Patent application number | Description | Published |
20130165415 | CHEMICAL COMPOUNDS - The present invention features compounds that are prodrugs of HIV integrase inhibitors and therefore are useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC. | 06-27-2013 |
20130172559 | POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY - The present invention is to provide a novel compound (I) shown below, having the anti-virus activity, particularly the HIV integrase inhibitory activity, and a drug containing the same, particularly an anti-HIV drug, as well as a process and an intermediate thereof. | 07-04-2013 |
20140200209 | POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY - The present invention is to provide a novel compound (I) shown below, having the anti-virus activity; particularly the HIV integrase inhibitory activity, and a drug containing the same, particularly an anti-HIV drug, as well as a process and an intermediate thereof. | 07-17-2014 |
Patent application number | Description | Published |
20130123089 | CENTRIFUGE SYSTEM AND WORKFLOW - Systems, methods and apparatus are described for a centrifuge module of a laboratory analysis system. Specimen containers may be weighed, loaded into a centrifuge adapter, and transported to a centrifuge module by an adapter shuttle. A centrifuge adapter gripper may transport the centrifuge adapter into a centrifuge for centrifugation. The centrifuge adapter may be transported by the centrifuge adapter gripper to an adapter shuttle for unloading of the specimen containers, which may be performed by a specimen container gripper. A centrifuge drawer that allows a centrifuge to be extended from its installed position is also described. Additional embodiments pertain to a sequence for replacing, in a centrifuge, a set of centrifuge adapters that have been centrifuged with a set of centrifuge adapters that have not been centrifuged. A sequence for loading specimen containers into centrifuge adapters is also described. | 05-16-2013 |
20130125675 | ALIQUOTTER SYSTEM AND WORKFLOW - A method is disclosed. The method includes aspirating an aliquot volume of a sample in a primary sample container located in an aspiration position in an aliquotter module, and dispensing the aliquot volume of the sample in a secondary sample container located in a dispensing position in the aliquotter module. The method also includes the step of causing the secondary sample container to leave the aliquotter module before the primary sample container. | 05-23-2013 |
20130126302 | MAGNETIC DAMPING FOR SPECIMEN TRANSPORT SYSTEM - A specimen transport system with magnetic damping and method for transporting specimens with magnetic damping are disclosed. A conveyance device transports sample carriers configured to carry specimen containers. One or more of the sample carriers include magnets. The system may also include a diverting arm having a magnet. When a first sample carrier is transported toward a second sample carrier, a first sample carrier magnet coupled to the first sample carrier repels a second sample carrier magnet coupled to the second sample carrier. When a sample carrier is transported toward a diverting arm, a diverting arm magnet of the diverting arm repels a sample carrier magnet of the sample carrier. | 05-23-2013 |
20130128035 | ROBOTIC ARM - An analytical laboratory system and method for processing samples is disclosed. A sample container is transported from an input area to a distribution area by a gripper comprising a means for inspecting a tube. An image is captured of the sample container. The image is analyzed to determine a sample container identification. A liquid level of the sample in the sample container is determined. A scheduling system determines a priority for processing the sample container based on the sample container identification. The sample container is transported from the distribution area to a subsequent processing module by the gripper. | 05-23-2013 |
20140240096 | MOUNT DEVICE UTILIZING PATTERNED FEATURES FOR RACK ORIENTATION DETECTION - An embodiment of the invention relates to systems and methods for detecting the orientation of sample carriers using two or more RFID tags. One or two dimensional matrix of equally spaced RFID reader antennas may be positioned beneath or within an area on which racks are placed. The first RFID tag defines the origin of the sample carrier and its geometry. The second and additional RFID tags define the orientations of the sample carrier relative to the matrix of the RFID reader antennas. At least two of the tag antennas on the rack align uniquely with two antennas on the reader matrix. The system energizes each reader antenna and associates the RFID tags aligned with them to the RFID reader antenna's physical position. | 08-28-2014 |
