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| 20130158232 | METHOD FOR SELECTING A CANDIDATE DRUG COMPOUND - The disclosure relates to the field of candidate drug testing and drug development. Described are methods for providing a compound composed of at least one molecule attached via at least two linkages to a molecular scaffold, the method comprising providing a scaffold comprising at least a first and a second reactive group; providing at least one molecule able to react with the at least first and second reactive group; and contacting the scaffold with at least one molecule to form at least two linkages between the scaffold and the molecule in a coupling reaction, wherein the formation of a linkage accelerates the formation of a consecutive linkage. The coupling reaction may be performed in solution, such as an aqueous solution. Furthermore, described is a method for selecting a candidate drug compound comprising providing a library of the compounds and determining the binding of a target molecule to the compounds. | 06-20-2013 |
| 20140296478 | METHOD FOR SELECTING A CANDIDATE DRUG COMPOUND - The disclosure relates to the field of candidate drug testing and drug development. Described are methods for providing a compound composed of at least one molecule attached via at least two linkages to a molecular scaffold, the method comprising providing a scaffold comprising at least a first and a second reactive group; providing at least one molecule able to react with the at least first and second reactive group; and contacting the scaffold with at least one molecule to form at least two linkages between the scaffold and the molecule in a coupling reaction, wherein the formation of a linkage accelerates the formation of a consecutive linkage. The coupling reaction may be performed in solution, such as an aqueous solution. Furthermore, described is a method for selecting a candidate drug compound comprising providing a library of the compounds and determining the binding of a target molecule to the compounds. | 10-02-2014 |
| 20140308303 | METHOD FOR SELECTING A CANDIDATE DRUG COMPOUND - The disclosure relates to the field of candidate drug testing and drug development. A method is provided for providing a compound composed of at least one molecule attached via at least two linkages to a molecular scaffold, the method comprising providing a scaffold comprising at least a first and a second reactive group; providing at least one molecule capable of reacting with the at least first and second reactive group; contacting the scaffold with at least one molecule to form at least two linkages between the scaffold and the at least one molecule in a coupling reaction, wherein the formation of a linkage accelerates the formation of a consecutive linkage, preferably wherein the coupling reaction is performed in solution, more preferably in an aqueous solution. Furthermore, a method is provided for selecting a candidate drug compound comprising providing a library of compounds hereof and determining the binding of a target molecule to the compounds. | 10-16-2014 |
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| 20150061166 | DEVICE AND METHOD FOR PRODUCING CUSTOM-MADE SPECTACLES - The invention relates to a device for producing custom-made spectacles comprising a scanning unit and a producing unit, wherein the scanning unit is configured for scanning at least a part of a customer's face and wherein the producing unit comprises at least a printing device for printing a spectacle lens and/or a spectacle frame, wherein the printing device is configured for printing the spectacle lens and/or the spectacle frame in dependency of scanning data of the scanning unit. | 03-05-2015 |
| 20150086754 | METHOD FOR PRINTING A THREE-DIMENSIONAL STRUCTURE, METHOD FOR CONTROLLING A PRINT HEAD AND PRINTED ARTICLE - The present invention relates to a method for printing a three-dimensional structure by depositing a plurality of droplets of printing material onto a substrate, wherein the substrate comprises a main plane and wherein the droplets are deposited in such a manner that layers of printing material are generated which are inclined to the main plane of the substrate. | 03-26-2015 |
| 20150093544 | METHOD FOR PRINTING A THREE-DIMENSIONAL STRUCTURE WITH SMOOTH SURFACES AND PRINTED ARTICLE - The present invention relates to a method for printing a three-dimensional structure with a smooth surface comprising the following steps of depositing multiple droplets of printing material at least partially side by side and one above the other and curing the deposited droplets by light irradiation to build up a three-dimensional pre-structure in a first step, and smoothing at least one surface of the three-dimensional pre-structure by targeted placement of compensation droplets in boundary areas of adjacent deposited droplets and/or in edges of the surface to be smoothed in a second step to build up the three-dimensional structure with a smooth surface. | 04-02-2015 |
