Patent application number | Description | Published |
20080273199 | Spectroscopic system and method for predicting outcome of disease - A system and method to predict the progression of disease of a test sample. A group of known biological samples is provided. Each known biological sample has an associated known outcome including a non-diseased sample or a diseased sample. A Raman data set is obtained for each known biological sample. Each Raman data set is analyzed to identify a diseased or non-diseased reference Raman data set depending on whether respective biological sample is the non-diseased sample or the diseased sample. A first database is generated where the first database contains reference Raman data sets for all diseased samples. A second database is generated where the second database contains reference Raman data sets for all non-diseased samples. A test Raman data set of a test biological sample is received, where the test biological sample has an unknown disease status. A diagnostic is provided as to whether the test sample is a non-diseased sample or a diseased sample. The diagnostic is obtained by comparing the test Raman data set against the reference Raman data sets in the first and the second databases using a chemometric technique. A prediction of the progression of disease may be then provided. | 11-06-2008 |
20080319324 | DISTINGUISHING BETWEEN INVASIVE DUCTAL CARCINOMA AND INVASIVE LOBULAR CARCINOMA USING RAMAN MOLECULAR IMAGING - A system and method to provide a diagnosis of the breast disease state of a test breast sample. A database containing a plurality of reference Raman data sets is provided where each reference Raman data set has an associated known breast sample and an associated known breast disease state. A test breast sample is irradiated with substantially monochromatic light to generate scattered photons resulting in a test Raman data set. The test Raman data set is compared to the plurality of reference Raman data sets using a chemometric technique. Based on the comparison, a diagnosis of a breast disease state of the test breast sample is provided. The breast disease state includes invasive ductal carcinoma or invasive lobular carcinoma disease state. | 12-25-2008 |
20090002702 | DISTINGUISHING BETWEEN RENAL ONCOCYTOMA AND CHROMOPHOBE RENAL CELL CARCINOMA USING RAMAN MOLECULAR IMAGING - A system and method to provide a diagnosis of the renal disease state of a test renal sample. A database containing a plurality of reference Raman data sets is provided where each reference Raman data set has an associated known renal sample and an associated known renal disease state. A test renal sample is irradiated with substantially monochromatic light to generate scattered photons resulting in a test Raman data set. The test Raman data set is compared to the plurality of reference Raman data sets using a chemometric technique. Based on the comparison, a diagnosis of a renal disease state of the test renal sample is provided. The renal disease state includes renal oncocytoma or chromophobe renal carcinoma disease state. | 01-01-2009 |
20090033930 | Spectral Imaging of Biofilms - A spectroscopic method and system to identify a biofilm of a microorganism. A sample containing a sample microorganism is irradiated with substantially monochromatic radiation. A Raman data set is obtained based on radiation scattered from the irradiated sample. A database is searched in accordance with the Raman data set in order to identify a known Raman data set from the database. The database contains a plurality of known Raman data sets where each known Raman data set is associated with a known sessile form of a corresponding known microorganism. A sessile form of the sample microorganism is identified based on the known Raman data set identified by the searching. | 02-05-2009 |
20090040517 | RAMAN DIFFERENCE SPECTRA BASED DISEASE CLASSIFICATION - A method to diagnosis a disease state of an unknown sample. A test Raman data set for an unknown sample is generated. A reference Raman database is provided where the database contains a plurality of reference Raman data sets and a plurality of reference Raman difference data sets. The reference Raman difference data set is generated by determining a difference between a first reference Raman data set and a second reference Raman data set. A first reference Raman data set is associated with first known sample and associated with one or more of: a first known disease state and a first known clinical outcome. A second reference Raman data set is associated with a second known sample and associated with one or more of: a second known disease state and a second known clinical outcome. A diagnosis is provided of whether the unknown sample has a first disease state or a second disease state by comparing the test Raman dataset to said plurality of reference Raman difference data sets in the reference Raman database using a chemometric technique. | 02-12-2009 |
