACTAMS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS - In one aspect, the invention relates to bicyclic triazole and pyrazole lactams, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 02-27-2014 |
20140213593 | BICYCLIC PYRAZOLE COMPOUNDS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS - In one aspect, the invention relates to bicyclic pyrazole compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 07-31-2014 |
20140329838 | SUBSTITUTED IMIDAZOPYRIMIDIN-5(6H)-ONES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS - In one aspect, the invention relates to imidazopyrimidin-5(6H)-one analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 11-06-2014 |
20140336381 | FAST-DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS - The present invention relates to 4-aryl-6-piperazin-1-yl-3-substituted-pyridazines that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects. | 11-13-2014 |
José Manuel Benito López, Almeria ES
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20110037034 | METHOD FOR PRODUCING AN ANTISTATIC ARTICLE MADE FROM AGGLOMERATED STONE AND RESULTING ARTICLE - The invention relates to a method for producing an article from agglomerated stone, for example a slab for construction or decoration, comprising the following steps: bringing into contact (i) an inorganic filler, (ii) a polyester resin precursor composition and (iii) a powdered electrically conductive component; mixing same to produce a uniform mass; distributing part of the mass on a substrate; pressing the distributed mass in a vibro-compaction press under vacuum conditions; and hardening the mass by means of polymerisation of the polyester resin. | 02-17-2011 |
José Manuel Benito López, Almeria ES
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20110037034 | METHOD FOR PRODUCING AN ANTISTATIC ARTICLE MADE FROM AGGLOMERATED STONE AND RESULTING ARTICLE - The invention relates to a method for producing an article from agglomerated stone, for example a slab for construction or decoration, comprising the following steps: bringing into contact (i) an inorganic filler, (ii) a polyester resin precursor composition and (iii) a powdered electrically conductive component; mixing same to produce a uniform mass; distributing part of the mass on a substrate; pressing the distributed mass in a vibro-compaction press under vacuum conditions; and hardening the mass by means of polymerisation of the polyester resin. | 02-17-2011 |
José Manuel Cameselle-Teijeiro, Santiago De Compostela ES
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20120184452 | METHODS FOR DIAGNOSING FOLLICULAR THYROID CANCER - Methods for diagnosing follicular thyroid cancer, providing a prognosis for follicular thyroid cancer, and monitoring treatment of follicular thyroid cancer, using biomarkers that are differentially expressed in follicular thyroid cancer are provided. | 07-19-2012 |
José Manuel Catala Civera, Valencia ES
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20080267678 | POWER SPLITTER FOR A MICROWAVE FUSER OF A REPRODUCTION APPARATUS - A microwave fuser device for heating printing matter in a reproduction apparatus with microwave energy from a suitable microwave source. The microwave fuser device supplies microwave energy through the bottom of a multi-channel resonator including a gap to enable transport of printing matter therethrough. The device includes a power splitter having plural channels for dividing microwave energy from the microwave source between the channels of the multi-channel resonator. The power splitter has a mechanism to provide variable geometry of its plural channels, whereby the effective width of microwave energy from the resonator of the microwave fuser device can be matched to the width of such printed matter having an image fused thereto substantially preventing undesirable high loss of energy and low yield. | 10-30-2008 |
20080267679 | MICROWAVE FUSER APPARATUS WITH OVERLAPING HEATER APPLICATORS - A microwave fuser apparatus, for a reproduction apparatus, the microwave fuser apparatus having at least two microwave applicators, staggered relative to a receiver member transport path with an area of overlap, for applying microwave energy to a receiver member traveling on such transport path relative to the microwave applicators to have toner images fused thereto. The microwave fuser apparatus has at least one additional microwave applicator, located adjacent to the overlapping area between the at least two staggered microwave applicators that applies microwave energy to the receiver member. The at least one additional microwave applicator effectively maintains an elevated temperature of a receiver member. | 10-30-2008 |
