Isabel
Isabel Aguilera Garcia, Sevilla ES
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20110039281 | METHOD OF IMMUNOLOGICAL ANALYSIS FOR DETECTION OF ANTIBODIES AGAINST HUMAN GSTT1 (ANTI-HGSTT1) - The subject of the present invention is a method of immunological analysis for detection in biological fluids of anti-bodies against human GSTT1 (anti-hGSTT1). The present invention also concerns the use of said immunological analysis method for the diagnosis, prognosis, follow-up and monitoring of pathological conditions associated with the presence of anti-GSTT1 in biological fluids, and also concerns a tool kit for putting said method into practice. | 02-17-2011 |
Isabel Amat Riera, Badalona (barcelona) ES
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20100068258 | PROPHYLACTIC TUBERCULOSIS VACCINE - The invention relates to the use of an immunotherapeutic agent containing cell wall fragments of a virulent strain of | 03-18-2010 |
Isabel Amat Riera, Barcelona ES
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20110268788 | IMMUNOTHERAPEUTIC AGENT SUITABLE FOR THE PRIMARY PROPHYLAXIS OF TUBERCULOSIS - The present invention relates to the use of an immunotherapeutic agent having cell wall fragments of a virulent strain of | 11-03-2011 |
20150050327 | LIPOSOME FORMULATION SUITABLE FOR TREATING OR PREVENTING TUBERCULOSIS - The invention provides liposome formulations comprising fragments from a | 02-19-2015 |
Isabel Anstett-Klein, Leinfelden-Echterdingen DE
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20090208571 | Dosage form containing pantoprazole as active ingredient - Dosage forms for the oral administration of the magnesium salt of pantoprazole are described. | 08-20-2009 |
20110171303 | DOSAGE FORM CONTAINING (S)-PANTOPRAZOLE AS ACTIVE INGREDIENT - Dosage forms for oral administration of the magnesium salt of (S)-pantoprazole are described. | 07-14-2011 |
Isabel Bartrina Y Manns, Berlin DE
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20120167254 | Disruption of CKX3 and at least one other CKX gene in a plant or plant cell leads to improved traits - The present invention is directed to isolated plant cells and transgenic plants comprising a disruption in at least a CKX3 gene and in one further gene encoding for a cytokininoxidase/dehydrogenase and being different from CKX3 well as to methods of producing such transgenic plants and to methods of increasing seed yield in a plant and/or plant height. | 06-28-2012 |
20120272409 | Rock2 and Rock3, Two New Gain-of-Function Variants of the Cytokinin Receptors AHK2 and AHK3 - The present invention relates to two new gain of function variants of the cytokinin receptor proteins AHK2 and AHK3, namely rock2 and rock3, to transgenic organisms comprising at least one of said new gain-of-function cytokinin receptor variants and to a method for the manufacturing of a transgenic plant comprising at least one of the new gain-of-function variants. | 10-25-2012 |
20140380526 | Disruption of CKX3 and at least one other CKX gene in a plant or plant cell leads to improved traits - The present invention is directed to isolated plant cells and transgenic plants comprising a disruption in at least a CKX3 gene and in one further gene encoding for a cytokininoxidase/dehydrogenase and being different from CKX3 well as to methods of producing such transgenic plants and to methods of increasing seed yield in a plant and/or plant height. | 12-25-2014 |
Isabel Carcia Bonilla, Barcelona ES
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20110198873 | ENERGY ABSORBER FOR A BUMPER ASSEMBLY OF A VEHICLE AND METHOD FOR THE MANUFACTURE THEREOF - An energy absorber for a bumper assembly of a vehicle and a method for the manufacture thereof are described. The absorber includes a tubular body ( | 08-18-2011 |
Isabel Carrilero Borbujo, Sarriguren (navarra) ES
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20130029839 | CATALYSTS FOR THE OXIDATIVE REFORMING OF ALCOHOLS - The present invention relates to processes for the oxidative reforming of alcohols catalysed by metal catalysts on an oxide support that can be carried out at temperatures lower than 500° C., also showing a high conversion index, but maintaining a high selectivity as regards product distribution. Preferably, the starting material used in the processes is glycerol. | 01-31-2013 |
20140332403 | SPEEK DIAPHRAGM FOR ALKALINE ELECTROLYSIS AND ITS USE - The present invention describes a diaphragm comprising SPEEK for alkaline electrolysis with a first layer having micropores and a second layer of macroporous channels which start at the contact surface between the first and the second layer then extending and forming the outer surface of the second layer, where said macroporous channels increase in section and change direction as they approach said outer surface of the second layer, and where the walls of the macrochannels are in turn macroporous. The invention also describes a production method for producing the diaphragm comprising the use of the chemically induced phase separation (CIPS) technique, and its use in alkaline electrolysis and in electrolyzers. | 11-13-2014 |
Isabel Climent-Johansson, Stockholm SE
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20080221129 | New compounds - The present invention relates to compounds of the formula (I): | 09-11-2008 |
Isabel Clinet, Villeneuve-Loubet FR
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20100111890 | USE IN PERFUMERY AND FLAVORING AND PROCESS FOR THE PREPARATION OF 5,5-DIMETHYL-3-ETHYL-3,4-DIHYDROFURAN-2-ONE - The invention relates to the use of 5,5-dimethyl-3-ethyl-3,4-dihydrofuran-2-one (A), named “Noxolide” by the applicant, as an olfactory agent in perfumery, and also as a food flavouring. The invention also relates to a novel process for the preparation of 5,5-dimethyl-3-ethyl-3,4-dihydrofuran-2-one. | 05-06-2010 |
Isabel Delacour, Basingstoke GB
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20090022363 | WATERMARKING AND TRANSFERRING MATERIAL - A client device for use in a system having a server, the client device including: a receiving device configured to receive information material from the server, the information material containing a reversible modification providing a perceptible disturbing effect to the information material, and to receive identifying information that distinguishes the information material from other information material available from the server and condition information which defines a predetermined condition that should be met in order for the reversible modification to be reversed; a transmission device which, in response to a user input providing enabling data which satisfies the predetermined condition, configured to transmit the identifying information and the enabling data to the server, wherein in response to the transmission of the enabling data and the identifying information, the receiving device is configured to receive a key and removing data defining an algorithm for removing the perceptible effect, the removing data being useable by a reversing device to reverse the perceptible effect; and a storage device configured to store the information material that has had the perceptible effect reversed. | 01-22-2009 |
Isabel De Vleeschauwer, Rixensart BE