20140240100 | RACK ORIENTATION DETECTION WITH MULTIPLE TAGS - A first embodiment of the invention relates to systems and methods for detecting the orientation of sample carriers using two or more RFID tags. One or two dimensional matrix of equally spaced RFID reader antennas may be positioned beneath or within an area on which racks are placed. The first RFID tag defines the origin of the sample carrier and its geometry. The second and additional RFID tags define the orientations of the sample carrier relative to the matrix of the RFID reader antennas. At least two of the tag antennas on the rack align uniquely with two antennas on the reader matrix. The system energizes each reader antenna and associates the RFID tags aligned with them to the RFID reader antenna's physical position. | 08-28-2014 |
20140305227 | SYSTEM AND METHOD FOR PROCESSING SAMPLES - An analytical laboratory system and method for processing samples is disclosed. The system includes a manager unit, as well as an aliquotter unit and a centrifuge unit. | 10-16-2014 |
Patent application number | Description | Published |
20110014511 | METHOD FOR CONVERTING A SEPARATOR PROCESSING MACHINE - The invention relates to a method for converting a separator processing machine for processing separators for a lead accumulator, comprising the steps of ending a supply of a first separator having a first separator width to the separator processing machine and supplying a second separator having a second separator width that differs from the first separator width to the separator processing machine. According to the invention, the separators comprise a base film body extending along a center line and a plurality of primary ribs, which are raised above the base film body along the center line by a primary rib height and are disposed mirror-symmetrically with respect to the center line, wherein the primary ribs of the second separator with respect to the center line are disposed in the same locations as the primary ribs of the first separator. | 01-20-2011 |
20110250496 | LAMINAR TEXTILE MATERIAL FOR A BATTERY ELECTRODE - The invention relates to a laminar textile material for covering a pasty active mass on a battery electrode. The invention further relates to a battery electrode having such a material, to a battery, and to a method for producing battery electrodes. Potential improvements of lead batteries are disclosed that are more practical than previously known solutions, and that stabilize the pasty active mass on the battery electrodes. A laminar textile materiel is disclosed to this end, comprising glass fibers and fibers made of a thermoplastic plastic, e.g. polyester. | 10-13-2011 |
20120308888 | SPREADING MEANS FOR THE ACTIVE MATERIAL OF A NEGATIVE ELECTRODE - The invention relates to performance improvements in lead-acid batteries by admixing so-called expanders or spreading materials to the active negative materials. Succinates are proposed as a new synthetic and consequently chemically clearly defined spreading means that can be used in place of lignin sulphonates, particularly iminodisuccinates or succinyl groups or oligomers containing iminosuccinyl groups or polymer compounds, individually or in any mixtures. | 12-06-2012 |
20150104715 | ELECTRODE PLATE OF AN ELECTROCHEMICAL BATTERY AND ELECTROCHEMICAL BATTERY COMPRISING SUCH ELECTRODE PLATE - An electrochemical battery is disclosed. The electrochemical battery has an electrode plate comprising a frame and a generally flat grid connected to the frame, the frame comprising at least a top frame member having a contact lug, wherein the grid comprises a plurality of grid wires and a plurality of window-like open areas between the grid wires, further comprising an active mass within the open areas and/or on the grid wires, wherein the electrode plate comprises on one outer surface or on both opposing outer surfaces of the active mass a pattern of grooves, wherein the grooves extend diagonally from a position closer to the top frame member to a position further away from the top frame member. A method for producing an electrode plate is also disclosed. | 04-16-2015 |
Patent application number | Description | Published |
20110240777 | MOTOR VEHICLE FOR COLLECTING PAPER - A motor vehicle collects paper. The motor vehicle includes a collection compartment configured to receive the paper. It also includes at least one of a bin lifting device configured to lift a bin to deposit the paper in the collection compartment and a moving floor configured to transport the paper within the collection compartment. The motor vehicle further includes at least one battery disposed within or attached to the collection compartment configured to power an actuator for at least one of the bin lifting device and the moving floor. | 10-06-2011 |