20100033717 | Raman Chemical Imaging of Implantable Drug Delivery Devices - A system and method of determining an attribute of a biological tissue sample or a drug delivery device. A sample is illuminated with substantially monochromatic light to thereby generate Raman scattered photons. The Raman scattered photons are assessed to thereby generate a spectroscopic data set wherein said spectroscopic data set comprises at least one of: a Raman spectra and a spatially accurate wavelength resolved image. Tile spectroscopic data set is evaluated to determine at least one of: an attribute of a biological tissue sample and a drug delivery device. In one embodiment, the biological tissue comprises arterial tissue. In another embodiment, the drug delivery device is a drug-eluting stent. In another embodiment, Raman chemical imaging can be used to evaluate a sample and identify at least one of: the tissue, a drug, a drug delivery device, and a matrix associated with a drug delivery device. | 02-11-2010 |
20100093015 | Spectroscopic systems and methods for classifying and pharmaceutically treating cells - A system and method to distinguish normal cells from cells having undergone a biochemical change. A pre-determined vector space is selected where the vector space mathematically describes a first plurality of reference spectral data sets for normal cells and a second plurality of reference spectral data sets for cells having undergone a biochemical change. A sample is irradiated to generate a target spectral data set based on photons absorbed, reflected, emitted, or scattered by the sample. The target spectral data set is transformed into a pre-determined vector space. A distribution of transformed data is analyzed in the pre-determined vector space. Based on the analysis, the sample is classified as containing normal cells, cells having undergone a biochemical change, and combinations thereof. The method includes treating the sample with a pharmaceutical agent prior to irradiating the sample and using the classification to assess the efficiency of the pharmaceutical agent. | 04-15-2010 |
20100225911 | System and Method for Classifying a Disease State Using Representative Data Sets - System and method for determining a disease state of a sample. A sample is positioned in a field of view and a first spectroscopic data set is obtained. The positional information is stored and the sample is treated with a contrast enhancing agent. The sample is repositioned in the field of view and a digital image is obtained. The spectroscopic data is linked with the digital image and a database comprising representative spectroscopic data sets is searched to classify the disease state of the sample. The disclosure also provides for the step of obtaining a processed derivative image and searching a database comprising representative processed derivative images to classify a disease state of the sample. | 09-09-2010 |
20100262378 | Cytological Analysis by Raman Spectroscopic Imaging - A method for generating an image of a sample that is informative of the disease state of a cell in the sample. A sample including the cell is irradiated with monochromatic light. The Raman scattered light is assessed. A digital brightfield image of the Raman scattered light is generated and combined with the Raman scattered light emitted by the cell whereby the Raman scattered light is informative of the disease state of the cell in the sample. The method can also be used to determine the metabolic activity of the cell, the inflammatory status of the cell and/or the infected status of the cell in the sample. | 10-14-2010 |
20100280762 | System and Method for Analyzing Biological Samples Using Raman Molecular Imaging - A system and method for determining at least one of: a disease state, a metabolic state, a clinical outcome, and a disease progression of a test renal or prostate sample. A test Raman data set is obtained from the sample wherein said test Raman data set may comprise at least one of a plurality of Raman spectra and a plurality of spatially accurate wavelength resolved Raman images. The test Raman data set is compared to a plurality of reference Raman data sets using a chemometric technique. For analysis of renal samples, each of these reference Raman data sets may have an associated known renal sample and an associated known metabolic state, clinical outcome, and/or disease progression. For analysis of prostate samples, each of these reference Raman data sets may have an associated known prostate sample and an associated known disease state, metabolic state, clinical outcome, and/or disease progression. | 11-04-2010 |
20100309464 | Raman Chemical Imaging of Threat Agents Using Pulsed Laser Excitation and Time-Gated Detection - The disclosure provides for a system and method for detecting a threat agent. A sample is illuminated to produce photons Raman scattered and emitted by the sample. The Raman scattered photons are collected using time-gated detection without collecting the emitted photons. A Raman spectroscopic data set is generated from said Raman scattered photons wherein said Raman spectroscopic data comprises at least one of a Raman spectrum and a Raman chemical image. The Raman spectroscopic data is assessed to thereby determine the presence or absence of a threat agent in the sample. The sample may be in a target area. The sample may be illuminated using a pulsed laser or an intensity modulated laser. The illumination source may be synchronized with a gating element that enables time-gated detection. | 12-09-2010 |
