Patent application number | Description | Published |
20080206809 | PEPTIDE TAGS FOR THE EXPRESSION AND PURIFICATION OF BIOACTIVE PEPTIDES - Peptide tags, referred to here as inclusion body tags, are disclosed and are useful for the generation of insoluble fusion peptides. The fusion peptides comprise at least one inclusion body tag operably linked to a peptide of interest. Expression of the fusion peptide in a host cell results in a product that is insoluble and contained within inclusion bodies in the cell and/or cell lysate. The inclusion bodies may then be purified and the protein of interest may be isolated after cleavage from the inclusion body tag. | 08-28-2008 |
20080207872 | Polytetrafluoroethylene binding peptides and methods of use - Combinatorially generated peptides are provided that have binding affinity for Polytetrafluoroethylene (NY). The peptides may be used to deliver benefit agents to various PTFE surfaces. | 08-28-2008 |
20080280810 | PEPTIDES HAVING AFFINITY FOR BODY SURFACES - Peptides having affinity for a body surface are provided. The peptides comprise a body surface-binding peptide block and at least one charged, terminal peptide block. These peptides have enhanced affinity for body surfaces and deposit more rapidly onto body surfaces than peptides lacking the charged terminal groups. The peptides are used to deliver and/or to seal benefit agents to body surfaces, thereby providing enhanced durability. | 11-13-2008 |
20080292576 | METHOD FOR IDENTIFYING HAIR CONDITIONER-RESISTANT HAIR-BINDING PEPTIDES AND HAIR BENEFIT AGENTS THEREFROM - A method for identifying hair conditioner-resistant hair-binding peptides is described. The hair conditioner-resistant hair-binding peptides bind strongly to hair from a hair conditioner matrix and are stable therein. Peptide-based benefit agents, such as hair conditioners and hair colorants, based on the hair conditioner-resistant hair binding peptides are described. The peptide-based hair conditioners and hair colorants consist of a hair conditioner-resistant hair-binding peptide coupled to a hair conditioning agent or a coloring agent, either directly or through an optional spacer. Hair care and hair coloring product compositions comprising these peptide-based hair conditioners and colorants are also described. | 11-27-2008 |
20090048428 | PEPTIDE TAGS FOR THE EXPRESSION AND PURIFICATION OF BIOACTIVE PEPTIDES - Peptide tags, referred to here as inclusion body tags, are disclosed and are useful for the generation of insoluble fusion peptides. The fusion peptides comprise at least one inclusion body tag operably linked to a peptide of interest. Expression of the fusion peptide in a host cell results in a product that is insoluble and contained within inclusion bodies in the cell and/or cell lysate. The inclusion bodies may then be purified and the protein of interest may be isolated after cleavage from the inclusion body tag. | 02-19-2009 |
20090070944 | HAIR BINDING PEPTIDES AND PEPTIDE-BASED HAIR REAGENTS FOR PERSONAL CARE - Peptides have been identified that bind with high affinity to hair. Peptide-based hair reagents formed by coupling a hair-binding peptide to a benefit agent are described. The peptide-based hair reagents include peptide-based hair conditioners and hair colorants. The peptide-based hair conditioners and hair colorants are comprised of at least one hair-binding peptide coupled to a hair conditioning agent or a coloring agent, respectively. | 03-19-2009 |
20090074694 | DYED-HAIR-BINDING PEPTIDES AND PEPTIDE-BASED HAIR REAGENTS FOR PERSONAL CARE - Peptides have been identified that bind with high affinity to dyed hair. Peptide-based hair reagents formed by coupling a dyed-hair-binding peptide to a benefit agent are described. The peptide-based hair reagents include peptide-based hair conditioners and hair colorants. The peptide-based hair conditioners and hair colorants are comprised of a dyed-hair-binding peptide coupled to a hair conditioning agent or a coloring agent, respectively. The peptide-based hair reagents or the dyed-hair-binding peptides may also be used as a protective sealant to improve color retention of dyed hair. | 03-19-2009 |
20090142283 | PEPTIDE-BASED ANTIDANDRUFF REAGENTS - Peptide-based antidandruff reagents, formed by coupling a skin-binding peptide with an antidandruff agent, are described. The skin-binding peptide part of the peptide-based antidandruff reagent binds strongly to the skin, thus keeping the antidandruff agent coupled to the skin for a long lasting effect. Hair care compositions comprising the peptide-based antidandruff reagents are also provided as well as methods for treating or preventing dandruff. | 06-04-2009 |
