Patent application number | Description | Published |
20090105118 | Preparation and applications of novel complexes made by gamma-polyglutamic acid and cisplatin - A series of complexes made by γ-polyglutamic acid (γ-PGA) and cisplatin, their preparation and applications in biomedical field, specifically in cancer treatment. The complexes may be made by binding free cisplatin on small molecule γ-PGA through the reaction between carboxylic group of γ-PGA and Cl of cisplatin. The complexes show effective anticancer effect and are easy and cost effective to prepare. | 04-23-2009 |
20090121120 | OPTICAL MOTION SENSING DEVICE - An optical motion tracking device ( | 05-14-2009 |
20100067746 | OPTICAL MOTION SENSING PROCESS - A motion sensing process senses a mouse moving relative to a surface by taking a reference image and a sample image of the surface. The process shifts the reference image to neighboring pixel positions arranged in certain patterns and compares the sample image with the reference image at its original pixel position at the shifted pixel positions. A motion vector describing a displacement of the object with respect to the surface is generated from such comparisons. In one embodiment, the pattern includes the original pixel position and neighboring pixel position arranged five rows and five columns with the total number of the pixel positions less than twenty five. In another embodiment, the process selects one of four elongated patterns based on the orientation of a predicted motion vector. In yet another specific embodiment, the process selects one of eight directional patterns based on the direction of the predicted motion vector. | 03-18-2010 |
20100325793 | EXAMINATION BED MOVEMENT DEVICE - An examination bed horizontal movement device including an examination bed, an examination bed connector fixed at the bottom of the examination bed, a support board and a fixed board is provided. Two tension wheels are installed at the front and back ends of the support board separately, and the two tension wheels are connected by an examination bed conveyor belt. A tension wheel and a driving wheel are fixed at both ends of the fixed board, and the tension wheel and the driving wheel are connected by a support board conveyor belt. A driving wheel is installed coaxially on the fixed board tension wheel, and the examination bed conveyor belt winds around the driving wheel. The movement device achieves a compact design of the horizontal structure for the examination bed in a strong magnetic field MRI system and provides long travel and highly repeatable positioning accuracy of the horizontal movement. | 12-30-2010 |
20110041633 | VERTICAL MOVEMENT DEVICE FOR AN EXAMINING TABLE - A vertical movement device for an examining table includes a driving wheel, a nut and screw pair and a direction-converting synchronization belt. The driving wheel is disposed on the examining table. The rotation axis of the nut is perpendicular to the rotation axis of the driving wheel, and the nut moves vertically on the screw when the nut rotates so as to carry the examining table to move vertically. The direction-converting synchronization belt converts the rotation of the driving wheel into the rotation of the nut so as to realize the vertical movement of the examining table. The self-locking vertical movement device reduces the noise and manufacturing costs, simplifies the structure, increases the maximum lifting weight and speeds up the lifting/lowering process. | 02-24-2011 |
20110254770 | OPTICAL DEVICE - An optical device comprises an outer case including a light transmitting work area, an optical lens inside the outer case, and an optical sensor device inside the outer case, wherein an imaging pathway from the work area through the optical lens to the optical sensor device is non-perpendicular to the work area. | 10-20-2011 |
20120015391 | BIOCHEMICAL REACTOR - A biochemical reactor involves an online cell examination microscope ( | 01-19-2012 |
20130205926 | PUSH CHAIN, LINEAR MOTION DRIVING DEVICE AND PATIENT TABLE - A push-chain includes a plurality of push-chain links, each push-chain link of the plurality of push-chain links including two strip-shaped mounting pieces disposed opposite one another and one connecting piece that connects at most half of an end face of the two mounting pieces at one side. Each of the two mounting pieces is provided with two mounting holes in the length direction. A distance between the two mounting holes is equal to half the length of the mounting piece. The mounting holes on the two mounting pieces are arranged opposite one another, and two corners on another side of each of the two mounting pieces are rounded corners allowing the push-chain to bend. Two adjacent push-chain links of the plurality of push-chain links are hinge-connected in a horizontally staggered arrangement by way of a chain pivot and the mounting holes. | 08-15-2013 |
20140006247 | SYSTEM, DEVICE AND METHOD FOR THE INTERACTION OF SECURITY INFORMATION | 01-02-2014 |
Patent application number | Description | Published |