20110007309 | Method for Analysis of Pathogenic Microorganisms Using Raman Spectroscopic Techniques - A method for assessing the presence of a pathogenic microorganism in a sample. A sample is illuminated to thereby produce a first plurality of interacted photons which may be scattered, emitted, reflected and/or absorbed by the sample. The first plurality of interacted photons are assessed to thereby generate a Raman data set representative of the sample. This Raman data set is analyzed to thereby determine at least one of: the presence of a pathogenic microorganism in said sample and the absence of a pathogenic microorganism in said sample. The Raman data set may comprise at least one of a Raman spectrum and/or a Raman chemical image representative of the sample. The analysis may comprise comparing said Raman data set to at least one reference Raman data set representative of a known sample. This may be achieved using a chemometric technique. | 01-13-2011 |
20110208462 | System and method for instrument correction using transmission efficiency - A system and method for providing an instrument response correction based on transmission efficiency. Test data may be acquired at a first operating point. A look-up table may be searched to determine an instrument response correction. This look-up table may comprise a plurality of instrument response corrections, each instrument response correction corresponding to an intensity response of the sample at an operating point. The instrument response correction may then be applied to correct for environmental factors that may affect transmission efficiency. A system may comprise an illumination source, a collection optics, a tunable filter, a detector, a sensor and a control unit. The detector may detect interacted photons generated by illuminating a sample and generate test data. The sensor may be configured to sense an operating condition and transmit this information to the control unit which is configured to search a look-up table to determine the appropriate instrument response correction. | 08-25-2011 |
20110211763 | System and method for instrument response correction based on independent measurement of the sample - A system and method for providing an instrument response correction. A sample is illuminated to generate a first plurality and a second plurality of interacted photons. The first plurality of interacted photons may be detected by a dispersive spectrometer to generate a reference spectrum representative of the sample. The second plurality of interacted photons may be passed through a tunable filter and detected using an imaging detector to generate at least one hyperspectral image. This hyperspectral image may comprise a Raman hyperspectral image or an infrared hyperspectral image. A system may comprise an illumination source, a collection optics, a dispersive spectrometer, a fiber optic, a tunable filter, and an imaging detector. | 09-01-2011 |
20120062873 | SYSTEM AND METHOD FOR DIAGNOSING THE DISEASE STATE OF BREAST TISSUE USING SWIR - A system and method to provide a diagnosis of the breast disease state of a test breast sample. A database containing a plurality of reference SWIR data sets is provided where each reference SWIR data set has an associated known breast sample and an associated known breast disease state. A test breast sample is irradiated with substantially monochromatic light to generate scattered photons resulting in a test SWIR data set. The test SWIR data set is compared to the plurality of reference SWIR data sets using a chemometric technique. Based on the comparison, a diagnosis of a breast disease state of the test breast sample is provided. The breast disease state includes invasive ductal carcinoma or invasive lobular carcinoma disease state. | 03-15-2012 |
20120078524 | System and method for diagnosis tissue samples using fluorescence and raman techniques - A system and method for determining a diagnosis of a test biological sample. A system comprising a first illumination source to illuminate a sample, a first detector for generating a fluorescence data set of said sample, a means for determining a region of interest, a second illumination source to illuminate said region of interest, a second detector to generate a Raman data set of said region of interest, and a means for determining a diagnosis of said sample. A method comprising illuminating a sample, generating a fluorescence data set of said sample, and assessing the fluorescence data set to identify a region of interest, illuminating a region of interest, and generating Raman data set. This Raman data set may be assessed to determine a diagnosis of the sample. A diagnosis may include a metabolic state, a clinical outcome, a disease progression, a disease state, and combinations thereof. | 03-29-2012 |