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20080220457 | Serum Bactericidal Assay for N. Meningitidis Specific Antisera - The present invention relates to the field of Serum Bactericidal Activity (SBA) assays for Gram negative bacteria, in particular | 09-11-2008 |
20110165590 | Vaccine Protection Assay - The present invention relates to the field of Serum Bactericidal Activity (SBA) assays for Gram negative bacteria, in particular | 07-07-2011 |
Isabel Diaz Del Consuelo, Barcelona ES
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20120202743 | SUSTAINED RELEASE FORMULATIONS COMPRISING GnRH ANALOGUES - The present invention relates to pharmaceutical compositions for the controlled and sustained release of active substance comprising a biodegradable polymer or copolymer. Furthermore, the invention relates to pharmaceutical compositions for the controlled and sustained release of at least one active substance such as peptides or hormones and analogues thereof and the manufacturing process of such pharmaceutical compositions. | 08-09-2012 |
Isabel Digón Juárez, Madrid ES
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20100280108 | Antitumoral Compounds - A compound of general formula (I) | 11-04-2010 |
20110034549 | Antitumoral Compounds - A compound of general formula (I) | 02-10-2011 |
20110105409 | Anticancer Compounds - Anticancer compounds of general formula I: | 05-05-2011 |
20120041063 | ANTITUMORAL COMPOUNDS - A compound of general formula (I) | 02-16-2012 |
Isabel Digón Juárez, Madrid ES
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20100280108 | Antitumoral Compounds - A compound of general formula (I) | 11-04-2010 |
20110034549 | Antitumoral Compounds - A compound of general formula (I) | 02-10-2011 |
20110105409 | Anticancer Compounds - Anticancer compounds of general formula I: | 05-05-2011 |
Isabel Dorronsoro Diaz, Madrid ES
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20110144148 | ACETYLCHOLINESTERASE DUAL INHIBITORS - The invention provides compounds of formula: | 06-16-2011 |
Isabel Dunach, Villeneuve-Loubet FR
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20110282090 | PROCESS FOR PREPARING BORONIC ACIDS AND ESTERS IN THE PRESENCE OF MAGNESIUM METAL - The present invention relates to the process for preparing a boronic acid or ester chemically, in which an aromatic compound is reacted with a boronating agent, in the presence of magnesium metal (Mg | 11-17-2011 |
20130184484 | PROCESS FOR PREPARING BORONIC ACIDS AND ESTERS IN THE PRESENCE OF MAGNESIUM METAL - The present invention relates to the process for preparing a boronic acid or ester chemically, in which an aromatic compound is reacted with a boronating agent, in the presence of magnesium metal (Mg | 07-18-2013 |
Isabel Fariñas Gómez, Valencia ES
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20100047212 | USE OF THE PEDF FACTOR TO INDUCE CELL REGENERATION - Use of the PEDF factor to induce cell regeneration. The present invention refers to the use of the molecule PEDF for the manufacture of medicines to activate processes included in the group of regenerative processes, such as skin regeneration, wound healing, cell therapy for cardiac, neural, or hematopoietic regeneration. It also refers to the manufacture/use of pharmaceutical compounds that contain an efficient quantity of the PEDF factor for stem cell self-renewal. | 02-25-2010 |
Isabel Fariñas Gómez, Valencia ES
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20100047212 | USE OF THE PEDF FACTOR TO INDUCE CELL REGENERATION - Use of the PEDF factor to induce cell regeneration. The present invention refers to the use of the molecule PEDF for the manufacture of medicines to activate processes included in the group of regenerative processes, such as skin regeneration, wound healing, cell therapy for cardiac, neural, or hematopoietic regeneration. It also refers to the manufacture/use of pharmaceutical compounds that contain an efficient quantity of the PEDF factor for stem cell self-renewal. | 02-25-2010 |
Isabel Fernandez Escapa, Madrid ES
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20130274510 | SYNTHESIS OF POLYHYDROXYALKANOATES (PHA) WITH THIOESTER GROUPS IN THE SIDE CHAIN - The present invention relates to a process for the synthesis of polyhydroxyalkanoates (PHAs) and PHAs obtained by the said process and the use of the said PHAs. The PHAs of the present invention, called PHACOS, have a novel monomeric composition, as they contain monomers with thioester groups in the side chain that confer new physicochemical properties and allow subsequent chemical modification. | 10-17-2013 |
Isabel Garcia Bonilla, St. Esteve ES
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20090174197 | METHOD FOR PRODUCING A SHOCK ABSORBER AND SHOCK ABSORBER THUS OBTAINED - The method includes providing a planar sheet part; forming the planar sheet part by drawing or conical spinning to the shape of a partially formed part made up of a plate and a provisional hollow portion extending from the plate with a revolution shape with respect to an axis perpendicular to the plate, and an end wall closing an end of the provisional hollow portion opposite to the plate; and elongating a section of the provisional hollow portion by cylindrical or conical spinning. The shock absorber is integral with a plate and an elongated hollow portion extending from the plate with a revolution shape. A section of the elongated hollow portion has a thickness that is thinner than the thickness of the plate. | 07-09-2009 |
Isabel Garcia Bonilla, Rubi ES
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20120228073 | SHOCK ABSORBING SYSTEM APPLICABLE TO THE BUMPER OF A VEHICLE - A shock absorbing system applicable to the bumper of a vehicle including a shock absorber with a deformable tube and a retaining device of the absorber including a mechanism susceptible to adopting at least one blocking position and one releasing position in which it prevents and allows, respectively, the displacement of a retaining portion of the absorber in an axial direction. The mechanism includes two rotating retaining connecting rods in a plane perpendicular to the longitudinal axis of the deformable tube, linked to one another such that the rotation of any one of the connecting rods is transmitted to the other to achieve a similar movement but in the opposite direction; and an electromechanical transducer to displace the mechanism from the blocking position to the releasing position. | 09-13-2012 |
Isabel Garcia Morales, Malaga ES
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20090326324 | ROBOTIC SYSTEM FOR ASSISTING IN MINIMALLY-INVASIVE SURGERY, WHICH CAN POSITION A SURGICAL INSTRUMENT IN RESPONSE TO ORDERS FROM A SURGEON, IS NOT ATTACHED TO THE OPERATING TABLE AND DOES NOT REQUIRE PRE-CALIBRATION OF THE INSERTION POINT - Robotic system for assisting in minimally-invasive surgery, which can position a surgical instrument in response to orders from a surgeon, is not attached to the operating table and does not require pre-calibration of the insertion point. The system includes: a manipulator robot having three active degrees of freedom, which is provided with an end actuator having two passive degrees of freedom, said actuator being used to attach a surgical instrument; a robot controller built into the structure thereof, which can perform a method for calculating the movement to be imparted to the carried surgical instrument so that it reaches the desired location without requiring pre-calibration and without the assembly having to be attached to the operating table; and an interface system for ordering the system to perform the desired actions. The assembly comprising the robot, the controller and the interface system is battery operated. | 12-31-2009 |
