Patent application number | Description | Published |
20100222872 | Methods, Compositions and Devices for Treating Lesioned Sites Using Bioabsorbable Carriers - Methods and compositions for the sustained release of treatment agents to treat an occluded blood vessel and affected tissue and/or organs are disclosed. Porous or non-porous bioabsorbable glass, metal or ceramic bead, rod or fiber particles can be loaded with a treatment agent, and optionally an image-enhancing agent, and coated with a sustained-release coating for delivery to an occluded blood vessel and affected tissue and/or organs by a delivery device. Implantable medical devices manufactured with coatings including the particles or embedded within the medical device are additionally disclosed. | 09-02-2010 |
20110027188 | Methods, Compositions and Devices for Treating Lesioned Sites Using Bioabsorbable Carriers - An implantable medical device is disclosed having a plurality of smaller particles contained in a plurality of larger particles and configured to be released from the larger particles when the device is implanted in a patient. The smaller particles and the larger particles are made of bioabsorbable metal, glass or ceramic. A substance can be associated with the smaller particles. The larger particles can be embedded within at least a portion of the device. | 02-03-2011 |
20110143014 | COATINGS WITH TUNABLE MOLECULAR ARCHITECTURE FOR DRUG-COATED BALLOON - A drug delivery balloon is provided, the a balloon having an outer surface, and a tunable coating disposed on at least a length of the balloon surface. The tunable coating includes a first therapeutic agent and a first excipient, and can include a second therapeutic agent and a second excipient. The first and second therapeutic agents have different dissolution rates during balloon inflation and therefore provide a coating that is tunable. | 06-16-2011 |
20110144577 | HYDROPHILIC COATINGS WITH TUNABLE COMPOSITION FOR DRUG COATED BALLOON - A tunable coating formulation is described for a drug delivery balloon comprising a therapeutic agent, an excipient and a plasticizer. The tunable coating includes a first therapeutic agent and a first excipient, and can have a second therapeutic agent and a second excipient. The first and second therapeutic agents have different dissolution rates during balloon inflation and therefore provide a coating that is tunable. The plasticizer in the formulation has a weigh ratio of excipient to plasticizer below 1:0.1. | 06-16-2011 |
20110144582 | COATINGS WITH TUNABLE SOLUBILITY PROFILE FOR DRUG-COATED BALLOON - A drug delivery balloon is provided, the a balloon having an outer surface, and a tunable coating disposed on at least a length of the balloon surface. The tunable coating includes a first therapeutic agent and a first excipient, and a second therapeutic agent and a second excipient. The first and second therapeutic agents have different dissolution rates during balloon inflation and therefore provide a coating that is tunable. | 06-16-2011 |
20110190871 | Crush Recoverable Polymer Scaffolds - A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold has a pattern including an asymmetric closed cell connecting links connecting the closed cells. | 08-04-2011 |
20110190872 | Crush Recoverable Polymer Scaffolds Having a Low Crossing Profile - A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold also has a reduced crimped profile and a modification of the scaffold's ring structure at the crowns that contributes to the reduced crimped profile. | 08-04-2011 |
20110270225 | METHOD FOR INCREASED UPTAKE OF BENEFICIAL AGENT AND EJECTION FRACTION BY POSTCONDITIONING PROCEDURES - A method for improving tissue uptake of beneficial agent and ejection fraction. | 11-03-2011 |
20110319866 | METHODS AND DEVICE FOR SYNERGISTIC MITIGATION OF REPERFUSION INJURY AFTER AN ISCHEMIC EVENT - A method for synergistic mitigation of reperfusion injury after an ischemia event in a subject. | 12-29-2011 |
20120276152 | SYSTEMS AND METHODS OF USING ZINC-CHELATOR TO TREAT MYOCARDIAL INFARCTION - Methods and systems for treating an infarct by delivery of zinc chelator to modulate tissue. | 11-01-2012 |
20120310142 | Drug Delivery System And Method Of Treatment Of Vascular Diseases Using Photodynamic Therapy - This invention relates to photodynamic therapy (PDT) of vulnerable plaque using two pluralities of nanoparticles, one plurality comprising a PDT agent that is sensitive to blue-green light wherein the nanoparticles are capable of penetrating only into the fibrous cap of the vulnerable plaque and one plurality comprising a PDT agent that is sensitive to red light wherein the nanoparticles are capable of penetrating into the core of the vulnerable plaque. | 12-06-2012 |
20130103138 | SURFACE MODIFICATION OF MEDICAL DEVICES TO ENHANCE ENDOTHELIAL ADHESION AND COVERAGE - Acceleration of the endothelialization process on implantable medical devices having at least one blood-contacting surface is achieved by a microscale pattern of sub-sections of EC-inductive coatings or EC-conductive coatings and nano/macro textured surfaces. The EC-inductive coating and EC-conductive coating can be applied either on the entire surface of the blood-contacting surface or selective placed on the blood-contacting surface, for example, in particular patterns. In this regard, the EC-conductive and EC-inductive coatings can be selectively placed relative to the textured surface to achieve a desired pattern of texture surface to coatings. | 04-25-2013 |
20130158509 | SYSTEM, APPARATUS, AND METHOD FOR DENERVATING AN ARTERY - The present disclosed subject matter is directed to a less invasive surgical system, apparatus and method including a guidable catheter for providing electroporation therapy to a subject suffering from heart or kidney disease. The system includes an electrical generator and an apparatus for denervating an artery. The apparatus includes a catheter having a proximal end, a distal end, a first lumen with a first exit port, a second lumen having a second exit port. The apparatus also includes a first needle including a first electrode. The apparatus also includes a displacement mechanism engaged to the catheter near the proximal end such that the displacement mechanism controls the linear position and angular position of the catheter. | 06-20-2013 |
20130333193 | TEMPERATURE CONTROLLED CRIMPING - This disclosure describes a method for crimping a stent with a polymer coating onto a catheter for percutaneous transluminal coronary angioplasty or other intraluminal interventions. The method comprises crimping the stent onto a catheter when the polymer coating is at a target temperature other than ambient temperature. The polymer coating can optionally comprise drug(s). | 12-19-2013 |
20140018903 | POLYMER SCAFFOLDS FOR PERIPHERAL VESSELS - A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold has a structure that produces a low late lumen loss when implanted within a peripheral vessel and also exhibits a high axial fatigue life. In a preferred embodiment the scaffold forms ring structures interconnected by links, where a ring has 12 crowns and at most two links connecting adjacent rings. | 01-16-2014 |
20140025005 | COATINGS WITH TUNABLE SOLUBILITY PROFILE FOR DRUG-COATED BALLOON - A drug delivery balloon is provided, the a balloon having an outer surface, and a tunable coating disposed on at least a length of the balloon surface. The tunable coating includes a first therapeutic agent and a first excipient, and a second therapeutic agent and a second excipient. The first and second therapeutic agents have different dissolution rates during balloon inflation and therefore provide a coating that is tunable. | 01-23-2014 |
20140031921 | CRUSH RECOVERABLE POLYMER SCAFFOLDS - A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold has a pattern including an asymmetric closed cell connecting links connecting the closed cells. | 01-30-2014 |
20140039604 | CRUSH RECOVERABLE POLYMER SCAFFOLDS - A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold has a pattern including an asymmetric closed cell connecting links connecting the closed cells. | 02-06-2014 |
20140058499 | Crush Recoverable Polymer Scaffolds - A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold has a pattern including an asymmetric closed cell connecting links connecting the closed cells. | 02-27-2014 |
20140067044 | Crush Recoverable Polymer Scaffolds - A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold has a pattern including an asymmetric closed cell connecting links connecting the closed cells. | 03-06-2014 |
20140075735 | Crush Recoverable Polymer Scaffolds - A method of crimping a stent is disclosed. The stent includes a minimum crimped diameter such that in the minimum crimped diameter, a pair of stent rings, between which marker support structures reside, do not make contact with the marker support structures. The crimped profile of the stent of the present invention can be as small as the crimped profile of a same stent but without the maker support structures. | 03-20-2014 |
20140090231 | Crush Recoverable Polymer Scaffolds - A method of manufacturing a stent is disclosed. The stent includes a minimum crimped diameter such that in the minimum crimped diameter, a pair of stent rings, between which marker support structures reside, do not make contact with the marker support structures. The crimped profile of the stent of the present invention can be as small as the crimped profile of a same stent but without the marker support structures. | 04-03-2014 |
20140114398 | TIME-DEPENDENT POLYMER SCAFFOLDS - A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold has a structure that produces a low late lumen loss when implanted within a peripheral vessel and also exhibits a high axial fatigue life. In a preferred embodiment the scaffold forms ring structures interconnected by links, where a ring has 12 crowns and at most two links connecting adjacent rings. | 04-24-2014 |
20140114399 | METHODS FOR VASCULAR RESTORATION THERAPY - A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold has a structure that produces a low late lumen loss when implanted within a peripheral vessel and also exhibits a high axial fatigue life. In a preferred embodiment the scaffold forms ring structures interconnected by links, where a ring has 12 crowns and at most two links connecting adjacent rings. | 04-24-2014 |
20140120053 | POLYESTERAMIDE PLATFORM FOR SITE SPECIFIC DRUG DELIVERY - A therapeutic agent delivery system formed of a specific type of poly(ester amide) (PEA), a therapeutic agent, and a water miscible solvent is described herein. A method of delivering the therapeutic agent delivery system by delivering the therapeutic agent delivery system formed of a PEA polymer, a therapeutic agent, and a water miscible solvent to a physiological environment and separating the phase of the therapeutic agent delivery system to form a membrane from the polymer to contain the therapeutic agent within the physiological environment is also described. Additionally disclosed is a kit including a syringe and a therapeutic agent delivery system within the syringe. | 05-01-2014 |
20140186446 | Delivery of Biologic Therapeutics - Formulations and methods are disclosed which provide controlled, sustained release of a biologic therapeutic to a space within the body. More specifically, formulations comprising a plurality of hydrophilic polymer strands, and methods of forming and administering such formulations, are disclosed. In some embodiments, the formulations exhibit a burst release, an initial release, a triphasic release, and release over thirty to ninety days of the biologic therapeutic. In some embodiments, the formulations exhibit reversible precipitation of the biologic therapeutic into precipitates having a diameter of about 50 nm to about 10 μm. | 07-03-2014 |
20140212355 | TRANS-ARTERIAL DRUG DELIVERY - It is provided herein methods, devices, and compositions for trans-arterial local delivery of therapeutic agent for the treatment of liver cancers. | 07-31-2014 |
20140276329 | TRANS-SCLERA PORTAL FOR DELIVERY OF THERAPEUTIC AGENTS - A portal through the sclera for delivery of an effective amount of therapeutic agent to the back of the eye. | 09-18-2014 |
20140276360 | ELECTROPHORECTIC DRUG COATED BALLOON AND CONDUCTIVE POLYMER COATING - Balloon catheter configured to deliver a therapeutic agent upon provision of electric potential to the balloon, the catheter comprising an electrode disposed proximate the outer surface of the expandable member, a coating disposed on at least a portion of the outer surface, the coating including a therapeutic agent; and a power source in electrical communication with the electrode is described. | 09-18-2014 |