| 20150093552 | METHOD FOR PRINTING A THREE-DIMENSIONAL STRUCTURE, METHOD FOR CONTROLLING A PRINT HEAD AND A PRINTED ARTICLE - The present invention relates to a method for printing a three-dimensional structure comprising the steps of providing structural parameters defining the shape of the three-dimensional structure in a first step, converting the structural parameters into an intensity image having multiple pixels which are arranged in a two-dimensional pattern and which comprises at least different intensities in a second step and controlling the print head in dependency of the intensity image in order to print the three-dimensional structure in a third step, wherein the print head moves to a certain position and deposits at least one droplet of printing material when processing a certain pixel and wherein the number of droplets and/or the amount of printing material deposited at the certain position by the print head is chosen in dependency of the intensity of the corresponding pixel. | 04-02-2015 |
| 20150104991 | METHOD FOR PROVIDING A LIGHT ASSEMBLY EMITTING LIGHT WITH A DESIRED COLOR TEMPERATURE AND SYSTEM FOR TESTING AND CORRECTING COLOR TEMPERATURES OF LIGHT ASSEMBLIES - The present invention refers to a method for providing a light assembly emitting light with a desired color temperature comprising the steps of providing a light source in a first step measuring the color temperature of the light source in a second step, comparing the measured color temperature with the desired color temperature in a third step and printing an optical compensation means for compensating differences between the measured color temperature and the desired color temperature in a fourth step, if the measured color temperature deviates from the desired color temperature. | 04-16-2015 |
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| 20110124835 | METHOD FOR MANUFACTURING HIGH MOLECULAR WEIGHT POLYETHYLENE FIBERS - A process for manufacturing high molecular weight polyethylene fibers, including subjecting a polyethylene tape with a weight average molecular weight of at least 500,000 grams/mole, a Mw/Mn ratio of at most 6, and a 200/110 uniplanar orientation parameter of at least 3 to a force in the direction of the thickness of the tape over the entire width of the tape. A polyethylene fiber having a Mw of at least 500 000 gram/mole, a Mw/Mn ratio of at most 6, and a 020 uniplanar orientation value of at most 55°. | 05-26-2011 |
| 20110268951 | POLYETHYLENE FILM AND METHOD FOR THE MANUFACTURE THEREOF - The present invention pertains to a polyethylene film and a process for manufacturing such film. The polyethylene film may have a ratio between the strength in a first direction in the film plane and the strength in a second direction in the film plane perpendicular to the first direction in the range of 0.1-10:1, the strength in at least one direction being at least 0.2 Gpa. The process for manufacturing a polyethylene film may have a starting UHMWPE polymer with an average molecular weight of at least 500,000 grams/mole, an elastic shear modulus determined directly after melting at 160° C. of at most 1.4 MPa, and a Mw/Mn ratio of at most 6 to a solvent-free compacting process and a stretching process under such conditions that at no point during the process the temperature of the intermediate polymer film is raised to a value above its melting point. | 11-03-2011 |
| 20110268952 | POLYETHYLENE FILM WITH HIGH TENSILE STRENGTH AND HIGH TENSILE ENERGY TO BREAK - An UHMWPE film having a tensile strength of at least 2.0 GPa, a tensile energy to break of at least 30 J/g, an Mw of at least 500 000 gram/mole, and a Mw/Mn ratio of at most 6, and a film width of at least 5 mm. The film may be manufactured via a process which comprises subjecting a starting UHMWPE with a weight average molecular weight of at least 500 000 gram/mole, an elastic shear modulus determined directly after melting at 160° C. of at most 1.4 MPa, and a Mw/Mn ratio of at most 6 to a compacting step and a stretching step under such conditions that at no point during the processing of the polymer its temperature is raised to a value above its melting point. The film may be used as starting material in any applications where high tensile strength and high energy to break are important. Suitable applications include ballistic applications, ropes, cables, nets, fabrics, and protective applications. | 11-03-2011 |
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| 20090138183 | Adaptive Positioning Method for an Actuator - In an adaptive positioning method for an actuator, in particular, for a throttle butterfly on an internal combustion engine, during the adaptive positioning method, after a request for a set position and selection of a pilot value a corresponding pilot position for the actuator is adopted. The pilot position is adjusted until said position corresponds to the requested set position. The control value actually required or this set position is subsequently measured and recorded as corrected pilot value for the corresponding set position. | 05-28-2009 |
