Patent application number | Description | Published |
20100045993 | METHOD OF DETECTING ANALYTE - A system and method is provided for detecting concentration of an analyte in a fluid. The method comprises detecting an optical property of a first region of two or more regions in a system, the first region located in a container having a reservoir for one or more modifiers of one or more optical properties of the first region. The movement of the one or more modifiers is responsive to changes in concentration of the analyte. A next step detects an optical property of a second region of the two or more regions in the system, the second region located in a container having a reservoir for one or more modifiers of one or more optical properties of the second region. The movement of the one or more modifiers is responsive to changes in concentration of a compound, where the compound is something other than the analyte. The detected optical property of the first region and the detected optical property of the second region are used in embodiments to separate the effect of the analyte on the detected optical property of the first region from the effect of the compound, where the compound is an interfering compound. | 02-25-2010 |
20100049015 | SPECIFICITY OF ANALYTE DETECTION IN ETALONS - A system and method is provided for detecting concentration of an analyte in a fluid. A first container includes (i) an optical cavity detection region, (ii) a reservoir for one or more modifiers of one or more optical properties of the optical cavity detection region, and (iii) a set of one or more bounding regions through which objects in the fluid can transfer into the container. The optical cavity detection region and the reservoir define separate areas of the first container. The movement of the one or more modifiers between the reservoir and the optical cavity detection region is responsive to changes in concentration of the analyte. A second container includes an optical cavity detection region, and a set of one or more bounding regions through which objects in the fluid can transfer into the container. Also provided are optical components for guiding light into the optical cavity detection regions of the first and second containers. | 02-25-2010 |
20100155572 | Obtaining Sensing Results and/or Data in Response to Object Detection - An encoder/sensor can obtain sensing results from objects in an encoding/sensing region; a trigger detector can respond to objects in a trigger detection region, providing respective trigger signals; and a relative motion component can cause relative motion of objects into the trigger detection region, from it into the encoding/sensing region, and within the encoding/sensing region. In response to an object's trigger signal, control circuitry can cause the encoder/sensor and/or the relative motion component to operate so that the encoder/sensor obtains sensing results indicating a time-varying waveform and processing circuitry can obtain data from the sensing results indicating a time-varying waveform. The time-varying waveform can include information resulting from the relative motion within the encoding/sensing region. The encoder/sensor and trigger detector can be implemented, for example, with discrete components or as sets of cells in a photosensing array on an integrated circuit. | 06-24-2010 |
20100155577 | Obtaining Sensing Results Indicating Time Variation - In response to objects having relative motion within an encoding/sensing region relative to an encoder/sensor that, e.g., photosenses emanating light or performs impedance-based sensing, sensing results can indicate sensed time-varying waveforms with information about the objects, about their relative motion, about excitation characteristics, about environmental characteristics, and so forth. An encoder/sensor can include, for example, a non-periodic arrangement of sensing elements; a longitudinal sequence of sensing elements with a combined sensing pattern that approximates a superposition or scaled superposition of simpler sensing patterns; and/or IC-implemented sensing elements that include photosensing arrays on ICs and readout/combine circuitry that reads out photosensed quantities from cells in groups in accordance with cell-group sensing patterns and combines the readout photosensed quantities to obtain the sensing results. Objects can move fluidically as in flow cytometry, through scanning movement as in document scanning, or in other ways. | 06-24-2010 |
20100185143 | SENSOR SYSTEM FOR DRUG DELIVERY DEVICE, DRUG DELIVERY DEVICE HAVING THE SAME AND METHOD OF USING THE SAME - A system for use with a drug delivery device includes a sensor unit and a deactivation unit operatively coupled to an output of the sensor unit and to a drug-retaining region of the drug delivery device, wherein the drug-retaining region contains a drug. The sensor unit is configured to detect a characteristic of a local environment and generate an output corresponding to a value of the detected characteristic. The deactivation unit is configured to render the drug ineffective when the output of the sensor unit satisfies a predetermined condition. | 07-22-2010 |
20110222062 | ANALYZERS WITH TIME VARIATION BASED ON COLOR-CODED SPATIAL MODULATION - A filter arrangement can transmit and/or reflect light emanating from a moving object so that the emanating light has time variation, and the time variation can include information about the object, such as its type. For example, emanating light from segments of a path can be transmitted/reflected through positions of a filter assembly, and the transmission functions of the positions can be sufficiently different that time variation occurs in the emanating light between segments. Or emanating light from a segment can be transmitted/reflected through a filter component in which simpler transmission functions are superimposed, so that time variation occurs in the emanating light in accordance with superposition of two simpler non-uniform transmission functions. Many filter arrangements could be used, e.g. the filter component could include the filter assembly, which can have one of the simpler non-uniform transmission functions. Time-varying waveforms from sensing results can be compared to obtain spectral differences. The filter arrangement, in a practical commercial embodiment, can be manufactured to be disposable, and used in a point-of-care device for use practically anywhere, at low cost, and can also be implemented in an in-line monitoring system. | 09-15-2011 |