20100293546 | METHOD AND SYSTEM FOR WEB PAGE BREADCRUMB - A breadcrumb method, system and computer program product for a website. In response to a request for visiting the website, a breadcrumb root node is generated in a tree structure. In response to receiving a request for visiting a first web task associated with the website, a first task node is generated in the tree structure at the breadcrumb root node. In response to sequentially receiving requests for multiple subtasks of the first web task, multiple subtask nodes of the first task node are sequentially established in the tree structure. The subtask nodes of the multiple subtask nodes of the first task node are sequentially connected to the first task node according to a sequential order of the sequentially received requests for the multiple subtasks of the first web task. The multiple subtask nodes of the first task node are processed based a policy of the first web task. | 11-18-2010 |
20130159435 | Method and System for Processing User Contact Information - Embodiments of the present invention relate to a method and a system for processing user contact information. Specifically, there is provided a method for processing user contact information, comprising: obtaining, at a user equipment of a first user, contact information associated with a second user; and initiating a social networking service (SNS) operation between the first user and the second user based on the contact information. Corresponding system is also disclosed. According to embodiments of the present invention, user contact information may be processed in a more effective and intelligent way. | 06-20-2013 |
20140244654 | DATA MIGRATION - In one embodiment, a method for data migration includes: receiving intermediate data and corresponding key value-row location information mapping list; importing each row of the intermediate data to a corresponding row of a target data table, where each row of the target data table has a target physical row ID; and establishing, by a computer processor, a target index of the target data table based on the target physical row IDs and the key value-row location information mapping list. With the method or system of this invention, the efficiency of reestablishing a data index after data migration can be improved. | 08-28-2014 |
Patent application number | Description | Published |
20090014065 | METHOD FOR THE PRODUCTION OF A TRANSPARENT CONDUCTIVE OXIDE COATING - The present invention concerns a method for the generation of a transparent conductive oxide coating (TCO layer), in particular a transparent conductive oxide coating as a transparent contact for thin section solar cells. The TCO layer consists at least of a first layer of high conductivity and a second layer of low conductivity, with the second layer generated by DC sputtering of at least one target, which contains zinc oxide and additionally aluminum, and the process atmosphere contains oxygen. Further, the present invention relates to a TCO layer as well as thin section solar cells on CIGS and CdTe basis. | 01-15-2009 |
20090061627 | METHOD FOR PRODUCING A METAL BACKSIDE CONTACT OF A SEMICONDUCTOR COMPONENT, IN PARTICULAR, A SOLAR CELL - The present invention relates to a method for manufacturing a backside contact of a semiconductor component, in particular, of a solar cell, comprising a metallic layer on the backside of a substrate in a vacuum treatment chamber, and the use of a vacuum treatment system for performing said method. Through this method and its use, in particular silicon based solar cells, can be provided with a back contact in a simple manner in a continuous process sequence, wherein the process sequence can be provided particularly efficient and economical, since no handling systems for rotating the substrate are required, and in particular silk screening steps can be dispensed with. | 03-05-2009 |
20100101946 | ROTATABLE SPUTTER TARGET BACKING CYLINDER, ROTATABLE SPUTTER TARGET, METHODS OF PRODUCING AND RESTORING A ROTATABLE SPUTTER TARGET, AND COATING INSTALLATION - A rotatable target base device for sputtering installations is provided, wherein the target base device is adapted for receiving thereon a solid target cylinder, the rotatable target base device comprising a target base cylinder having a lateral surface, a middle part, a first end region and a second end region opposite to the first end region, wherein at least one of the first and the second end regions has a maximum outer diameter substantially equal to or less than an outer diameter of the middle part. | 04-29-2010 |
20100101949 | ROTATABLE SPUTTER TARGET BACKING CYLINDER, ROTATABLE SPUTTER TARGET, METHOD OF PRODUCING A ROTATABLE SPUTTER TARGET, AND COATING INSTALLATION - A rotatable target device for sputtering installations, the rotatable target device including: a rotatable target base adapted for holding a solid target cylinder, the solid target cylinder having an inner axial face, an outer axial face and at least one front face connecting the inner axial face with the outer axial face; wherein the rotatable target base comprises a flexible element, a first face adapted to the shape of the inner axial face of the solid target cylinder and a second face adapted to hold the flexible element outside of the solid target cylinder. | 04-29-2010 |
20100236920 | DEPOSITION APPARATUS WITH HIGH TEMPERATURE ROTATABLE TARGET AND METHOD OF OPERATING THEREOF - A deposition apparatus and a method for sputtering material on a substrate is provided with a substrate holder for holding the substrate, a rotatable target adapted for being sputtered, and a heating system including a back side heating for heating the substrate from the back and a front side heating for heating the substrate from the front. The rotatable target acts as the front side heating and is adapted for heating the substrate to a temperature of at least 100° C. A method for performing this method is disclosed. | 09-23-2010 |