| 20100064664 | METHOD FOR CHECKING THE SEAL OF A REAGENT INJECTOR - In a method for checking the seal of a reducing agent injector of an SCR exhaust gas aftertreatment system of an internal combustion engine comprising at least one reducing agent tank, a reducing agent pump, a reducing agent injector and an NOx sensor connected downstream from the SCR catalytic converter, the following steps are carried out: a) Generation and/or detection of a release state of the SCR system in which no reducing agent is stored in the SCR catalytic converter; b) Determining a setpoint NOx value in the exhaust gas; c) Starting the seal check with a closed reducing agent injector by increasing the reducing agent pressure; d) Detecting the NOx signal at the NOx sensor, and a) Evaluating the NOx signal. | 03-18-2010 |
| 20100218484 | METHOD AND DEVICE FOR CONTROLLING AN SCR-EXHAUST GAS AFTER-TREATMENT SYSTEM OF AN INTERNAL COMBUSTION ENGINE - A method for controlling an SCR-exhaust gas after-treatment system ( | 09-02-2010 |
| 20100257842 | METHOD FOR DETECTING THE MINIMUM OPENING TIME OF A REDUCING AGENT FEED DEVICE IN AN EXHAUST GAS AFTERTREATMENT SYSTEM COMPRISING AN SCR CATALYST - In a method for adapting the reducing agent feed in an exhaust gas aftertreatment system having an SCR catalyst for removing nitrogen oxides from the exhaust gas of an internal combustion engine and at least one reducing agent feed device, the minimum opening time of the reducing agent feed device is determined during operation and while suspending nitrogen emission, carrying out the following steps: a) the opening time of the reducing agent feed device is gradually prolonged until b) a reducing agent-sensitive sensor in the exhaust gas aftertreatment system detects a reducing agent signal. An exhaust gas aftertreatment system is designed accordingly for carrying out the method and a device is designed for controlling an exhaust gas aftertreatment system. | 10-14-2010 |
| 20110239625 | METHOD AND DEVICE FOR ADAPTING THE INJECTION AGENT SUPPLY IN AN INJECTION SYSTEM, AND EXHAUST GAS AFTERTREATMENT SYSTEM - In a method and a device for adapting the injection agent supply for an emission control system, the following steps are carried out: a) setting of a agent pressure target value in the line upstream of the pump in relation to the ambient pressure; b) opening of the pressure relief valve for a predetermined time t; c) determining the pressure difference between the target and the injection agent pressure, caused in step b), immediately after step b); d) setting a target value for the agent pressure in the line downstream of the pump in relation to the exhaust gas pressure in the system; e) opening of the injector for a predetermined time t; f) determining the pressure difference between the target and the agent pressure, caused in step e), immediately after step e); g) comparing the pressure differences from steps c) and f); and h) optional adaptation of the injector opening time. | 10-06-2011 |
| 20120319833 | Method for Assisting in Maintenance of a Motor Vehicle - A method for assisting in maintenance of a motor vehicle having a drive motor, an drive energy storage device, and a filling level measuring device. A request for a maintenance process is identified by a self-monitoring device with the maintenance request being transmitted as a maintenance indication to a driver by an information device. The maintenance indication is transmitted to the driver as a function of a switch-off filling level present when the vehicle drive motor is switched off and detected by the filling level measuring device. The maintenance indication is transmitted when the switch-off filling level is lower than a preset filling level threshold value or when a filling level difference between a switch-on filling level, present when the vehicle drive motor is subsequently switched on again and detected by the filling level measuring device, and the preceding switch-off filling level indicates a positive filling level value. | 12-20-2012 |
| 20130200919 | Method And Apparatus For Determining At Least One Operating Parameter Of A Thermoelectric System In A Vehicle - A method is provided for determining at least one operating parameter of a thermoelectric system in a vehicle, wherein the thermoelectric system comprises an energy conversion device having at least one photovoltaic element for converting thermal radiation, which is emitted by a heat source of the vehicle, into electrical energy. The method includes measuring an electrical power of the photovoltaic device, and determining an operating parameter of the thermoelectric system based on the measured electrical power of the photovoltaic device. | 08-08-2013 |