20120132255 | Solar Energy Harvesting Device Using Stimuli-Responsive Material - A solar energy harvesting system including a sunlight concentrating member (e.g., a lens array) for focusing direct sunlight at predetermined focal points inside a waveguide containing a stimuli-responsive material (SRM) that is evenly distributed throughout the waveguide material such that the SRM assumes a relatively high transparency state away from the focused sunlight, and small light-scattering portions of the SRM change to a relatively opaque (light scattering) state only in focal zone regions adjacent to the concentrated sunlight. The outer waveguide surfaces are locally parallel (e.g., planar) and formed such that sunlight scattered by the light-scattering SRM portions is transmitted by total internal reflection through the remaining transparent waveguide material, and outcoupled to one or more solar energy receivers (e.g., PV cells) that are disposed outside the waveguide (e.g., along the peripheral edge). | 05-31-2012 |
20130016746 | Vertical Surface Emitting Semiconductor Device - A semiconductor light emitting device includes a pump light source, a gain structure, and an out-coupling mirror. The gain structure is comprised of InGaN layers that have resonant excitation absorption at the pump wavelength. Light from the pump light source causes the gain structure to emit light, which is reflected by the out-coupling mirror back to the gain structure. A distributed Bragg reflector causes internal reflection within the gain structure. The out-coupling mirror permits light having sufficient energy to pass therethrough for use external to the device. A frequency doubling structure may be disposed between the gain structure and the out-coupling mirror. Output wavelengths in the deep-UV spectrum may be achieved. | 01-17-2013 |
20130037726 | COMPACT ANALYZER WITH SPATIAL MODULATION AND MULTIPLE INTENSITY MODULATED EXCITATION SOURCES - A compact analyzer includes a flow cell having a flow channel through which a sample is made to pass. First and second light sources are arranged to emit first and second excitation light into first and second overlapping portions of the flow channel, respectively. The first excitation light stimulates a first light emission from particles of a first particle type that may be present in the sample; the second excitation light stimulates a second light emission from particles of a second particle type. A detector receives the first and second light emission from the corresponding particles present in the sample in a detection portion of the flow channel, and provides a detector output based on the received light emission. The light sources are modulated at different frequencies so that a frequency analysis of the detector output can provide separate information about the first and second particle types. | 02-14-2013 |
20130085352 | Controlling Transfer of Objects Affecting Optical Characteristics - An implantable product such as an article, device, or system can include analyte and non-analyte containers in parts that can be operated as optical cavities. The product can also include fluidic components such as filter assemblies that control transfer of objects that affect or shift spectrum features or characteristics such as by shifting transmission mode peaks or reflection mode valleys, shifting phase, reducing maxima or contrast, or increasing intermediate intensity width such as full width half maximum (FWHM). Analyte, e.g. glucose molecules, can be predominantly included in a set of objects that transfer more rapidly into the analyte container than other objects, and can have a negligible or zero rate of transfer into the non-analyte container; objects that transfer more rapidly into the non-analyte container can include objects smaller than the analyte or molecules of a set of selected types, including, e.g., sodium chloride. Output light from the containers accordingly includes information about analyte. | 04-04-2013 |
20130153771 | TRAFFIC MONITORING BASED ON NON-IMAGING DETECTION - Traffic monitors based on non-imaging radiation detectors are described. A traffic monitor includes a non-imaging radiation detector that senses spatially patterned radiation emanating from objects moving in a traffic pattern. The detector generates a time varying output signal based on the sensed radiation. Signal processing circuitry is used to analyze the time varying output signal using time domain analysis to provide the traffic information. | 06-20-2013 |
20140087971 | MULTIPLEXED FLOW ASSAY BASED ON ABSORPTION-ENCODED MICRO BEADS - Analysis of a system and/or sample involves the use of absorption-encoded micro beads. Each type of micro bead is encoded with amounts of the k dyes in a proportional relationship that is different from proportional relationships of the k dyes of others of the n types of absorption-encoded micro beads. A system and/or a sample can be analyzed using information obtained from detecting the one or more types of absorption-encoded micro beads. | 03-27-2014 |
20140192359 | ANALYZERS WITH TIME VARIATION BASED ON COLOR-CODED SPATIAL MODULATION - A filter arrangement can transmit and/or reflect light emanating from a moving object so that the emanating light has time variation, and the time variation can include information about the object, such as its type. For example, emanating light from segments of a path can be transmitted/reflected through positions of a filter assembly, and the transmission functions of the positions can be sufficiently different that time variation occurs in the emanating light between segments. Or emanating light from a segment can be transmitted/reflected through a filter component in which simpler transmission functions are superimposed, so that time variation occurs in the emanating light in accordance with superposition of two simpler non-uniform transmission functions. Many filter arrangements could be used, e.g. the filter component could include the filter assembly, which can have one of the simpler non-uniform transmission functions. Time-varying waveforms from sensing results can be compared to obtain spectral differences. The filter arrangement, in a practical commercial embodiment, can be manufactured to be disposable, and used in a point-of-care device for use practically anywhere, at low cost, and can also be implemented in an in-line monitoring system. | 07-10-2014 |
20140273009 | COMPOSITIONS AND METHODS FOR PERFORMING ASSAYS - The disclosure relates to compositions for use in assays, the compositions comprising at least one latent fluorophore including at least one enzyme-reactive quenching group and a conjugative group; and a support connectable to the latent fluorophore by the conjugative group. The disclosure further relates to methods of measuring the presence and/or concentration of an analyte, as well as methods of measuring the relative activity of at least two enzymes. | 09-18-2014 |