20110240778 | MOTOR VEHICLE FOR COLLECTING PAPER AND HAVING BATTERY TO ASSIST IN PROPULSION - A motor vehicle for collecting paper for shredding including an electric motor configured to at least assist in propelling the motor vehicle; a compartment configured to receive paper; at least one of a bin lifting device, a shredder mechanism, a conveyance device, and a dumping device; and at least one battery. The bin lifting device is configured to lift a bin and deposit the paper in the compartment, the shredder mechanism is configured to shred the paper in the compartment, the conveyance device is configured to transport the paper from a first location to a second location within the compartment, and the dumping device is configured to discharge the paper from the compartment. The at least one battery is configured to power (i) the electric motor and (ii) the at least one of the bin lifting device, the shredder mechanism, the conveyance device, and the dumping device. | 10-06-2011 |
20130259614 | MOTOR VEHICLE FOR COLLECTING AND SORTING MATERIAL AND METHOD OF DOING SAME - A motor vehicle for collecting and sorting material includes at least one container disposed in a material-storage compartment of the motor vehicle, a bin tipper configured to receive a collection bin containing the material, and a hopper configured to receive the material from the collection bin and transport the material to a selected location in the material-storage compartment of the motor vehicle. | 10-03-2013 |
Patent application number | Description | Published |
20140199990 | Communication Network - A wired network may be used to carry signals for a wireless network, in a frequency-shifted manner, to extend the range of the wireless network. A wired network may detect signal interference emanating from a wireless service provider, and received through a leak in the wired network's infrastructure. Devices may be installed or leveraged in the vicinity of the interference to extend the wireless service to geographic areas that may have poor reception. The devices may amplify wireless downstream signals and transmit them wirelessly, and may receive upstream wireless communications and transmit them upstream in the wired network's protocol. | 07-17-2014 |
20140269270 | SCHEDULED TRANSMISSION OF DATA - A method and system may allow for the scheduling of transmissions. A device may send a transmission request over a network where the request may be an upload request or a download request. Traffic may be monitored on the network and the traffic may determine when the transmission is to be scheduled. Depending on the traffic and the type of transmission, the transmission may be scheduled for a future time or may be added to a queue of pending transmissions. Once commenced, the transmission may be paused and resumed based on continually monitored traffic on the network. | 09-18-2014 |
20140280701 | DISTRIBUTED COMPUTING - Methods, systems, computer readable media, and apparatuses that manage distributed computing tasks based on information received at lower levels of the Open Systems Interconnection (OSI) model are described herein. Some embodiments relate to using a Data Over Cable Service Interface Specification (DOCSIS) capable device to manage distributed computing tasks at Layer 2. For example, registered device may send ranging requests a termination system that include additional information related to the capacity and ability for a registered device to handle a resource associated with a distributed computing task. Based on the information included in the ranging request, the system may determine that the registered device is available for resource data and, thereafter, may distribute the resource to the registered device in connection with performing the distributed computing task. | 09-18-2014 |
Patent application number | Description | Published |
20140280746 | MANIFEST CHUNKING IN CONTENT DELIVERY IN A NETWORK - Implementations described and claimed herein provide a system and methods for dynamic re-localization and manifest chunking in a content delivery network. In one implementation, a request for content is received. A first manifest subset is provided using a network component in response to the request for content. The first manifest subset identifies a first set of one or more content segments and a second manifest subset. The first set of one or more content segments constitute a portion of the content, and the second manifest subset is identified at a tail of the first manifest subset. The first set of one or more content segments is served in response to separate requests. A request for the second manifest subset identifying a second set of one or more content segments is received. In another implementation, localization errors are remedied by replacing a relative identifier with an absolute identifier. | 09-18-2014 |
20140280906 | DYNAMICALLY OPTIMIZING CONTENT DELIVERY USING MANIFEST CHUNKING - Implementations described and claimed herein provide a system and methods for dynamic re-localization and manifest chunking in a content delivery network. In one implementation, one or more stimuli corresponding to a connection to deliver content from a content source over a network to a user device along a network path are detected. The one or more stimuli indicate a connection issue. An optimized network path through which to deliver the content to the user device is determined based on current network conditions. The optimized network path responds to the connection issue. The user device is dynamically rerouted to the optimized path while providing a substantially continuous delivery of content to the user device. | 09-18-2014 |