20130284590 | SYSTEMS AND METHODS FOR FORMING A LAYER OF SPUTTERED MATERIAL - The present disclosure describes a method of coating a substrate, the method including forming a layer of sputtered material on the substrate. Forming the layer of sputtered material may include: sputtering material from at least one rotatable target over the substrate; varying the relative position between the at least one target and the substrate. In addition, the present disclosure describes varying the distance between a target and a substrate during the sputter process. The present disclosure further describes a system for coating a substrate. | 10-31-2013 |
20140332369 | MULTIDIRECTIONAL RACETRACK ROTARY CATHODE FOR PVD ARRAY APPLICATIONS - A cathode assembly for a sputter deposition apparatus and a method for coating a substrate is provided. The cathode assembly has a coating side for coating on a substrate. Further, the cathode assembly includes a rotary target assembly adapted for rotating a target material around a rotary axis; at least a first magnet having an inner magnet pole and at least one outer magnet poles and being adapted for generating one or more plasma regions. The cathode assembly has a first angular coordinate for a magnet pole, the magnet pole being provided for the coating side, and a second angular coordinate for a further magnet pole, the magnet pole being provided for the coating side; wherein the first angular coordinate and the second angular coordinate define an angle a larger than about 20 degrees and smaller than about 160 degrees. | 11-13-2014 |
Patent application number | Description | Published |
20100229212 | METHOD AND TERMINAL FOR SHARING INFORMATION IN IPTV SERVICE SYSTEM - A method and a terminal for sharing information in an IPTV service system are disclosed herein. A method includes generating a recommendation email which carries a mailbox identifier of the recommendation recipient and an index of the recommended content and sending the recommendation email according to the mailbox identifier. Another method includes sending an email receiving request according to a preset recommendation receiving policy, receiving an email, judging whether the received email is a recommendation email and, if the received email is a recommendation email, resolving the recommendation email to obtain information about recommended content, and obtaining media stream data of the recommended content according to the information about the recommended content. The embodiments of the present disclosure implement the information sharing service without deploying any IM subsyste, thus reducing the cost. | 09-09-2010 |
20130261285 | METHOD FOR PREPARING ATOSIBAN ACETATE - The present invention provides a method for preparing atosiban acetate. The method comprises the following steps of: synthesizing to obtain linear atosiban; dissolving the linear atosiban in an acetonitrile aqueous solution, adjusting the pH value with ammonia water, adding H | 10-03-2013 |
20140214406 | METHOD AND SYSTEM OF ADDING PUNCTUATION AND ESTABLISHING LANGUAGE MODEL - A method of processing information content based on a language model is performed at a computer, the method including the following steps: identifying a plurality of expressions in the information content that is queued to be processed; dividing the plurality of expressions into a plurality of characteristic units according to semantic features and predetermined characteristics associated with each of the plurality of characteristic units, each characteristic unit including a subset of the plurality of expressions and the predetermined characteristics at least including a respective integer number of expressions that are included in the characteristic unit; extracting, from the language model, a plurality of probabilities for a plurality of punctuation marks associated with each of the plurality of characteristic units; and in accordance with the extracted probabilities, associating a respective punctuation mark with each of the plurality of characteristic units included in the information content. | 07-31-2014 |
20140214416 | METHOD AND SYSTEM FOR RECOGNIZING SPEECH COMMANDS - A method of recognizing speech commands includes generating a background acoustic model for a sound using a first sound sample, the background acoustic model characterized by a first precision metric. A foreground acoustic model is generated for the sound using a second sound sample, the foreground acoustic model characterized by a second precision metric. A third sound sample is received and decoded by assigning a weight to the third sound sample corresponding to a probability that the sound sample originated in a foreground using the foreground acoustic model and the background acoustic model. The method further includes determining if the weight meets predefined criteria for assigning the third sound sample to the foreground and, when the weight meets the predefined criteria, interpreting the third sound sample as a portion of a speech command. Otherwise, recognition of the third sound sample as a portion of a speech command is forgone. | 07-31-2014 |