20090143295 | PEPTIDE-BASED ANTIACNE REAGENTS - Peptide-based antiacne reagents, formed by coupling a skin-binding peptide with an antiacne agent, are described. The skin-binding peptide portion of the peptide-based antiacne reagent binds strongly to the skin, thus keeping the antiacne agent coupled to the skin for a long lasting effect. Skin care compositions comprising the peptide-based antiacne reagents are also provided as well as a method of treating or preventing skin acne. | 06-04-2009 |
20100158822 | PEPTIDES THAT BIND TO SILICA-COATED PARTICLES - Peptides having strong affinity for silica as well as surfaces comprising silica are described. The silica-binding peptides may be used to construct peptide based-reagents suitable for delivery of a silica-coated particulate benefit agent to a surface, such as body surface, for personal care and cosmetic applications. Peptide-based reagents formed by coupling at least one of the silica-binding peptides to at least one body surface-binding peptide, either directly or through a spacer, are described. The peptide-based reagents may be used in conjunction with at least one silica-coated colorant to color body surfaces. | 06-24-2010 |
20100158823 | PEPTIDE LINKERS FOR EFFECTIVE MULTIVALENT PEPTIDE BINDING - Short single chain peptides having affinity for a target surface often lack the binding durability required for certain commercial applications. One way to improve durability is to promote multivalent binding by linking together binding sequences using peptide linkers. However, the resulting single chain binding peptides often suffer from linker entropy. It has been discovered that the use of rigid peptide linkers when linking together multiple binding sequences enhances the binding affinity of the resulting single chain peptide. | 06-24-2010 |
20100158837 | IRON OXIDE-BINDING PEPTIDES - Peptides having strong affinity for iron oxide pigment particles have been identified. Peptide-based reagents comprising at least one of the present iron oxide-based pigment-binding peptides and at least one body surface-binding peptide are described. The peptide-based reagents may be used in conjunction with at least one iron oxide-based pigment to color body surfaces. | 06-24-2010 |
20100159513 | GENES THAT INCREASE PEPTIDE PRODUCTION - Several endogenous genes have been identified in | 06-24-2010 |
20100189670 | METHOD FOR ENHANCING EFFECTS OF COLORANTS AND CONDITIONERS - Methods are provided for enhancing the longevity of the binding of various benefit agents to hair and skin. Applications of traditional and non-traditional colorants and conditioners to hair and skin are amended with compositions of hair or skin-binding peptides respectively. The presence of the hair or skin-binding peptide compositions act to increase the longevity of the applied colorant or conditioner on the hair or skin. | 07-29-2010 |
20100234568 | Identification of peptide tags for the production of insoluble peptides by sequence scanning - A method is provided to identify short peptide tags, referred to here as inclusion body tags (IBTs), useful for the generation of insoluble fusion peptides. A library of genetic constructs were prepared encoding fusion peptides comprising an inclusion body tag of 10-50 contiguous amino acids from a full-length insoluble protein operably linked to a peptide of interest. The library was designed to include a sufficient number of overlapping inclusion body tags to ensure that the entire length of the full-length insoluble protein was represented. Host cells transformed and expressing the genetic constructs were evaluated for inclusion body formation. | 09-16-2010 |
20100247457 | PEPTIDE-BASED TOOTH WHITENING REAGENTS - Peptide-based reagents comprising at least one tooth surface-binding peptide for delivery of at least one polymer-coated white colorant to the surface of teeth are provided. The peptide-based reagent may comprise at least one tooth-binding peptide coupled to, either directly or through one or more spacers, a polymer-binding peptide capable of binding to the polymeric coating on a polymer-coated white colorant. Methods of delivering a polymer-coated white colorant to a tooth surface are also provided as well as oral care compositions comprising the present peptide-based reagents. The peptide-based reagents may be used in conjunction with at least one polymer-coated white colorant to improve the cosmetic appearance of teeth. | 09-30-2010 |