20140276747 | SYSTEM AND METHOD FOR DENERVATION - A catheter apparatus for treatment of a human patient is described, the catheter apparatus having a central axis and comprising a shaping structure moveable between a delivery state having a first helical shape, and a deployed state having a second helical shape. The shaping structure is configured to have a reverse taper with a structural diameter that varies over the length of the shaping structure such that the structural diameter of the shaping structure at the proximal end is smaller than the structural diameter of the shaping structure at the distal end. | 09-18-2014 |
20140277331 | Reducing Recoil in Peripherally-Implanted Scaffolds - A peripherally implanted polymer scaffold having a high degree of recoil is worked to reduce recoil in the scaffold when initially deployed at a target lesion in the body. The scaffold is plastically deformed from a crimped state to an expanded state by a balloon catheter. The scaffold is contained within a sheath to prevent recoil up until the point of use. Before the scaffold is introduced to the body, the restraining sheath is removed from the scaffold. | 09-18-2014 |
20140277344 | CROSS-LINKED COATING DELIVERED BY A BALLOON - The present invention relates to systems for and corresponding methods of delivering a therapeutic agent to a vessel wall of a body lumen by providing a compound capable of being crosslinked after intraluminal release onto a vessel wall so that the therapeutic agent is temporarily retained at the site of delivery by the crosslinked compound. | 09-18-2014 |
20140277372 | Polymer Scaffolds Having Enhanced Axial Fatigue Properties - A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold has a morphology resulting from a biaxially expanded tube arranged to provide a more balanced, or less anisotropic axial and radial mechanical properties. The scaffold has improved mechanical properties suited for use as a balloon expandable scaffold implanted in a peripheral vessel of the body. | 09-18-2014 |
20140330363 | POLYMER SCAFFOLDS HAVING A LOW CROSSING PROFILE - A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold also has a reduced crimped profile and a modification of the scaffold's ring structure at the crowns that contributes to the reduced crimped profile. | 11-06-2014 |
20140364935 | COUPLED SCAFFOLD SEGMENTS - A scaffold is formed by several segments joined or connected to each other by only at least one coupling. The coupling decouples the segments in the axial direction over a finite distance of axial displacement. The scaffold when implanted in a peripheral vessel reduces loading on rings of a segment due to the decoupling of the segments in the axial direction over the finite distance. | 12-11-2014 |
Patent application number | Description | Published |
20090238854 | PLASTICIZERS FOR COATING COMPOSITIONS - A biocompatible plasticizer useful for forming a coating composition with a biocompatible polymer is provided. The coating composition may also include a biobeneficial polymer and/or a bioactive agent. The coating composition can form a coating on an implantable device. The implantable device can be used to treat or prevent a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof. | 09-24-2009 |
20090263457 | BLOCK COPOLYMER COMPRISING AT LEAST ONE POLYESTER BLOCK AND A POLY(ETHYLENE GLYCOL) BLOCK - The present invention provides a block copolymer for a coating on an implantable device for controlling release of drug and methods of making and using the same. | 10-22-2009 |
20100116785 | METHOD OF MAKING A VARIABLE SURFACE AREA STENT - A stent of variable surface area as determined by stent struts. The stent can have a variable surface area per unit length which accommodates a therapeutic agent. A patterned distribution of therapeutic agent can be provided throughout the stent. The stent can have an increased level of therapeutic agent near an end of the stent. A decreased level of therapeutic agent can be provided near an end of one embodiment of a stent. Indentations can be provided at the surface of the stent with therapeutic agent disposed therein. The stent can be cut with struts of variable thickness to provide the variable stent surface area. | 05-13-2010 |
