| Patent application number | Description | Published |
|---|
| 20080318949 | Pyrazolopyrimidinone Derivatives, Their Preparation And Their Use - The invention discloses a series of pyrazolopyrimidinone derivatives, which have the following chemical structure, their preparation methods and use, | 12-25-2008 |
| 20090149488 | Tetrahydroprotoberberine Compounds, the Synthetic Method and the Use Thereof - The present invention relates to tetrahydroprotoberberines of the formula (I) and the physiologically acceptable salts thereof. The invention also relates to the use of the compounds of the formula (I) or pharmaceutically acceptable salts thereof for preparing a pharmaceutical composition for the treatment of a medical disorder susceptible to treatment with dopamine receptor ligand, such as schizophrenia. | 06-11-2009 |
| 20100048897 | PROCESS FOR THE PREPARATION OF SILDENAFIL AND INTERMEDIATES THEREOF - The present invention discloses a process for preparing sildenafil and its intermediates having the structures outlined below: | 02-25-2010 |
| 20110190495 | N-BUTYRAMIDE, THE PREPARATION METHOD AND USE THEREOF - Disclosed are N-{1-[3-(2-ethoxy-5-(4-ethylpiperazinyl)sulfonylphenyl)-4,5-dihydro-5-oxo-1,2,4-triazin-6-yl]ethyl}butyramide (which is represented by formula III), its preparation method, intermediates during preparation procedure, preparation method for such intermediates and a method for preparing vardenafil from the compound. In the method for preparing vardenafil, a chloro-sulfonation reaction carries out in the early stage of the preparation procedure. | 08-04-2011 |
| 20110263860 | PREPARATION METHODS OF 6-SUBSTITUTED AMINO-3-CYANOQUINOLINE COMPOUNDS AND THE INTERMEDIATES THEREOF - The present invention relates to a method for preparing 6-substituted amino-3-cyanoquinoline compounds (compound A for short) and the intermediates thereof, more particularly, to a compound of the following formula (I), the preparation method thereof, the intermediates thereof and use thereof for preparing the compound A. The compound of the formula (I) is cyclized in the presence of an alkali to give a compound of formula A, wherein W is OH; or the compound of the formula (I) is cyclized in the presence of an alkali, and then chlorinated to give a compound of the formula A, wherein W is Cl. Compared with the known methods in the literature, the method for preparing the compound A from the compound of formula (I) according to the present invention can avoid using high-temperature condition and high boiling point solvents, and is safe and environment-friendly, mild in reaction condition, easy in operation with a high yield and high product purity. | 10-27-2011 |
| 20110301109 | Phenylpyrimidone Compounds, the Pharmaceutical Compositions, Preparation Methods and Uses Thereof - The present invention relates to a class of phenylpyrimidone compounds, the pharmaceutical composition, the preparation method and the use thereof. More specifically, the present invention relates to a type of phenylpyrimidone compounds of the following formula I, the pharmaceutically acceptable salts or solvates thereof and to the pharmaceutical composition as well as the preparation method of the compounds. The compounds of formula I according to the present invention can effectively inhibit type V phosphodiesterase (PDE5), and thus can be used for the treatment of various vascular disorders, such as male erectile dysfunction, pulmonary hypertension and the like. | 12-08-2011 |
| 20120123118 | Process For The Preparation Of Nitroorotic Acid - Subject of the present invention is a new improved process for the preparation of nitroorotic acid via nitration of orotic acid. | 05-17-2012 |
| 20130163873 | Detecting Separator Lines in a Web Page - A system and method of detecting separator lines in a web page may include determining coordinates of visible web elements on a web page, generating an edge image of the web page based on the coordinates of the web elements, filtering edges belonging to non-separator line elements within the edge image, detecting horizontal lines within the edge image, detecting vertical lines within the edge image, and filtering short lines within the edge image. A system for detecting separator lines in a web page may include a memory device, and a processor communicatively coupled to the memory, in which the processor determines coordinates of visible web elements on a web page, generates an edge image of the web page based on the coordinates of the web elements, filters edges belonging to non-separator line elements within the edge image, detects horizontal lines within the edge image, detects vertical lines within the edge image, and filters short lines within the edge image. | 06-27-2013 |
| 20130303760 | New Process For The Preparation Of Nitroorotic Acid - Subject of the present invention is a new improved process for the preparation of nitroorotic acid via nitration of orotic acid. | 11-14-2013 |
| 20140031554 | PROCESS FOR PREPARING RACEMIC NICOTINE - Provided is a process for preparing racemic nicotine from 1-methyl-3-nicotinoyl-2-pyrrolidone or a salt thereof using one-pot process. The process comprises the following steps: 1) in a reaction vessel, reacting 1-methyl-3-nicotinoyl-2-pyrrolidone or a salt thereof in the presence of a suitable solvent and a strong acid by heat; after the reaction is complete, cooling the same and adjusting the pH to 7-8 with alkali; and 2) directly adding a reductant into the above vessel, and after the reaction, purifying the product so as to obtain high purity racemic nicotine or a salt thereof. | 01-30-2014 |
| 20140309241 | SALT AND POLYMORPH OF PYRAZOLOPYRIMIDINONE COMPOUND, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME, PREPARATION METHOD AND USE THEREOF - The present invention relates to new salts of pyrazolopyrimidinone represented by formula (I), and pharmaceutically acceptable polymorph, solvate, hydrate, dehydrate, co-crystallization, anhydrous, or amorphous form thereof, the pharmaceutical compositions, and a pharmaceutical unit dosage form containing the same, wherein x represents organic or inorganic acids, preferable maleic acid, succinic acid, methanesulfonic acid, hydrochloric acid, etc. The invention further relates to co-crystals or complexes of compounds of pyrazolopyrimidinone and pharmaceutical compositions containing the same. The present invention also relates to a process for the preparation, use thereof and pharmaceutical preparation containing the salts or crystalline forms. | 10-16-2014 |