20110043223 | NON INVASIVE METHOD FOR MONITORING THE CURING PROCESS OF A THERMOSET PLASTIC MATERIAL THROUGH THE USE OF MICROWAVES AND MICROWAVE DEVICE FOR THE APPLICATION THEREOF - The invention refers to a method for the non-invasive monitoring of the chemical reaction linked to the curing process of a thermoset plastic material using microwaves, from the real-time measurements of the reflection coefficient of a resonator sensor using a detector that simultaneously provides modulus and phase values. | 02-24-2011 |
José Manuel Catala Civera, Valencia ES
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20110043223 | NON INVASIVE METHOD FOR MONITORING THE CURING PROCESS OF A THERMOSET PLASTIC MATERIAL THROUGH THE USE OF MICROWAVES AND MICROWAVE DEVICE FOR THE APPLICATION THEREOF - The invention refers to a method for the non-invasive monitoring of the chemical reaction linked to the curing process of a thermoset plastic material using microwaves, from the real-time measurements of the reflection coefficient of a resonator sensor using a detector that simultaneously provides modulus and phase values. | 02-24-2011 |
José Manuel Corcelles Pereira, Alcobendas-Madrid ES
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20110019443 | SERIES VOLTAGE COMPENSATOR AND METHOD FOR SERIES VOLTAGE COMPENSATION IN ELECTRICAL GENERATORS - Series voltage compensator connected in series between an electrical generator and an electrical grid that comprises a filter and an electronic power converter per phase. The compensator generates a voltage to dynamically compensate for sudden voltage drops in the electrical grid, with it being additionally possible to control the angle of the voltage in relation to the current with the aim of controlling the reactive power injected (or absorbed) by the series voltage compensator to the grid. | 01-27-2011 |
José Manuel Corcelles Pereira, Alcobendas-Madrid ES
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20110019443 | SERIES VOLTAGE COMPENSATOR AND METHOD FOR SERIES VOLTAGE COMPENSATION IN ELECTRICAL GENERATORS - Series voltage compensator connected in series between an electrical generator and an electrical grid that comprises a filter and an electronic power converter per phase. The compensator generates a voltage to dynamically compensate for sudden voltage drops in the electrical grid, with it being additionally possible to control the angle of the voltage in relation to the current with the aim of controlling the reactive power injected (or absorbed) by the series voltage compensator to the grid. | 01-27-2011 |
José Manuel Correia De Costa, Oliveira De Azemeis PT
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20100151482 | DIAGNOSIS OF FASCIOLOSIS BY SKIN TEST (INTRADERMOREACTION) USING THE ANTIGEN FH8 (FASCIOLIN) - Fasciolosis is an anthropozoonotic disease caused by the Trematoda | 06-17-2010 |
José Manuel Correia De Costa, Oliveira De Azemeis PT
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20100151482 | DIAGNOSIS OF FASCIOLOSIS BY SKIN TEST (INTRADERMOREACTION) USING THE ANTIGEN FH8 (FASCIOLIN) - Fasciolosis is an anthropozoonotic disease caused by the Trematoda | 06-17-2010 |
José Manuel García Fernández, Sevilla ES
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20120129919 | POLYCATIONIC AMPHIPHILIC CYCLOOLIGOSACCHARIDES AND THE USE THEREOF AS MOLECULAR TRANSPORTERS - The present invention relates to a group of polycationic amphiphilic cyclooligosaccharides which, due to their molecular structure, may be used as molecular transporters to the interior of cells. Furthermore, the present invention also relates to the use of said compounds in the preparation of a medicament, to the use of this medicament for gene therapy and to a pharmaceutical composition that comprises one of said compounds. | 05-24-2012 |
José Manuel Garcia González, Waldkirch DE
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20100171551 | AMPLIFIER AND SWITCHED CAPACITOR AMPLIFIER CIRCUIT - An amplifier (V) for an integrated circuit amplifier circuit (IC) having a switched capacitor circuit (C | 07-08-2010 |
José Manuel Garcia González, Waldkirch DE
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20100171551 | AMPLIFIER AND SWITCHED CAPACITOR AMPLIFIER CIRCUIT - An amplifier (V) for an integrated circuit amplifier circuit (IC) having a switched capacitor circuit (C | 07-08-2010 |
José Manuel Gonzalez De Buitrago, Salamanca ES
José Manuel GutiÉrrez FernÁndez, El Astillero (cantabria) ES
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20120186937 | ACTUATING ROD FOR THE HAND BRAKE OF A MOTOR VEHICLE - The invention relates to a rod comprising a long plastic body ( | 07-26-2012 |
José Manuel Herrera Van Der Nood, Hellevoetsluis NL
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20090037706 | Processor Lock - A data processing system has an embedded processor and a system memory. The embedded processor has access to a specific one of multiple sets of instructions pre-stored in the system memory, only if a control code valid for the specific set is supplied from a source external to the system. | 02-05-2009 |
20090103429 | Method and System for Remote Power Feeding of a DSL Communication Device - The invention relates to a method and system of remote power feeding of a DSL communication device. The system for performing the method comprises a central DSL system connectable to a plurality of DSL communication devices via a plurality of associated subscriber lines. A subscriber line provides a plurality of communication channels for signal transmission between the central DSL system and the DSL communication device. The method involves receiving a power failure indication signal from the at least one DSL communication device. Following the transmission of the power failure indication signal, one or more communication channels are selected from the plurality of communication channels for signal transmission over the subscriber line. Then, power is fed to the at least one DSL communication device in combination with signal transmission over said selected one or more communication channels of the subscriber line. | 04-23-2009 |
20090278996 | Method and system for selecting a broadcast-signal in a multi-user environment - There is disclosed a system comprising, a source-tuner having a receiver for receiving external broadcast-signals, and a transmitter for broadcasting internal broadcast-signals to a network that communicatively links the source-tuner to a number of tuners. The source-tuner is adapted to receive control-signals from the tuners and to select external broadcast-signals as the source of the internal broadcast-signals, on the basis of the control-signal received from the tuner. | 11-12-2009 |
José Manuel Herrera Van Der Nood, Hellevoetsluis NL
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20090278996 | Method and system for selecting a broadcast-signal in a multi-user environment - There is disclosed a system comprising, a source-tuner having a receiver for receiving external broadcast-signals, and a transmitter for broadcasting internal broadcast-signals to a network that communicatively links the source-tuner to a number of tuners. The source-tuner is adapted to receive control-signals from the tuners and to select external broadcast-signals as the source of the internal broadcast-signals, on the basis of the control-signal received from the tuner. | 11-12-2009 |
José Manuel Inchausti Sancho, Igorre (vizcaya) ES
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20130062313 | GAS CIRCUIT BREAKER - The disclosure relates to a gas circuit breaker switch ( | 03-14-2013 |
José Manuel Llado, Madrid ES
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20110125669 | SYSTEMS AND METHODS FOR PROVIDING CUSTOMIZED FINANCIAL PRODUCTS AND FOR HEDGING RISK EXPOSURE - Systems and methods for creating and managing user-customized financial products are operable to create a plurality of user-customized financial products, each a discrete financial instrument comprising a baseline financial product comprised of a combination of one or more underlying product components, where each underlying product components comprises one or more user-customized component parameters. Once created, the plurality of user-customized financial products are disaggregated into their respective underlying product components and associated component values. Next, all component values associated with each of the underlying product components are aggregated, and at least one back-to-back hedging transaction for the aggregated component value of at least one of the underlying product components is executed. | 05-26-2011 |
José Manuel Menéndez Martin, Boadilla Del Monte ES
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20110303357 | PROCEDURE FOR THE MANUFACTURE OF LARGE PARTS OF COMPOSITE MATERIAL CONTROLLING THE THICKNESS OF THE EDGES THEREOF - Procedure for the manufacture of large parts of composite material, controlling the thickness of the edges thereof. It relates to the manufacture of a part ( | 12-15-2011 |
José Manuel Montero Duran, Madrid ES
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20130173479 | SYSTEM AND METHOD OF DIAGNOSIS OF INCIDENTS AND TECHNICAL SUPPORT REGARDING COMMUNICATION SERVICES - System and method of diagnosis of incidents and provision of technical support in a communication service which gathers information both from the user and from previous incidents whose information is stored in a database, and provides an identification of the problem, as well as a solution if possible, by dynamically determining data about the incident and requesting information according to the data. | 07-04-2013 |
José Manuel Palacios Valverde, Madrid ES
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20120324541 | METHOD AND SYSTEM FOR SUBSCRIBING TO SERVICES VIA EXTENDED UPNP STANDARD AND NASS TISPAN AUTHENTICATION - The present invention relates to a subscription method and system providing a modification of the UPnP standard, which by means of TISPAN delegated NASS authentication allows a user to play contents provided by a service provider via subscription by means of a control point which can be any consumer electronic device of the user. The modification of the standard is based on adding a field called ‘subscriptionURL’ and a variable called ‘subscriptionStatus’. These modifications, the association established by the TISPAN CLF module between the user IP and the user IMSI and the implementation of a UPnP device in the user equipment, allow subscribing to the services provided by several service providers. | 12-20-2012 |
José Manuel Pingarrón Carrazón, Madrid ES
José Manuel Rodríguez Fernández, Barcelona ES
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20110001428 | MULTI-SIGNAL EXTERNAL REAR-VIEW MIRROR ASSEMBLY FOR VEHICLES - A multi-signal exterior rear-view mirror assembly that includes: | 01-06-2011 |
José Manuel Rodríguez Fernández, Barcelona ES
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20110001428 | MULTI-SIGNAL EXTERNAL REAR-VIEW MIRROR ASSEMBLY FOR VEHICLES - A multi-signal exterior rear-view mirror assembly that includes: | 01-06-2011 |
José Manuel Rodriguez Ramos, Tenerife ES
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20100091146 | WAVEFRONT ABERRATION AND DISTANCE MEASUREMENT PHASE CAMERA - A system consisting of a phase camera with microlenses placed in the focal point of a converging lens, wherein the camera data, processed using a combined Fourier “Slice” and fast Fourier transform edge detection technique, provide both a three-dimensional wavefront map and a real scene depth map within a broad range of volumes. The invention is suitable for use in any field where wavefronts need to be known such as earth-based astronomical observation, ophthalmology, etc., as well as in fields requiring metrology, e.g. real scenes, CCD polishing, automobile mechanics, etc. The invention is applied to the particular case of atmospheric tomography using ELTs (large-diameter telescopes: 50 or 100 meters). | 04-15-2010 |
José Manuel Rodriguez Ramos, Tenerife ES
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20100091146 | WAVEFRONT ABERRATION AND DISTANCE MEASUREMENT PHASE CAMERA - A system consisting of a phase camera with microlenses placed in the focal point of a converging lens, wherein the camera data, processed using a combined Fourier “Slice” and fast Fourier transform edge detection technique, provide both a three-dimensional wavefront map and a real scene depth map within a broad range of volumes. The invention is suitable for use in any field where wavefronts need to be known such as earth-based astronomical observation, ophthalmology, etc., as well as in fields requiring metrology, e.g. real scenes, CCD polishing, automobile mechanics, etc. The invention is applied to the particular case of atmospheric tomography using ELTs (large-diameter telescopes: 50 or 100 meters). | 04-15-2010 |
José Manuel Rodríguez Ramos, La Laguna (tenerife) ES
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20110032337 | METHOD AND CAMERA FOR THE REAL-TIME ACQUISITION OF VISUAL INFORMATION FROM THREE-DIMENSIONAL SCENES - The invention relates to a method for calculating the focal stack associated with an object space from the plenoptic function thereof, using a sum transform along the length of constrained planes in discrete hypercubes, which allows the computing time to be considerably reduced. The invention also relates to a method for increasing the resolution of the focal stack obtained. In addition, the invention relates to two methods for the real-time recovery of the depths and moduli and phases of the complex amplitude of the wavefront respectively in each position of the surfaces of a three-dimensional scene and to a system adapted for carrying out the aforementioned methods. | 02-10-2011 |
José Manuel Rodríguez Ramos, La Laguna (tenerife) ES
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20110032337 | METHOD AND CAMERA FOR THE REAL-TIME ACQUISITION OF VISUAL INFORMATION FROM THREE-DIMENSIONAL SCENES - The invention relates to a method for calculating the focal stack associated with an object space from the plenoptic function thereof, using a sum transform along the length of constrained planes in discrete hypercubes, which allows the computing time to be considerably reduced. The invention also relates to a method for increasing the resolution of the focal stack obtained. In addition, the invention relates to two methods for the real-time recovery of the depths and moduli and phases of the complex amplitude of the wavefront respectively in each position of the surfaces of a three-dimensional scene and to a system adapted for carrying out the aforementioned methods. | 02-10-2011 |
José Manuel SÁnchez Giraldez, Montellano (seville) ES