| 20130238180 | Method for Distributing Energy in an Electric Vehicle and Electric Vehicle - A method is disclosed for distributing energy in an electric vehicle including at least one electric energy store and at least one conditioning module, which can be used to generate electric energy from fuel, as energy sources, wherein driving-related information, or information about a state of the electric vehicle, is recorded before driving, or when beginning to drive, the electric vehicle and, while driving, energy is distributed in the vehicle on the basis of the information. | 09-12-2013 |
| 20150324744 | SYSTEM FOR DELIVERING SHIPPING ITEMS - A system for delivering shipping items in vehicles includes a first communication module establishing a communication link to a communication terminal of a delivery person, the communication terminal receiving authorization data via a communication network; a first identification routine unambiguously identifying a delivery person; a second communication module establishing, via a wireless communication network, a communication link to a communication device of a control unit of the access arrangement on a vehicle; a second identification routine for unambiguously identifying the system by the access arrangement; a third communication module for receiving update request data from the driver; and an update routine for updating authorization data in a memory of the system. Upon updating authorization data, information is wirelessly transmitted relating to the successful delivery and the content of the delivery to the access arrangement. The driver assistance system displays an alert message about the delivery. | 11-12-2015 |
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| 20100152115 | DETECTION OF PHYSIOLOGICALLY ACCEPTABLE POLYMER MOLECULES USING NEAR INFRARED SPECTROSCOPY - The present invention relates, in general, to methods for detecting the amount of a polymer on a protein using near-infrared spectroscopy. Measurement of the number of polymer moieties per protein molecule allows for production of molecules having a uniform number of polymer moieties, which is useful in the production of pharmaceutical compositions. | 06-17-2010 |
| 20100318048 | HEMOSTATIC SPONGE - The present invention provides a hemostatic porous sponge comprising a matrix of a fibrous biomaterial and particles of a fluid absorbing, particulate material adhered to said matrix material, a method of producing these sponges and their use for wound healing. | 12-16-2010 |
| 20110202026 | HEMOSTATIC SPONGE - The present invention provides a hemostatic composite sponge comprising a porous matrix of a biomaterial and a material enhancing the adherence of said sponge to the applied tissue stably associated with at least one surface of said sponge, a method of producing these sponges and their use in hemostasis. | 08-18-2011 |
| 20110251574 | HEMOSTATIC SPONGE - The present invention provides a hemostatic porous composite sponge comprising
| 10-13-2011 |
| 20130028975 | HEMOSTATIC SPONGE - The present invention provides a hemostatic porous composite sponge comprising i) a matrix of a biomaterial and ii) one hydrophilic polymeric component comprising reactive groups wherein i) and ii) are associated with each other so that the reactivity of the polymeric component is retained, wherein associated means that—said polymeric component is coated onto a surface of said matrix of a biomaterial, or—said matrix is impregnated with said polymeric material, or—both. | 01-31-2013 |
| 20130090291 | HEMOSTATIC COMPOSITIONS - The invention discloses a hemostatic composition comprising:
| 04-11-2013 |
| 20130096062 | HEMOSTATIC COMPOSITIONS - The invention discloses a hemostatic composition comprising:
| 04-18-2013 |
| 20130096063 | HEMOSTATIC COMPOSITIONS - The invention discloses a hemostatic composition comprising:
| 04-18-2013 |
| 20140308325 | HEMOSTATIC SPONGE - The present invention provides a hemostatic porous composite sponge comprising
| 10-16-2014 |
| 20140378928 | HEMOSTATIC SPONGE - The present invention provides a hemostatic composite sponge comprising a porous matrix of a biomaterial and a material enhancing the adherence of said sponge to the applied tissue stably associated with at least one surface of said sponge, a method of producing these sponges and their use in hemostasis. | 12-25-2014 |
| 20150132362 | HEMOSTATIC SPONGE - The present invention provides a hemostatic porous sponge comprising a matrix of a fibrous biomaterial and particles of a fluid absorbing, particulate material adhered to said matrix material, a method of producing these sponges and their use for wound healing. | 05-14-2015 |