20140344331 | SELECTING A CONTENT PROVIDING SERVER IN A CONTENT DELIVERY NETWORK - Aspects of the present disclosure involve systems, methods, computer program products, and the like, for managing the distribution of content from a content distribution network (CDN). In general, the system receives a request for content from the CDN from a user of the network and determines a server within the CDN to provide the content to the user. In addition, the system of the present disclosure may determine a preferred server or group of servers from which the content is provided to the user. This preference may be based on information received from a Border Gateway Protocol feed or Interior Gateway Protocol feed and one or more business determinations, such as the cost of providing the content through the CDN and particular egress port associated with the CDN. | 11-20-2014 |
Patent application number | Description | Published |
20130318056 | Lightweight Integrity Protection for Web Storage-Driven Content Caching - Methods, systems, and computer-readable storage media for providing integrity protection for web storage-driven content caching. Implementations include receiving a web page from a server, the web page being associated with a script library and one or more items that can be stored in web storage of a web browser executed on a client computing device, each of the one or more items being associated with a pre-determined checksum value, and loading the script library, such that a local storage API is overwritten using a wrapper function, the script library being executable to, in response to a request for an item from web storage, perform operations including: determining a generated checksum value based on the item, and verifying an integrity of the item based on the generated checksum value and a pre-determined checksum value associated with the item. | 11-28-2013 |
20140041023 | FLEXIBLE AND SECURE CLICKJACKING PROTECTION MECHANISM - Methods, systems, and computer-readable storage media for preventing a clickjacking attack on a web page. Implementations include inhibiting rendering of content of the web page, receiving a message from an embedding web page, the embedding web page having called the web page, the message including metadata, and determining whether the embedding web page is trusted based on the metadata, wherein rendering of content of the web page remains inhibited if the embedding web page is untrusted, and rendering of content of the web page is executed if the embedding web page is trusted. | 02-06-2014 |
20140101446 | SECURE CLIENT-SIDE KEY STORAGE FOR WEB APPLICATIONS - Implementations of the present disclosure include methods, systems, and computer-readable storage mediums for secure client-side key storage for authentication tracking. Implementations include actions of determining, at a browser executed on a client-side computing device, that an application is authentic, the application being executed on a server-side computing device, in response to determining that the application is authentic, receiving a session signing key (SSK) at a sub-domain of an application domain, the sub-domain including a static script that handles the SSK and that selectively provides request signatures, receiving, at the sub-domain, a message requesting a request signature, determining that the message originated from an authentic origin, and in response to determining that the message originated from an authentic origin, providing a request signature to a source of the message, the request signature being based on the SSK. | 04-10-2014 |
20140101447 | Mutual Authentication Schemes - Implementations of the present disclosure are directed to web-based authentication. Implementations include receiving user credentials at a browser, transmitting a first request to an application, the first request including a first user credential, receiving a first response, the first response including an encrypted server public key (SPK) and a user-specific salt value, decrypting the encrypted SPK to provide a SPK, the encrypted SPK being decrypted based on the user-specific salt value and a second user credential, determining a browser public key (BPK) and a client-side session signing key (SSK), encrypting the BPK to provide an encrypted BPK, transmitting a second request to the application, the second request including the encrypted BPK and a request signature, the request signature having been provided based on the client-side SSK, and receiving a second response, the second response including a response signature and indicating that a user has been authenticated by the application. | 04-10-2014 |