20140350219 | METHOD FOR SOLID PHASE SYNTHESIS OF LIRAGLUTIDE - Provided is a method for solid phase synthesis of liraglutide, comprising the following steps: A), Fmoc-Gly-resin being obtained by coupling resin solid phase carrier with glycine with N-end protected by Fmoc(Fmoc-Gly-OH) in the presence of activator system; B) according to the peptide sequence of the main chain of liraglutide, successively coupling with amino acids with N-ends protected by Fmoc and protected side chains by the method for solid phase synthesis, wherein lysine employs Fmoc-Lys(Alloc)-OH; C) removing the protective group, Alloc, from the side chain of lysine; D) couplilng the side chain of lysine with Palmitoyl-Glu-Offiu by the method for solid phase synthesis; E) cleavage, removing protection groups and resin to obtain crude liraglutide; F) purifying and lyophilizing to obtain liraglutide. | 11-27-2014 |
20140350918 | METHOD AND SYSTEM FOR ADDING PUNCTUATION TO VOICE FILES - A method and system for adding punctuation to a voice file is disclosed. The method includes: utilizing silence or pause duration detection to divide a voice file into a plurality of speech segments for processing, the voice file includes a plurality of features units; identifying all features units that appear in the voice file according to every term or expression and semantics features of the every term or expression that form each of the plurality of speech segments; using a linguistic model to determine a sum of weight of various punctuation modes in the voice file according to all the feature units, the linguistic model is built upon semantics features of various parsed out terms or expressions from a body text of a spoken sentence according to a language library; and adding punctuations to the voice file based on the determined sum of weight of the various punctuation modes. | 11-27-2014 |
20140350939 | Systems and Methods for Adding Punctuations - Systems and methods are provided for adding punctuations. For example, one or more first feature units are identified in a voice file taken as a whole; the voice file is divided into multiple segments: one or more second feature units are identified in the voice file; a first aggregate weight of first punctuation states of the voice file and a second aggregate weight of second punctuation states of the voice file are determined, using a language model established based on word separation and third semantic features; a weighted calculation is performed to generate a third aggregate weight based on at least information associated with the first aggregate weight and the second aggregate weight; and one or more final punctuations are added to the voice file based on at least information associated with the third aggregate weight. | 11-27-2014 |
20150137754 | CHARGING SYSTEM, VEHICLE COMPRISING THE SAME AND METHOD FOR CONTROLLING CHARGING VEHICLE WITH THE SAME - A charging system for a vehicle, a vehicle comprising the charging system, and a method for controlling charging a vehicle with the charging system are provided. The charging system comprises: a battery; a first charging branch comprising a first rectifying unit and a first charging interface, in which the battery is connected with the first charging interface via the first rectifying unit; a second charging branch comprising a second rectifying unit and a second charging interface, in which the battery is connected with the second charging interface via the second rectifying unit; and a control unit connected with the first rectifying unit and the second rectifying unit respectively and configured to control the first charging branch and the second charging branch to charge the battery. | 05-21-2015 |
20150153836 | METHOD FOR OPERATING TERMINAL DEVICE WITH GESTURE AND DEVICE - A method for operation a terminal device with gesture and a device are provided. The method includes obtaining a gesture video segment comprising a preset number of frames of images, obtaining gesture track information of a user according to a location of a finger of the user in each frame of image of the gesture video segment, searching in a preset corresponding relationship between the gesture track information and an operation according to the gesture track information, obtaining the operation corresponding to the gesture track information of the user and performing the operation. With the technical scheme of the present disclosure, the gesture track information of the user is obtained via analyzing each frame of image in the obtained gesture video segment. The gesture track information of the user in a dimensional plane is concerned and the corresponding operation thereof is obtained via the gesture track information. This technical scheme may enrich the methods for triggering the operation, operate the terminal device without directly touching the terminal device and reduce the dependence on the peripheral devices, such as the mouse and the keyboard. | 06-04-2015 |
20150153837 | METHOD AND APPARATUS FOR LOGGING IN AN APPLICATION - According to an example, a user device obtains a gesture track of a user and queries a gesture track database according to the gesture track obtained, wherein the gesture track database stores a relationship between the gesture track and account information of the user. The user device obtains the account information corresponding to the gesture track and provides the account information to a log-in server, so as to log in the application. | 06-04-2015 |