20120083678 | System and method for raman chemical analysis of lung cancer with digital staining - The present disclosure provides for a system and method for diagnosing biological samples that combines the visual staining features familiar to pathologists with the accurate, reliable, and nondestructive capabilities of Raman chemical imaging. The invention disclosed herein may be applied to diagnose lung cancer samples. A method may comprise illuminating a biological sample to generate interacted photons, filtering said interacted photons using a tunable filter, and detecting interacted photons to generate a test Raman data set representative of said sample. The method may further comprise applying at least one chemometric technique and/or a digital stain to said test Raman data set. This test Raman data set may be analyzed to diagnose said sample as comprising at least one of: adenocarcinoma, mesothelioma, and combinations thereof. A system may comprise an illumination source, a tunable filter, and a detector configured to generate a test Raman data set representative of a biological sample. | 04-05-2012 |
20120200850 | CYTOLOGICAL METHODS FOR DETECTING A CONDITION SUCH AS TRANSPLANT EFFICIENCY BY RAMAN SPECTROSCOPIC IMAGING - Raman molecular imaging (RMI) is used to detect mammalian cells of a particular phenotype. The disclosure includes the use of RMI to detect transplanted and/or grafted cells, to differentiate between normal and diseased cells or tissues, as well as in determining the grade of said cancer cells. Raman scattering data may be analyzed to determine the transplant efficiency, disease state, clinical outcome, and/or prognosis of cells or tissue. This data may be combined with visual image data to produce hybrid images which depict both a magnified view of the cellular structures and information relating to the disease state of the individual cells in the field of view. Also, RMI techniques may be combined with visual image data and validated with other detection methods to produce confirm the matter obtained by RMI. | 08-09-2012 |
20120310538 | System and Method for Diagnosing a Biological Sample - The present disclosure provides for a system and method for analyzing biological samples to thereby provide a diagnosis. A system may comprise an illumination source, a filter and a detector configured to generate at least one of: a visible data set representative of a biological sample, a SWIR data set representative of a biological sample, and combinations thereof. A method may comprise illuminating a biological sample to generate a plurality of photons, filtering a said plurality of interacted photons, detecting | 12-06-2012 |
20130003044 | System and Method for Raman Based Chronic Exposure Detection - The present disclosure provides for a system and method for assessing chronic exposure of a biological sample, such as a bodily fluid, to an analyte of interest. A biological sample may be illuminated to thereby generate a one or more pluralities of interacted photons. These interacted photons may be detected to thereby generate one or more spectroscopic data sets representative of a biological sample. Spectroscopic data sets generated may be compared to at least one reference data set. Each reference data set may be associated with a known exposure to a known analyte. The present disclosure contemplates that the system and method disclosed herein may be used to analyze exposure of biological samples to at least one analyte over time. Data sets may be obtained at various time intervals to assess changes in a molecular composition as a result of chronic exposure to an analyte. | 01-03-2013 |
20130027701 | System and Method for Correcting Spectral Response Using a Radiometric Correction Filter - The present disclosure provides for a correction filter that may be configured to comprise a predetermined arrangement of thin film layers. This arrangement of thin film layers may be such that it effectively enables a correction filter to generate a predetermined spectral response, wherein said predetermined spectral response is substantially the same as a determined instrument response correction associated with an instrument. The invention of the present disclosure therefore provides for effectively compensating for transmission inefficiencies associated with an instrument without the need for separate reference measurements to determine and correct for instrument response. | 01-31-2013 |
20140016116 | System and method for raman-based chronic exposure detection - The present disclosure provides for a system and method for assessing chronic exposure of a biological sample, such as a bodily fluid, to an analyte of interest. A biological sample may be illuminated to thereby generate a one or more pluralities of interacted photons. These interacted photons may be detected to thereby generate one or more spectroscopic data sets representative of a biological sample. Spectroscopic data sets generated may be compared to at least one reference data set. Each reference data set may be associated with a known exposure to a known analyte. The present disclosure contemplates that the system and method disclosed herein may be used to analyze exposure of biological samples to at least one analyte over time. Data sets may be obtained at various time intervals to assess changes in a molecular composition as a result of chronic exposure to an analyte. | 01-16-2014 |