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20130216662 | OLIVE-BASED RECONSTITUTED PRODUCT AND PRODUCTION PROCESS - The present invention relates to the process of obtaining reconstituted foods from natural raw materials and the products obtained following said process. It relates particularly to the process of producing a reconstituted product comprising two concentrically distributed portions such that the outer portion comprises reconstituted olive and the inner portion comprises reconstituted pepper. | 08-22-2013 |
José Manuel Saniger Blesa, Mexico MX
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20110215073 | Method and device for mirrors position adjustment of a solar concentrator - The present invention consists of developing a technology with different processes to realize an optimal solar approach using a solar concentrator where distance screws are used that, when moving, allow the positioning of the mirrors whereby the reflected solar beam is directed to a focal point; the advantage of these processes is that each movement of the screws involves adjusting the position of all the neighboring mirrors, which allow a perfect alignment and adjustment of the mirrors. | 09-08-2011 |
José Manuel Santos Gómez, Madrid ES
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20120072004 | Automatic mould stripping system - An automatic mould stripping system for moulding modules ( | 03-22-2012 |
José Manuel Santos GÓmez, Pinto (madrid) ES
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20110290421 | AUTOMATIC SYSTEM FOR QUALITY CONTROL AND POSITION CORRECTION OF TAPED PARTS - An object ( | 12-01-2011 |
José Manuel Serra Alfaro, Valencia ES
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20110183221 | CATALYTIC LAYER FOR OXYGEN ACTIVATION ON IONIC SOLID ELECTROLYTES AT HIGH TEMPERATURE - The present invention relates to a catalytic porous layer for oxygen activation that can be used in solid oxide fuel cells (SOFC) and dense ceramic membranes for oxygen separation at a high temperature. This porous layer is mainly composed of an electron and oxygen ion mixed conductive material and has a structure selected from simple perovskite-type structures, double perovskite-type structures or perovskite-related structures, i.e. structures such as the Ruddlesden-Popper, Dion-Jacobson and Aurivillius type. The composition of this crystalline phase has the following general formula: | 07-28-2011 |
José Manuel Serra Alfaro, Sevilla ES
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20120202898 | METHOD FOR OBTAINING A MULTIMETALLIC SULFUREOUS CATALYST AND USE THEREOF IN A METHOD FOR PRODUCING HIGHER ALCOHOLS BY CATALYTIC CONVERSION OF SYNTHESIS GAS - The present invention relates to a sulphided multi-metallic catalyst, the process for obtaining it by sulphidation of a multi-metallic solid and use thereof in a process for producing higher alcohols (C | 08-09-2012 |
20120208904 | METHOD FOR PRODUCING A MULTIMETALLIC SULFUREOUS SOLID AND USE THEREOF AS A CATALYST IN A METHOD FOR PRODUCING HIGHER ALCOHOLS FROM SYNTHESIS GAS - The present invention relates to a sulphided multi-metallic catalyst, a process for obtaining it by preparing a metal mixture and subsequent sulphidation thereof and its use in a process for producing higher alcohols (C | 08-16-2012 |
José Manuel Silvestre Monteiro, Cascais PT
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20100075775 | GOLF PUTTER WITH A CIRCULAR, PLAIN, VERTICAL, SMOOTH AND GRADED HEAD - This utility model refers to a golf putter that, contrary to a head with a straight and plain face, has a circular, plain, vertical, smooth and graded face. | 03-25-2010 |
José Manuel Silvestre Monteiro, Cascais PT
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20100075775 | GOLF PUTTER WITH A CIRCULAR, PLAIN, VERTICAL, SMOOTH AND GRADED HEAD - This utility model refers to a golf putter that, contrary to a head with a straight and plain face, has a circular, plain, vertical, smooth and graded face. | 03-25-2010 |
José Manuel Vega De Prada, Madrid ES
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20100250212 | COMPUTER-AIDED METHOD FOR A COST-OPTIMIZED CALCULATION OF VARIABLE DISTRIBUTIONS OVER AN AERODYNAMIC SURFACE - A computer-aided method suitable for assisting in the design of an aircraft by providing a variable distribution V over an aircraft surface inside a predefined parameter space by means of a reconstruction of the results obtained through computations for an initial group of points in the parameter space using a CFD model comprising in each of said computations the following steps: a) Selecting relevant shock wave structures being defined by its thickness δ | 09-30-2010 |
José Manuel Villalgordo-Soto, Murcia ES
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20100063026 | ANTIBACTERIAL QUINOLINE DERIVATIVES - The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or Formula (Ib): | 03-11-2010 |
José Manuel Villalgordo-Soto, Murcia ES
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20100063026 | ANTIBACTERIAL QUINOLINE DERIVATIVES - The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or Formula (Ib): | 03-11-2010 |