Isabel Gimeno Verdejo, Zaragoza ES
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20100230916 | STACKABLE SHOPPING BASKET - The invention relates to a shopping basket in self service stores and/or supermarkets, of the type of those which can be stacked and incorporate rolling means ( | 09-16-2010 |
20140265184 | SHOPPING CART - The present invention relates to a shopping cart of the types used by shoppers in supermarkets and/or self-service stores or shops and of the types stored by being horizontally fitted into one another, which has several improved maneuverability and handling features and which basically comprises a basket ( | 09-18-2014 |
Isabel Gómez-Gómez, G. A. Madero MX
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20120255071 | MUTANT BACILLUS THURINGIENSIS CRY GENES AND METHODS OF USE - The invention provides nucleic acids obtained from strains of | 10-04-2012 |
Isabel Gomila Muñiz, Palma De Mallorca ES
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20110172194 | COMPOSITION OF DIALYSIS LIQUID COMPRISING CRYSTALLISATION INHIBITOR SUBSTANCES - This invention relates to a composition that comprises inositol phosphates and/or bisphosphonates, and to the use thereof to prevent the loss of substances of biological interest in the body of patients subjected to dialysis and to maintain sufficient physiological levels of said substances to regulate physiological and/or pathological processes, these substances being inhibitors of pathological crystallisation. | 07-14-2011 |
Isabel Gomila Muñoz, Palma De Mallorca ES
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20130032494 | PORTABLE DEVICE FOR ANALYSING pH OR ANOTHER VARIABLE BY ELECTROCHEMICAL MEASUREMENT - Portable device ( | 02-07-2013 |
Isabel Guenette, Palo Alto, CA US
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20130338839 | FLEXIBLE FUNCTIONALITY PARTITIONING WITHIN INTELLIGENT-THERMOSTAT-CONTROLLED HVAC SYSTEMS - The current application is directed to an intelligent-thermostat-controlled environmental-conditioning system in which computational tasks and subcomponents with associated intelligent-thermostat functionalities are distributed to one or more of concealed and visible portions of one or more intelligent thermostats and, in certain implementations, to one or more intermediate boxes. The intelligent thermostats are interconnected to intermediate boxes by wired and/or wireless interfaces and intelligent thermostats intercommunicate with one another by wireless communications. Wireless communications include communications through a local router and an ISP, 3G and 4G wireless communications through a mobile service provider. Components of the intelligent-thermostat-controlled thermostat-controlled environmental-conditioning system may also be connected by wireless communications to remote computing facilities. | 12-19-2013 |
20140058806 | METHODS FOR ENCOURAGING ENERGY-EFFICIENT BEHAVIORS BASED ON A NETWORK CONNECTED THERMOSTAT-CENTRIC ENERGY EFFICIENCY PLATFORM - A home energy efficiency platform is described having as its fundamental component a network-connected, multi-sensing learning thermostat that leverages a visually pleasing interactive display associated therewith to encourage energy-saving behavior by a competitive gamesmanship modality, either in terms of self-competition in which a users energy-saving performance is measured against themselves over time, or in terms of community competition in which a users energy-saving behavior is measured against a relevant community. | 02-27-2014 |
Isabel Haro Villar, Madrid ES
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20100216173 | CITRULLINATED FIBRIN-FILAGGRIN CHIMERIC POLYPEPTIDE CAPABLE OF DETECTING THE ANTIBODIES GENERATED IN RHEUMATOID ARTHRITIS - The present invention concerns a chimeric polypeptide, capable of detecting the antibodies generated in rheumatoid arthritis, comprising at least two citrulinated peptide subunits: (i) one derived from the α or β chain of the fibrin and (ii) a second derived from the filaggrin. In addition, the invention comprises an antigenic composition, a method and a kit for the diagnosis of rheumatoid arthritis, from the detection of the autoantibodies generated during the course of said disease. | 08-26-2010 |
Isabel Hoffmann, Walzbachtal DE
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20130050822 | DISPLAY ELEMENT WITH POLARIZING FILM FOR A DISPLAY UNIT IN A VEHICLE - The invention relates to a display element for a display unit of a vehicle, said display element being formed from a substrate and a polarizing film. The display element may be backlit by means of a light source. The substrate may be imprinted with graphic symbols. The polarizing film may be a circular polarizing film. | 02-28-2013 |
20130076498 | DISPLAY DEVICE - A display device for a motor vehicle is proposed, wherein the display device has a first display area and a second display area, wherein the first display area is provided by way of a first display in the central area of a dial, wherein the second display area is designed so as to display a display information in an electroless manner. | 03-28-2013 |
20140327536 | Combination Display Instrument in a Vehicle - A combination display instrument in a vehicle has a plurality of display elements and/or display scales inserted into or attached onto a common base. A polarizing film, which is designed to correspond to the base, is arranged in the line of vision of an observer in front of the base. The polarizing film is held in position on the base in a form-fitting and/or force-fitting manner in an assembled state of the combination display instrument by corresponding molded sections in or on a housing of the combination display instrument. | 11-06-2014 |
Isabel Ibañez Garcia, Valencia ES
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20120309872 | BITUMINOUS MATERIAL AND ITS USE FOR THE CONSTRUCTION OF SUB-BALLAST - The present invention relates to a novel bituminous material using vulcanized rubber powder from out-of-use tires, and the use of the same for the construction of sub-ballast. | 12-06-2012 |
Isabel Jado Garcia, Madrid ES
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20080248473 | Method and Kit for the Detection of Bacterial Species by Means of Dna Analysis - The present invention relates to the detection and identification of different bacterial species, all of which cause zoonosis, based on DNA analysis. More specifically, the invention provides the primers, probes, genes and genic regions required to apply a method for the simultaneous detection of bacteria and bacterial groups belonging to the genera | 10-09-2008 |
20090004654 | METHOD FOR THE DETECTION OF BACTERIAL SPECIES OF THE GENERA ANAPLASMA/EHRLICHIA AND BARTONELLA - The present invention relates to a method for the detection and identification of bacterial species belonging to the genera | 01-01-2009 |
