Hong Wang
Hong Wang, Santa Clara, CA US
Patent application number | Description | Published |
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20100042765 | Dynamically Migrating Channels - In one embodiment, the present invention includes a method of determining a relative priority between a first agent and a second agent, and assigning the first agent to a first channel and the second agent to a second channel according to the relative priority. Depending on the currently programmed status of the channels, information stored in at least one of the channels may be dynamically migrated to another channel based on the assignments. Other embodiments are described and claimed. | 02-18-2010 |
20100281471 | METHODS AND APPARATUSES FOR COMPILER-CREATING HELPER THREADS FOR MULTI-THREADING - Methods and apparatuses for compiler-created helper thread for multi-threading are described herein. In one embodiment, exemplary process includes identifying a region of a main thread that likely has one or more delinquent loads, the one or more delinquent loads representing loads which likely suffer cache misses during an execution of the main thread, analyzing the region for one or more helper threads with respect to the main thread, and generating code for the one or more helper threads, the one or more helper threads being speculatively executed in parallel with the main thread to perform one or more tasks for the region of the main thread. Other methods and apparatuses are also described. | 11-04-2010 |
20100299479 | OBSCURING MEMORY ACCESS PATTERNS - For each memory location in a set of memory locations associated with a thread, setting an indication associated with the memory location to request a signal if data from the memory location is evicted from a cache; and in response to the signal, reloading the set of memory locations into the cache. | 11-25-2010 |
20110106522 | VIRTUAL PLATFORM FOR PROTOTYPING SYSTEM-ON-CHIP DESIGNS - A system to prototype a system-on-chip design is presented. In one embodiment, the system includes an electronic board comprising a logic device programmable to emulate system components. The system further comprises a processor to execute a virtual machine monitor which redirects an input/output request to the system components via an interconnect. | 05-05-2011 |
20110153529 | METHOD AND APPARATUS TO EFFICIENTLY GENERATE A PROCESSOR ARCHITECTURE MODEL - A method and apparatus for efficiently generating a processor architecture model that accurately predicts performance of the processor for minimizing simulation time are described. In one embodiment, the method comprises: identifying a performance benchmark of a processor; sampling a portion of a design space for the identified performance benchmark; simulating the sampled portion of the design space to generate training data; generating a processor performance model from the training data by modifying the training data to predict an entire design space; and predicting performance of the processor for the entire design space by executing the processor performance model. | 06-23-2011 |
20110153990 | SYSTEM, APPARATUS, AND METHOD FOR SUPPORTING CONDITION CODES - An apparatus is described having decode circuitry to decode a first instruction, wherein the first instruction indicates that a copy of a plurality of condition codes bits is to be copied from a first register to a second register. The apparatus also has first execution circuitry to copy a plurality of condition code bits from a first register to a second register. | 06-23-2011 |
20110258632 | Dynamically Migrating Channels - In one embodiment, the present invention includes a method of determining a relative priority between a first agent and a second agent, and assigning the first agent to a first channel and the second agent to a second channel according to the relative priority. Depending on the currently programmed status of the channels, information stored in at least one of the channels may be dynamically migrated to another channel based on the assignments. Other embodiments are described and claimed. | 10-20-2011 |
20110307876 | REGISTER MAPPING TECHNIQUES FOR EFFICIENT DYNAMIC BINARY TRANSLATION - Generally, the present disclosure provides a system and method for mapping registers from a system with more registers to a system with fewer registers. Regions may be formed that include one or more blocks of code with relatively frequent register accesses. The most frequently accessed source registers may be mapped to target registers. Each block in the region may be bounded by a prologue and at least one epilogue. The prologue may be configured to implement register mapping and the epilogue(s) may be configured to manage program flow from a block in the region to another block in the region or to a block not in the region. | 12-15-2011 |
20110314480 | Apparatus, System, And Method For Persistent User-Level Thread - Embodiments of the invention provide a method of creating, based on an operating-system-scheduled thread running on an operating-system-visible sequencer and using an instruction set extension, a persistent user-level thread to run on an operating-system-sequestered sequencer independently of context switch activities on the operating-system-scheduled thread. The operating-system-scheduled thread and the persistent user-level thread may share a common virtual address space. Embodiments of the invention may also provide a method of causing a service thread running on an additional operating-system-visible sequencer to provide operating system services to the persistent user-level thread. Embodiments of the invention may further provide apparatus, system, and machine-readable medium thereof. | 12-22-2011 |
20130073835 | PRIMITIVES TO ENHANCE THREAD-LEVEL SPECULATION - A processor may include an address monitor table and an atomic update table to support speculative threading. The processor may also include one or more registers to maintain state associated with execution of speculative threads. The processor may support one or more of the following primitives: an instruction to write to a register of the state, an instruction to trigger the committing of buffered memory updates, an instruction to read the a status register of the state, and/or an instruction to clear one of the state bits associated with trap/exception/interrupt handling. Other embodiments are also described and claimed. | 03-21-2013 |
20130111194 | METHOD AND SYSTEM TO PROVIDE USER-LEVEL MULTITHREADING | 05-02-2013 |
20130205122 | INSTRUCTION SET ARCHITECTURE-BASED INTER-SEQUENCER COMMUNICATIONS WITH A HETEROGENEOUS RESOURCE - In one embodiment, the present invention includes a method for directly communicating between an accelerator and an instruction sequencer coupled thereto, where the accelerator is a heterogeneous resource with respect to the instruction sequencer. An interface may be used to provide the communication between these resources. Via such a communication mechanism a user-level application may directly communicate with the accelerator without operating system support. Further, the instruction sequencer and the accelerator may perform operations in parallel. Other embodiments are described and claimed. | 08-08-2013 |
20130219096 | PROGRAMMABLE EVENT DRIVEN YIELD MECHANISM WHICH MAY ACTIVATE OTHER THREADS - Method, apparatus, and program means for a programmable event driven yield mechanism that may activate other threads. In one embodiment, an apparatus includes execution resources to execute a plurality of instructions and a monitor to detect a condition indicating a low level of progress. The monitor can disrupt processing of a program by transferring to a handler in response to detecting the condition indicating a low level of progress. In another embodiment, thread switch logic may be coupled to a plurality of event monitors which monitor events within the multithreading execution logic. The thread switch logic switches threads based at least partially on a programmable condition of one or more of the performance monitors. | 08-22-2013 |
20130219399 | MECHANISM FOR INSTRUCTION SET BASED THREAD EXECUTION OF A PLURALITY OF INSTRUCTION SEQUENCERS - In an embodiment, a method is provided. The method includes managing user-level threads on a first instruction sequencer in response to executing user-level instructions on a second instruction sequencer that is under control of an application level program. A first user-level thread is run on the second instruction sequencer and contains one or more user level instructions. A first user level instruction has at least 1) a field that makes reference to one or more instruction sequencers or 2) implicitly references with a pointer to code that specifically addresses one or more instruction sequencers when the code is executed. | 08-22-2013 |
20130275735 | Apparatus, System, And Method For Persistent User-Level Thread - Embodiments of the invention provide a method of creating, based on an operating-system-scheduled thread running on an operating-system-visible sequencer and using an instruction set extension, a persistent user-level thread to run on an operating-system-sequestered sequencer independently of context switch activities on the operating-system-scheduled thread. The operating-system-scheduled thread and the persistent user-level thread may share a common virtual address space. Embodiments of the invention may also provide a method of causing a service thread running on an additional operating-system-visible sequencer to provide operating system services to the persistent user-level thread. Embodiments of the invention may further provide apparatus, system, and machine-readable medium thereof. | 10-17-2013 |
20140089942 | SYSTEM TO PROFILE AND OPTIMIZE USER SOFTWARE IN A MANAGED RUN-TIME ENVIRONMENT - Method, apparatus, and system for monitoring performance within a processing resource, which may be used to modify user-level software. Some embodiments of the invention pertain to an architecture to allow a user to improve software running on a processing resources on a per-thread basis in real-time and without incurring significant processing overhead. | 03-27-2014 |
20140208042 | PROVIDING HARDWARE SUPPORT FOR SHARED VIRTUAL MEMORY BETWEEN LOCAL AND REMOTE PHYSICAL MEMORY - In one embodiment, the present invention includes a memory management unit (MMU) having entries to store virtual address to physical address translations, where each entry includes a location indicator to indicate whether a memory location for the corresponding entry is present in a local or remote memory. In this way, a common virtual memory space can be shared between the two memories, which may be separated by one or more non-coherent links. Other embodiments are described and claimed. | 07-24-2014 |
20140258757 | Methods And Apparatuses For Reducing Power Consumption Of Processor Switch Operations - Methods and apparatuses for reducing power consumption of processor switch operations are disclosed. One or more embodiments may comprise specifying a subset of registers or state storage elements to be involved in a register or state storage operation, performing the register or state storage operation, and performing a switch operation. The embodiments may minimize the number of registers or state storage elements involved with the standby operation by specifying only the subset of registers or state storage elements, which may involve considerably fewer than the total number of registers or state storage or elements of the processor. The switch operation may be switch from one mode to another, such as a transition to or from a sleep mode, a context switch, or the execution of various types of instructions. | 09-11-2014 |
20150070368 | Instruction Set Architecture-Based Inter-Sequencer Communications With A Heterogeneous Resource - In one embodiment, the present invention includes a method for directly communicating between an accelerator and an instruction sequencer coupled thereto, where the accelerator is a heterogeneous resource with respect to the instruction sequencer. An interface may be used to provide the communication between these resources. Via such a communication mechanism a user-level application may directly communicate with the accelerator without operating system support. Further, the instruction sequencer and the accelerator may perform operations in parallel. Other embodiments are described and claimed. | 03-12-2015 |
20150277949 | SECURING SHARED INTERCONNECT FOR VIRTUAL MACHINE - A processing system includes an interconnect and a processing core, coupled to the interconnect, to execute a plurality of virtual machines each being identified by a respective identifier, and tag, by an identifier of the first virtual machine, a first transaction initiated by a first virtual machine to access the interconnect. | 10-01-2015 |
20150278119 | HARDWARE-ASSISTED VIRTUALIZATION FOR IMPLEMENTING SECURE VIDEO OUTPUT PATH - Systems and methods for employing hardware-assisted virtualization for implementing a secure video output path. An example processing system comprises: a memory; a shared interconnect; and a processing core communicatively coupled to the memory via the shared interconnect, the processing core to: initialize a first virtual machine and a second virtual machine; responsive to receiving a memory access transaction initiated by the first virtual machine to access a memory buffer, tag the memory access transaction with an identifier of the first virtual machine; and responsive to receiving a digital content decoder access transaction initiated by the second virtual machine, tag the digital decoder access transaction with an identifier of the second virtual machine. | 10-01-2015 |
20160004533 | Methods And Apparatuses For Reducing Power Consumption Of Processor Switch Operations - Methods and apparatuses for reducing power consumption of processor switch operations are disclosed. One or more embodiments may comprise specifying a subset of registers or state storage elements to be involved in a register or state storage operation, performing the register or state storage operation, and performing a switch operation. The embodiments may minimize the number of registers or state storage elements involved with the standby operation by specifying only the subset of registers or state storage elements, which may involve considerably fewer than the total number of registers or state storage or elements of the processor. The switch operation may be switch from one mode to another, such as a transition to or from a sleep mode, a context switch, or the execution of various types of instructions. | 01-07-2016 |
20160019067 | MECHANISM FOR INSTRUCTION SET BASED THREAD EXECUTION ON A PLURALITY OF INSTRUCTION SEQUENCERS - In an embodiment, a method is provided. The method includes managing user-level threads on a first instruction sequencer in response to executing user-level instructions on a second instruction sequencer that is under control of an application level program. A first user-level thread is run on the second instruction sequencer and contains one or more user level instructions. A first user level instruction has at least 1) a field that makes reference to one or more instruction sequencers or 2) implicitly references with a pointer to code that specifically addresses one or more instruction sequencers when the code is executed. | 01-21-2016 |
Hong Wang, Guangdong Province CN
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20110065321 | PORTABLE MULTI-FUNCTIONAL DATA STORAGE TRANSMITTING AND CONNECTING DEVICE - A multi-functional data storage and transmitting and connecting device for an electronic device, includes a data transfer cable having a predetermined length, at least a first and a second connector provided at two ends of the data transfer cable respectively and a coupling element. The coupling element includes a plurality of connector sockets adapted for fittedly and detachably receiving the connectors so as to detachably couple the connectors into a handy structure, a control circuitry received in the coupling element, and a hanging device. The control circuitry includes an integrated circuit chipset, a rechargeable battery provided within the coupling element for recharging the electronic device, a call receiving circuitry electrically connected with the integrated circuit chipset, a speakerphone electrically connected with sad call receiving circuitry, an amplifier adapted for amplifying audio signal, and a wireless transceiver electrically connected with the integrated circuit chipset for wirelessly receiving and transmitting signal. | 03-17-2011 |
Hong Wang, San Jose, CA US
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20080215861 | METHOD AND APPARATUS FOR EFFICIENT RESOURCE UTILIZATION FOR PRESCIENT INSTRUCTION PREFETCH - Embodiments of an apparatus, system and method enhance the efficiency of processor resource utilization during instruction prefetching via one or more speculative threads. Renamer logic and a map table are utilized to perform filtering of instructions in a speculative thread instruction stream. The map table includes a yes-a-thing bit to indicate whether the associated physical register's content reflects the value that would be computed by the main thread. A thread progress beacon table is utilized to track relative progress of a main thread and a speculative helper thread. Based upon information in the thread progress beacon table, the main thread may effect termination of a helper thread that is not likely to provide a performance benefit for the main thread. | 09-04-2008 |
20110035555 | METHOD AND APPARATUS FOR AFFINITY-GUIDED SPECULATIVE HELPER THREADS IN CHIP MULTIPROCESSORS - Apparatus, system and methods are provided for performing speculative data prefetching in a chip multiprocessor (CMP). Data is prefetched by a helper thread that runs on one core of the CMP while a main program runs concurrently on another core of the CMP. Data prefetched by the helper thread is provided to the helper core. For one embodiment, the data prefetched by the helper thread is pushed to the main core. It may or may not be provided to the helper core as well. A push of prefetched data to the main core may occur during a broadcast of the data to all cores of an affinity group. For at least one other embodiment, the data prefetched by a helper thread is provided, upon request from the main core, to the main core from the helper core's local cache. | 02-10-2011 |
Hong Wang, Shanghai CN
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20090151855 | Localized heating via an infrared heat source array of edge seals for a vacuum insulating glass unit, and/or unitized oven with infrared heat source array for accomplishing the same - Certain example embodiments of this invention relate to edge sealing techniques for vacuum insulating glass (VIG) units. More particularly, certain example embodiments relate to techniques for providing localized heating to edge seals of units, and/or unitized ovens for accomplishing the same. In certain example embodiments, a unit is pre-heated to one or more intermediate temperatures, localized heating via at least one substantially two-dimensional array of heat sources is provided proximate to the peripheral edges of the unit so as to melt frits placed thereon, and cooled. In certain non-limiting implementations, the pre-heating and/or cooling may be provided in one or more steps. An oven for accomplishing the same may include multiple zones for performing the above-noted steps, each zone optionally including one or more chambers. Accordingly, in certain example embodiments, a temperature gradient proximate to the edges of the unit is created, thereby reducing the chances of breakage and/or at least some de-tempering of the substrates. | 06-18-2009 |
20100215967 | Techniques for applying mar reducing overcoats to articles having layer stacks disposed thereon - Certain example embodiments of this invention relate to techniques for applying an overcoat (e.g., which may include an organic material) to a coated article having a layer stack already disposed thereon in order to reduce the potential for surface marring. An evacuative process may be used to deposit the mar reducing overcoat. The coated article including the mar-reducing overcoat has a contact angle greater than, and a surface friction less than, a contact angle and a surface friction of the single- or multi-layer stack supported by the substrate alone. Any marring due to cat-scratching or the like preferably would not be visible at 4× magnification following application of the mar reducing overcoat. | 08-26-2010 |
20100279038 | Edge profiles for vacuum insulated glass (VIG) units, and/or VIG unit including the same - Certain example embodiments of this invention relate to vacuum insulated glass (VIG) units. The VIG unit may comprise first and second substrates with inner and outer substantially planar surfaces. For either or both of the first and second substrates, when considered along a side cross-section, a portion of the inner planar surface is removed proximate to an outer edge of the glass substrate so as to form a shoulder portion. An inner surface of the shoulder portion is angled (a negative number of degrees, zero degrees, or a positive number of degrees) relative to the inner and outer planar surfaces. The shoulder portion at its smallest height is at least about 50% of the glass substrate at its largest height. A side portion of the step proximate the edge also may be angled, e.g., so that it is or is not perpendicular to the planar surfaces. | 11-04-2010 |
20130108848 | COATED ARTICLE WITH LOW-E COATING INCLUDING TIN OXIDE INTERLAYER | 05-02-2013 |
20130298606 | LOCALIZED HEATING VIA AN INFRARED HEAT SOURCE ARRAY OF EDGE SEALS FOR A VACUUM INSULATING GLASS UNIT, AND/OR UNITIZED OVEN WITH INFRARED HEAT SOURCE ARRAY FOR ACCOMPLISHING THE SAME - Certain example embodiments of this invention relate to edge sealing techniques for vacuum insulating glass (VIG) units. More particularly, certain example embodiments relate to techniques for providing localized heating to edge seals of units, and/or unitized ovens for accomplishing the same. In certain example embodiments, a unit is pre-heated to one or more intermediate temperatures, localized heating via at least one substantially two-dimensional array of heat sources is provided proximate to the peripheral edges of the unit so as to melt frits placed thereon, and cooled. In certain non-limiting implementations, the pre-heating and/or cooling may be provided in one or more steps. An oven for accomplishing the same may include multiple zones for performing the above-noted steps, each zone optionally including one or more chambers. Accordingly, in certain example embodiments, a temperature gradient proximate to the edges of the unit is created, thereby reducing the chances of breakage and/or at least some de-tempering of the substrates. | 11-14-2013 |
20140242407 | In-situ Compressed Specimen for Evaluating Mechanical Property of Copper Interconnection Micro Column and Preparation Method thereof - An in-situ compressed specimen of copper interconnection micro column, which is a circular metal column formed in a PDMS hole, includes: a specimen part and a fixed end part for fixing the specimen; wherein the fixed end part is a circular or square plate structure, the specimen part is an upper part of the fixed end part; a main body of the present invention is of micron order, a forced direction of the specimen is consistent with a growth direction of the metal column. A method of electroplating copper column by adopting PDMS as template substrate is applied to overcome a problem that TSV is corrosive to the copper column during a silicon etching process so as to affect a mechanical property accuracy test, the method is advanced in shortening test process period, achieving good reproducibility and high yield. | 08-28-2014 |
20160107919 | LOCALIZED HEATING VIA AN INFRARED HEAT SOURCE ARRAY OF EDGE SEALS FOR A VACUUM INSULATING GLASS UNIT, AND/OR UNITIZED OVEN WITH INFRARED HEAT SOURCE ARRAY FOR ACCOMPLISHING THE SAME - Certain example embodiments of this invention relate to edge sealing techniques for vacuum insulating glass (VIG) units. More particularly, certain example embodiments relate to techniques for providing localized heating to edge seals of units, and/or unitized ovens for accomplishing the same. In certain example embodiments, a unit is pre-heated to one or more intermediate temperatures, localized heating via at least one substantially two-dimensional array of heat sources is provided proximate to the peripheral edges of the unit so as to melt fits placed thereon, and cooled. In certain non-limiting implementations, the pre-heating and/or cooling may be provided in one or more steps. An oven for accomplishing the same may include multiple zones for performing the above-noted steps, each zone optionally including one or more chambers. Accordingly, in certain example embodiments, a temperature gradient proximate to the edges of the unit is created, thereby reducing the chances of breakage and/or at least some de-tempering of the substrates. | 04-21-2016 |
Hong Wang, San Carlos, CA US
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20100255508 | USE OF BIOMARKERS FOR ASSESSING TREATMENT OF GASTROINTESTINAL INFLAMMATORY DISORDERS WITH BETA7 INTEGRIN ANTAGONISTS - The present invention is directed to methods of using biomarkers to assess treatment of gastrointestinal inflammatory disorders with beta7 antagonists. More particularly, the present invention relates to methods of using the level of gut-homing lymphocytes in peripheral blood, the level of drug occupancy on gut-homing lymphocytes, and/or the level of beta7 integrin receptors on gut-homing lymphocytes as indicators (or biomarkers) of the effect, efficacy, safety, prognosis, and/or dosing of therapeutic agents, such as beta7 integrin antagonists, for the treatment of gastrointestinal inflammatory disorders. | 10-07-2010 |
20130109032 | USE OF BIOMARKERS FOR ASSESSING TREATMENT OF GASTROINTESTINAL INFLAMMATORY DISORDERS WITH BETA7 INTEGRIN ANTAGONISTS | 05-02-2013 |
Hong Wang, Malden, MA US
Hong Wang, Milpitas, CA US
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20100183488 | DEVICES AND METHODS FOR THE SYNTHESIS OF NUCLEIC ACIDS - Cylindrical devices (frits) are prepared by embedding aminoalkyl- or mercaptoalkyl-modified Controlled Pore Glass (CPG) in high-density polyethylene. Methods and devices pertaining to their use in the synthesis of nucleic acids are described. A reusable synthesis column or a reusable 96-chamber synthesis plate have been designed to hold one to 96 of the said frits that are inserted reproducibly into the synthesis chambers with a frit insertor. A short gas surpressure is required to drive entry of chemical reagents into the said frit. Reagents are retained into the frit until a second, longer surpressure is applied to drain the said reagents. | 07-22-2010 |
Hong Wang, Xi'An CN
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20100105538 | Microwave Dielectric Ceramics And Method For Manufacturing The Same - A method for manufacturing microwave dielectric ceramics has the steps of: mixing multiple A-metal compounds and sintering multiple A-metal compounds between 1350˜1450° C. for 2˜4 hr to make a first component Ba | 04-29-2010 |
Hong Wang, Hamilton CA
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20100003703 | ASSAY SYSTEM FOR GLP-2 RECEPTOR LIGANDS - Disclosed herein is a method for measuring the contractility of intestinal tissue upon treatment with GLP-2 or a GLP-2 ligand. Also disclosed is an assay which directly measures the activity of GLP-2 or GLP-2 ligands ex vivo and permits the screening of putative GLP-2 ligands in native tissue. | 01-07-2010 |
20120003681 | EX VIVO METHOD FOR DETERMINING POTENTIAL GLP-2 RECEPTOR MODULATIONS - Disclosed herein is a method for measuring the contractility of intestinal tissue upon treatment with GLP-2 or a GLP-2 ligand. Also disclosed is an assay which directly measures the activity of GLP-2 or GLP-2 ligands ex vivo and permits the screening of putative GLP-2 ligands in native tissue. | 01-05-2012 |
20120295298 | EX VIVO METHOD FOR DETERMINING POTENTIAL GLP-2 RECEPTOR MODULATORS - Disclosed herein is a method for measuring the contractility of intestinal tissue upon treatment with GLP-2 or a GLP-2 ligand. Also disclosed is an assay which directly measures the activity of GLP-2 or GLP-2 ligands ex vivo and permits the screening of putative GLP-2 ligands in native tissue. | 11-22-2012 |
20150153329 | ASSAY SYSTEM FOR GLP-2 RECEPTOR LIGANDS - Disclosed herein is a method for measuring the contractility of intestinal tissue upon treatment with GLP-2 or a GLP-2 ligand. Also disclosed is an assay which directly measures the activity of GLP-2 or GLP-2 ligands ex vivo and permits the screening of putative GLP-2 ligands in native tissue. | 06-04-2015 |
Hong Wang, East Brunswick, NJ US
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20090137420 | METHODS, COMPOUNDS AND COMPOSITIONS WITH GENOTYPE SELECTIVE ANTICANCER ACTIVITY - This invention is directed to methods for screening and identification of compounds capable of selectively eliminating cancer cells with specific loss-of-function alterations, including but not limited to mutations, deletions, hypermethylations, and other types of gene silencing. This invention is also directed to novel compounds that selectively eliminate cancer cells with specific loss-of-function alterations. Furthermore, this invention is directed to methods for production and therapeutic use of compounds that selectively eliminate cancer cells with specific loss-of-function alterations. | 05-28-2009 |
Hong Wang, Havertown, PA US
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20080307536 | Voltage-Gated, Ph-Sensitive Anion Channel And Its Novel Splice Variant Involved In Taste Sensation - The invention provides a novel splice-variant of the ClC-4 protein, termed ClC-4A. ClC-4A is expressed in taste bud cells and is involved in sour taste perception. The invention provides ClC-4A polynucleotides and ClC-4A polypeptides, vectors, host cells and ClC-4A specific antibodies as well as designing high potency taste stimuli, determining taste preferences in animals, developing breed-specific foods, and modifying the taste of foods and medications. | 12-11-2008 |
20090123456 | Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists - A method of treating a patient suffering from pancreatitis comprising treating said patient with a therapeutically effective amount of a cholinergic agonist selective for an α7 nicotinic receptor in an amount sufficient to decrease the amount of the proinflammatory cytokine that is released from a macrophage wherein said condition is acute pancreatitis. The compounds of the present invention include a quaternary analog of cocaine; (1-aza-bicyclo[2.2.2]oct-3-yl)-carbamic acid 1-(2-fluorophenyl)-ethyl ester; a compound of formula (I), a compound of formula (II), a compound of formula (III), a compound of formula (IV), and an oligonucleotide or mimetic capable of attenuating the symptoms of acute pancreatitis wherein the oligonucleotide or mimetic consists essentially of a sequence greater than 5 nucleotides long that is complementary to an mRNA of an α7 cholinergic receptor. The variables of formulae (I), (II), (III) and (IV) are described herein. | 05-14-2009 |
20110166148 | TREATMENT OF INFLAMMATION USING ALPHA 7 RECEPTOR-BINDING CHOLINERGIC AGONISTS - A method of treating a patient suffering from pancreatitis comprising treating said patient with a therapeutically effective amount of a cholinergic agonist selective for an α7 nicotinic receptor in an amount sufficient to decrease the amount of the proinflammatory cytokine that is released from a macrophage wherein said condition is acute pancreatitis. The compounds of the present invention include a quaternary analog of cocaine; (1-aza-bicyclo[2.2.2]oct-3-yl)-carbamic acid 1-(2-fluorophenyl)-ethyl ester; a compound of formula (I), a compound of formula (II), a compound of formula (III), a compound of formula (IV), and an oligonucleotide or mimetic capable of attenuating the symptoms of acute pancreatitis wherein the oligonucleotide or mimetic consists essentially of a sequence greater than 5 nucleotides long that is complementary to an mRNA of an α7 cholinergic receptor. The variables of formulae (I), (II), (III) and (IV) are described herein. | 07-07-2011 |
20110245286 | TREATMENT OF INFLAMMATION USING ALPHA 7 RECEPTOR-BINDING AGONISTS - Methods of inhibiting release of a proinflammatory cytokine from a macrophage are provided. The methods comprise treating the macrophage with a cholinergic agonist in an amount sufficient to decrease the amount of the proinflammatory cytokine that is released from the macrophage, wherein the cholinergic agonist is selective for an α7 nicotinic receptor. Methods for inhibiting an inflammatory cytokine cascade in a patient are also provided. The methods comprise treating the patient with a cholinergic agonist in an amount sufficient to inhibit the inflammatory cytokine cascade, wherein the cholinergic agonist is selective for an α7 nicotinic receptor. Methods for determining whether a compound is a cholinergic agonist reactive with an α7 nicotinic receptor are also provided. The methods comprise determining whether the compound inhibits release of a proinflammatory cytokine from a mammalian cell. Additionally, methods for determining whether a compound is a cholinergic antagonist reactive with an α7 nicotinic receptor are provided. These methods comprise determining whether the compound reduces the ability of a cholinergic agonist to inhibit the release of a proinflammatory cytokine from a mammalian cell. Oligonucleotides or mimetics capable of inhibiting attenuation of lipopolysaccharide-induced TNF release from a mammalian macrophage upon exposure of the macrophage to a cholinergic agonist are also provided. The oligonucleotides or mimetics consist essentially of a sequence greater than 5 nucleotides long that is complementary to an mRNA of an α7 receptor. Additionally, methods of inhibiting attenuation of TNF release from a mammalian macrophage upon exposure of the macrophage to a cholinergic agonist are provided. These methods comprise treating the macrophage with the above-described oligonucleotide or mimetic. | 10-06-2011 |
20150359785 | TREATMENT OF INFLAMMATION USING ALPHA 7 RECEPTOR-BINDING AGONISTS - Methods of inhibiting release of a proinflammatory cytokine from a macrophage are provided. The methods comprise treating the macrophage with a cholinergic agonist in an amount sufficient to decrease the amount of the proinflammatory cytokine that is released from the macrophage, wherein the cholinergic agonist is selective for an α7 nicotinic receptor. Methods for inhibiting an inflammatory cytokine cascade in a patient are also provided. The methods comprise treating the patient with a cholinergic agonist in an amount sufficient to inhibit the inflammatory cytokine cascade, wherein the cholinergic agonist is selective for an α7 nicotinic receptor. Methods for determining whether a compound is a cholinergic agonist reactive with an α7 nicotinic receptor are also provided. The methods comprise determining whether the compound inhibits release of a proinflammatory cytokine from a mammalian cell. Additionally, methods for determining whether a compound is a cholinergic antagonist reactive with an α7 nicotinic receptor are provided. These methods comprise determining whether the compound reduces the ability of a cholinergic agonist to inhibit the release of a proinflammatory cytokine from a mammalian cell. Oligonucleotides or mimetics capable of inhibiting attenuation of lipopolysaccharide-induced TNF release from a mammalian macrophage upon exposure of the macrophage to a cholinergic agonist are also provided. The oligonucleotides or mimetics consist essentially of a sequence greater than 5 nucleotides long that is complementary to an mRNA of an α7 receptor. Additionally, methods of inhibiting attenuation of TNF release from a mammalian macrophage upon exposure of the macrophage to a cholinergic agonist are provided. These methods comprise treating the macrophage with the above-described oligonucleotide or mimetic. | 12-17-2015 |
Hong Wang, Somerville, MA US
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20090099099 | Isoflavone Glycosides as Peroxisome Proliferator-Activated Receptor-alpha Modulator - A method of treating or preventing diseases related to modulation of PPAR-α in comprising administering to a human or other mammals in need of such treatment an effective amount of plant material derived from plants of the genera | 04-16-2009 |
Hong Wang, Kennet Square, PA US
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20080317691 | PEPTIDE-BASED CONDITIONERS AND COLORANTS FOR HAIR, SKIN, AND NAILS - Peptides have been identified that bind with high affinity to hair, skin, and nails. Peptide-based hair conditioners, hair colorants, skin conditioners, skin colorants, and nail colorants based are described. The peptide-based hair conditioners and hair colorants consist of a hair-binding peptide coupled to a hair conditioning agent or a coloring agent, respectively. The peptide-based skin conditioners and skin colorants consist of a skin-binding peptide coupled to a skin conditioning agent or a colorant, respectively. The peptide-based nail colorants consist of a nail-binding peptide coupled to a coloring agent. In all these compositions, the peptide may be directly coupled to the active agent or the coupling may be via a spacer. Personal care compositions containing these peptide-based conditioners and colorants are also described. | 12-25-2008 |
Hong Wang, Ellicott City, MD US
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20080249054 | METHOD OF MEASURING LIPID DROPLETS AND APPLICATIONS OF USING THE SAME - The invention relates to methods of screening agents for the ability to regulate lipid metabolism and using said agents to treat diseases or disorders related to lipid metabolism (e.g., obesity, diabetes [non-insulin and insulin dependent], hypertension, coronary artery disease, hyperlipidemia (e.g., LDL, TAGs), hypolipidemia (e.g., HDL), lipid metabolism disorders, lipid deposition disorders, lipodystrophies). In specific embodiments, the invention relates to using a PAT family protein to screen agents for the ability to regulate lipid metabolism and using the same to treat diseases or disorders related to lipid metabolism. In further embodiments, the invention relates to high throughput screening (HTS) methods that can be used in the drug discovery process for screening agents for the ability to regulate lipid metabolism. | 10-09-2008 |
Hong Wang, Belleville, MI US
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20110117371 | Coated article with low-E coating including tin oxide interlayer - A coated article is provided which may be heat treated thermally tempered) in certain instances. In certain example embodiments, an interlayer of or including a metal oxide such as tin oxide is provided under an infrared (IR) reflecting layer so as to be located between respective layers comprising silicon nitride and zinc oxide. It has been found that the use of such a tin oxide inclusive interlayer results in significantly improved mechanical durability, thermal stability and/or haze characteristics. | 05-19-2011 |
20120141806 | COATED ARTICLE WITH LOW-E COATING INCLUDING TIN OXIDE INTERLAYER - A coated article is provided which may be heat treated (e.g., thermally tempered) in certain instances. In certain example embodiments, an interlayer of or including a metal oxide such as tin oxide is provided under an infrared (IR) reflecting layer so as to be located between respective layers comprising silicon nitride and zinc oxide. It has been found that the use of such a tin oxide inclusive interlayer results in significantly improved mechanical durability, thermal stability and/or haze characteristics. | 06-07-2012 |
Hong Wang, Centennial, CO US
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20110214195 | Methods For Treating Clinical Conditions Associated With Lipoprotein Lipase Activity - The present invention provides methods for treating a clinical condition associated with lipoprotein lipase activity in the brain of a subject. | 09-01-2011 |
Hong Wang, New York, NY US
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20110288083 | METHOD OF TREATING CANCER BY INHIBITION OF PROTEIN KINASE-LIKE ENDOPLASMIC RETICULUM PROTEIN KINASE - The present invention relates to a method of identifying compounds useful in inhibiting protein kinase-like endoplasmic reticulum protein kinase (PERK). The method comprises providing a first model comprising PERK active domains, where the said active domains are selected from the group consisting of the peptide spanning from amino acid residue Asp144 to amino acid residue Ser191 of SEQ ID NO: 1 and a peptide comprising the amino acid residue at position 7 of SEQ ID NO: 1, providing one or more candidate compounds, evaluating contact between the candidate compounds and the first model to determine which of the one or more candidate compounds have an ability to bind to and/or fit in the first model, and identifying the compounds which, based on said evaluating, have the ability to bind to and/or fit in the first model as compounds potentially useful for inhibiting PERK. The present invention further relates to compounds that can be used for inhibition of PERK, for example human PERK, and methods related to treatment of PERK-mediated diseases. | 11-24-2011 |
Hong Wang, Guangdong CN
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20120019020 | INTEGRATED REFRIGERATOR CAR CARRIAGE STRUCTURE AND MOUNTING METHOD THEREOF - An integrated refrigerator car carriage structure is disclosed. The carriage structure has a protection layer ( | 01-26-2012 |
20120031912 | WALL STRUCTURE OF LARGE-SIZED REFRIGERATED STORAGE AND CONSTRUCTION METHOD THEREOF - A wall structure of a large-sized refrigerated storage and a construction method thereof are provided. The wall structure comprises an interior wall board ( | 02-09-2012 |
20120037582 | SUSPENDED CEILING STRUCTURE FOR REFRIGERATED STORAGE AND CONSTRUCTION METHOD THEREOF - A suspended ceiling structure for a refrigerated storage and a construction method thereof are provided. The suspended ceiling structure comprises a ceiling grid which comprises a main grid, hanging members and an attachment grid. An insulating strip made of polyurethane foam is placed on the main grid so as to serve as a cushion block. An upper color-coated steel sheet is provided above the insulating strip and a lower color-coated steel sheet is arranged below the main grid. A thermal break component is arranged between the main grid and the lower steel sheet, and a polyurethane insulating material is sprayed in successive layers between the upper and lower color coated steel sheets. The ceiling structure can improve the insulation effect of the refrigerated storage and save energy. | 02-16-2012 |
Hong Wang, Guangzhou CN
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20120043729 | CARRIAGE SEALING STRUCTURE FOR REFRIGERATOR CAR AND WORKING METHOD THEREOF - A carriage sealing structure for refrigerator car is disclosed. The carriage is composed of core carriage plates provided with a heat preservation layer that is made of polyurethane. The carriage plates include a left side plate ( | 02-23-2012 |
20140059833 | Wall Structure Of Large-Sized Refrigerated Storage And Construction Method Thereof - A method for constructing a wall structure, which comprises an interior wall board, an exterior wall board and a skeleton positioned between the interior wall board and the exterior wall board. The method for construction the wall comprises the following steps: A. building the wall skeleton; B. mounting a color steel plate on the outer surface of the skeleton to form an exterior wall board of the wall; C. painting the polyurethane spraying material on the exterior wall board layer by layer for multiple times, and reserving a pouring apace at a distance of 40 to 80 mm from the installation position of a interior wall board; and D. taking the color steel plate of the interior wall as a mould plate and pouring space at the color steel plate of the interior wall to form the interior wall board of the wall. | 03-06-2014 |
20140350225 | ANTI-BFGF HUMANIZED DOUBLE-STRANDED ANTIBODY WITH STABLE DISULFIDE BOND, PREPARATION METHOD AND APPLICATION THEREOF - Disclosed are an anti-bFGF humanized double-stranded antibody with stable disulfide bond, the preparation method and the applications thereof. The amino acid sequence of the anti-bFGF humanized ds-Diabody is shown in SEQ ID NO. 1. The nucleotide sequence of gene encoding the anti-bFGF humanized ds-Diabody is shown in SEQ ID NO. 2. By site-directed mutation, two cysteine residues are introduced into each single-stranded antibody, thus introducing the disulfide bond and form ds-Diabody. It is shown by experiments that the obtained ds-Diabody has the following advantages: enhanced stability; better affinity when binding to the specific antigen bFGF; moderate relative molecular weight, good tumor targeting, more powerful in tumor tissue penetration, and higher blood clearance rate, showing a broad application prospects in the clinic diagnosis and tumor therapy. | 11-27-2014 |
Hong Wang, Tianjin CN
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20120090988 | ANTI-POLLUTION ELECTROCATALYSIS COMPOSITE MEMBRANE AND MEMBRANE REACTOR - The present invention relates an antifouling electrocatalytic composite membrane and a membrane reactor. The electrocatalytic composite membrane ( | 04-19-2012 |
20150152201 | BENZOCROWN ETHER GRAFT POLYMER WITH LITHIUM ISOTOPIC SEPARATION EFFECT AND PREPARATION METHOD THEREOF - Disclosed in the present invention is a benzocrown ether graft polymer with a lithium isotopic separation effect and a preparation method thereof. The polymer is a benzocrown ether graft polymer formed by the linkage of chemical bonds, which takes the main chain of a polymer containing chloromethyl group, chloroformyl group or hydroxyl group as main chain, and takes a benzocrown ether as pendant group. The preparation process of the polymer comprises the following steps: preparing polymer solution with certain concentration by dissolving a polymer containing chloromethyl group, chloroformyl group or hydroxyl group in a solvent; then blending a catalyst and a benzocrown ether containing carboxyl group or aldehydyl group and dissolving in the polymer solution containing hydroxyl group, or blending an acid-binding agent and a benzocrown ether containing amino group or hydroxyl group and dissolving in the polymer solution containing chloromethyl group or chloroformyl group, reacting at a certain temperature and for a certain time, linking the benzocrown ether to the main chain of polymer by chemical bonds, and precipitating by adding a precipitating agent to obtain the graft polymer. The grafting polymer has excellent characteristic of lithium isotopic separation. | 06-04-2015 |
Hong Wang, Suzhou CN
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20120092196 | METHOD FOR INPUTTING TEXT USING NUMERIC KEYPAD - A method for inputting text using the keys of 0-9 of a numeric keypad. The code length of digital encoding may be from 4 to 5 bits. For Chinese-characters, the total number of strokes expressed by two figures may correspond to the first two bits, the first three stroke codes may correspond to the third to the fifth bits, respectively, and inputting the termination code when the total code length is less than 5 bits. For letters, figures, and symbols, two bits express the serial number, the third bit is an identification code, and the fourth bit is the termination code, Chinese-characters and other characters may be inputted with the same input method without switching the input state. The probability of repeated codes is low. The methods can be used by various kinds of input devices with numeric keys. | 04-19-2012 |
Hong Wang, Waltham, MA US
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20120177741 | POSITIVELY-CHARGED POLY (D,L-LACTIDE-CO-GLYCOLIDE) NANOPARTICLES AND FABRICATION METHODS OF THE SAME - The present technology provides compositions with positively-charged poly(d,l-lactide-co-glycolide) nanoparticles capable of releasing a bioactive substance in a body tissue for extended periods of time, as well as methods for manufacture of the same and methods for prophylactic and therapeutic treatment of a subject in need thereof. | 07-12-2012 |
20120225834 | OCULAR IONTOPHORESIS OF CHARGED MICELLES CONTAINING BIOACTIVE AGENTS - This invention is related to pharmaceutical compositions consisting of charged micelles containing bioactive agents. The invention is also related to the methods of delivery of charged micelles to the eye of a mammal by iontophoresis. | 09-06-2012 |
Hong Wang, Bejing CN
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20120258767 | METHOD FOR GUARANTEEING ESTABLISHMENT OF LOCAL IP ACCESS CORRECTLY - A method for guaranteeing correct establishment of Local IP Access service includes: obtaining the service type of a user equipment (UE) and the equipment capability type of a base station. The method also includes determining whether the UE and the base station are consistent. The method also includes, in response to determining that the UE and the base station are consistent, establishing LIPA service for the UE. The method also includes, in response to determining that the UE and the base station are inconsistent, deciding whether to establish LIPA service for the UE according to the preserved strategy. | 10-11-2012 |
Hong Wang, Huzhou CN
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20130029232 | LITHIUM ION SECONDARY BATTERY INCLUDING IONIC LIQUID ELECTROLYTE - A lithium ion secondary battery includes a positive electrode, a negative electrode, a separator and an ionic liquid electrolyte. The separator is a polar porous membrane. The ionic liquid electrolyte and the separator made of the polar porous are used in the lithium ion secondary batteries, which can improve the electrochemical performance of the lithium ion secondary batteries. | 01-31-2013 |
Hong Wang, Oro Valley, AZ US
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20130122516 | DETECTING TARGETS USING MASS TAGS AND MASS SPECTROMETRY - Particular disclosed embodiments disclosed herein concern using a one or more various mass tags, which can be specifically deposited at targets through direct or indirect enzymatic-catalyzed transformation, to provide a method for identifying targets in tissue samples. The mass tags may be labeled with stable isotopes to produce mass tags having the same chemical structure but different masses. