Patent application number | Description | Published |
20110161987 | SCALING NOTIFICATIONS OF EVENTS IN A SOCIAL NETWORKING SYSTEM - A social networking system notification system is scaled so a user is notified of an event when a unit or level of notification utility has been reached. For the average user, a single event may be noteworthy enough for which to receive a notification. However, when this user is especially important or highly connected (or received a large number of interactions), that user will have decreasing utility for each additional comment he has received. To manage these types of situations, and avoid inundating users with notifications that are of less utility to the user, the notifications are filtered/aggregated so that these users are notified less often. The notification scheme is optimized for each user, so the user is notified only when he has reached a level of notification utility. | 06-30-2011 |
20130013720 | Scaling Notifications of Events in a Social Networking System - A social networking system notification system is scaled so a user is notified of an event when a unit or level of notification utility has been reached. For the average user, a single event may be noteworthy enough for which to receive a notification. However, when this user is especially important or highly connected (or received a large number of interactions), that user will have decreasing utility for each additional comment he has received. To manage these types of situations, and avoid inundating users with notifications that are of less utility to the user, the notifications are filtered/aggregated so that these users are notified less often. The notification scheme is optimized for each user, so the user is notified only when he has reached a level of notification utility. | 01-10-2013 |
Patent application number | Description | Published |
20100297777 | SUB-DIFFRACTION LIMIT IMAGE RESOLUTION AND OTHER IMAGING TECHNIQUES - The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be separated by a distance of less than about 1000 nm, or less than about 300 nm for visible light. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. A first entity may be activated and determined (e.g., by determining light emitted by the entity), then a second entity may be activated and determined The entities may be immobilized relative to each other and/or to a common entity. The emitted light may be used to determine the positions of the first and second entities, for example, using Gaussian fitting or other mathematical techniques, and in some cases, with sub-diffraction limit resolution. The methods may thus be used, for example, to determine the locations of two or more entities immobilized relative to a common entity, for example, a surface, or a biological entity such as DNA, a protein, a cell, a tissue, etc. The entities may also be determined with respect to time, for example, to determine a time-varying reaction. Other aspects of the invention relate to systems for sub-diffraction limit image resolution, computer programs and techniques for sub-diffraction limit image resolution, methods for promoting sub-diffraction limit image resolution, methods for producing photoswitchable entities, and the like. | 11-25-2010 |
20110002530 | SUB-DIFFRACTION LIMIT IMAGE RESOLUTION IN THREE DIMENSIONS - The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques, including imaging in three dimensions. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be separated by a distance of less than about 1000 nm, or less than about 300 nm for visible light. In some cases, the position of the entities can be determined in all three spatial dimensions (i.e., in the x, y, and z directions), and in certain cases, the positions in all three dimensions can be determined to an accuracy of less than about 1000 nm. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. A first entity may be activated and determined (e.g., by determining light emitted by the entity), then a second entity may be activated and determined. The emitted light may be used to determine the x and y positions of the first and second entities, for example, by determining the positions of the images of these entities, and in some cases, with sub-diffraction limit resolution. In some cases, the z positions may be determined using one of a variety of techniques that uses intensity information or focal information (e.g., a lack of focus) to determine the z position. Non-limiting examples of such techniques include astigmatism imaging, off-focus imaging, or multi-focal-plane imaging. | 01-06-2011 |
20140038201 | SUB-DIFFRACTION LIMIT IMAGE RESOLUTION IN THREE DIMENSIONS - The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques, including imaging in three dimensions. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. In some cases, the position of the entities can be determined in all three spatial dimensions (i.e., in the x, y, and z directions), and in certain cases, the positions in all three dimensions can be determined to an accuracy of less than about 1000 nm. In some cases, the z positions may be determined using one of a variety of techniques that uses intensity information or focal information (e.g., a lack of focus) to determine the z position. Non-limiting examples of such techniques include astigmatism imaging, off-focus imaging, or multi-focal-plane imaging. | 02-06-2014 |
20140063194 | SUB-DIFFRACTION LIMIT IMAGE RESOLUTION IN THREE DIMENSIONS - The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques, including imaging in three dimensions. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. In some cases, the position of the entities can be determined in all three spatial dimensions (i.e., in the x, y, and z directions), and in certain cases, the positions in all three dimensions can be determined to an accuracy of less than about 1000 nm. In some cases, the z positions may be determined using one of a variety of techniques that uses intensity information or focal information (e.g., a lack of focus) to determine the z position. Non-limiting examples of such techniques include astigmatism imaging, off-focus imaging, or multi-focal-plane imaging. | 03-06-2014 |
Patent application number | Description | Published |
20120209652 | SYSTEM AND METHOD FOR RESOURCE ALLOCATION AND MANAGEMENT - To improve the scheduling and tasking of resources, the present disclosure describes an improved planning system and method for the allocation and management of resources. The planning system uses a branch and bound approach of tasking resources using a heuristic to expedite arrival at a deterministic solution. For each possible functional mode of the resources, an upper bound is determined. The upper bounds are employed in an objective function for the branch and bound process to determine the functional mode in which to place the resources and to determine movement paths for the resources, all in an environment where a hostile force may attempt to destroy the resources. | 08-16-2012 |
20150193854 | AUTOMATED COMPILATION OF GRAPH INPUT FOR THE HIPERGRAPH SOLVER - One embodiment of the present invention provides a system for generating a product recommendation by translating transaction data to graph representation for input to a graph analytics application. During operation, the system generates a transaction table to store transaction data, a customer table to store customer data, and a product table to store products data. The system generates a table containing topology and edge identifier information and a table containing edge attribute information. Next, the system generates headers that include data describing the customer table and/or the product table and/or the table containing edge attribute information. The system then generates files containing the one or more headers and data from the tables, in which the data describes a graph with edges representing transactions and vertices representing customers or products. Subsequently, the system submits the one or more files as input to the graph analytics application to generate a product recommendation. | 07-09-2015 |
20150234875 | GRAPH PRUNING IN HIPERGRAPH - One embodiment of the present invention provides a system for graph pruning. During operation, the system identifies a connected component in a graph comprising one or more vertices. A respective vertex of the graph represent an element in a data set, an edge between two vertices represents a type and strength of relationship between the vertices. The system identifies a connected component to be smaller than a minimum graph traversal threshold associated with a query for the graph. This minimum graph traversal threshold indicates a minimum number of traversal steps needed for the query. The system then generates a second graph by pruning the connected component from the graph. This second graph is processed to extract information of interest from the data set. | 08-20-2015 |
Patent application number | Description | Published |
20120218191 | MULTI-DISPLAY TYPE DEVICE INTERACTIONS - An electronic device including two or more display elements can provide enhanced functionality with improved rates of power consumption. A user can cause information that does not change rapidly to be provided or moved to a relatively static display element, such as an electronic ink display, which enables that information to be displayed for a period of time with little additional power consumption. Similarly, content (e.g., video) that changes rapidly can be displayed on a relatively dynamic display element, such as and LCD or OLED display. Each display can be touch sensitive, such that a user can move content between the displays by pressing on, or making a motion in contact with, at least one of the displays. Various modes can be activated which cause certain types of content to be displayed on the dynamic and/or static display element. | 08-30-2012 |
20120314914 | ENHANCED FACE RECOGNITION IN VIDEO - The computational resources needed to perform processes such as image recognition can be reduced by determining appropriate frames of image information to use for the processing. In some embodiments, infrared imaging can be used to determine when a person is looking substantially towards a device, such that an image frame captured at that time will likely be adequate for facial recognition. In other embodiments, sound triangulation or motion sensing can be used to assist in determining which captured image frames to discard and which to select for processing based on any of a number of factors indicative of a proper frame for processing. | 12-13-2012 |
20140126777 | ENHANCED FACE RECOGNITION IN VIDEO - The computational resources needed to perform processes such as image recognition can be reduced by determining appropriate frames of image information to use for the processing. In some embodiments, infrared imaging can be used to determine when a person is looking substantially towards a device, such that an image frame captured at that time will likely be adequate for facial recognition. In other embodiments, sound triangulation or motion sensing can be used to assist in determining which captured image frames to discard and which to select for processing based on any of a number of factors indicative of a proper frame for processing. | 05-08-2014 |
20150078623 | ENHANCED FACE RECOGNITION IN VIDEO - The computational resources needed to perform processes such as image recognition can be reduced by determining appropriate frames of image information to use for the processing. In some embodiments, infrared imaging can be used to determine when a person is looking substantially towards a device, such that an image frame captured at that time will likely be adequate for facial recognition. In other embodiments, sound triangulation or motion sensing can be used to assist in determining which captured image frames to discard and which to select for processing based on any of a number of factors indicative of a proper frame for processing. | 03-19-2015 |
20150120965 | APPARATUS AND METHOD FOR COPYING RULES BETWEEN DEVICES - Devices, systems, and methods are described for allowing rules that are applied to one device to be applied to another device based on a user's interaction with only the devices. A rule-copy action, such as simultaneous shaking of the two devices, proximity of the two devices to each other, and/or the relative positions of the two devices, may be detected at one of the devices (e.g., a first device to which the user desires the rules or a copy of the rules to apply). In response to the rule-copy action, another device (e.g., a second device configured to operate according to the at least one rule) may be identified. The at least one rule may then be caused to be applied to the first device in response to detection of the rule-copy action, so as to configure the first device to operate according to the at least one rule. | 04-30-2015 |
Patent application number | Description | Published |
20110003384 | COMPOSITIONS AND METHODS OF USE FOR MGD-CSF IN DISEASE TREATMENT - Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss. | 01-06-2011 |