20100129825 | METHOD FOR THE DETECTION OF BACTERIAL SPECIES OF THE GENERA ANAPLASMA/EHRLICHIA AND BARTONELLA - The present invention relates to a method for the detection and identification of bacterial species belonging to the genera | 05-27-2010 |
20110104696 | KIT FOR DETECTION OF BACTERIAL SPECIES BY MEANS OF DNA ANALYSIS - The present invention relates to the detection and identification of different bacterial species, all of which cause zoonosis, based on DNA analysis. More specifically, the invention provides the primers, probes, genes and genic regions required to apply a method for the simultaneous detection of bacteria and bacterial groups belonging to the genera | 05-05-2011 |
Isabel Jimenez-Acquarone, London GB
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20100198092 | METHOD AND APPARATUS FOR PHYSIOLOGICAL ASSESSMENT IN MAMMALS - A method and tool for comparing mammals, such as horses, the tool including an electrode; an electronic heartbeat measurement instrument; an analyzer for determining an output indicative of adaptability, reactivity, or equanimity; and a plotting system for plotting the temperament parameter or temperament quotient on a grid. The tool is used to provide a value for the sympathetic nervous system index (SNSI), the parasympathetic nervous system index (PNSI), or the standard deviation of average mode normal to normal intervals (SDMNN). This value is correlated to a selected characteristic of the mammal. | 08-05-2010 |
Isabel Kalofonos, Cambridge, MA US
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20100069389 | NOVEL FORMS OF REBOXETINE - The invention relates to novel crystalline forms of (2R)-2-[(R)-(2-ethoxyphenoxy)-phenylmethyl]morpholine hydrochloride. In various embodiments, the novel crystalline forms may be substantially enantiopure. The preparation and characterization of the novel crystalline forms of (2R)-2-[(R)-(2-ethoxyphenoxy)-phenylmethyl]morpholine hydrochloride is also described. The invention also relates to pharmaceutical compositions containing novel crystalline forms of (2R)-2-[(R)-(2-ethoxyphenoxy)-phenylmethyl]morpholine hydrochloride, which are useful to treat and/or prevent various conditions such as nervous system and pain disorders. | 03-18-2010 |
20110275679 | FLUPIRTINE HYDROCHLORIDE MALEIC ACID COCRYSTAL - The invention relates to crystalline forms of flupirtine, particularly to 1:1 flupirtine hydrochloride maleic acid cocrystal. The preparation and characterization of 1:1 flupirtine hydrochloride maleic acid cocrystal is described. The invention also relates to the therapeutic use of the flupirtine hydrochloride maleic acid cocrystal to treat nervous system disorders, pain disorders, and musculoskeletal disorders and to pharmaceutical compositions containing the cocrystal. | 11-10-2011 |
20110275681 | NOVEL SOLID FORMS OF EPALRESTAT - The invention relates to novel crystalline salts of 5-[(1Z,2E)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid and a novel betaine cocrystal of 5-[(1Z,2E)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid. The preparation and characterization of the novel crystalline salts and cocrystal according to various embodiments of the invention is described. The invention also relates to pharmaceutical compositions containing the novel crystalline salts and cocrystal and the therapeutic use of the novel crystalline salts and cocrystal to treat and/or prevent various conditions, including treating and/or preventing diabetic complications, inhibiting aldose reductase, and affording cardioprotection in patients who may be non-diabetic. | 11-10-2011 |
20110275682 | NOVEL CHOLINE COCRYSTAL OF EPALRESTAT - The invention relates to a novel choline cocrystal of 5-[(1Z,2E)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid. The preparation and characterization of the novel choline cocrystal according to various embodiments of the invention is described. The invention also relates to pharmaceutical compositions containing the novel choline cocrystal and the therapeutic use of the novel choline cocrystal to treat and/or prevent various conditions, including treating and/or preventing diabetic complications, treating and/or preventing homocystinuria reducing levels of homocysteine in blood serum, inhibiting aldose reductase, and affording cardioprotection in non-diabetic patients. | 11-10-2011 |
20110275695 | CRYSTALLINE FORMS OF ZOTEPINE HYDROCHLORIDE - The invention relates to crystalline forms of zotepine hydrochloride, including the crystalline hydrochloride salt of zotepine and two cocrystals of zotepine hydrochloride with benzoic acid. The preparation and characterization of these crystalline forms of zotepine hydrochloride is described. The invention also relates to the therapeutic use of the crystalline forms of zotepine hydrochloride to treat central nervous system disorders and to pharmaceutical compositions containing them. | 11-10-2011 |
20110281911 | NOVEL FORMS OF EPERISONE - The invention relates to substantially enantiopure crystalline salt forms of (2RS)-I-(4-Ethylphenyl)-2-methyl-3-piperidin-1-ylpropan-1-one. The preparation and characterization of the substantially enantiopure crystalline salt forms according to various embodiments of the invention is described. The invention also relates to pharmaceutical compositions containing the substantially enantiopure crystalline salt forms, which are useful to treat and/or prevent various conditions such as pathological muscle contracture, myotome conditions, and spastic paralysis or spasticity caused by various neurologic conditions, and are also useful for the treatment and/or prevention of various types of pain and pathological muscle tension. | 11-17-2011 |
20120028930 | FLUPIRTINE SALTS AND POLYMORPHS - The present invention includes salts and polymorphs of flupirtine including, but not limited to carboxylic acid salts and sulfonic acid salts and their polymorphs. The present invention also includes pharmaceutical compositions comprising the salts and polymorphs of flupirtine. The invention also relates to the therapeutic use of the flupirtine salts and polymorphs to treat nervous system disorders, pain disorders, musculoskeletal disorders, and other diseases and conditions. | 02-02-2012 |
20120196895 | NOVEL FORMS OF EPERISONE - The invention relates to novel crystalline forms of (2RS)-1-(4-ethylphenyl)-2-methyl-3-piperidin-1-yl-propan-1-one. The preparation and characterization of the novel crystalline forms according to various embodiments of the invention is described. The invention also relates to pharmaceutical compositions containing the novel crystalline forms, which are useful to treat and/or prevent various conditions such as pathological muscle contracture, myotonic conditions, and spastic paralysis or spasticity caused by various neurologic conditions, and are also useful for the treatment and/or prevention of various types of pain and pathological muscle tension. | 08-02-2012 |
20140221438 | NOVEL SOLID FORMS OF EPALRESTAT - The invention relates to novel crystalline salts of 5-[(1Z,2E)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid and a novel betaine cocrystal of 5-[(1Z,2E)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid. The preparation and characterization of the novel crystalline salts and cocrystal according to various embodiments of the invention is described. The invention also relates to pharmaceutical compositions containing the novel crystalline salts and cocrystal and the therapeutic use of the novel crystalline salts and cocrystal to treat and/or prevent various conditions, including treating and/or preventing diabetic complications, inhibiting aldose reductase, and affording cardioprotection in patients who may be non-diabetic. | 08-07-2014 |