20100331819 | Drug Delivery System and Method of Treatment of Vascular Diseases Using Photodynamic Therapy - This invention relates to photodynamic therapy (PDT), more specifically PDT for atherosclerotic plaque via delivering PDT-loaded nanoparticles such as liposomes, polymersomes, micelles and polymeric nanoparticles into the diseased vascular tissue. This invention provides method and formulations for delivering multiple drugs and delivering drugs to specific targeted site. | 12-30-2010 |
20120225040 | METHODS AND COMPOSITIONS FOR TREATING TISSUE USING SILK PROTEINS - Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications. | 09-06-2012 |
20120225041 | METHODS AND COMPOSITIONS FOR TREATING TISSUE USING SILK PROTEINS - Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications. | 09-06-2012 |
20130251764 | METHODS AND COMPOSITIONS FOR TREATING TISSUE USING SILK PROTEINS - Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications. | 09-26-2013 |
Patent application number | Description | Published |
20100104506 | Nanoparticle-Coated Medical Devices And Formulations For Treating Vascular Disease - Nanoparticle-coated medical devices, nanoparticle-containing formulations and methods of using for treating a vascular disease are disclosed. The medical device includes a coating that comprises a plurality of nanoparticles, wherein the nanoparticles comprise one or more bioactive agents encapsulated within, adhered to a surface of or integrated into the structure of the nanoparticles and further comprise one or more contrast enhancing agents encapsulated within, adhered to a surface of or integrated into the structure of the nanoparticles. | 04-29-2010 |
20100104653 | Nanoparticle-Coated Medical Devices And Formulations For Treating Vascular Disease - Nanoparticle-coated medical devices, nanoparticle-containing formulations and methods of using for treating a vascular disease are disclosed. The method for treating a vascular disease includes providing a formulation comprising a plurality of nanoparticles having a density different from that of blood and further comprising one or more bioactive agents encapsulated within, adhered to a surface of or integrated into the structure of the nanoparticles; and administering a therapeutically effective amount of the formulation to a vascular disease locale in a patient. | 04-29-2010 |
20110144741 | Coating Construct With Enhanced Interfacial Compatibility - The present invention provides a method of forming a coating on a medical device having a topcoat and a basecoat and an improved compatibility between a topcoat and a basecoat on the medical device. | 06-16-2011 |
20110196187 | MAGNETICALLY SENSITIVE DRUG CARRIERS AND DELIVERY DEVICES - Apparatuses for delivering compositions of matter comprising a magnetically sensitive drug carrier and a related drug and methods for causing the drug carriers to localize within the patient using an internal or external magnetic field are described. | 08-11-2011 |
20110196474 | MAGNETICALLY SENSITIVE DRUG CARRIERS FOR TREATMENT OR TARGETED DELIVERY - Compositions of matter comprising a magnetically sensitive drug carrier and a related drug as well as methods for administering these compositions and causing them to localize within the patient using an internal or external magnetic field are described. | 08-11-2011 |
20110207843 | Polymer-Bioceramic Composite Implantable Medical Devices - Methods and devices relating to polymer-bioceramic composite implantable medical devices are disclosed. | 08-25-2011 |
20110281022 | Methods For Controlling The Release Rate And Improving The Mechanical Properties Of A Stent Coating - Methods for controlling the release rate and improving the mechanical properties of a stent coating are disclosed. | 11-17-2011 |
20120265283 | REPERFUSION INJURY DEVICES - A catheter configured for performing reperfusion by alternatively occluding a vessel so as to prevent fluid flow and removing that occlusion to allow fluid flow is described. A first catheter includes an outer member and a retractable valve to allow and prevent fluid flow in the vessel. A second catheter includes a sheathed expansion member that can be deployed and recaptured to prevent and allow, respectively, fluid flow. A third catheter includes an angioplasty balloon to open a vessel occlusion, in which an occlusion balloon is used to allow and disallow fluid flow. A fourth catheter includes an expandable member for providing mechanical plunging action to urge thrombotic material to a more distal location. A fifth catheter includes an accessory catheter that can be used to perform reperfusion with another catheter. A sixth catheter includes an inner balloon within an outer balloon configured to perform reperfusion. | 10-18-2012 |