20150047051 | Managing Access to Secured Content - Techniques for preventing unauthorized access to protected network resources include accessing, from a client appliance connected in a distributed network, a computing appliance through the world wide web, the computing appliance including a DNS server addressed by a particular domain name; receiving, from the computing appliance, a portion of code at the client appliance through a web browser of the client appliance, receiving, to a server appliance connected in the distributed network, a request to access secure content stored on the server appliance by the portion of code; comparing the domain name of the DNS server with a server-origin of the secure content; and based on the domain name of the DNS server being exclusive of a set of server-origin values that includes the server-origin, denying access to the request. | 02-12-2015 |
Patent application number | Description | Published |
20100134761 | ALERTNESS SENSING SPECTACLES - Spectacles for use in an eye monitoring system include a pair of ocular frames and a sensor unit adapted to be positioned adjacent an eye of the wearer. A nose bridge connects the ocular frames and incorporates an adjustment mechanism for adjusting the vertical position of the sensor unit relative to the eye. A frame arm extends from the outer edge of each ocular frame and is adapted to fit over the ear of a wearer. The sensor unit incorporates two infra red emitters at different angles and an infra red detector recessed into the surface of the unit to reduce the proportion of signal received by said detector which is not from the signal emitter reflected by the eye or eyelids. | 06-03-2010 |
20110121976 | ALERTNESS SENSING DEVICE - A head worn device for monitoring alertness and attention which includes a) sensors to monitor eyelid and eye movement, b) a motion sensor and c) data storage means for storing data from said sensors. The motion sensor is an accelerometer to provide data that allows the head position to be analysed and to determine the direction of gaze. The device collects data from an accelerometer worn by the driver to detect if the vehicle is in motion and whether the head is tilted vertical plane. If the vehicle is not in motion data is not processed. When the direction of gaze is downward sensor signals from the eye movement sensors is ignored. However if the duration of downward gaze is greater than a predetermined minimum period and the vehicle is in motion, an alarm is triggered because the driver is inattentive. The device may be used to assess whether workers are sufficiently alert before they commence work. The method of measuring a subjects fitness for a particular task uses the alertness monitor or a video camera to monitor eye and eyelid movement with or without head movement data while the subject is tested with a series of tests that require the subject to follow predetermined images or lights. If the subject is unable to satisfactorily track the images the subject is not fit for work. | 05-26-2011 |
20130215390 | FITNESS FOR WORK TEST - A system for measuring fitness for duty which includes a) a visual stimulus display b) eye monitoring equipment for measuring eye and eyelid movements c) a central processing unit and data storage device to collect and store the data from the eye monitoring equipment d) a data analysis device programmed to calculate one or more of the measures of blink latency, measures of the relative velocity of upper eyelid closing and opening movements during blinks, the product of the amplitude to velocity ratio of eyelid closing and opening, the duration of blinks, the variability of eyelid movements during blinks, the failure to respond appropriately with a voluntary blink following each said brief visual stimulus e) said data analysis device programmed to place the values for said measures into an algorithm for measuring fitness for duty. | 08-22-2013 |
Patent application number | Description | Published |
20130027429 | SYSTEM AND METHOD FOR LOCATIONAL MESSAGING - Herein is disclosed a positional content platform and related systems and methods. According to some embodiments, the platform includes a mobile processing and communication device and a service layer executing on a server. The mobile processing and communication device communicates with the service layer. By virtue of the communication, a user of the mobile device is able to locate and view digital content that has been created and stored on the platform. The aforementioned content is associated with a geographic location, and, according to some embodiments, the content is represented in a user interface by an icon that is superimposed over a field of view representative of a geographic region. | 01-31-2013 |
20130219217 | SYSTEM AND METHOD FOR AUTOMATED TEST CONFIGURATION AND EVALUATION - A comprehensive system for enabling automated configuration and testing of software applications and services is disclosed. The system includes test interfaces, a test database and test functionality. Configuration functionality allows for rapid, accurate and efficient set up of one or more test accounts. Data manipulation interfaces and methods allow for the inspection of state variables and manipulating state-based data to simulate, initiate and reverse transactional data. Application programming interfaces enable the testing of external systems with a target system that is simulated in the testing environment. | 08-22-2013 |