20150232503 | METHOD FOR PREPARING EXENATIDE - Disclosed in the present invention is a method for preparing Exenatide. Serine resin is obtained through a first coupling of serine and resin and successively with amino acids through a second coupling to obtain a peptide resin with a sequence as shown by SEQ ID No. 1; Exenatide resin is obtained through a third coupling of histidine containing a protecting group or salts thereof and the peptide resin with a sequence as shown by SEQ ID No. 1, then it is cracked and purified to obtain purified Exenatide peptide. The method for preparing Exenatide of the present invention inhibits the formation of D-His-Exenatide, and thereby improves the yield and purity of Exenatide. | 08-20-2015 |
20150295950 | METHOD, APPARATUS AND SYSTEM FOR DEFENDING AGAINST NETWORK ATTACK - A method, apparatus and system for defending against a network attack are provided in the disclosure. The method includes: receiving, by a defending server, data submitted by a client; extracting by the defending server, a first authentication value from the data; calculating by the defending server, a second authentication value based on a predetermined algorithm; and forwarding by the defending server, the data to a corresponding network server in a case that the first authentication value matches with the second authentication value. The method, apparatus and system for defending against a network attack described above may effectively defend against the network attack. | 10-15-2015 |
20150295951 | METHOD, SERVER, AND SYSTEM FOR AUTOMATICALLY RATING REPUTATION OF A WEB SITE - The present disclosure discloses a method, server, and system for automatically rating the reputation of a web site, wherein the method comprises: when a web address of the web site is triggered and intercepted, detecting whether the web address of the web site is a malicious web address or a non-malicious web address; making statistics of the number of malicious and non-malicious visits to the web addresses under the web site during a predefined time period and saving the statistics to a database; and reading records from the database and calculating an average reputation of the web site by weighting the statistics of visiting the web site during the predefined time period and history statistics. The present disclosure is able to mark the reputation of a web site in time and efficiently, thus improving the security of using the network. | 10-15-2015 |
20150326596 | CLOUD BASED METHOD AND APPARATUS FOR MONITORING INTERNET USAGE - A cloud based method and apparatus for monitoring internet usage are provided. The method comprises: receiving a website inquiry instruction sent by a client, wherein the instruction comprises a website identifier; determining whether the website is a website to be monitored; and if the website is a website to be monitored, processing the website inquiry instruction in accordance with a security policy pre-stored in a server, wherein the security policy is set by the client. Since the security policy is stored on a server, it cannot be easily circumvented by the user, and its effectiveness is enhanced. | 11-12-2015 |
20160086609 | SYSTEMS AND METHODS FOR AUDIO COMMAND RECOGNITION - The present application discloses a method, an electronic system and a non-transitory computer readable storage medium for recognizing audio commands in an electronic device. The electronic device obtains audio data based on an audio signal provided by a user and extracts characteristic audio fingerprint features from the audio data. The electronic device further determines whether the corresponding audio signal is generated by an authorized user by comparing the characteristic audio fingerprint features with an audio fingerprint model for the authorized user and with a universal background model that represents user-independent audio fingerprint features, respectively. When the corresponding audio signal is generated by the authorized user of the electronic device, an audio command is extracted from the audio data, and an operation is performed according to the audio command. | 03-24-2016 |
Patent application number | Description | Published |
20090170863 | Acylated Spiropiperidine Derivatives as Melanocortin-4 Receptor Modulators - Certain novel N-acylated spiropiperidine derivatives are ligands of the human melanocortin receptor(s) and, in particular, are selective ligands of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of MC-4R, such as obesity, diabetes, nicotine addiction, alcoholism, sexual dysfunction, including erectile dysfunction and female sexual dysfunction. | 07-02-2009 |
20090253744 | Acylated piperidine derivatives as melanocortin-4 receptor modulators - Certain novel N-acylated spiropiperidine derivatives are ligands of the human melanocortin receptor(s) and, in particular, are selective ligands of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of MC-4R, such as obesity, diabetes, nicotine addiction, alcoholism, sexual dysfunction, including erectile dysfunction and female sexual dysfunction. | 10-08-2009 |
20100004280 | Substituted imidazoles as bombesin receptor subtype-3 modulators - Certain novel substituted imidazoles are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of BRS-3, such as obesity, and diabetes. | 01-07-2010 |
20100184758 | BETA CARBOLINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS - Beta-carboline derivatives of structural formula I are selective antagonists of the somatostatin subtype receptor 3 (SSTR3) and are useful for the treatment of Type 2 diabetes mellitus and of conditions that are often associated with this disease, including hyperglycemia, insulin resistance, obesity, lipid disorders, and hypertension. The compounds are also useful for the treatment of depression and anxiety. | 07-22-2010 |