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| 20150235104 | METHOD AND SYSTEM FOR REGISTRATION/ALIGNMENT OF 3D DIGITAL MODELS - Systems and methods, devices and software are described for use in image comparison such as required for medical planning such as in dental implantology or other applications that require registration of digital images. A method and system is described for automatically finding correspondences between two or more digital representations such as images of one or more 3D objects with an identical, partially identical or similar geometry. The method and system, devices and software have the advantage that although the different digital representations of the object may be influenced by either noise, or scatter, or occlusion, or clutter, or any combination of these, correspondence can be found. | 08-20-2015 |
| 20150248538 | 3D MODELLING OF BODIES - System or components such as software for 3D modelling of bodies is described. This can be realized by a computer based method for modelling a body by scanning a determined space divided into elementary spaces, each elementary space being assigned a signed distance parameter indicative of the distance of said elementary space to said body and a weight parameter indicative of the importance of the distance parameter; said scanning of said body providing scanned points and each scanned point thus obtained possibly modifying said signed distance and weight parameters of each elementary space of said determined space; wherein, each one of selected elementary spaces is modified by subdividing said selected elementary space into higher level elementary spaces defined by the same parameters; wherein, in order to decrease details of the model of said body, said elementary spaces are modified by replacing selected elementary spaces with lower level elementary spaces. | 09-03-2015 |
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| 20100038736 | SUSPENDED GERMANIUM PHOTODETECTOR FOR SILICON WAVEGUIDE - A vertical stack of a first silicon germanium alloy layer, a second epitaxial silicon layer, a second silicon germanium layer, and a germanium layer are formed epitaxially on a top surface of a first epitaxial silicon layer. The second epitaxial silicon layer, the second silicon germanium layer, and the germanium layer are patterned and encapsulated by a dielectric cap portion, a dielectric spacer, and the first silicon germanium layer. The silicon germanium layer is removed between the first and second silicon layers to form a silicon germanium mesa structure that structurally support an overhanging structure comprising a stack of a silicon portion, a silicon germanium alloy portion, a germanium photodetector, and a dielectric cap portion. The germanium photodetector is suspended by the silicon germanium mesa structure and does not abut a silicon waveguide. Germanium diffusion into the silicon waveguide and defect density in the germanium detector are minimized. | 02-18-2010 |
| 20100111470 | LOW-LOSS LOW-CROSSTALK INTEGRATED DIGITAL OPTICAL SWITCH - An optical switch includes a plurality of optical interferometric structures is serially connected between at least one optical input node and two optical output nodes. A primary waveguide directly connects an optical input node and a first optical output node. A complementary waveguide, which is directly connected to a second optical output node, is evanescently coupled with the primary waveguide in a pair of optically coupled sections provided in each optical interferometric structure. Each optical interferometric structure also includes a pair of decoupled sections, which includes a primary decoupled section embedding a portion of the primary waveguide and a complementary decoupled section which includes a portion of the complementary waveguide. The complementary decoupled section is embedded in a phase tuning structure that allows modulation of the phase of the optical signal passing through. The optical switch provides less insertion loss, less crosstalk, and wider bandwidth than prior art optical switches. | 05-06-2010 |
| 20110143482 | SUSPENDED GERMANIUM PHOTODETECTOR FOR SILICON WAVEGUIDE - A vertical stack of a first silicon germanium alloy layer, a second epitaxial silicon layer, a second silicon germanium layer, and a germanium layer are formed epitaxially on a top surface of a first epitaxial silicon layer. The second epitaxial silicon layer, the second silicon germanium layer, and the germanium layer are patterned and encapsulated by a dielectric cap portion, a dielectric spacer, and the first silicon germanium layer. The silicon germanium layer is removed between the first and second silicon layers to form a silicon germanium mesa structure that structurally support an overhanging structure comprising a stack of a silicon portion, a silicon germanium alloy portion, a germanium photodetector, and a dielectric cap portion. The germanium photodetector is suspended by the silicon germanium mesa structure and does not abut a silicon waveguide. Germanium diffusion into the silicon waveguide and defect density in the germanium detector are minimized. | 06-16-2011 |
