Patent application number | Description | Published |
20100034865 | OSTEOINDUCTIVE CALCIUM PHOSPHATES - The invention relates to a porous osteoinductive calcium phosphate material having an average grain size in a range of 0.1-1.50 μm, having a porosity consisting essentially only of micropores in a size range of 0.1-1.50 μm, and having a surface area percentage of micropores in a range of 10-40%. | 02-11-2010 |
20110020419 | OSTEOINDUCTIVE CALCIUM PHOSPHATES - The invention relates to a porous osteoinductive calcium phosphate material having an average grain size in a range of 0.1-1.50 μm, having a porosity consisting essentially only of micropores in a size range of 0.1-1.50 μm, and having a surface area percentage of micropores in a range of 10-40%. | 01-27-2011 |
20110111004 | OSTEOINDUCTIVE NANOCOMPOSITES - The present invention relates porous osteoinductive nanocomposites and for the methods to prepare osteoinductive nanocomposites. The osteoinductive composites consist of biocompatible polymers and non-heated (or non-sintered), needle-shaped or plate-like calcium phosphate nanocrystals and the methods comprise the steps of: a. adding phosphate to a calcium solution thereby evoking precipitation of calcium phosphate nanocrystals; b. washing the nanocrystals with water and suspending them in an organic solvent or getting dry calcium phosphate nanocrystals after evaporating organic solvent; c. adding polymers (previously dissolved in an organic solvent) to calcium phosphate nanocrystal suspension, rotational mixing of the components using beads, mixing with porogenic agents, moulding the composite material and evaporating of the organic solvent; or mixing polymers (not dissolved in an organic solvent but raw powder), dry calcium phosphate nanocrystals and porogenic agents with melting intrusion and moulding the composites; d. leaching porogenic agents in water. | 05-12-2011 |
20110293584 | Tissue Regeneration - The present invention relates to a method of treating a tissue defect in a human or animal body comprising the steps of implanting into said body an unseeded scaffold; allowing or effecting a wound healing response at the site of said defect; allowing said scaffold to be vascularized until a substantially sufficient fluid flow through said scaffold is assured for the transport of nutrients and/or waste products, and seeding said vascularised scaffold with a suitable population of tissue-regenerating cells. | 12-01-2011 |
20120021008 | INJECTABLE AND MOLDABLE CERAMIC MATERIALS - Disclosed is an injectable and moldable ceramic material comprising porous calcium phosphate having surface-microporosity, and a water-free carrier, wherein the carrier is selected so as to disintegrate under physiological circumstances. The latter refers to the property of a carrier to dissolve, disassociate, or otherwise disintegrate after placement (e.g. through injection or implantation) into the human body. By selection of a water-free polymer or polymer blend which is combined with surface-microporous calcium phosphates, the favourable osteoinductive properties by virtue of the surface-microporosity can be retained for prolonged shelf life. | 01-26-2012 |
20130059383 | CELL-CULTURE-BAG - The present invention is directed to a method to expand adherent cells comprising addition of adherent cells to an expansion container comprising microcarriers and culture medium; removing medium from the expansion container through a 8-20 mm filter; allowing cells to attach to microcarriers and keeping the expansion container in motion with an angle of between 30 to 90° and −30 to −90°. The present invention is also directed to a device suitable in the method. The advantage of the present invention is that fewer steps are needed to expand adherent cells, including stem cells like MSC opening the way for the use of autologeous and allogenous stem cell therapy. In addition, contamination risk is limited since the present invention may be carried out in a closed, disposable system. | 03-07-2013 |
20130157353 | CELL-CULTURE-BAG - A cell-culture-bag for use in the expansion of stem cells from a crude biopsy, comprising: outer walls; a chamber located within the walls; a first inlet, and first and second outlets, providing fluid communication with the chamber, for connection to a perfusion apparatus; and a filter arrangement constructed to allow passage of red blood cells and block passage of stem cells from the first outlet, and block passage of microcarriers from the second outlet. | 06-20-2013 |
20160067382 | Osteoinductive Calcium Phosphates - The invention relates to a porous osteoinductive calcium phosphate material having an average grain size in a range of 0.1-1.50 μm, having a porosity consisting essentially only of micropores in a size range of 0.1-1.50 μm, and having a surface area percentage of micropores in a range of 10-40%. | 03-10-2016 |