20130346205 | SYSTEM AND METHOD FOR LOCATIONAL MESSAGING - Positional communication systems and methods include receiving a definition of a first geographic area including a first commercial location by a computer system and storing the first geographic area in a memory. The location of a mobile device in the possession of a customer is determined, and if the mobile device is determined to be at a location within the first geographic area, an incentive message for the customer to leave the location and go to a second commercial location is sent to the mobile device. | 12-26-2013 |
Patent application number | Description | Published |
20130185133 | RECOMMENDING VIRTUAL REWARD OFFERS AND AWARDING VIRTUAL REWARDS - In an embodiment, a method performed by one or more computing devices comprises storing, for one or more marketplace associated applications, interaction information that identifies, for each particular application of said one or more marketplace associated applications, a list of devices that interacted with an instance of the particular application; receiving, from a requesting device, a request for a list of offer eligible applications; determining, based on said interaction information, a set of applications associated with the requesting device; based on said determination of the set of applications associated with the requesting device, sending a list of one or more selected eligible applications to the requesting device. | 07-18-2013 |
20140324562 | RECOMMENDING VIRTUAL REWARD OFFERS AND AWARDING VIRTUAL REWARDS - In an embodiment, a method performed by one or more computing devices comprises storing, for one or more marketplace associated applications, interaction information that identifies, for each particular application of said one or more marketplace associated applications, a list of devices that interacted with an instance of the particular application; receiving, from a requesting device, a request for a list of offer eligible applications; determining, based on said interaction information, a set of applications associated with the requesting device; based on said determination of the set of applications associated with the requesting device, sending a list of one or more selected eligible applications to the requesting device. | 10-30-2014 |
Patent application number | Description | Published |
20140245521 | Visor with Plug In Accessory Sockets - Visors and methods of using a soft type foam visor formed from a pliable and flexible material, such as but not limited to EVA (ethylene vinyl acetate) having patterns of through-holes and partial cutouts for allowing accessories such as labels, charms, badges, puncture tool and sunglass/eyeglass supports and the like, to be plugged into the holes and cut-outs and easily removable and interchangeable with other accessories. A removable rear head strap be attached to the visor, having a plurality of holes with fasteners to adjust the strap to different head sizes. | 09-04-2014 |
20150059637 | Standup Paddle Board Station - Portable stations, consoles, seats, storage containers, compartments and easy to attach and detach accessories and methods of using accessory devices and apparatus for use with standup paddle boards and decks on other watercraft. The stations can be formed from lightweight plastic, and are floatable. The stations have plural seats and storage compartments for gear, food, beverages, gloves and other items, and include holders to support fishing rods and posts for shade covers. | 03-05-2015 |
Patent application number | Description | Published |
20100092475 | TREATMENT METHOD USING EGFR ANTIBODIES AND SRC INHIBITORS AND RELATED FORMULATIONS - The present invention relates to the treatment of EGFR-mediated disease, particularly cancer by inhibiting or blocking EGFR and src in combination or simultaneously. The invention relates to treatment, prevention, or modulation of cancer, particularly EGFR-mediated disease, with one or more EGFR modulator and src inhibitor in combination. The invention further relates to the treatment of cancer with anti-EGFR antibodies and src inhibitors. Methods and compositions for treatment of cancer with the antibody anti-EGFR mAb806 in combination or series with a src inhibitor or src inhibitors are described. | 04-15-2010 |
20110150759 | MONOCLONAL ANTIBODY 175 TAGETING THE EGF RECEPTOR AND DERIVATIVES AND USES THEREOF - The present invention relates to antibodies, particularly antibody 175, and fragments thereof or antibodies derived therefrom, which bind to the EGF receptor, particularly to amplified or overexpressed epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. These antibodies are useful in the diagnosis and treatment of cancer. Recombinant or hybrid antibodies having the variable region heavy or light chain sequence(s) of antibody 175 are also provided. The antibodies of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof. | 06-23-2011 |