| 20120288971 | Co-Integration of Photonic Devices on a Silicon Photonics Platform - Disclosed are methods for co-integration of active and passive photonic devices on a planarized silicon-based photonics substrate. In one aspect, a method is disclosed that includes providing a planarized silicon-based photonics substrate comprising a silicon waveguide structure, depositing a dielectric layer over the planarized silicon-based photonics substrate, selectively etching the dielectric layer, thereby exposing at least a portion of the silicon waveguide structure, selectively etching the exposed portion of the silicon waveguide structure to form a template, using the silicon waveguide structure as a seed layer to selectively grow in the template a germanium layer that extends above the dielectric layer, and planarizing the germanium layer to form a planarized germanium layer, wherein the planarized germanium layer does not extend above the dielectric layer. | 11-15-2012 |
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| 20120014964 | ALPHA SYNUCLEIN TOXICITY - Present inventions demonstrates that alpha synuclein toxicity such as α-synuclein mediated cell death, alpha synuclein induced reactive oxygen species (ROS) in a cell requires the proapoptotic endonuclease G and that the deletion of the endonuclease G or suppressing of the endonuclease G apoptotic pathway attenuates or counteracts such alpha synuclein toxicity. The present invention compositions and methods for inhibition of α-synuclein toxicity. The inhibiting α-synuclein toxicity can be used in methods of treatment of synucleinopathies, such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), pure autonomic failure (PAF), and multiple system atrophy (MSA) and the manufacture of medicaments for such treatment. In particular The subject matter provided in herein relates to a pharmaceutical compositions containing inhibitors of endonuclease G, and their use in the treatment of synucleinopathies, such as Parkinson's disease, dementia with Lewy bodies, pure autonomic failure, and multiple system atrophy and the manufacture of medicaments for such treatment. Furthermore the present invention relates to a method for the identification of compounds attenuating the synuclein toxicity, said method comprising evaluating the inhibitory action of said compound on the endonuclease G dependent apoptosis. | 01-19-2012 |
| 20120015901 | METHODS AND PREPARATIONS FOR PROTECTING CRITICALLY ILL PATIENTS - The present invention relates to a method of treating a life threatening condition in a critically ill human patient with a non-infectuous disorder, wherein the critically ill patient is a patient receiving enteral or parenteral nutrition, the method comprising the step of administering to said patient an autophagy inducing agent. | 01-19-2012 |
| 20140093494 | ALPHA SYNUCLEIN TOXICITY - It is demonstrated that alpha synculein toxicity such as α-synuclein mediated cell death, and alpha synuclein induced reactive oxygen species (ROS) in a cell requires proapoptotic endonuclease G and that the deletion of the endonuclease G or suppressing of the endonuclease G apoptotic pathway attenuates or counteracts such alpha synuclein toxicity. In view of these observations, compositions and methods for inhibition of α-synuclein toxicity are provided. The inhibiting α-synuclein toxicity can be used in methods for the treatment of synucleinopathies, such as Parkinsons disease (PD), dementia with Lewy bodies (DLB), pure autonomic failure (PAF), and multiple system atroypy (MSA) and the manufacture of medicaments for such treatment. In particular, pharmaceutical compositions containing inhibitors of endonuclease G, and their use in the treatment of synucleinopathies such as Parkinson's disease, dementia with Lew bodies, pure autonomic failure, and multiple system atrophy and the manufacture of medicaments for such treatment are presented. In addition, methods for the identification of compounds for attenuating the synuclein toxicity are also provided. | 04-03-2014 |
| 20140161875 | ANTIBODIES TO PHOSPHORYLATED TAU AGGREGATES - This invention concerns affinity tools for oligomeric forms of tau protein. It relates to the field of neurodegeneration, more particularly to the field of tau-related diseases and tauopathy. The invention provides novel tau antibodies and antibody fragments, nucleic acids encoding such antibodies and antibody fragments, cell lines producing such antibodies and antibody fragments, antibody compositions, and kits for the detection of aggregated tau and for the diagnosis of diseases involving aggregated tau. The invention further provides methods for the detection of aggregated tau, for the diagnosis of diseases involving aggregated tau, and for the identification of compositions interfering with the formation and/or stability of tau aggregates. | 06-12-2014 |