20120328770 | Methods For Modulating The Release Rate Of A Drug-Coated Stent - Methods for modulating the release rate of a drug coated stent are disclosed. | 12-27-2012 |
20130023507 | HYALURONIC ACID BASED COPOLYMERS - Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof. | 01-24-2013 |
20130023508 | HYALURONIC ACID BASED COPOLYMERS - Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof. | 01-24-2013 |
20130023509 | HYALURONIC ACID BASED COPOLYMERS - Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof. | 01-24-2013 |
20130041065 | METHOD OF MAKING POLYMER-BIOCERAMIC COMPOSITE IMPLANTABLE MEDICAL DEVICES - Methods and devices relating to polymer-bioceramic composite implantable medical devices are disclosed. | 02-14-2013 |
20130071449 | COATINGS OF ACRYLAMIDE-BASED COPOLYMERS - An implantable device including a conjugate formed of an acrylamide-based copolymer and a bioactive agent is provided. | 03-21-2013 |
20130085563 | RUBBER TOUGHENED BIORESORBABLE POLYMER PERIPHERAL SCAFFOLDS - Bioabsorbable scaffolds are disclosed with a rigid polymer component and a rubbery polymer component. The rubbery polymer component is miscible, partially miscible, or immiscible with the rigid polymer component. | 04-04-2013 |
20130085564 | MODIFIED SCAFFOLDS FOR PERIPHERAL APPLICATIONS - Stent scaffolds that include a polymeric structure or structures bonded to the scaffold and extending along their length are disclosed. The polymeric structure extends across some or all of the gaps in struts along the length of the scaffold. Segmented scaffolds are also disclosed that include two or more axial segments arranged end to end not connected by link struts. | 04-04-2013 |
20130129794 | Poly(Ester Amide)-Based Drug Delivery Systems - Implantable medical devices including a coating having a bioactive agent and a poly(ester amide) polymer. Methods of forming these coatings are also described. | 05-23-2013 |
20130142939 | Methods of Forming Coatings with a Crystalline or Partially Crystalline Drug for Implantable Medical Devices using Sonocrystallization - Methods for making coatings on an implantable device such as a drug-eluting stent comprising a polymer and nano or microparticles of a drug in slow-dissolving polymorph, implantable devices produced by the methods and methods of using the coatings are provided. | 06-06-2013 |
20130149430 | Methods of forming coatings with a crystalline or partially crystalline drug for implantable medical devices using supercritical fluid assisted sorption - Methods for making coatings on an implantable device such as a drug-eluting stent comprising a polymer and nano or microparticles of a drug in slow-dissolving polymorph, implantable devices produced by the methods and methods of using the coatings are provided. | 06-13-2013 |
20130149431 | Methods of Forming Coatings with a Crystalline or Partially Crystalline Drug for Implantable Medical Devices - Methods for making coatings on an implantable device such as a drug-eluting stent comprising a polymer and nano or microparticles of a drug in slow-dissolving polymorph, implantable devices produced by the methods and methods of using the coatings are provided. | 06-13-2013 |
20130230564 | Semi-Crystalline Composition For Coating - The present invention provides a coating comprising a semi-crystalline polymer on an implantable device and methods of making and using the same. | 09-05-2013 |
20130324636 | METHOD OF MAKING POLYMER-BIOCERAMIC COMPOSITE IMPLANTABLE MEDICAL DEVICES - Methods and devices relating to polymer-bioceramic composite implantable medical devices are disclosed. | 12-05-2013 |
20140025161 | SHAPE MEMORY BIORESORBABLE POLYMER PERIPHERAL SCAFFOLDS - Bioabsorbable scaffolds having high crush recoverability, high fracture resistance, and reduced or no recoil due to self expanding properties at physiological conditions are disclosed. The scaffolds are made from a random copolymer of PLLA and a rubbery polymer such as polycaprolactone. | 01-23-2014 |