20120258071 | Compositions and Methods of Use for MGD-CSF in Disease Treatment - Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss. | 10-11-2012 |
Patent application number | Description | Published |
20140279094 | MOBILE DEVICE PAYMENTS - Methods, systems, and apparatus, including computer programs encoded on computer storage media, for conducting cardless payment transactions. One of the methods includes receiving from a merchant computer an indication of a payment transaction by a user associated with a mobile phone number. A text message is provided to a device associated with the mobile phone number requesting approval for the payment transaction, wherein the message includes an approval code. A message is received from the device associated with the mobile phone number. If the text message from the device associated with the mobile phone number includes the provided approval code, account information associated with the mobile phone number is obtained, authorization for the payment transaction is obtained using the account information, and notification of authorization of the payment transaction is provided to a merchant conducting the payment transaction. | 09-18-2014 |
20150081556 | Mobile Device Payments - Methods, systems, and apparatus, including computer programs encoded on computer storage media, for conducting cardless payment transactions. One of the methods includes receiving from a merchant computer an indication of a payment transaction by a user associated with a mobile phone number. A text message is provided to a device associated with the mobile phone number requesting approval for the payment transaction, wherein the message includes an approval code. A message is received from the device associated with the mobile phone number. If the text message from the device associated with the mobile phone number includes the provided approval code, account information associated with the mobile phone number is obtained, authorization for the payment transaction is obtained using the account information, and notification of authorization of the payment transaction is provided to a merchant conducting the payment transaction. | 03-19-2015 |
Patent application number | Description | Published |
20090011415 | REGULATION OF NEURONAL EXPRESSION OF APOLIPOPROTEIN E - The present invention provides nucleic acids comprising a nucleotide sequence encoding an apolipoprotein E (apoE) splice variant, e.g., an unprocessed apoE, that retains intron 3; and vectors and host cells comprising same. The present invention further provides screening methods to identify agents that inhibit cleavage of intron-3 from the apoE splice variant. The present invention further provides methods of treating apoE-related neurological disorders, involving administering an agent that inhibits removal of intron-3 from a precursor apoE mRNA. | 01-08-2009 |
20090082271 | AGENTS THAT REDUCE APOE-INDUCED IMPAIRMENT OF MITOCHONDRIA AND METHODS OF USE THEREOF - The present invention provides isolated cells comprising a nucleic acid encoding a toxic form of apoE. The present invention further provides screening methods for identifying compounds that reduce apoE-induced impairment of mitochondrial integrity and/or function. The present invention further provides kits for use in carrying out a subject screening method. The present invention provides agents that reduce apoE-induced impairment of mitochondrial integrity and/or function; and use of such agents in the treatment of apoE-related disorders. | 03-26-2009 |
20090136456 | METHODS OF TREATING NEURODEGENERATIVE DISORDERS - The present invention provides a selected population of neural cells, including neural stem cells, neural progenitor cells, neural precursor cells, and progeny thereof, which neural cells are selected for an apoE4 | 05-28-2009 |
20110135611 | METHODS FOR TREATING APOLIPOPROTEIN E4-ASSOCIATED DISORDERS - The present disclosure provides methods of reducing apoE4 fragment-mediated toxicity of interneurons, e.g, GABAergic interneurons. The present disclosure provides methods of treating apoE4-mediated neurological disorders in an apoE4-positive individual. | 06-09-2011 |
20110135613 | METHODS FOR TREATING APOLIPOPROTEIN E4-ASSOCIATED DISORDERS - The present disclosure provides a method of increasing the functionality of a GABAergic interneuron in the hilus of the hippocampus of an individual having at least one apolipoprotein E4 (apoE4) allele. The method generally involves reducing tau levels in the interneuron. | 06-09-2011 |
20120129782 | Inhibition of ApoE Cleavage Activity in the Treatment of ApoE-Related Disorders - The present invention provides methods for treating apoE-related disorders. The methods generally involve administering an effective amount of an agent that inhibits activity of an enzyme that cleaves apoE. | 05-24-2012 |
20120269778 | METHODS OF GENERATING NEURAL STEM CELLS - The present disclosure provides methods of generating neural stem cells from differentiated somatic cells. The present disclosure also provides induced neural stem cells generated using a subject method, as well as differentiated cells generated from a subject induced neural stem cell. A subject neural stem cell, as well as differentiated cells derived from a subject neural stem cell, is useful in various applications, which are also provided in the present disclosure. | 10-25-2012 |
20130017251 | Antibody Specific for Apolipoprotein and Methods of Use Thereof - The present disclosure provides synthetic antibodies specific for an epitope present on an apolipoprotein E polypeptide. The antibodies are useful in various treatment, diagnostic, and monitoring applications, which are also provided. | 01-17-2013 |
20150017139 | Methods of Generating Neural Stem Cells - The present disclosure provides methods of generating neural stem cells from differentiated somatic cells. The present disclosure also provides induced neural stem cells generated using a subject method, as well as differentiated cells generated from a subject induced neural stem cell. A subject neural stem cell, as well as differentiated cells derived from a subject neural stem cell, is useful in various applications, which are also provided in the present disclosure. | 01-15-2015 |
20150267198 | METHODS FOR TREATING APOLIPOPROTEIN E4-ASSOCIATED DISORDERS - The present disclosure provides a method of increasing the functionality of a GABAergic interneuron in the hilus of the hippocampus of an individual having at least one apolipoprotein E4 (apoE4) allele. The method generally involves reducing tau levels in the interneuron. | 09-24-2015 |