Hu, MA
Andy Hu, Lexington, MA US
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20130023427 | METHODS FOR ASSESSING GENOMIC INSTABILITIES IN TUMORS - The invention generally relates to methods for assessing genomic instabilities in a tumor sample. The invention may further be used to predict grade, stage, and prognosis of cancer in a patient. The invention further relates to cataloging the efficacy of therapeutics on specific genomic instabilities and generating a personalized therapeutic regimen for a cancer patient based upon their genomic instabilities. | 01-24-2013 |
Bi-Huang Hu, Watertown, MA US
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20100087622 | Method of Synthesizing Acetonide-Protected Catechol-Containing Compounds and Intermediates Produced Therein - The inventors disclose here a novel, facile approach to the synthesis of acetonide-protected catechol-containing compounds having at least one amine group. In specific embodiments, the invention provides novel methods of synthesizing 3,4-dihydroxyphenylalanine (H-DOPA(acetonide)-OH (6)), Fmoc-protected H-DOPA(acetonide)-OH (Fmoc-DOPA(acetonide)-OH (7)), Fmoc-protected dopamine (Fmoc-dopamine(acetonide) (10)), TFA-protected dopamine (TFA-dopamine(acetonide) (13)) and acetonide-protected 4-(2-aminoethyl)benzene-1,2-diol (acetonide-protected dopamine (14)). | 04-08-2010 |
Carl Hu, Arlington, MA US
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20100180146 | Dynamic Membership Management in a Distributed System - Transactional database replication techniques are disclosed that do not require altering of the database management system implementation. A replicator module includes a dynamic membership manager, which is configured to manage the persistent membership of a coordination group. The persistent membership can be, for example, a durable set of sites that can replicate changes amongst themselves. Changes from sites not in the persistent membership are discarded. The set of recovered members is a subset of the persistent membership. The persistent membership changes incrementally by either removing or adding members. Failed members may still be part of the persistent membership. The dynamic membership manager module manages the modification of the persistent membership, initialization of replicas, and propagation of membership information. | 07-15-2010 |
Chaolin Hu, North Billerica, MA US
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20110005922 | Methods and Apparatus for Protecting Plasma Chamber Surfaces - A method for creating a protective layer over a surface of an object comprising aluminum and magnesium for use in a semiconductor processing system, which includes oxidizing the surface of the object using a plasma electrolytic oxidation process. The method also includes generating a halogen-comprising plasma by exciting a gas comprising a halogen. The method also includes exposing the oxidized surface to the halogen-comprising plasma or excited gas. | 01-13-2011 |
20130118589 | Toroidal Plasma Channel with Varying Cross-Section Areas Along the Channel - An assembly for adjusting gas flow patterns and gas-plasma interactions including a toroidal plasma chamber. The toroidal plasma chamber has an injection member, an output member, a first side member and a second side member that are all connected. The first side member has a first inner cross-sectional area in at least a portion of the first side member and a second inner cross-sectional area in at least another portion of the first side member, where the first inner cross-sectional area and the second inner-cross-sectional area being different. The second side member has a third inner cross-sectional area in at least a portion of the second side member and a fourth inner cross-sectional area in at least another portion of the second side member, where the third inner cross-sectional area and the fourth inner-cross-sectional area being different. | 05-16-2013 |
Cheng Hu, Belmont, MA US
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20110253634 | TREATMENT OF WASTEWATER - The present invention provides systems, methods and devices for removing contaminants from an aqueous stream. In embodiments, these systems and methods may be applied to particular applications, for example removal of contaminants in aqueous streams associated with the petroleum industry. | 10-20-2011 |
Chunwei Jerry Hu, Canton, MA US
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20100029420 | Football and Method for Manufacturing Same - A football includes an inflatable bladder; a layer of wound filament fibers surrounding the inflatable bladder; a carcass surrounding the layer of wound filament fibers, including raised areas and recessed areas and a plurality of panels positioned within the recessed areas of the carcass. An outer surface of the plurality of panels is flush with an outer surface of the raised areas of the carcass, which includes the appearance of at least one of stitching, seams and a pebbled outer surface. A method of manufacturing a football includes providing an inflatable bladder, winding filament fibers around the bladder and molding a carcass around the fibers. The carcass is molded to include recessed areas, raised areas and the appearance of at least one of seams, stitching and a pebbled surface on the raised areas. Panels are then laminated to the recessed areas of the carcass. | 02-04-2010 |
Chun-Yi Hu, Lexington, MA US
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20080255809 | Locally Updating a Three-Dimensional Model - Updating a three-dimensional model includes generating a three-dimensional model comprised of components, modifying one of the components, determining other components having a possible changing effect on the three-dimensional model as a result of modifying the one component, and constructing a modified version of the three-dimensional model by regenerating the modified component and the other components having the possible changing effect while not regenerating remaining ones of the components not having the possible changing effect. The modified version achieves the same result as revising the three-dimensional model by regenerating each one of components. | 10-16-2008 |
Evelyn Hu, Cambridge, MA US
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20150158911 | PIGMENT STRUCTURES, PIGMENT GRANULES, PIGMENT PROTEINS, AND USES THEREOF - The present invention is based, at least in part, on the isolation of intact pigment granules from the brown chromatophores in the skin of the cuttlefish, | 06-11-2015 |
Evelyn L. Hu, Cambridge, MA US
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20100090240 | PHOTOELECTROCHEMICAL ETCHING FOR CHIP SHAPING OF LIGHT EMITTING DIODES - A photoelectrochemical (PEC) etch is performed for chip shaping of a device comprised of a III-V semiconductor material, in order to extract light emitted into guided modes trapped in the III-V semiconductor material. The chip shaping involves varying an angle of incident light during the PEC etch to control an angle of the resulting sidewalls of the III-V semiconductor material. The sidewalls may be sloped as well as vertical, in order to scatter the guided modes out of the III-V semiconductor material rather than reflecting the guided modes back into the III-V semiconductor material. In addition to shaping the chip in order to extract light emitted into guided modes, the chip may be shaped to act as a lens, to focus its output light, or to direct its output light in a particular way. | 04-15-2010 |
20100195684 | PHOTOELECTROCHEMICAL ETCHING FOR LASER FACETS - A method for fabricating a semiconductor laser device, by etching facets using a photoelectrochemical (PEC) etch, so that the facets are sufficiently smooth to support optical modes within a cavity bounded by the facets. | 08-05-2010 |
20120018758 | OPTOELECTRONIC DEVICES WITH EMBEDDED VOID STRUCTURES - An optoelectronic structure, and method of fabricating same, comprised of semiconductors having growth-embedded void-gap gratings or photonic crystals in one or two dimensions, which are optimized to yield high interaction of the guided light and the photonic crystals and planar epitaxial growth. Such structure can be applied to increase light extraction efficiency in LEDs, increase modal confinement in lasers or increase light absorption in solar cells. The optimal dimensions of the growth-embedded void-gap gratings or photonic crystals are calculated by numerical simulation using scattering matrix formalism. The growth-embedded void-gap gratings are applicable to any semiconductor device, as well as optoelectronic devices, such as light-emitting diodes, laser diodes and solar cells. | 01-26-2012 |
20130099277 | SELECTIVE DRY ETCHING OF N-FACE (Al,In,Ga)N HETEROSTRUCTURES - A method of selective dry etching of N-face (Al,In,Ga)N heterostructures through the incorporation of an etch-stop layer into the structure, and a controlled, highly selective, etch process. Specifically, the method includes: (1) the incorporation of an easily formed, compatible etch-stop layer in the growth of the device structure, (2) the use of a laser-lift off or similar process to decouple the active layer from the original growth substrate, and (3) the achievement of etch selectivity higher than 14:1 on N-face (Al,In,Ga)N. | 04-25-2013 |
20140252396 | HIGHLY EFFICIENT GALLIUM NITRIDE BASED LIGHT EMITTING DIODES VIA SURFACE ROUGHENING - A gallium nitride (GaN) based light emitting diode (LED), wherein light is extracted through a nitrogen face (N-face) of the LED and a surface of the N-face is roughened into one or more hexagonal shaped cones. The roughened surface reduces light reflections occurring repeatedly inside the LED, and thus extracts more light out of the LED. The surface of the N-face is roughened by an anisotropic etching, which may comprise a dry etching or a photo-enhanced chemical (PEC) etching. | 09-11-2014 |
Evelyn Lynn Hu, Cambridge, MA US
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20120018853 | PHOTOELECTROCHEMICAL ETCHING OF P-TYPE SEMICONDUCTOR HETEROSTRUCTURES - A method for photoelectrochemical (PEC) etching of a p-type semiconductor layer simply and efficiently, by providing a driving force for holes to move towards a surface of a p-type cap layer to be etched, wherein the p-type cap layer is on a heterostructure and the heterostructure provides the driving force from an internal bias generated internally in the heterostructure; generating electron-hole pairs in a separate area of the heterostructure than the surface to be etched; and using an etchant solution to etch the surface of the p-type layer. | 01-26-2012 |
Guofu Hu, Wellesley, MA US
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20110262459 | Neamine Compositions and Methods of Use Thereof - Provided herein are compositions containing neamine, or a composition containing an agent that possesses one or more activities of neamine, and the research, diagnostic and therapeutic uses of such compounds, such as for the treatment of cancer. | 10-27-2011 |
20140105903 | Modulators of Plexin B2 Activity - Disclosed herein are novel compositions and methods for the inhibition of Plexin B2-mediated Angiogenin activity. Such compositions and methods are useful, for example, for the treatment of cancer, the treatment of wet AMD and the inhibition of angiogenesis. Also disclosed herein are methods of determining whether a test agent is a modulator of Plexin B2 activity. | 04-17-2014 |
Guo-Fu Hu, Wellesley, MA US
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20110078804 | Angiogenin and Amyotrophic Lateral Sclerosis - Methods and compositions for treating neurodegenerative disorders are provided. Transgenic animal models of neurodegenerative disorders are provided. Knockout animal models of neurodegenerative disorders are also provided. Mutant angiogenin polypeptides are also provided. | 03-31-2011 |
20130136727 | Angiogenin and Variants Thereof for Treatment of Neurodegenerative Diseases - Methods and compositions for treating neurodegenerative disorders using angiogenin and/or angiogenin variants are provided. | 05-30-2013 |
Haijun Hu, Wellesley, MA US
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20150098617 | Method and Apparatus for Establishing a North Reference for Inertial Measurement Units using Scene Correlation - A scene correlation-based target system and related methods are provided. A reference image depicts a remotely-positioned object having identifiable characteristics, wherein a reference directional vector is established relative to the reference image. A target image of a general vicinity of the remotely-positioned object has an unknown directional vector, the target image having at least a portion of the identifiable characteristics. An inertial measuring unit has a scene correlation system, wherein the scene correlation system matches the portion of the identifiable characteristics of the target image with the identifiable characteristics of the reference image, wherein a slew angle between the reference image and the target image is calculated. A target image directional vector is derived from the calculated slew angle and the reference directional vector. | 04-09-2015 |
Henry Hu, Andover, MA US
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20120172740 | Oxygen Mask - An anatomical shaped oxygen face mask with ports allows medical procedures to take place while the mask remains affixed to patient's face covering both mouth and nose. The mask is specially designed to allow the patient to ventilate spontaneously while at the same time instrument to access is provided by means of ports located at the front of the mask. One port may be used for procedures while an other port can be used for suctioning of secretion and blood. | 07-05-2012 |
Hui Hu, Woburn, MA US
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20110177619 | IN VITRO DIAGNOSTIC MARKERS COMPRISING CARBON NANOPARTICLES AND KITS - This invention relates to luminescent markers for in vitro diagnostic applications, and kits using those markers. In some embodiments, those markers comprise luminescent carbon nanoparticles. Some embodiments provide a method for investigating an analyte comprising correlating a marker to the analyte and observing the luminescence from the marker, wherein the marker comprises a nanoparticle having a carbon core. In vitro kits, including those employing a marker comprising a nanoparticle having a carbon core, are also provided. | 07-21-2011 |
Jianjuen Hu, Boxborough, MA US
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20090123896 | METHOD AND APPARATUS FOR HAPTIC SIMULATION - A haptic simulation method determines a location of a needle assembly within a magneto-rheological fluid. The needle assembly within the magneto-rheological fluid is associated with a desired resistance value. A viscosity control signal representative of the desired resistance value is generated. The viscosity control signal is applied to a viscosity control device to vary a viscosity of the magneto-rheological fluid to achieve the desired resistance value. | 05-14-2009 |
20140100491 | Lower Extremity Robotic Rehabilitation System - To achieve “ecological” robotic rehabilitation therapy, the present invention provides the system capacity of training of patients in different ambulatory tasks utilizing motorized footplates that guide the lower limbs according to human gait trajectories generated for different ambulatory tasks of interest. A lower extremity robotic rehabilitation system comprises an active pelvic/hip device which applies series elastic actuation to achieve an intrinsically safe and desirable impedance control. A robotic unit features the telepresence operation control that allows a patient stay at home or nursing home to continue his or her rehabilitation training under a physician's remote supervision and monitoring. The robot unit utilizes an affective patient-robot interface to capture emotional information of the patient, to allow for real-time adaptation of the robotic system and adjustments of treatment protocol, and to enhance the quality and effectiveness of rehabilitation | 04-10-2014 |
20150182403 | A Mobile Robotic Lifting and Transferring System for Bariatric Patients - Obesity has grown into one of the world's most significant health problems. The field of bariatrics and the quantity of bariatric surgical procedures is projected to continue to increase rapidly each year. This trend presents a challenge to healthcare providers and facilities striving to provide dignified care that is effective and safe both for the patient and the provider. There is a great demand for new approaches to bariatric patient care. The present invention is a robotic patient lifting system, targeted for, but not limited to, bariatric patient care. Without the need for difficult, time consuming slings and hoists associated with currently available systems, the invented lifting and transferring system utilizes rapidly deployable, articulated robotic arms with gentle conveyor belts. A unique linkage system allows powerful, safe, and flexible lifting and positioning of the patient with a minimal number of actuators. The lifting mechanism is mounted on a low profile, stable and flexible footprint, omnidirectional robotic mobile base. A simple, intuitive user interface allows control by a single caregiver with minimal training | 07-02-2015 |
Jianping Hu, Arlington, MA US
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20090140824 | Baluns, a fine balance and impedance adjustment module, a multi-layer transmission line, and transmission line NMR probes using same - A pseudo-Marchand balun, compound balun and tunable multi-resonant coaxial balun, and NMR probes employing each such balun, and a fine balance and impedance adjustment module and a multi-layer transmission line for use in such NMR probes. | 06-04-2009 |
20110285397 | Baluns, a fine balance and impedance adjustment module, a multi-layer transmission line, and transmission line NMR probes using same - A pseudo-Marchand balun, compound balun and tunable multi-resonant coaxial balun, and NMR probes employing each such balun, and a fine balance and impedance adjustment module and a multi-layer transmission line for use in such NMR probes. | 11-24-2011 |
Jingshi Hu, Revere, MA US
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20090315551 | Linear magnetoresistance sensor - A linear (or substantially linear) magnetoresistance sensor is provided. The magnetoresistance sensor may use one of the following magnetotransport mechanisms: classical magnetoresistance (MR) or quantum MR effects. In the classical regime, the sensor may be composed of a polycrystalline narrow gap semiconductor that has a varying mobility (instead of a constant mobility). The material's varying mobility enables the magnetoresistive sensor to have: (1) a linear magnetoresistance; (2) a high temperature response; and (3) an ability to respond to the highest possible fields. In the quantum regime, the sensor may be composed of a single crystal narrow gap semiconductor that is sufficiently doped so that the material may exhibit a linear response in a temperature range of 50K-175 K. | 12-24-2009 |
John Hu, Boxborough, MA US
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20120283746 | Mobile Medical Robotic System - A medical robotic system comprises a drive track unit being operable for moving the medical robotic system along a floor. An upper torso unit is joined to the drive track unit. The upper torso unit comprises at least one actuator assembly. At least one bimanual dexterous manipulator is joined to the actuator assembly in which the actuator assembly imparts torque and movement to the bimanual dexterous manipulator for lifting an object. The bimanual dexterous manipulator comprises a pair of dexterous manipulators. Each of the dexterous manipulators comprises a length being configured to support lifting an adult patient, and an end comprising a planar structure being configured for placing between the adult patient and a patient platform. The drive track unit is operable for moving the medical robotic system to the patient platform and the bimanual dexterous manipulator is operable for lifting the adult patient from the patient platform. | 11-08-2012 |
20120283872 | System for Stabilization Control of Mobile Robotics - A system comprises a platform being configured for locomotion in a plurality of directions over a surface. A robotic unit is configured for dexterous manipulation comprising at least lifting of objects. The robotic unit is joined to the platform. At least one extender unit is joined to the platform and is configured for controlled extension beyond the platform to contact the surface to stabilize the system at least during the manipulation by the robotic unit. At least one controlling unit is configured to be operable for at least determining a center of gravity and a zero moment point for the system and for at least controlling an extension of the extender unit. | 11-08-2012 |
20140150806 | Robotic First Responder System and Method - A robotic first responder system provides injured patients with first response medical care and extracts the injured patient from a dangerous or remote area. After assessing of the level of consciousness of an injured patient, the robotic unit utilizes an inflatable immobilization device for safe robotic rescue of injured patients. The robotic unit lifts and transfers an injured patient to an extraction vehicle, a secure, bullet-proof wheeled system that can be pulled by the robot to safe location. The extraction vehicle continues serving as the evacuation stretcher to a medical station. The robotic unit utilizes zero moment point control to maintain stability while lifting the patient. A robot first responder tows the extraction vehicle or the extraction vehicle self-navigates incorporating with power drive and autonomous navigation systems. | 06-05-2014 |
Johnny Hao Hu, Cambridge, MA US
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20150071900 | SWITCHABLE GRNAS COMPRISING APTAMERS - Some aspects of this disclosure provide compositions, methods, systems, and kits for controlling the activity and/or improving the specificity of RNA-programmable endonucleases, such as Cas9. For example, provided are guide RNAs (gRNAs) that are engineered to exist in an “on” or “off” state, which control the binding and hence cleavage activity of RNA-programmable endonucleases. | 03-12-2015 |
20150071901 | mRNA-Sensing Switchable gRNAs - Some aspects of this disclosure provide compositions, methods, systems, and kits for controlling the activity and/or improving the specificity of RNA-programmable endonucleases, such as Cas9. For example, provided are guide RNAs (gRNAs) that are engineered to exist in an “on” or “off” state, which control the binding and hence cleavage activity of RNA-programmable endonucleases. Some aspects of this disclosure provide mRNA-sensing gRNAs that modulate the activity of RNA-programmable endonucleases based on the presence or absence of a target mRNA. | 03-12-2015 |
20150071902 | Extended DNA-Sensing GRNAS - Some aspects of this disclosure provide compositions, methods, systems, and kits for controlling the activity and/or improving the specificity of RNA-programmable endonucleases, such as Cas9. For example, provided are guide RNAs (gRNAs) that are engineered to exist in an “on” or “off” state, which control the binding and hence cleavage activity of RNA-programmable endonucleases. Some aspects of this disclosure provide gRNAs that modulate the activity of an RNA-programmable endonuclease based on the presence or absence of an extended DNA (xDNA). | 03-12-2015 |
Joseph W. Hu, Lexington, MA US
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20130166630 | Method and System for Data Exchange and Exception Handling in a Data Processing Environment - System, method, computer program product embodiments and combinations and sub-combinations thereof for data exchange and exception handling in a data processing environment are described. Aspects include providing a generic data structure to store a value object and a collection of value Objects based upon built-in programming capabilities of a client system and a server system that achieve a rich Internet application experience within a data processing network, and utilizing the generic data structure to exchange data between the client system and the server system of the data processing network. A specialized result form of the generic data structure is also provided and utilized to manage generated exceptions of the data exchanges. | 06-27-2013 |
20150134678 | Multi-Pass, Parallel Merge for Partitioned Intermediate Pages - Multi-pass parallel merging in a database includes identifying characteristics of non-final pages during database query operations. A phase of page consolidation is triggered based on the identified characteristics and a final page is stored. | 05-14-2015 |
Joseph Weizhen Hu, Lexington, MA US
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20110289119 | METHODS AND SYSTEMS FOR MONITORING SERVER CLOUD TOPOLOGY AND RESOURCES - Systems, methods and articles of manufacture for monitoring server cloud topology and resources are described herein. An embodiment includes determining a topological relationship of the computing nodes in the server cloud and constructing a data structure representing the topological relationship. The constructed data structure includes a plurality of node managed objects (MOs), where each node managed object corresponds to a computing node in the server cloud. The constructed data structure also includes a plurality of link managed objects, where each link managed object corresponds to inter-node communications between two or more computing nodes represented by the node managed objects. The node managed objects and the link managed objects publish events corresponding to changes affecting computing nodes in the server cloud. Embodiments of the invention generate and display a topology view based on the topological relationship and update the displayed topology view (or portions thereof) based on the published events. | 11-24-2011 |
20110296376 | Dynamically Injecting Behaviors Into Flex View Components - Systems, methods and articles of manufacture for dynamically injecting behaviors into view components are described herein. In an embodiment, a view component resides in an MXML file, while its behavior code (e.g., ACTIONSCRIPT) is stored in a separate file (e.g., .as file). In this way, the view component can be reused in separate applications where different behaviors may be applied to the same view component. In addition, because the behavior code is stored in a separate file, the behavior code is easier to read and maintain. Furthermore, behaviors can be dynamically (i.e., at runtime) injected into and un-injected from the view component. Embodiments of the invention also allow multiple behaviors to be injected into the same view component. | 12-01-2011 |
20130173686 | Monitoring Distributed Task Execution Using a Chained Text Messaging System - Embodiments of a system, method, and computer program product for monitoring task processing in a distributed system are provided. A task controller is provided with a task. The task controller generates a plurality of subtasks from the provided task, where each subtask includes a callback function. The subtasks are distributed for execution to multiple computing devices in the distributed system. As each subtask is executed by a computing device, the callback function is invoked, the invocation generating a message. The message includes the process and status information of the executing subtasks. The process and status information included in the message for each subtask is monitored, analyzed and aggregated, and is transmitted for a display on a client device. | 07-04-2013 |
Juejun Hu, Cambridge, MA US
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20100187419 | THERMO-OPTIC INFRARED PIXEL AND FOCAL PLANE ARRAY - A surface plasmon polariton (SPP) pixel structure is provided. The SPP pixel structure includes a coupling structure that couples the probing light into the SPP mode by matching the in-plane wave vector by changing the refractive index of the coupling structure using thermo-optic effects to vary the coupling strength of the probing light into the SPP mode. An absorber layer is positioned on the coupling structure for absorbing incident infrared/thermal radiation being detected. | 07-29-2010 |
20100187530 | PHOTOCONDUCTORS FOR MID-/FAR-IR DETECTION - An infrared photodiode structure is provided. The infrared photodiode structure includes a doped semiconductor layer having ions of certain conductivity. An active photodetecting region is positioned on the doped semiconductor layer for detecting an infrared light signal. The active photodetecting region includes one or more amorphous semiconductor materials so as to allow for high signal-to-noise ratio being achieved by invoking carrier hopping and band conduction, under dark and illuminated conditions. | 07-29-2010 |
20100238536 | INTEGRATED SILICON/SILICON-GERMANIUM MAGNETO-OPTIC ISOLATOR - A magneto-optical isolator device is provided. The isolator device includes a substrate and a bottom cladding layer that is formed on the substrate. An optical resonator structure is formed on the bottom cladding layer. The resonator structure includes crystalline or amorphous diamagnetic silicon or silicon-germanium so as to provide non-reciprocal optical isolation. A top cladding layer is formed on the resonator structure. One or more magnetic layers positioned on the top cladding layer or between the top cladding or bottom cladding layers and the optical resonator structure. | 09-23-2010 |
20110127547 | CAVITY-ENHANCED MULTISPECTRAL PHOTONIC DEVICES - A multispectral pixel structure is provided that includes a plurality of stacked cavity arrangements for emitting or detecting a plurality of specified wavelengths, wherein each stacked cavity arrangement having a photoactive layer for spectral emission or detection of one of the specified wavelengths. The photoactive layer is positioned within a resonant cavity stack and the resonant cavity stack being positioned between two adjacent mirror stacks. A plurality of coupling-matching layers are positioned between one or more of the stack mirror arrangements for controlling optical phase and coupling strength between emitted or incident light and resonant modes in each of the stacked cavity arrangements. | 06-02-2011 |
20130039618 | PATTERNED NON-RECIPROCAL OPTICAL RESONATOR - A patterned nonreciprocal optical resonator structure is provided that includes a resonator structure that receives an optical signal. A top cladding layer is deposited on a selective portion of the resonator structure. The top cladding layer is patterned so as to expose the core of the resonator structure defined by the selective portion. A magneto-optically active layer includes a magneto-optical medium being deposited on the exposed core of the resonator structure so as to generate optical non-reciprocity. | 02-14-2013 |
Kan-Nian Hu, Brighton, MA US
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20140235703 | THIOPHENE COMPOUNDS - Polymorph Forms M, H, P, X, and ZA of Compound (1) represented by the following structural formula: | 08-21-2014 |
Kan-Nian Hu, Cambridge, MA US
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20090302842 | BIRADICAL POLARIZING AGENTS FOR DYNAMIC NUCLEAR POLARIZATION - The present invention provides methods for performing dynamic nuclear polarization using biradicals with a structure of formula (I) as described herein. In general, the methods involve (a) providing a frozen sample in a magnetic field, wherein the frozen sample includes a biradical of formula (I) and an analyte with at least one spin half nucleus; (b) polarizing the at least one spin half nucleus of the analyte by irradiating the frozen sample with radiation having a frequency that excites electron spin transitions in the biradical; (c) optionally melting the sample to produce a molten sample; and (d) detecting nuclear spin transitions in the at least one spin half nucleus of the analyte in the frozen or molten sample. The present invention also provides biradicals with a structure of formula (I) with the proviso that Q | 12-10-2009 |
20090311189 | TEMPERATURE-JUMP DYNAMIC NUCLEAR POLARIZATION - In one aspect, the present invention provides a method for enhancing the sensitivity of liquid-state NMR or MRI experiments. In general, the method involves providing a frozen sample in a magnetic field, wherein the frozen sample includes a polarizing agent with at least one unpaired electron and an analyte with at least one spin half nucleus; polarizing the at least one spin half nucleus of the analyte by irradiating the frozen sample with radiation having a frequency that excites electron spin transitions in the at least one unpaired electron of the polarizing agent; melting the frozen sample to produce a molten sample; and (d) detecting nuclear spin transitions in the at least one spin half nucleus of the analyte in the molten sample. In certain embodiments, the methods further comprise a step of freezing a sample in a magnetic field to provide the frozen sample in a magnetic field. | 12-17-2009 |
Kenneth Hu, Littleton, MA US
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20120290263 | Evaluating And Predicting Computer System Performance Using Kneepoint Analysis - The present invention provides methods, systems, apparatus, and computer software/program code products adapted for operating in, or in conjunction with, an otherwise conventional computing system, and which enable evaluating, monitoring and predicting the performance of computer systems and individual elements or groups of elements within such computer systems. | 11-15-2012 |
20140350889 | EVALUATING AND PREDICTING COMPUTER SYSTEM PERFORMANCE USING KNEEPOINT ANALYSIS - The present invention provides methods, systems, apparatus, and computer software/program code products adapted for operating in, or in conjunction with, an otherwise conventional computing system, and which enable evaluating, monitoring and predicting the performance of computer systems and individual elements or groups of elements within such computer systems. | 11-27-2014 |
Lejun Hu, Somerville, MA US
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20130070805 | ON-CHIP TEMPERATURE SENSOR USING INTERCONNECT METAL - An accurate, cost-efficient temperature sensor may be integrated into an integrated circuit (IC) using common materials as the IC's interconnect metallization. The temperature sensor may include an impedance element having a length of metal made of the interconnect metal, a current source connected between a first set of contacts at opposite ends of the impedance element, and an analog-to-digital converter connected between a second set of contacts at opposite ends of the impedance element. The temperature sensor may exploits the proportional relationship between the metal's resistance and temperature to measure ambient temperature. Alternatively, such a temperature sensor may be used on disposable chemical sensors where the impedance element is made of a common metal as conductors that connect a sensor reactant to sensor contacts. In either case, because the impedance element is formed of a common metal as other interconnect, it is expected to incur low manufacturing costs. | 03-21-2013 |
20130119502 | ELECTRICAL OVERSTRESS PROTECTION USING THROUGH-SILICON-VIA (TSV) - A semiconductor device formed on a substrate includes a first diode junction formation, a second diode junction formation, and at least one through-silicon-via (TSV), in which a cathode and an anode of the first diode are cross-connected to an anode and cathode of the second diode through the at least one TSV for achieving electrical robustness in through-silicon-via based integrated circuits, including photosensitive devices and circuits for signal processing applications. | 05-16-2013 |
20130175669 | ELECTRICAL OVERSTRESS PROTECTION USING THROUGH-SILICON-VIA (TSV) - A semiconductor device formed on a substrate includes a first diode junction formation, a second diode junction formation, and at least one through-silicon-via (TSV), in which a cathode and an anode of the first diode are cross-connected to an anode and cathode of the second diode through the at least one TSV for achieving electrical robustness in through-silicon-via based integrated circuits, including photosensitive devices and circuits for signal processing applications. | 07-11-2013 |
Lieyu Hu, Lexington, MA US
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20120305445 | Accessory for Portable Electronic Devices That Enhances the Grip and Comfort of the User - An apparatus and method of using the apparatus is presented. The apparatus includes a base protective housing includes a back portion and side panels. The base protective housing is operable for joining to a portable electronic device where the back portion at least covers a back of the portable electronic device. A finger pocket includes a cavity. The finger pocket is joined to the back portion and is operable for receiving a plurality of fingers into the cavity to grasp the back portion. The method includes joining a base protective housing comprising a back portion and side panels to a portable electronic device where the back portion at least covers a back of the portable electronic device. The method further includes inserting one or more fingers into a finger pocket joined to the back portion to grasp the back portion and the portable electronic device. | 12-06-2012 |
Linden Hu, Sharon, MA US
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20140127176 | ORAL BACTERIA AND USES THEREOF - The present invention relates to compositions and methods for preventing and treating periodontitis and other conditions. In particular, the present invention relates to oral bacteria for use in treating and preventing diseases and conditions. | 05-08-2014 |
Lin-Wen Hu, Lexington, MA US
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20100206527 | In-Situ Treatment of Metallic Surfaces - A method for in-situ treatment of a metallic surface utilizing a nanoparticle dispersion to increase at least one of (i) the critical heat flux. (ii) the boiling heat transfer rate, or (iii) the corrosion resistance of the metallic surface when in operation without a nanofluid heat transfer liquid, comprising: (1) cleaning the metallic surface: (2) conditioning the metallic surface to enhance nanoparticle binding to the metallic surface by applying a polymeric binding agent; (3) forming at least one thin film layer of nanoparticles on the metallic surface by contacting the nanoparticle dispersion with the metallic surface at a temperature and pressure sufficient to boil the nanoparticle dispersion; and, optionally (4) curing the nanoparticle layer by heating the metallic surface to a temperature higher than the temperature sufficient to boil the nanoparticle dispersion. | 08-19-2010 |
20100224638 | Nanoparticle Thin-Film Coatings for Enhancement of Boiling Heat Transfer - A superhydrophilic thin film is formed on a metal surface of a boiler vessel to alter the wettability and roughness of the surface, which, in turn, changes the boiling behavior at the surface. The superhydrophilic film is formed by depositing a layer of a first ionic species on the surface from a solution. A second ionic species having a charge opposite to the that of the first ionic species is then deposited from solution onto the surface to produce a bilayer of the first ionic species and the oppositely charged second ionic species. The depositions are then repeated to form a plurality of bilayers, on top of the preceding bilayer. The bilayers are then heated, leaving the second ionic species on the metal surface to form a superhydrophilic film. | 09-09-2010 |
Peng Hu, Boston, MA US
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20100060277 | METHODS AND APPARATUS FOR NON-CONTRAST ENHANCED PULMONARY MAGNETIC RESONANCE IMAGING - In one aspect, a method of inducing nuclear magnetic resonance (NMR) signals from a region of an object having at least a portion of at least one pulmonary vein using at least one coil adapted to emit electromagnetic signals to induce an NMR effect is provided. The method comprises operating the at least one coil to provide at least one imaging sequence at an effective off-resonance frequency adapted to cause NMR signals to be emitted from the at least one pulmonary vein, and detecting at least some of the NMR signals to obtain NMR data corresponding to the at least one pulmonary vein. | 03-11-2010 |
Peng Hu, Brookline, MA US
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20110028829 | SYSTEM AND METHOD FOR NON-CONTRAST ENHANCED PULMONARY VEIN MAGNETIC RESONANCE IMAGING - A system and method for non-contrast enhanced pulmonary vein magnetic resonance imaging substantially suppresses the signal from cardiac tissue adjacent to the left atrium and pulmonary vein is provided. Significant conspicuity of the left atrium and pulmonary vein versus adjacent anatomical structures is produced. In this manner, more accurate measurements of pulmonary vein ostia size are facilitated, as well as more accurate registration of imaging volumes with a radiofrequency ablation catheter during pulmonary vein isolation procedures. In addition, more robust three-dimensional volume views of the left atrium and pulmonary vein are produced without the administration of contrast agents. | 02-03-2011 |
20110175609 | Method for Motion Correction in Magnetic Resonance Imaging Using Radio Frequency Coil Arrays - A method for motion correction using coil arrays, termed “MOCCA,” is provided, in which coil-dependent motion-related signal variations are employed to determine information related to motion in two and three directions. With such a method, navigator echoes are not required, nor is the acquisition of additional data required to resolve complex motions in more than one direction. The motion estimation and compensation method provided by MOCCA is also applicable to applications of cardiac, respiratory, and other physiological self-gating techniques. | 07-21-2011 |
20130187652 | Method for Motion Correction in Magnetic Resonance Imaging Using Radio Frequency Coil Arrays - A method for motion correction using coil arrays, termed “MOCCA,” is provided, in which coil-dependent motion-related signal variations are employed to determine information related to motion in two and three directions. With such a method, navigator echoes are not required, nor is the acquisition of additional data required to resolve complex motions in more than one direction. The motion estimation and compensation method provided by MOCCA is also applicable to applications of cardiac, respiratory, and other physiological self-gating techniques. | 07-25-2013 |
Qian Hu, Lexington, MA US
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20100076996 | SYSTEM AND METHOD FOR AUDIO HOT SPOTTING - Audio hot spotting is accomplished by specifying query criterion to include a non-lexical audio cue. The non-lexical audio cue can be, e.g., speech rate, laughter, applause, vocal effort, speaker change or any combination thereof. The query criterion is retrieved from an audio portion of a file. A segment of the file containing the query criterion can be provided to a user. The duration of the provided segment can be specified by the user along with the files to be searched. A list of detections of the query criterion within the file can also be provided to the user. Searches can be refined by the query criterion additionally including a lexical audio-cue. A keyword index of topic terms contained in the file can also be provided to the user. | 03-25-2010 |
20150178487 | METHODS AND SYSTEMS FOR BIOMETRIC-BASED USER AUTHENTICATION BY VOICE - Disclosed herein are system, method, and computer program product embodiments for authentication of users of electronic devices by voice biometrics. An embodiment operates by comparing a power spectrum and/or an amplitude spectrum within a frequency range of an audio signal to a criterion, and determining that the audio signal is one of a live audio signal or a playback audio signal based on the comparison. | 06-25-2015 |
Qichao Hu, Somerville, MA US
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20130236764 | RECHARGEABLE LITHIUM BATTERY FOR WIDE TEMPERATURE OPERATION - Presented herein is a rechargeable lithium battery that includes a cathode, a liquid electrolyte, a solid electrolyte, and an anode. The anode is at least partially coated or plated with the solid electrolyte. The cathode may be porous and infiltrated by the liquid electrolyte. The cathode may also include a binder having a solid graft copolymer electrolyte (GCE). In certain embodiments, the liquid electrolyte is a gel that includes a PIL and a GCE. The battery achieves a high energy density and operates safely over a wide range of temperatures. | 09-12-2013 |