20140296309 | MODIFIED RELEASE COMPOSITIONS OF EPALRESTAT OR A DERIVATIVE THEREOF AND METHODS FOR USING THE SAME - Modified release pharmaceutical compositions of epalrestat are provided. Methods of manufacturing the tablets and treating various diseases and conditions, including diabetes and diabetic complications, by administering the modified release compositions to patients in need thereof are also provided. | 10-02-2014 |
20150057319 | NOVEL CHOLINE COCRYSTAL OF EPALRESTAT - The invention relates to a novel choline cocrystal of 5-[(1Z,2E)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid. The preparation and characterization of the novel choline cocrystal according to various embodiments of the invention is described. The invention also relates to pharmaceutical compositions containing the novel choline cocrystal and the therapeutic use of the novel choline cocrystal to treat and/or prevent various conditions, including treating and/or preventing diabetic complications, treating and/or preventing homocystinuria reducing levels of homocysteine in blood serum, inhibiting aldose reductase, and affording cardioprotection in non-diabetic patients. | 02-26-2015 |
Isabel Lasanta Carrasco, Madrid ES
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20110017354 | MATERIALS FOR THE PRODUCTION OF ECOLOGICAL AMMUNITION AND OTHER APPLICATIONS - The present invention provides an ODS type material (Oxide dispersion strengthened or particle dispersion) which comprises an alloy metal matrix and a dispersion of strengthening particles distributed therein which provide the same with optimum density and deformability. Said metal matrix is constituted by an alloy of zinc and bismuth, of zinc and aluminium, of tin and bismuth, or of tin and zinc, the strengthening material being of tungsten or ferro tungsten, oxides of both, carbides of both, or derivatives of the same. Said new material can substitute for lead in the production of ecological ammunition, hooks for fishing, inertial counterweights in automobiles, X-rays and ionising radiation screens, golf sticks, water pipes and plumbing fittings, as well as in electrical and magnetic applications. The invention also provides an ecological ammunition manufactured from said composite material, such as, for example, pellets. | 01-27-2011 |
Isabel Lizardi, Wallingford, CT US
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20120020033 | Skin-Safe Conductive Ink and Method for Application on the Body - An ink comprising a particulate conductive material, a binder and a humectant, the conductive material being present in sufficient amount that the ink, once dry, is electrically conductive, may be applied, for example, to the human or animal body and enables such a body to function as part of an electrical circuit. | 01-26-2012 |
Isabel Macias Borrego, Fuenlabrada ES
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20090142808 | NOVEL ENZYME WITH FRUCTOFURANOSIDASE ACTIVITY, WHICH IS USED TO OBTAIN PREBIOTIC OLIGOSACCHARIDES - The invention relates to a method of obtaining industrially-viable prebiotic oligosaccharides, using a novel extracellular enzyme (fructofuranosidase) of | 06-04-2009 |
Isabel Marco Martínez, Madrid ES
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20110105409 | Anticancer Compounds - Anticancer compounds of general formula I: | 05-05-2011 |
Isabel Marco Martínez, Madrid ES
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20110105409 | Anticancer Compounds - Anticancer compounds of general formula I: | 05-05-2011 |
Isabel Masip Masip, Barcelona ES
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20090088438 | NEW TYROSINE DERIVATIVES AS PPARy MODULATORS - Compounds of general formula I, | 04-02-2009 |
20100075984 | DICARBONYLIC COMPOUNDS WITH ANTIBACTERIAL ACTIVITY - Compounds of formula (I), and their pharmaceutically acceptable salts and solvates, wherein X represents —O—, —NH—, —S—, —NHC(═O)— or —NHC(═S)—; R1 represents —H or a hydrocarbon chain; R2 represents —H, alkoxy, amino, a hydrocarbon chain or a radical of a cycle; R3 represents —H, a hydrocarbon chain or a radical of a cycle; R4 represents —H or a hydrocarbon chain; alternatively R3 and R4 form together a cycle; R5 and R6 represent —H or halogen, and R7 represents —H, a hydrocarbon chain or heteroaryl, are useful against bacterial infections in animals, including humans. | 03-25-2010 |
20110160189 | COMPOUND THAT CAN INHIBIT UBC13-UEV INTERACTIONS, PHARMACEUTICAL COMPOSITIONS AND THERAPEUTIC USES - The invention relates to a compound (I) wherein R is a heterocyclyl radical; R | 06-30-2011 |
20120122868 | APAF-1 INHIBITOR COMPOUNDS - Derivatives of 2,5-piperazinedione of formula (I) are apoptotic peptidase activating factor 1 (Apaf-1) inhibitors, therefore they are useful as active pharmaceutical ingredients for the prophylaxis and/or treatment of a pathological and/or physiological condition associated with an increase of apoptosis. | 05-17-2012 |
20130237529 | COMPOUND THAT CAN INHIBIT UBC13-UEV INTERACTIONS, PHARMACEUTICAL COMPOSITIONS AND THERAPEUTIC USES - The invention relates to a compound (I) wherein R is a heterocyclyl radical; R | 09-12-2013 |
Isabel Masip Masip, Esplugues De Llobregat (barcelona) ES
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20110207769 | STABLE CRYSTALLINE SALT OF (R)-3-FLUOROPHENYL-3,4,5-TRIFLUOROBENZYLCARBAMIC ACID 1-AZABICYCLO [2.2.2]OCT-3-YL ESTER - The present invention refers to a stable crystalline salt of (R)-3-fluorophenyl-3,4,5-trifluorobenzylcarbamic acid 1-azabicyclo[2.2.2]oct-3-yl ester and its use as medicament, in particular for the treatment of urinary incontinence or other diseases involving genitourinary disorders | 08-25-2011 |
20140051721 | STABLE CRYSTALLINE SALT OF (R)-3-FLUOROPHENYL-3,4,5-TRIFLUOROBENZYLCARBAMIC ACID 1-AZABICYCLO [2.2.2]OCT-3-YL ESTER - The present invention refers to a stable crystalline salt of (R)-3-fluorophenyl-3,4,5-trifluorobenzylcarbamic acid 1-azabicyclo [2.2.2]oct-3-yl ester and its use as medicament, in particular for the treatment of urinary incontinence or other diseases involving genitourinary disorders | 02-20-2014 |
Isabel Medina Mendez, Vigo ES
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20120309699 | COMPOUNDS HAVING ANTI-INFLAMMATORY ACTIVITY - Compounds of general formula (I) for the treatment of inflammatory processes involved in numerous diseases such as intestinal inflammatory diseases. The invention moreover refers to compounds included within such general formula and to the procedure of the obtainment thereof. | 12-06-2012 |
Isabel Montero Herrero, Madrid ES
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20090261926 | METHOD AND STRUCTURE FOR INHIBITING MULTIPACTOR - A method of reducing multipactor effect occurrence on surfaces in a high energy field, e.g., RF devices, is provided and RF devices having a configuration produced by the method are provided. The method includes forming wall structures formed of a metallic wall material and defining a channel through which the RF energy travels, the wall material having a wall material surface. A porous layer is disposed over the wall material surface and has a porous layer upper surface opposite a porous layer lower surface facing the wall material surface. The porous layer defines pores with openings distributed in the porous layer upper surface. A conductive layer is disposed over the porous layer upper surface. | 10-22-2009 |