20100247589 | PEPTIDE COMPOSITIONS FOR ORAL CARE SYSTEMS - Oral care compositions, oral care systems, oral surface-binding peptides, and a method for applying particles to an oral surface are provided. The oral care system comprises at least one peptidic component comprising a first binding element having affinity for an oral surface and a second binding element having affinity for a ligand property of a particle. | 09-30-2010 |
20100247590 | Peptide-Based Systems For Delivery Of Cosmetic Agents - The present invention relates to compositions and systems comprising peptide-based reagents for delivery of cosmetic benefit agents to human hair, human skin, or human nail. | 09-30-2010 |
20100298231 | PMMA BINDING PEPTIDES - Peptides are provided that have binding affinity for polymethyl methacrylate (PMMA). The polymethyl methacrylate-binding peptides may be used to prepare peptide-based reagents suitable for use in a variety of applications. The peptide-based reagents may be used to couple benefit agents to a PMMA polymer surface or may be used to couple a benefit agent comprising a PMMA polymer surface to a target surface, such as a body surface. | 11-25-2010 |
20100298240 | PMMA BINDING PEPTIDES - Peptides are provided that have binding affinity for polymethyl methacrylate (PMMA). The polymethyl methacrylate-binding peptides may be used to prepare peptide-based reagents suitable for use in a variety of applications. The peptide-based reagents may be used to couple benefit agents to a PMMA polymer surface or may be used to couple a benefit agent comprising a PMMA polymer surface to a target surface, such as a body surface. | 11-25-2010 |
20100298241 | PMMA BINDING PEPTIDES - Peptides are provided that have binding affinity for polymethyl methacrylate (PMMA). The polymethyl methacrylate-binding peptides may be used to prepare peptide-based reagents suitable for use in a variety of applications. The peptide-based reagents may be used to couple benefit agents to a PMMA polymer surface or may be used to couple a benefit agent comprising a PMMA polymer surface to a target surface, such as a body surface. | 11-25-2010 |
20100298531 | PMMA BINDING PEPTIDES - Peptides are provided that have binding affinity for polymethyl methacrylate (PMMA). The polymethyl methacrylate-binding peptides may be used to prepare peptide-based reagents suitable for use in a variety of applications. The peptide-based reagents may be used to couple benefit agents to a PMMA polymer surface or may be used to couple a benefit agent comprising a PMMA polymer surface to a target surface, such as a body surface. | 11-25-2010 |
20100298532 | PMMA BINDING PEPTIDES - Peptides are provided that have binding affinity for polymethyl methacrylate (PMMA). The polymethyl methacrylate-binding peptides may be used to prepare peptide-based reagents suitable for use in a variety of applications. The peptide-based reagents may be used to couple benefit agents to a PMMA polymer surface or may be used to couple a benefit agent comprising a PMMA polymer surface to a target surface, such as a body surface. | 11-25-2010 |
20100298533 | PMMA BINDING PEPTIDES - Peptides are provided that have binding affinity for polymethyl methacrylate (PMMA). The polymethyl methacrylate-binding peptides may be used to prepare peptide-based reagents suitable for use in a variety of applications. The peptide-based reagents may be used to couple benefit agents to a PMMA polymer surface or may be used to couple a benefit agent comprising a PMMA polymer surface to a target surface, such as a body surface. | 11-25-2010 |
20100298534 | PMMA BINDING PEPTIDES - Peptides are provided that have binding affinity for polymethyl methacrylate (PMMA). The polymethyl methacrylate-binding peptides may be used to prepare peptide-based reagents suitable for use in a variety of applications. The peptide-based reagents may be used to couple benefit agents to a PMMA polymer surface or may be used to couple a benefit agent comprising a PMMA polymer surface to a target surface, such as a body surface. | 11-25-2010 |
20100298535 | PMMA BINDING PEPTIDES - Peptides are provided that have binding affinity for polymethyl methacrylate (PMMA). The polymethyl methacrylate-binding peptides may be used to prepare peptide-based reagents suitable for use in a variety of applications. The peptide-based reagents may be used to couple benefit agents to a PMMA polymer surface or may be used to couple a benefit agent comprising a PMMA polymer surface to a target surface, such as a body surface. | 11-25-2010 |
20100310495 | PEPTIDES HAVING AFFINITY FOR POLY (BENZYL METHACRYLATE-CO-METHACRYLIC ACID) POTASSIUM SALT COPOLYMERS AND METHODS OF USE - Peptides are provided that have binding affinity for poly(benzyl methacrylate-co-methacrylic acid) potassium salt copolymers (“BzMA-binding peptides”). The BzMA-binding peptides may be used to prepare peptide-based reagents suitable for use in a variety of applications. The peptide-base reagents may be used to couple benefit agents to a poly(benzyl methacrylate-co-methacrylic acid) potassium salt copolymer surface or may be used to couple a benefit agent comprising a poly(benzyl methacrylate-co-methacrylic acid) potassium salt copolymer surface to a target surface, such as a body surface. | 12-09-2010 |
20110014674 | CARBON NANOTUBE BINDING PEPTIDES - Peptides have been generated that have binding affinity to carbon nanostructures and particularly carbon nanotubes. Peptides of or the invention are generally about twelve amino acids in length. Methods for generating carbon nanotube binding peptides are also disclosed. | 01-20-2011 |
20110014682 | CARBON NANOTUBE BINDING PEPTIDES - Peptides have been generated that have binding affinity to carbon nanostructures and particularly carbon nanotubes. Peptides of or the invention are generally about twelve amino acids in length. Methods for generating carbon nanotube binding peptides are also disclosed. | 01-20-2011 |
20110020902 | CARBON NANOTUBE BINDING PEPTIDES - Peptides have been generated that have binding affinity to carbon nanostructures and particularly carbon nanotubes. Peptides of or the invention are generally about twelve amino acids in length. Methods for generating carbon nanotube binding peptides are also disclosed. | 01-27-2011 |
20110020903 | CARBON NANOTUBE BINDING PEPTIDES - Peptides have been generated that have binding affinity to carbon nanostructures and particularly carbon nanotubes. Peptides of or the invention are generally about twelve amino acids in length. Methods for generating carbon nanotube binding peptides are also disclosed. | 01-27-2011 |
20110020904 | CARBON NANOTUBE BINDING PEPTIDES - Peptides have been generated that have binding affinity to carbon nanostructures and particularly carbon nanotubes. Peptides of or the invention are generally about twelve amino acids in length. Methods for generating carbon nanotube binding peptides are also disclosed. | 01-27-2011 |
20110020905 | CARBON NANOTUBE BINDING PEPTIDES - Peptides have been generated that have binding affinity to carbon nanostructures and particularly carbon nanotubes. Peptides of or the invention are generally about twelve amino acids in length. Methods for generating carbon nanotube binding peptides are also disclosed. | 01-27-2011 |
20110020906 | CARBON NANOTUBE BINDING PEPTIDES - Peptides have been generated that have binding affinity to carbon nanostructures and particularly carbon nanotubes. Peptides of or the invention are generally about twelve amino acids in length. Methods for generating carbon nanotube binding peptides are also disclosed. | 01-27-2011 |
20110021348 | CARBON NANOTUBE BINDING PEPTIDES - Peptides have been generated that have binding affinity to carbon nanostructures and particularly carbon nanotubes. Peptides of or the invention are generally about twelve amino acids in length. Methods for generating carbon nanotube binding peptides are also disclosed. | 01-27-2011 |
20110028315 | CARBON NANOTUBE BINDING PEPTIDES - Peptides have been generated that have binding affinity to carbon nanostructures and particularly carbon nanotubes. Peptides of or the invention are generally about twelve amino acids in length. Methods for generating carbon nanotube binding peptides are also disclosed. | 02-03-2011 |
20110028316 | CARBON NANOTUBE BINDING PEPTIDES - Peptides have been generated that have binding affinity to carbon nanostructures and particularly carbon nanotubes. Peptides of or the invention are generally about twelve amino acids in length. Methods for generating carbon nanotube binding peptides are also disclosed. | 02-03-2011 |
20110052508 | PEPTIDE-BASED ORAL CARE SURFACE REAGENTS FOR PERSONAL CARE - Peptides have been identified that bind to oral surfaces such as teeth and gums. Peptide based oral care reagents have been created by couple such peptides to oral care benefit agents such as whiteners. | 03-03-2011 |
20120317733 | ENZYMATIC PERACID GENERATION FOR USE IN HAIR CARE PRODUCTS - Disclosed herein are compositions and methods to treat hair with a peracid-based benefit agent. The peracid benefit agent can be used for hair bleaching, hair weakening, hair removal, hair waiving, hair straightening or any combination thereof. The peracid may be enzymatically generated from a carboxylic acid ester substrate using an enzyme having perhydrolytic activity (perhydrolase) in the presence of a source of peroxygen. A fusion protein comprising the perhydrolase coupled to a hair-binding domain, either directly or through an optional linker, may be used to target the perhydrolytic activity to the hair surface. | 12-20-2012 |
20120321581 | TARGETED PERHYDROLASES - Disclosed herein are compositions and methods to target enzymatic peracid production to a target surface. The peracid benefit agent produced by the targeted perhydrolytic enzyme can be use for a variety of applications such as bleaching, whitening, disinfecting, destaining, deodorizing, and combinations thereof. Specifically, a fusion protein comprising a perhydrolytic enzyme and at least one peptidic component having affinity for a target surface (excluding body surfaces and oral care surfaces) is used in combination with a suitable substrate and a source of peroxygen to enzymatically produce a peracid on or near the surface of the target material. In a preferred aspect, the target surface is a cellulosic material. | 12-20-2012 |
20120328534 | ENZYMATIC PERACID GENERATION FOR USE IN ORAL CARE PRODUCTS - Disclosed herein are compositions and methods to treat an oral cavity surface with a peracid-based benefit agent. The peracid benefit agent can be use for oral surface bleaching, whitening, disinfecting, destaining, deodorizing, decreasing or removing biofilm, and combinations thereof. The peracid is enzymatically generated from a carboxylic acid ester substrate using a CE-7 carbohydrate esterase having perhydrolytic activity (perhydrolase) in the presence of a source of peroxygen. A fusion protein comprising the perhydrolase coupled to a peptidic component having affinity for an oral cavity surface, either directly or through an optional linker, may be used to target the perhydrolytic activity to the oral cavity surface. | 12-27-2012 |
20130171217 | ENZYMATIC PERACID GENERATION FOR USE IN SKIN CARE PRODUCTS - Disclosed herein are compositions and methods to treat skin with a peracid-based benefit agent. The peracid benefit agent can be used for a benefit such as the prevention or treatment of acne, skin whitening, skin bleaching, skin conditioning, reducing the appearance of skin wrinkles, skin rejuvenation, reducing dermal adhesions, and preventing, reducing or eliminating body odors or any combination thereof. The peracid may be enzymatically generated from a carboxylic acid ester substrate using an enzyme having perhydrolytic activity (perhydrolase) in the presence of a source of peroxygen. A fusion protein comprising the perhydrolase coupled to a skin-binding domain, either directly or through an optional linker, may be used to target the perhydrolytic activity to the skin surface. | 07-04-2013 |
20140073029 | TARGETED PERHYDROLASES - Disclosed herein are compositions and methods to target enzymatic peracid production to a target surface. The peracid benefit agent produced by the targeted perhydrolytic enzyme can be use for a variety of applications such as bleaching, whitening, disinfecting, destaining, deodorizing, and combinations thereof. Specifically, a fusion protein comprising a perhydrolytic enzyme and at least one peptidic component having affinity for a target surface (excluding body surfaces and oral care surfaces) is used in combination with a suitable substrate and a source of peroxygen to enzymatically produce a peracid on or near the surface of the target material. In a preferred aspect, the target surface is a cellulosic material. | 03-13-2014 |
20140241999 | PEPTIDE LINKERS FOR EFFECTIVE MULTIVALENT PEPTIDE BINDING - Short single chain peptides having affinity for a target surface often lack the binding durability required for certain commercial applications. One way to improve durability is to promote multivalent binding by linking together binding sequences using peptide linkers. However, the resulting single chain binding peptides often suffer from linker entropy. It has been discovered that the use of rigid peptide linkers when linking together multiple binding sequences enhances the binding affinity of the resulting single chain peptide. | 08-28-2014 |
20140314829 | PERACID-GENERATING COMPOSITIONS - Described herein are tooth whitening strips comprising an hydratable adhesive film having a granular bleaching ingredient attached thereto, wherein upon hydration, the granular bleaching ingredient releases hydrogen peroxide which is used by an enzyme catalyst having perhydrolytic activity to enzymatically produce an effective amount of peracid bleaching agent from an acyl donor substrate. Methods of making and use the tooth whitening strips are also provided. | 10-23-2014 |