Patent application number | Description | Published |
20140264009 | DIFFERENTIAL MOBILITY SPECTROMETER AND METHODS THEREOF - An apparatus and method are provided for analyzing samples of molecules. The apparatus comprises a mass analysis system including a differential mobility spectrometer, which includes at least three filter electrodes defining two ion flow paths where the filter electrodes generate electric fields for passing through selected portions of the sample ions based on the mobility characteristics of the sample ions. The differential mobility spectrometer also includes a voltage source that provides DC and RF voltages to at least one of the filter electrodes to generate the electric field, a first and a second ion inlet that receive sample ions, and an ion outlet that outputs the selected portion of the sample ions. A mass spectrometer receives some or all of the selected portion of the sample ions. | 09-18-2014 |
20140353491 | CREATING AN ION-ION REACTION REGION WITHIN A LOW-PRESSURE LINEAR ION TRAP - Methods and systems for creating a region for ion-ion reactions within a mass spectrometer are described. In various aspects, the methods and systems can confine a first group of ions in a sub-volume of a multipole ion trap, and introduce a second group of oppositely-charged ions into the multipole ion trap while maintaining the first group of ions within the sub-volume. In various embodiments, the methods and systems can operated at reduced pressures. | 12-04-2014 |
20140357502 | Windowing Combined with Ion-Ion Reactions for Chemical Noise Elimination - In a first location of a mass spectrometer, a plurality of ionized molecules of an ion source are selected that have mass-to-charge ratios within a mass-to-charge ratio window width. The plurality of selected ionized molecules are transmitted from a first to a second location. Reagent ions are transmitted to the second location to reduce a charge state of one or more of the plurality of selected ionized molecules. A mass analyzer is used to analyze the plurality of reduced ionized molecules and produce a mass spectrum. A compound is identified from a peak of the spectrum that has a mass-to-charge ratio less than or equal to the highest mass-to-charge ratio in the window width if the noise is multiply charged and greater than the highest mass-to-charge ratio in the window width if the noise is singly charged. | 12-04-2014 |
20140374591 | IN SITU GENERATION OF OZONE FOR MASS SPECTROMETERS - In some embodiments, a mass spectrometer capable of performing OzID is disclosed that can provide ozone in situ within an evacuated chamber of the spectrometer, e.g., within a collision cell or within the vacuum chamber of the mass spectrometer. In some embodiments, a corona discharge generated within the evacuated chamber can be employed to convert an ozone precursor delivered to the chamber into ozone. | 12-25-2014 |
20150097113 | Modulation of Instrument Resolution Dependant upon the Complexity of a Previous Scan - Systems and methods are used to analyze a sample using variable detection scan resolutions. A tandem mass spectrometer is instructed to perform at least two scans of a sample with different detection scan resolutions using a processor. The tandem mass spectrometer includes a mass analyzer that allows variable detection scan resolutions. The selection of the different detection scan resolutions can be based on one or more properties of sample compounds. The properties may include a sample compound molecular weight distribution that is calculated from a molecular weight distribution of expected compounds or is determined from a list of molecular weights for one or more known compounds. The tandem mass spectrometer can also be instructed to perform an analysis of the sample before instructing the tandem mass spectrometer to perform the at least two scans of the sample. | 04-09-2015 |
20150129762 | REDUCING INTERFERENCES IN ISOBARIC TAG-BASED QUANTIFICATION - Methods and systems for performing mass spectrometry of analytes labeled with isobaric tags are provided herein. In accordance with various aspects of the applicants' teachings, the methods and systems can enable enhanced discrimination between an analyte of interest and one or more interfering species when using isobaric tagging techniques. | 05-14-2015 |
20150235828 | METHOD AND SYSTEM FOR QUANTITATIVE AND QUALITATIVE ANALYSIS USING MASS SPECTROMETRY - In some embodiments, a quantitative analysis of at least one ion signal associated with a sample, which is detected by a mass spectrometer having at least two tandem quadrupole instruments, is employed to select one of the following operational modes for further mass analysis of the sample: (a) utilizing both quadrupole instruments as mass resolving filters, and (b) utilizing one quadrupole instrument as a mass resolving filter and utilizing the other as a linear ion trap. In some embodiments, the quantitative analysis of the ion signal comprises comparing the ion signal intensity with a predefined threshold. | 08-20-2015 |
20150260684 | METHOD AND APPARATUS FOR ION MOBILITY SPECTROMETRY - Methods and systems for performing mass spectrometry are provided herein. The method includes ionizing one or more compounds to generate ions, passing the ions into an ion mobility spectrometer, providing ozone, reacting the ions with ozone to produce ozone-induced fragment ions, and performing mass analysis and detection of the ozone-induced fragment ions. The system can comprise an ion source for ionizing one or more compounds to generate ions, an ion mobility spectrometer for receiving and separating the ions, an ozone supply for introducing ozone into the system; a reaction region for reacting the ions with the ozone to produce ozone-induced fragment ions, and a mass spectrometer for performing mass analysis and detection of the ozone-induced fragment ions. | 09-17-2015 |