20100204236 | Substituted imidazoles as bombesin receptor subtype-3 modulators - Certain novel substituted imidazoles are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of BRS-3, such as obesity, and diabetes. | 08-12-2010 |
20110201615 | TRIAZOLE BETA CARBOLINE DERIVATIVES AS ANTI-DIABETIC AGENTS - Beta-carboline derivatives of structural formula (I) are selective antagonists of the somatostatin subtype receptor 3 (SSTR3) and are useful for the treatment of Type 2 diabetes mellitus and of conditions that are often associated with this disease, including hyperglycemia, insulin resistance, obesity, lipid disorders, and hypertension. The compounds are also useful for the treatment of depression and anxiety. | 08-18-2011 |
20120088788 | SUBSTITUTED IMIDAZOLES AS BOMBESIN RECEPTOR SUBTYPE-3 MODULATORS - Certain novel substituted imidazoles are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of BRS-3, such as obesity, and diabetes. | 04-12-2012 |
20120264777 | OXADIAZOLE BETA CARBOLINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS - Beta-carboline derivatives of structural formula I are selective antagonists of the somatostatin sub-type receptor 3 (SSTR3) and are useful for the treatment of Type 2 diabetes mellitus and of conditions that are often associated with this disease, including hyperglycemia, insulin resistance, obesity, lipid disorders, and hypertension. The compounds are also useful for the treatment of depression and anxiety. | 10-18-2012 |
20130109649 | FUSED BICYCLIC OXAZOLIDINONE CETP INHIBITOR | 05-02-2013 |
20140088124 | IMIDAZOLE DERIVATIVES - Described herein are compounds of formula (I), The compounds of formula I act as DGAT1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperlipidemia, diabetes mellitus and obesity. | 03-27-2014 |
20140206681 | BTK INHIBITORS - The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I | 07-24-2014 |
20140221333 | BTK INHIBITORS - Provided are 6-5 membered fused pyridine ring compounds according to Formula (I) or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising these compounds and their use in therapy. In particular, provided is the use of membered fused pyridine ring compounds in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders. | 08-07-2014 |
20140378493 | Fused Bicyclic Oxazolidinone CETP Inhibitor - Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. | 12-25-2014 |
20150353565 | BTK INHIBITORS - The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or pharmaceutically acceptable salts thereof. Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders. | 12-10-2015 |
20150353570 | BTK INHIBITORS - The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders. | 12-10-2015 |
Patent application number | Description | Published |
20080312174 | WATER SOLUBLE CROSSLINKED POLYMERS - Compositions for siRNA delivery are described which include water soluble degradable crosslinked cationic polymers having a water soluble polyethylene glycol component, a cationic polyethyleneimine component and a degradable unit component. The composition may be used to deliver siRNA to cells, particularly cancer cells. The composition may be applied to a solid surface such as a multiwell plate so that the delivery of siRNA may be carried out on the solid surface. | 12-18-2008 |
20090105179 | DRUG CARRIERS - Compositions that can include a cationic polymeric carrier, targeting agent, and therapeutic agent are disclosed herein. The therapeutic agent may have a therapeutic activity such as inhibiting fibrosis within a target organ or tissue or inhibiting the growth of a cancer cell. | 04-23-2009 |
20100160210 | GUANIDINIUM DELIVERY CARRIERS - Disclosed herein are transmembrane transporter compounds containing guanidinium groups. Also disclosed herein are methods for transporting a biologically active moiety across a biological membrane using the transmembrane transporter compounds. Particularly, this invention provides a method for the delivery of a biologically active moiety across the biological membranes of such membranes as endothelial tissues. | 06-24-2010 |
20100160239 | PEPTIDE NUCLEIC ACID BASED GUANIDINIUM COMPOUNDS - Disclosed herein are transmembrane transporter compounds containing guanidinium groups to enhance transport across biomembranes. Therapeutic and other biologically active moieties may be attached to the compounds. The transmembrane transporter compounds may include peptide nucleic acid monomer units. | 06-24-2010 |
20110257249 | DRUG CARRIERS - Compositions that can include a cationic polymeric carrier, targeting agent, and therapeutic agent are disclosed herein. The therapeutic agent may have a therapeutic activity such as inhibiting fibrosis within a target organ or tissue or inhibiting the growth of a cancer cell. | 10-20-2011 |
20120093762 | NUCLEIC ACID DELIVERY COMPOUNDS - Polymers including two or more different recurring units are disclosed herein. Also disclosed herein are methods of using such polymers to deliver nucleic acids to a cell. | 04-19-2012 |
20120094924 | NUCLEIC ACID DELIVERY COMPOUNDS - Polymers including two or more different recurring units are disclosed herein. Also disclosed herein are methods of using such polymers to deliver nucleic acids to a cell. | 04-19-2012 |