Qing Hu, Wellesley, MA US
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20100002739 | LENS COUPLED QUANTUM CASCADE LASER - Terahertz quantum cascade (QC) devices are disclosed that can operate, e.g., in a range of about 1 THz to about 10 THz. In some embodiments, QC lasers are disclosed in which an optical element (e.g., a lens) is coupled to an output facet of the laser's active region to enhance coupling of the lasing radiation from the active region to an external environment. In other embodiments, terahertz amplifier and tunable terahertz QC lasers are disclosed. | 01-07-2010 |
20110101250 | FREQUENCY TUNABLE WIRE LASERS - The present invention provides frequency tunable solid-state radiation-generating devices, such as lasers and amplifiers, whose active medium has a size in at least one transverse dimension (e.g., its width) that is much smaller than the wavelength of radiation generated and/or amplified within the active medium. In such devices, a fraction of radiation travels as an evanescent propagating mode outside the active medium. It has been discovered that in such devices the radiation frequency can be tuned by the interaction of a tuning mechanism with the propagating evanescent mode. | 05-05-2011 |
20140008553 | Frequency Tunable Wire Lasers - The present invention provides frequency tunable solid-state radiation-generating devices, such as lasers and amplifiers, whose active medium has a size in at least one transverse dimension (e.g., its width) that is much smaller than the wavelength of radiation generated and/or amplified within the active medium. In such devices, a fraction of radiation travels as an evanescent propagating mode outside the active medium. It has been discovered that in such devices the radiation frequency can be tuned by the interaction of a tuning mechanism with the propagating evanescent mode. | 01-09-2014 |
Qi-Ying Hu, Cambridge, MA US
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20120071514 | BENZOXAZOLONE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS - The present invention provides a compound of formula I; | 03-22-2012 |
20140141034 | TYROSINE LIGATION PROCESS - A process is provided for preparing a conjugate of Formula (I-A) or (I) comprising a polypeptide containing n number of tyrosine units, where n is an integer greater than or equal to 1, dispersed within the amino acid chain | 05-22-2014 |
Shou-Ih Hu, Cambridge, MA US
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20130122004 | METHODS AND COMPOSITIONS USING FGF23 VARIANT POLYPEPTIDES - The present disclosure is directed to methods, kits and compositions for preventing or treating age-related conditions or metabolic disorders. The fusion polypeptides of the disclosure include FGF23 or an active fragment thereof. In one embodiment, the fusion polypeptide comprises (a) a polypeptide comprising fibroblast growth factor 23 (FGF23), or a functionally active variant or derivative thereof, wherein FGF23 has a mutation at one or more of the positions Q156, C206 and C244; and (b) either a modified Fc fragment having decreased affinity for Fc-gamma-receptor and/or increased serum half-life, or a polypeptide comprising at least one extracellular subdomain of a Klotho protein, or a functionally active variant or derivative thereof; and, optionally (c) a linker. The Klotho fusion proteins are useful in the treatment and prevention of a variety of age-related conditions and metabolic disorders. In another embodiment, the fusion polypeptide comprises a FGF (such as FGF23), or a functionally active variant or derivative thereof and a modified Fc fragment, or a functionally active variant or derivative thereof. In various embodiments of the fusion polypeptides, FGF23 has mutations which decrease aggregation and protease-mediated cleavage. | 05-16-2013 |
Shou-Lh Hu, Cambridge, MA US
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20110195077 | METHODS AND COMPOSITIONS USING FGF23 FUSION PPOLYPEPTIDES - The present disclosure is directed to methods, kits and compositions for preventing or treating age-related conditions or metabolic disorders. The fusion polypeptides of the disclosure include FGF23 or an active fragment thereof. In one embodiment, the fusion polypeptide comprises (a) a polypeptide comprising fibroblast growth factor 23 (FGF23), or a functionally active variant or derivative thereof, wherein FGF23 has a mutation at one or more of the positions Q156, C206 and C244; and (b) either a modified Fc fragment having decreased affinity for Fc-gamma-receptor and/or increased serum half-life, or a polypeptide comprising at least one extracellular subdomain of a Klotho protein, or a functionally active variant or derivative thereof; and, optionally (c) a linker. The Klotho fusion proteins are useful in the treatment and prevention of a variety of age-related conditions and metabolic disorders. In another embodiment, the fusion polypeptide comprises a FGF (such as FGF23), or a functionally active variant or derivative thereof; and a modified Fc fragment, or a functionally active variant or derivative thereof. In various embodiments of the fusion polypeptides, FGF23 has mutations which decrease aggregation and protease-mediated cleavage. | 08-11-2011 |
Tiancen Hu, Cambridge, MA US
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20140301946 | ANTIBODY DRUG CONJUGATES - The present invention relates to anti-FGFR2 and FGFR4 antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer. | 10-09-2014 |
20140308201 | ANTIBODY DRUG CONJUGATES - The present invention relates to anti-FGFR2 antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer. | 10-16-2014 |
20150218274 | ANTIBODY MOLECULES TO TIM-3 AND USES THEREOF - Antibody molecules that specifically bind to TIM-3 are disclosed. The anti-TIM-3 antibody molecules can be used to treat, prevent and/or diagnose immune, cancerous, or infectious conditions and/or disorders. | 08-06-2015 |
Weifang Hu, Shrewsbury, MA US
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20150051729 | RAMP STRUCTURES IN COMPOSITE PARTS - Methods for generating ramp structures in composite part models and corresponding systems and computer-readable mediums. A method includes receiving a model of a composite part, the model including a topological definition for the composite part that has a plurality of defined constant-thickness areas. The method includes determining ramp areas from the topological definition, and determining adjacency relationships between constant-thickness areas and ramp areas. The method includes determining ramp structure points, constant rails, and ramp rails for the model. The method includes creating a set of normal curves connecting corresponding ramp structure points of on-surface geometries and offset geometries of the model. The method includes producing offset geometries corresponding to each ramp rail and generating a ramp surface for each ramp area. The method includes storing the model including the generated ramp surfaces. | 02-19-2015 |
Weiguo Hu, Hadley, MA US
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20090149613 | Crystallizable Propylene Copolymers - A propylene copolymer is described comprising at least 70 mol % of units derived from propylene, up to 30 mol % of units derived from a combination of ethylene, at least one alpha-olefin having from 4 to 10 carbon atoms, such that the molar ratio of ethylene-derived units to said alpha-olefin-derived units in said combination is from about 1:9 to about 9:1, and from 0 to about 3 mol % of units derived from a copolymerizable diene. The copolymer has isotactically arranged propylene derived sequences, an overall heat of fusion as determined by differential scanning calorimetry (DSC) of less than 65 J/g, a second melting point as determined by DSC of less than 100° C., less than one 1,3 insertion error per 1000 carbon atoms and a weight average molecular weight as determined by gel permeation chromatography (GPC) of from about 100,000 to about 500,000. | 06-11-2009 |
Weiguo Hu, Quincy, MA US
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20100111949 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PROLIFERATIVE DISEASES - The invention features peptides containing domain 4 of the | 05-06-2010 |
20100291024 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PROLIFERATIVE AND PATHOGENIC DISEASES - The invention features peptide fragments containing domain 4 of the | 11-18-2010 |
20120269801 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PROLIFERATIVE AND PATHOGENIC DISEASES - The invention features proteins including an antibody, or functional derivatives thereof, that bind hCD59 and have the activity of domain 4 of the | 10-25-2012 |
Wen Hu, Boston, MA US
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20150225755 | Ergothioneine Production Through Metabolic Engineering - The present disclosure relates to the production of ergothioneine through either in vitro enzymatic transformations or fermentations using microbials created by metabolic engineering. Also disclosed are transformed cells useful in such methods and ergothioneine produced by such methods. Transformed cells of the disclosure are capable of converting histidine and cysteine or hercynine and cysteine into ergothioneine in greater efficiency than the untransformed wild-type cells. | 08-13-2015 |
Xiaohui Hu, Woburn, MA US
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20140234923 | FERMENTATION OF GLYCEROL TO ORGANIC ACIDS - The present invention is in the field of producing organic acids and other useful chemicals via biological fermentation using glycerol as a source of carbon. Novel microorganisms and fermentation processes are described that are capable of converting glycerol to useful organic acids in high yield and high purity. | 08-21-2014 |
Xiaolong Hu, Cambridge, MA US
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20130099358 | ELECTRONIC, OPTICAL AND/OR MECHANICAL APPARATUS AND SYSTEMS AND METHODS FOR FABRICATING SAME - Flexible electronic structure and methods for fabricating flexible electronic structures are provided. An example method includes applying a first layer to a substrate, creating a plurality of vias through the first layer to the substrate, and applying a second polymer layer to the first layer such that the second polymer forms anchors contacting at least a portion of the substrate. At least one electronic device layer is disposed on a portion of the second polymer layer. At least one trench is formed through the second polymer layer to expose at least a portion of the first layer. At least a portion of the first layer is removed by exposing the structure to a selective etchant to providing a flexible electronic structure that is in contact with the substrate. The electronic structure can be released from the substrate. | 04-25-2013 |
Yanping Hu, Westborough, MA US
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20110280827 | METHODS AND COMPOSITIONS FOR TREATING HEMATOLOGICAL MALIGNANCIES - The invention relates to methods and compositions for treating a subject afflicted with a hematological malignancy using a combination of a CXCR4 antagonist and an immunotherapeutic agent. | 11-17-2011 |
Yongbo Hu, Chestnut Hill, MA US
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20110172427 | PROCESS FOR PREPARING CERTAIN CINNAMIDE COMPOUNDS - This invention relates to a new synthesis, intermediates and precursors leading to a mixture of the compounds 11 and 12 as shown below. It also relates to the resolution of the stereoisomeric mixture to provide in substantial stereochemical purity compound 12. The synthesis of the invention involves preparation of compound 7 and compound 10 as shown below and their reaction to prepare a mixture of compound 11 and compound 12. | 07-14-2011 |
Yongbo Hu, Westborough, MA US
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20120029213 | INTERMEDIATES FOR THE PREPARATION OF ANALOGS OF HALICHONDRIN B - Intermediates and methods of their use in the synthesis of analogs of halichondrin B are provided. | 02-02-2012 |
Yongbo Hu, Winchester, MA US
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20120172345 | HETEROARYLS AND USES THEREOF - This invention provides compounds of formula IA-i-a or IB-i-a and subsets thereof: | 07-05-2012 |
20120178723 | HETEROARYLS AND USES THEREOF - This invention provides compounds of formula IA-a or IB-a and subsets thereof: | 07-12-2012 |
20130165464 | HETEROARYLS AND USES THEREOF - This invention provides compounds of formula IB: | 06-27-2013 |
20130165472 | HETEROARYLS AND USES THEREOF - This invention provides compounds of formula IA: | 06-27-2013 |
20130165483 | HETEROARYLS AND USES THEREOF - This invention provides compounds of formula IB: | 06-27-2013 |
20130267563 | HETEROARYLS AND USES THEREOF - This invention provides compounds of formula IA or IB: wherein HY, R | 10-10-2013 |
20150175563 | HETEROARYLS AND USES THEREOF - This invention provides compounds of formula IA-i-a or IB-i-a and subsets thereof: | 06-25-2015 |
20150175593 | HETEROARYLS AND USES THEREOF - This invention provides compounds of formula IA-a or IB-a and subsets thereof: | 06-25-2015 |
20150225422 | HETEROARYLS AND USES THEREOF - The present invention provides a compound of formula I: | 08-13-2015 |
Yongbo Hu, Malden, MA US
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20110054194 | Halichondrin B Analogs - The invention includes halichondrin B analogs having pharmaceutical activity; in some cases, crystalline forms thereof, and in some cases, halichondrin B analogs having a further utility as synthetic intermediates. | 03-03-2011 |
20140163244 | HALICHONDRIN B ANALOGS - The invention includes halichondrin B analogs having pharmaceutical activity; in some cases, crystalline forms thereof, and in some cases, halichondrin B analogs having a further utility as synthetic intermediate. | 06-12-2014 |
20150158881 | METHODS USEFUL IN THE SYNTHESIS OF HALICHONDRIN B ANALOGS - In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate). | 06-11-2015 |
Yonghan Hu, Burlington, MA US
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20100137298 | Biaryl Sulfonamides and Methods for Using Same - The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors. | 06-03-2010 |
Zhigen Hu, Newton Center, MA US
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20120178723 | HETEROARYLS AND USES THEREOF - This invention provides compounds of formula IA-a or IB-a and subsets thereof: | 07-12-2012 |
20130267563 | HETEROARYLS AND USES THEREOF - This invention provides compounds of formula IA or IB: wherein HY, R | 10-10-2013 |
20150175593 | HETEROARYLS AND USES THEREOF - This invention provides compounds of formula IA-a or IB-a and subsets thereof: | 06-25-2015 |