Isabel Moreira De Almeida, Saint-Arnoult-En-Yvelines FR
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20120076910 | Baked Dough Including A Specific Flour - The object of the present invention is to provide baked dough having a water activity (Aw) between 0.6 and 0.80 and including at least a flour having a median particulate size in volume less than or equal to 40 μm. It is also an object of the invention to provide a food product including said baked dough, and a use of a flour having a median particulate size in volume less than or equal to 40 μm as a substitute for sugars and/or sugar derivatives in dough baked or intended to be baked. | 03-29-2012 |
20150080336 | ASSOCIATION OF BETA-GLUCANS AND ARABINOXYLANS - The present invention relates to an association of beta-glucans from a first cereal and arabinoxylans from a second cereal different from the first cereal, and their use to improve the microbiota balance in human gut. | 03-19-2015 |
Isabel MÜehlen-Bartmer, Frankfurt Am Main DE
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20130203666 | PHARMACEUTICAL COMBINATION FOR USE IN GLYCEMIC CONTROL IN DIABETES TYPE 2 PATIENTS - The present invention refers to a pharmaceutical combination for use in glycemic control in diabetes type 2 patients. | 08-08-2013 |
Isabel Navarro Muñoz, Barcelona ES
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20100240656 | COMPOUNDS AS HSP90 INHIBITORS - The invention provides novel compounds of formula (I) wherein: one of the a, b, c or d members is a nitrogen atom and the remaining members are carbon atoms; and R | 09-23-2010 |
20100331355 | Substituted Quinolines for the Treatment of Cancer - Compounds of formula G | 12-30-2010 |
Isabel Navarro Muñoz, Barcelona ES
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20100129800 | POLYMERS AND THEIR USE AS FLUORESCENT LABELS - The present invention relates to a polymer composed by two to ten monomers of formula (I) as well as to a process for its preparation and its use as fluorophore wherein: X is a radical of formula (II) wherein —R | 05-27-2010 |
20100240656 | COMPOUNDS AS HSP90 INHIBITORS - The invention provides novel compounds of formula (I) wherein: one of the a, b, c or d members is a nitrogen atom and the remaining members are carbon atoms; and R | 09-23-2010 |
20100331355 | Substituted Quinolines for the Treatment of Cancer - Compounds of formula G | 12-30-2010 |
20150087715 | POLYMORPHIC FORM OF A LONG-ACTING BETA-2 ADRENOCEPTOR AGONIST - New polymorphic form of a long-acting beta-2 adrenoceptor agonist A new polymorphic form of arformoterol tartrate, designated as form D, is provided and which is characterised by at least one of the following: (i) a powder X-ray diffraction pattern having peaks at approximately 6.8, 13.3, 13.6, 3.8, 14.1, 18.2, 18.7, 20.0±0.2 degrees two theta; or (ii) a DSC thermogram showing an endothermic peak with an onset at approximately 19-120° C., and a maximum at approximately 129-131° C., followed by an exothermic peak with a maximum at approximately 137-138° C.; wherein the DSC thermogram of form D has a further endothermic peak with an onset at approximately 168-170° C.1 Processes for preparing the new polymorphic form, uses thereof and intermediates for the preparation thereof, are also provided. | 03-26-2015 |
Isabel Ordas Arnal, Madrid ES
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20130335510 | SYSTEM FOR EXCHANGING PTT MESSAGES FOR BRIEF MULTI VIDEO CONFERENCES - The invention relates to a system which can be used for exchanging short multimedia messages between two or more users. The system is used, without distinction, for client-server implementations ( | 12-19-2013 |
Isabel Puig Pey, Barcelona ES
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20100304987 | METHODS AND KITS FOR DIAGNOSIS AND/OR PROGNOSIS OF THE TOLERANT STATE IN LIVER TRANSPLANTATION - The long-term survival of transplanted grafts critically depends on the life-long administration of immunosuppressive drugs to prevent graft rejection. These drugs are very effective at preventing graft rejection, but they are also associated with severe side effects. Inventors have selected a set of genes whose expression characterizes the tolerant state in liver transplantation in humans. Based on the expression level profile of this set of genes, inventors provide a non-invasive method to assess diagnosis and/or prognosis of the tolerant state in liver transplantation in humans, and kits to perform it. These kits are simpler and cheaper than others based on a great number of genes, such as commercial microarrays with thousands of probes. | 12-02-2010 |
Isabel Reig López, Sant Joan Despi ES
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20120289553 | ORAL LIQUID PHARMACEUTICAL COMPOSITION OF NIFEDIPINE - It relates to an oral liquid pharmaceutical composition comprising: a) nifedipine in an amount comprised between 0.1% and 1% w/w; b) ethanol in an amount comprised between 38% and 58% w/w; c) water in an amount comprised between 4% and 12% w/w; d) glycerine in an amount comprised between 30% and 50% w/w; and e) optionally, other pharmaceutical excipients or carriers, the sum total of components being 100% w/w, provided that the composition is substantially free of polyethyleneglycol and derivatives thereof. | 11-15-2012 |
Isabel Remory, Vlekkem BE
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20090306189 | Methods for Controlling Pests Using Rnai - The present invention relates to methods for controlling pest infestation using double stranded RNA molecules. The invention provides methods for producing transgenic cells expressing the double stranded RNA molecules, as well as compositions and commodity products containing or treated with such molecules. | 12-10-2009 |
Isabel Ribeiro Dos Santos, Eaunes FR
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20100041703 | RAPID DISINTEGRATION MONOLAYER FILM FOR THE ORAL ADMINISTRATION OF ACTIVE SUBSTANCES - Rapid-disintegration monolayer film for the oral administration of active substances, comprising a water-soluble support containing at least one active substance, characterized in that it comprises a polymeric mixture of a hydrophilic film-forming agent formed from a copolymer of polyvinyl alcohol and of polyethylene glycol (PVA-PEG), of an active substance and of a hydrophilic gelling agent. | 02-18-2010 |
20150045748 | TRANSDERMAL DEVICE INCLUDING POROUS MICROPARTICLES - The present invention relates to a transdermal device including porous microparticles capable of containing an active principle, in particular nicotine, and to the use thereof as a drug, in particular for tobacco cessation. The present invention further relates to a method for preparing a transdermal device including porous microparticles filled with an active principle. | 02-12-2015 |
Isabel RodrÍguez FernÁndez, Singapore SG