20140046431 | SEGMENTED SCAFFOLD DESIGNS - Segmented scaffolds composed of disconnected scaffold segments with overlapping end rings are disclosed. Scaffolds with at least one discontinuous link are also disclosed. | 02-13-2014 |
20140074224 | COATING OF FAST ABSORPTION OR DISSOLUTION - A coating of fast absorption or fast dissolution on an implantable device and methods of making and using of the coating are provided. | 03-13-2014 |
20140079742 | COATING OF FAST ABSORPTION OR DISSOLUTION - A coating of fast absorption or fast dissolution on an implantable device and methods of making and using of the coating are provided. | 03-20-2014 |
20140079743 | COATINGS OF ACRYLAMIDE-BASED COPOLYMERS - An implantable device including a conjugate formed of an acrylamide-based copolymer and a bioactive agent is provided. | 03-20-2014 |
20140107592 | COATING COMPRISING A TERPOLYMER COMPRISING CAPROLACTONE AND GLYCOLIDE - The present invention provides a coating comprising a reservoir layer comprising a terpolymer comprising caprolactone and glycolide and a primer layer comprising an amorphous polymer on an implantable device and methods of making and using the same. | 04-17-2014 |
20140127279 | Implantable Device Having a Slow Dissolving Polymer - The present invention provides an implantable device having a coating including a slow dissolving polymer or material and the methods of making and using the same. | 05-08-2014 |
20140221418 | HYALURONIC ACID BASED COPOLYMERS - Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof. | 08-07-2014 |
20140287033 | LIPID THERAPY - A method including introducing into a blood stream a delipidated high density lipoprotein (HDL) and a bioactive agent. A composition including a delipidated high density lipoprotein (HDL) and an auxiliary agent in a form suitable for delivery into a blood vessel. A composition including Apo A1 comprising a hydrophobic ligand suitable to interact with cell surface binding sites. A composition including Apo A1 and an agent selected to one of increase the ATP-binding cassette protein 1 (ABCA1) transporter expression in macrophages and protect ABCA1 from thiol-mediated degradation. | 09-25-2014 |
20140294912 | AMORPHOUS POLY(D,L-LACTIDE) COATING - Implantable devices formed of or coated with a material that includes an amorphous poly(D,L-lactide) formed of a starting material such as meso-D,L-lactide are provided. The implantable device can be used for the treatment, mitigation, prevention, or inhibition of a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, patent foramen ovale, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof. | 10-02-2014 |
20140330360 | SEGMENTED SCAFFOLD DESIGNS - Segmented scaffolds composed of disconnected scaffold segments with overlapping end rings are disclosed. Scaffolds with at least one discontinuous link are also disclosed. | 11-06-2014 |
20140330361 | SEGMENTED SCAFFOLD DESIGNS - Segmented scaffolds composed of disconnected scaffold segments with overlapping end rings are disclosed. Scaffolds with at least one discontinuous link are also disclosed. | 11-06-2014 |
20140370072 | PROHEALING PIEZOELECTRIC COATINGS - Provided herein is a prohealing piezoelectric coating and the method of making and using the same. | 12-18-2014 |
20150024039 | BLOOD VESSEL PERMEABILITY-ENHANCEMENT FOR THE TREATMENT OF VASCULAR DISEASES - This invention relates to methods of enhancing the permeability of blood vessels to therapeutic agents. | 01-22-2015 |
20150073535 | Treatment of coronary artery lesions with a scaffold having vessel scaffold interactions that reduce or prevent angina - Methods of treating coronary artery disease (CAD) with bioresorbable stents resulting in reduced angina or non-ischemic chest pain are described. Methods of treatment and devices for treatment of angina and post-procedural chest pain that include anti-angina agents incorporated into the device are disclosed. | 03-12-2015 |
20150081000 | BRAIDED SCAFFOLDS - A braided polymeric scaffold, made at least in part from a bioresorbable material is deployed on a catheter that uses a push-pull mechanism to deploy the scaffold. A drug coating is disposed on the scaffold. A plurality of scaffold segments on a catheter is also disclosed. | 03-19-2015 |