20110293511 | SPECIFIC BINDING PROTEINS AND USES THEREOF - The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to EGFR on tumor cells that overexpress EGFR, and on tumor cells that express the truncated version of the EGFR receptor, de2-7 EGF. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof. | 12-01-2011 |
20110313230 | SPECIFIC BINDING PROTEINS AND USES THEREOF - The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to EGFR on tumor cells that overexpress EGFR, and on tumor cells that express the truncated version of the EGFR receptor, de2-7 EGF. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof. | 12-22-2011 |
20130266573 | Specific binding proteins and uses thereof - The invention relates to specific binding members, particularly antibodies and active fragments thereof, which recognize an aberrant post-translationally modified, particularly an aberrant glycosylated form of the EGFR. The binding members, particularly antibodies and fragments thereof, of the invention do not bind to EGFR on normal cells in the absence of amplification of the wild-type gene and are capable of binding the de2-7 EGFR at an epitope which is distinct from the junctional peptide. Antibodies of this type are exemplified by the novel antibody 806 whose VH and VL sequences are illustrated as SEQ ID NOs: 2 and 4 and chimeric antibodies thereof as exemplified by ch806. | 10-10-2013 |
20140255410 | Specific binding proteins and uses thereof - The invention relates to specific binding members, particularly antibodies and active fragments thereof, which recognize an aberrant post-translationally modified, particularly an aberrant glycosylated form of the EGFR. The binding members, particularly antibodies and fragments thereof, of the invention do not bind to EGFR on normal cells in the absence of amplification of the wild-type gene and are capable of binding the de2-7 EGFR at an epitope which is distinct from the junctional peptide. Antibodies of this type are exemplified by the novel antibody 806 whose VH and VL sequences are illustrated as SEQ ID NOs: 2 and 4 and chimeric antibodies thereof as exemplified by ch806. | 09-11-2014 |
Patent application number | Description | Published |
20110076232 | SPECIFIC BINDING PROTEINS AND USES THEREOF - The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof. | 03-31-2011 |
20120183471 | SPECIFIC BINDING PROTEINS AND USES THEREOF - The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof. | 07-19-2012 |
20140322130 | SPECIFIC BINDING PROTEINS AND USES THEREOF - The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to EGFR on tumor cells that overexpress EGFR, and on tumor cells that express the truncated version of the EGFR receptor, de2-7 EGF. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof. | 10-30-2014 |
Patent application number | Description | Published |
20090137782 | SPECIFIC BINDING PROTEINS AND USES THEREOF - The invention relates to specific binding members, particularly antibodies and active fragments thereof, which recognize an aberrant post-translationally modified, particularly an aberrant glycosylated form of the EGFR. The binding members, particularly antibodies and fragments thereof, of the invention do not bind to EGFR on normal cells in the absence of amplification of the wild-type gene and are capable of binding the de2-7 EGFR at an epitope which is distinct from the junctional peptide. Antibodies of this type are exemplified by the novel antibody 806 whose VH and VL sequences are illustrated as SEQ ID NOs: 2 and 4 and chimeric antibodies thereof as exemplified by ch806. | 05-28-2009 |
20090220510 | Specific binding proteins and uses thereof - The invention relates to specific binding members, particularly antibodies and active fragments thereof, which recognize an aberrant post-translationally modified, particularly an aberrant glycosylated form of the EGFR. The binding members, particularly antibodies and fragments thereof, of the invention do not bind to EGFR on normal cells in the absence of amplification of the wild-type gene and are capable of binding the de2-7 EGFR at an epitope which is distinct from the junctional peptide. Antibodies of this type are exemplified by the novel antibody 806 whose VH and VL sequences are illustrated as SEQ ID NOs: 2 and 4 and chimeric antibodies thereof as exemplified by ch806. | 09-03-2009 |
20100322937 | EGF receptor epitope peptides and uses thereof - The present invention relates generally to growth factor receptor epitope peptides, particularly EGF family receptor epitope peptides. The invention also relates to the use of the receptor peptides in generating antibodies which have anti-tumor or anti-cancer activity or in stimulating an immunological response. The invention further relates to antibodies specifically directed against the receptor peptides. Methods for generating an immune response and for treatment of tumors and cancer are also provided. | 12-23-2010 |