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20110122504 | VARIABLE FOCUS MICROLENS - A microlens chip comprises a variable focus fluidic microlens and actuator. The actuator varies the pressure in a fluidic channel in the microlens chip which is coupled to an aperture opening containing the microlens. Applying an electric field to the actuator creates changes in fluid pressure in the fluidic channel, which in turn changes the radius of curvature (i.e., focal length) of the fluidic microlens. | 05-26-2011 |
20110217350 | SUBSTRATE HAVING A SURFACE FOR INHIBITING ADHESION OF A TARGET CELL THEREON AND A METHOD OF PREPARING THE SAME - A substrate having a surface for inhibiting adhesion of a target cell thereon, the substrate comprising an array of generally longitudinal projections having a longitudinal axis that extends from the surface of said substrate and having an aspect ratio of at least 2.5, wherein adjacent projections of said array are configured on the substrate such that the projections at least partially inhibit adhesion of a target cell thereon. | 09-08-2011 |
Isabel Rodriguez Moreno, Madrid ES
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20080248473 | Method and Kit for the Detection of Bacterial Species by Means of Dna Analysis - The present invention relates to the detection and identification of different bacterial species, all of which cause zoonosis, based on DNA analysis. More specifically, the invention provides the primers, probes, genes and genic regions required to apply a method for the simultaneous detection of bacteria and bacterial groups belonging to the genera | 10-09-2008 |
20090004654 | METHOD FOR THE DETECTION OF BACTERIAL SPECIES OF THE GENERA ANAPLASMA/EHRLICHIA AND BARTONELLA - The present invention relates to a method for the detection and identification of bacterial species belonging to the genera | 01-01-2009 |
20100129825 | METHOD FOR THE DETECTION OF BACTERIAL SPECIES OF THE GENERA ANAPLASMA/EHRLICHIA AND BARTONELLA - The present invention relates to a method for the detection and identification of bacterial species belonging to the genera | 05-27-2010 |
20110104696 | KIT FOR DETECTION OF BACTERIAL SPECIES BY MEANS OF DNA ANALYSIS - The present invention relates to the detection and identification of different bacterial species, all of which cause zoonosis, based on DNA analysis. More specifically, the invention provides the primers, probes, genes and genic regions required to apply a method for the simultaneous detection of bacteria and bacterial groups belonging to the genera | 05-05-2011 |
Isabel Salla Cabau, Els Omellons ES
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20100330235 | MYCOTOXIN ADSORBENT - The present invention relates to a mycotoxin adsorbent, as well as to the process for the preparation of said adsorbent. The adsorbent of the invention is based on the combination of an organic silicate with an amorphous structure and dodecylamine, that is to say, a primary amine having an apolar, linear, aliphatic long-chain of twelve carbon atoms. The invention also relates to the use of said adsorbent in feeds for the adsorption of mycotoxins, especially for the adsorption of mycotoxins such as aflatoxins, zearalenone, ochratoxin A or fumonisin B1. Furthermore, the invention relates, on the one hand, to a feed additive comprising said adsorbent and, on the other hand, to the feeds comprising said additive. | 12-30-2010 |
Isabel Sanchez Perez, Madrid ES
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20090202503 | SEQUENCE OF NUCLEOTIDES AND PEPTIDES GSE 24.2 OF DYSKERIN, WHICH CAN INDUCE TELOMERASE ACTIVITY, METHOD FOR OBTAINING SAME, THERAPEUTIC COMPOSITIONS AND APPLICATIONS THEREOF - This invention relates to a compound that induces or activates telomerase activity based on the nucleotide sequence of the GSE 24.2 fragment of dyskerin or the protein or peptide sequence encoded by said nucleotide sequence. Another part of the invention relates to vectors that comprise said sequence and cells transformed thereby, and pharmaceutical compositions that contain all these elements. These compositions may be used in the treatment of diseases from the following group: ageing or acceleration of ageing, neurodegenerative diseases and dyskeratosis congenita. | 08-13-2009 |
20110300115 | USE OF INDUCTOR AGENTS GSE24.2 FOR PRODUCING PHARMACEUTICAL COMPOSITIONS FOR TREATING ILLNESSES RELATING TO CELLULAR SENESCENCE - This invention describes the use of an inductor or activator compound GSE24.2 for producing a medicament or pharmaceutical composition for treating a preferably human illness or pathological situation caused by a senescence process. Said pharmaceutical composition can be useful for a treatment of tissue regeneration, for example of epithelial tissues or haematopoietic cells, and also for the immortalisation of eukaryote cells for use of same in biotechnological research or processes. | 12-08-2011 |
Isabel Santaolalla Ruiz De Galarreta, Obedullo Lopez De Uralde ES
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20110151458 | METHODS AND REAGENTS FOR THE DETECTION OF SALMONELLA SPP - The invention relates to an in vitro method for the detection of bacteria of the | 06-23-2011 |
Isabel Schemainda, Munich DE
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20100227896 | USE OF VITAMIN PP COMPOUNDS - Vitamin PP compounds and compounds with anti-pellagra activity such as nicotinic acid and nicotinamide are useful for the reduction, elimination, and prevention of side-effects of immunosuppressive and anti-cancer chemotherapy and diagnosis, especially those induced by the use of substituted pyridine carboxamides of formula I. Combinations containing compounds of formula I and the vitamin PP compounds and compounds with anti-pellagra activity are provided for these chemotherapies and diagnoses. | 09-09-2010 |
Isabel Sequeira Lopes, Oeiras PT
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20090068673 | UTILIZATION OF COMPATIBLE SOLUTES TO IMPROVE THE PERFORMANCE OF THE TECHNIQUES USING IMMOBILIZED BIOLOGIC MATERIALS - This invention is based upon the application of compatible solutes to immobilized biological materials or to immobilize in order to improve the technical performance using the same, namely nucleic acid and proteins or biosensors micronets. The above mentioned compatible solutes are selected from a group that includes Mannosylglycerate (MG) and its 3 derivatives manno-sylglyceramide (MGA), -mannosylglycerol (MGOH), and mannosyl-lactate (MGLac), 1,1-di-glycerol phosphate (DGP), ectoin, hydroxyectoin, and or derivatives or combinations thereof. The improved performance of the above mentioned techniques might be due to: a better state of preservation of the material to be immobilized, increasing the life expectancy of the material, and/or decreasing the storage and/or transport requirements, a more efficient and uniform deposition of the material on the support, more efficiency and/or specificity of hybridation of the marked material, all this originating an increase of the signal-to-noise ratio. | 03-12-2009 |
Isabel Sola Gurpegui, Madrid ES
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20090202588 | Nucleic acids encoding TGEV and PRRSV sequences for improved expression of PRRSV sequences - The present invention relates to nucleic acids comprising: | 08-13-2009 |
20120114683 | Nucleic Acid Encoding TGEV and PRRSV Sequences for Improved Expression of PRRSV Sequences - The present invention relates to nucleic acids comprising: | 05-10-2012 |