20120107264 | NUCLEIC ACID DELIVERY COMPOUNDS - Polymers including two or more different recurring units are disclosed herein. Also disclosed herein are methods of using such polymers to deliver nucleic acids to a cell. | 05-03-2012 |
20130011336 | IMAGING AGENTS OF FIBROTIC DISEASES - Agents and methods for imaging a cell and/or a portion of tissue characterized by fibrosis, as well as to agents and methods for determining and/or diagnosing fibrotic diseases are disclosed herein. Also disclosed herein are polymer conjugates that can include a detectable label, a retinoid and a polymer. The polymer conjugates can be used to image a portion of tissue, deliver a detectable label to a portion of tissue or a cell and/or diagnosis a condition or disease. | 01-10-2013 |
Patent application number | Description | Published |
20090035787 | ENZYMATIC SYNTHESIS OF SULFATED POLYSACCHARIDES WITHOUT IDURONIC ACID RESIDUES - Iduronic acid (IdoUA)-free heparan sulfate (HS)-like compounds are provided. Also provided are methods of synthesizing IdoUA-free HS-like compounds. The methods can include providing at least one O-sulfotransferase (OST) enzyme and a reaction mixture comprising 3′-phosphoadenosine 5′-phosphosulfate (PAPS); and incubating a polysaccharide substrate with the at least one OST and the reaction mixture, whereby the HS-like compounds are synthesized. Also disclosed are methods of synthesizing a library of HS-like compounds and methods of determining the mechanism of activity of HS-like compounds. | 02-05-2009 |
20090197308 | Enzymatic synthesis of sulfated polysaccharides - A method of sulfating a polysaccharide is provided. The method can include providing a reaction mixture comprising at least one O-sulfotransferase (OST) enzyme and 3′-phosphoadenosine 5′-phosphosulfate (PAPS); incubating a polysaccharide substrate with the reaction mixture, wherein production of the sulfated polysaccharide from the polysaccharide substrate is catalyzed by the OST enzyme with a conversion of the PAPS to adenosine 3′,5′-diphosphate (PAP); and providing a reaction condition which modifies PAP to reduce an inhibitory effect of PAP on the polysaccharide sulfation. | 08-06-2009 |
20120322114 | ENZYMATIC SYNTHESIS OF SULFATED POLYSACCHARIDES - Heparosan is sulfated at the iduronic acid residue by providing a reaction mixture comprising C5 epimerase to convert glucuronic acid to iduronic acid, and at least one O-sulfotransferase (OST) enzyme and 3′-phosphoadenosine 5′-phosphosulfate (PAPS). | 12-20-2012 |
20130296540 | CHEMOENZYMATIC SYNTHESIS OF STRUCTURALLY HOMOGENEOUS ULTRA-LOW MOLECULAR WEIGHT HEPARINS - Methods for preparing synthetic heparins are provided. Synthetic heparin compounds, including ultralow molecular weight heparin compounds are provided. Also provided are methods of chemoenzymatically synthesizing structurally homogeneous ultra-low molecular weight heparins. Heparin compounds provided herein can have anticoagulant activity. | 11-07-2013 |
20150105345 | USES OF ANTAGONISTS OF HYALURONAN SIGNALING - Described herein is the finding that hyaluronan antagonists that inhibit hyaluronan signaling are capable of inhibiting airway inflammation and airway hyperresponsiveness (AHR). The present disclosure provides a method of preventing or reducing AHR in a subject suffering from or at risk for AHR by administering a hyaluronan antagonist. Also provided is a method of treating an airway disease or disorder in a subject by administering a hyaluronan antagonist. Hyaluronan antagonists include, for example, heparosan and hyaluronan oligosaccharides (oHAs). In some embodiments, the hyaluronan antagonist is administered locally to the airway, such as with an inhaler or nebulizer. | 04-16-2015 |
Patent application number | Description | Published |
20120163396 | QUEUE SPEED-UP BY USING MULTIPLE LINKED LISTS - One embodiment of the present invention provides a switch that includes a transmission mechanism configured to transmit frames stored in a queue, and a queue management mechanism configured to store frames associated with the queue in a number of sub-queues which allow frames in different sub-queues to be retrieved independently, thereby facilitating parallel processing of the frames stored in the sub-queues. | 06-28-2012 |
20130031077 | Longest Prefix Match Scheme - A LPM search engine includes a plurality of exact match (EXM) engines and a moderately sized TCAM. Each EXM engine uses a prefix bitmap scheme that allows the EXM engine to cover multiple consecutive prefix lengths. Thus, instead of covering one prefix length L per EXM engine, the prefix bitmap scheme enables each EXM engine to cover entries having prefix lengths of L, L+1, L+2 and L+3, for example. As a result, fewer EXM engines are potentially underutilized, which effectively reduces quantization loss. Each EXM engine provides a search result with a determined fixed latency when using the prefix bitmap scheme. The results of multiple EXM engines and the moderately sized TCAM are combined to provide a single search result, representative of the longest prefix match. In one embodiment, the LPM search engine supports 32-bit IPv4 (or 128-bit IPv6) search keys, each having associated 15-bit level 3 VPN identification values. | 01-31-2013 |