Isabel Tejedor, Madison, WI US
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20080213632 | LIGHT-POWERED MICROBIAL FUEL CELLS - Devices and methods for generating electricity utilizing a light-powered microbial fuel cell that includes a light-admitting reaction chamber containing a biological catalyst, such as a photosynthetic bacteria, in a growth medium, an anode and cathode disposed upon or within the reaction chamber, and a conductive material in electrical communication between the anode and cathode. The anode includes an oxidation catalyst, while the cathode includes a reduction catalyst that is accessible to oxygen gas. Preferably, the devices and methods utilize a single light-admitting chamber within which both cathodic and anodic reactions take place. | 09-04-2008 |
20110171496 | LIGHT-POWERED MICROBIAL FUEL CELLS - Devices and methods for generating electricity utilizing a light-powered microbial fuel cell that includes a light-admitting reaction chamber containing a biological catalyst, such as a photosynthetic bacteria, in a growth medium, an anode and cathode disposed upon or within the reaction chamber, and a conductive material in electrical communication between the anode and cathode. The anode includes an oxidation catalyst, while the cathode includes a reduction catalyst that is accessible to oxygen gas. Preferably, the devices and methods utilize a single light-admitting chamber within which both cathodic and anodic reactions take place. | 07-14-2011 |
Isabel Trogh, Burcht BE
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20130101699 | COMPOSITIONS RICH IN ARABINOXYLAN OLIGOSACCHARIDES - A method for preparing a liquid composition having a high arabinoxylan oligosaccharides content (AXOS), the product obtained by this method, and its use in food applications, in particular in baked products. | 04-25-2013 |
Isabel Unterstrasser, Rimsting DE
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20120135475 | LIQUEFIED BIOMASS - The invention is directed to a liquefied sugar beet and/or sugar cane biomass material as well as production methods and uses thereof. The liquefied biomass is storage stable and can be used for the production of a product resulting from fermentation. | 05-31-2012 |
20130109062 | THERMOSTABLE XYLANASE FOR THE SELECTIVE HYDROLYSIS OF PENTOSE-CONTAINING POLYSACCHARIDES | 05-02-2013 |
20130123115 | OPTIMIZED CELLULASE ENZYMES - The invention discloses cellulase enzymes with optimized properties for processing of cellulose- and lignocellulose-containing substrates. In particular, cellobiohydrolase enzymes with preferred characteristics are disclosed. The present invention provides fusion, insertion, deletion and/or substitution variants of such enzymes. Enzyme variants have enhanced thermostability, proteolytic stability, specific activity and/or stability at extreme pH. Nucleic acid molecules encoding said enzymes, a composition comprising said enzymes, a method for preparation, and the use for cellulose processing and/or for the production of biofuels are disclosed. | 05-16-2013 |
Isabel Velasco Umpierrez, Sevilla ES
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20100234567 | METHODS FOR SEPARATING RECOMBINANT PROTEINS IN AQUEOUS TWO-PHASE SYSTEMS - The object of the present invention is a procedure for the distribution, separation and purification in aqueous solution of recombinant proteins, based on the utilization of polypeptides with choline affinity. The invention is based on a phenomenon consisting of that two aqueous solutions with determinated components can be mixed, being distributed finally in two phases with different density. The fusionated proteins to said polypeptides with choline affinity are preferably located in one of the phases, while most of the cell extract proteins tend to go to the opposite phase. After a series of washings for removing the rest of the not desired material, this location can be inverted through the addition of a soluble molecule with affinity by the polypeptide fusionated to the protein of interest. This procedure allows modulating at convenience the presence of the protein or polypeptide of interest in one phase or another, possibiliting its purification with a high yield and purity grade. The invention represents an economic and scalable way of recombinant protein separation labelled preferably with choline-binding domains. | 09-16-2010 |
Isabel Witzemann, Karlsruhe DE
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20090135580 | DISPLAY DEVICE FOR A MOTOR VEHICLE PROVIDED WITH A SWIVELLING INDICATOR HAVING FIRST AND/OR SECOND OPTICAL WAVE GUIDE AREAS - The invention relates to a motor vehicle display device comprising a display area oriented in a viewing direction, wherein a swiveling indicator rotatable about an axis of rotation is provided in the viewing direction behind the displaying area, a printed circuit board, which is provided with a first lighting device arranged thereon, is positioned in the viewing direction behind the swiveling indicator and a first optical wave guide area enables a first light emitted by the first lighting device to be transmitted to the display area further the swiveling indicator. | 05-28-2009 |
Isabel Zaror, Berkeley, CA US
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20090311216 | RECOMBINANT INTERFERON-BETA WITH ENHANCED BIOLOGICAL ACTIVITY - Human interferon-β protein analogs in which the asparagine at position 25, numbered in accordance with native human interferon-β, is recombinantly replaced with an aspartate residue exhibit a biological activity of human interferon-β (e.g. IFN-β 1b) at an increased level relative to IFN-β 1b. These analogs are obtained by introducing a gene coding for Asp25 IFN-β into a cell and expressing the recombinant protein. The resulting IFN-β protein analog is suitable for large scale manufacturing for incorporation in HA-containing or HA-free therapeutics for treatment of diseases including multiple sclerosis. A reduced Lys endoproteinase-C peptide map technique that produces a fingerprint profile for proteins using an enzymatic digest followed by RP-HPLC is also useful in quality control as an ID test for the IFN-β protein analog products. | 12-17-2009 |
Isabel Zaror, El Cerrito, CA US
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20080254026 | ANTAGONIST ANTI-CD40 MONOCLONAL ANTIBODIES AND METHODS FOR THEIR USE - Compositions and methods of therapy for treating diseases mediated by stimulation of CD40 signaling on CD40-expressing cells are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of human CD40-expressing cells, such as B cells. | 10-16-2008 |
20130011405 | ANTAGONIST ANTI-CD40 MONOCLONAL ANTIBODIES AND METHODS FOR THEIR USE - Compositions and methods of therapy for treating diseases mediated by stimulation of CD40 signaling on CD40-expressing cells are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of human CD40-expressing cells, such as B cells. | 01-10-2013 |
20140205602 | ANTAGONIST ANTI-CD40 MONOCLONAL ANTIBODIES AND METHODS FOR THEIR USE - Compositions and methods of therapy for treating diseases mediated by stimulation of CD40 signaling on CD40-expressing cells are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of human CD40-expressing cells, such as B cells. | 07-24-2014 |