20140241357 | TECHNIQUES FOR CUSTOMIZING FORWARDING DECISIONS VIA A HARDWARE LOOKUP RESULT - Techniques for customizing forwarding decisions in a network device via a hardware lookup table result are provided. In one embodiment, a network processor of the network device can perform a lookup into a lookup table based on one or more sections of a received packet. The network processor can then determine, based on the lookup, an entry in the lookup table and retrieve, using a pointer included in the lookup table entry, a mode value from a results table. The mode value can identify an operational flow (e.g., a series of forwarding decisions) to be carried out by the network processor for forwarding the received packet. | 08-28-2014 |
20140294014 | QUEUE SPEED-UP BY USING MULTIPLE LINKED LISTS - One embodiment of the present invention provides a switch that includes a transmission mechanism configured to transmit frames stored in a queue, and a queue management mechanism configured to store frames associated with the queue in a number of sub-queues which allow frames in different sub-queues to be retrieved independently, thereby facilitating parallel processing of the frames stored in the sub-queues. | 10-02-2014 |
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20130006584 | Methods, Systems, and Computer-readable Media for Simulating Interconnects in Electronic Packaging Structures - Methods, systems, and computer-readable media for simulating an electronic packaging structure are disclosed. The methods include providing an electromagnetic simulation framework for simulating the electronic packaging structure that includes at least two planes and an interconnect transitional component. The framework includes solvers for simulation based on parallel-plate, strip line, and microstrip line modes. The method also includes defining ports of the component based on modes, computing a network function characterizing the properties of the component; and associating ports with solvers of the framework. | 01-03-2013 |
20130124181 | Methods, Systems, and Computer-readable Media for Improving Accuracy of Network Parameter in Electromagnetic Simulation and Modeling - Method, system, and computer readable medium are disclosed for analyzing electrical properties of a circuit. The method may comprise: providing a network model including at least one network parameter, the network parameter being defined over a frequency range; converting the network parameter into an intermediate network parameter having first and second portions; identifying first and second frequencies defining a frequency sub-range; replacing the first portion of the intermediate network parameter with a DC value when a frequency associated with the intermediate network parameter is lower than the first frequency; replacing the first portion of the intermediate network parameter with a transitional value when the frequency associated with the intermediate network parameter is within the frequency sub-range; and converting the intermediate network parameter with the replaced first portion into an updated network parameter. | 05-16-2013 |
20130138417 | METHODS, SYSTEMS, AND COMPUTER-READABLE MEDIA FOR MODEL ORDER REDUCTION IN ELECTROMAGNETIC SIMULATION AND MODELING - Methods, systems, and computer readable media are disclosed for simulating a circuit. The method may comprise a step of providing a network model of the circuit having a plurality of ports, the plurality of ports being associated with one or more net pairs. The method may also comprise combining the plurality of ports into one or more groups based on the net pairs, each group corresponding to a net pair. In addition, the method may comprise calculating, for each group, one or more expansion elements, wherein the one or more expansion elements are associated with a shared property among all ports of the group. Moreover, the method may comprise simulating the circuit using a combination of the expansion elements calculated for each group. | 05-30-2013 |
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20130337471 | CELL IDENTIFICATION WITH NANOPARTICLES, COMPOSITIONS AND METHODS RELATED THERETO - The present disclosure provides a method for identifying rare or low-abundant biological entities such as Hodgkin's and Reed-Sternberg cells, circulating tumor cells in peripheral blood, circulating fetal cells, stem cells, somatic cells, HIV-infected T cells, bacteria or viruses in water, adenoviruses, enteroviruses, hepatitis A and E, dengue, Swine Flu, bovine diarrhea, and protozpa/helminthes. The method uses a suite of nanoparticle-conjugated agents to mark biological targets of interest for subsequent fluorescence imaging. In certain embodiments, the nanoparticle-conjugated agents are fluorescent semiconductor nanocrystals conjugated with antibodies with affinity for CD15, CD30, CD45, and Pax5. In certain embodiments, a method is developed to differentiate Hodgkin's and Reed-Sternberg (HRS) cells from amongst surrounding immune cells such as T and B lymphocytes with greater specificity and precision than traditional immunohistochemistry (IHC) for the diagnosis of Hodgkin's lymphoma. | 12-19-2013 |
20140322169 | Recombinant Virus Products and Methods for Inhibition of Expression of DUX4 - The present invention relates to RNA interference-based methods for inhibiting the expression of the DUX4 gene, a double homeobox gene on human chromosome 4q35. Recombinant adeno-associated viruses of the invention deliver DNAs encoding microRNAs that knock down the expression of DUX4. The methods have application in the treatment of muscular dystrophies such as facioscapulohumeral muscular dystrophy. | 10-30-2014 |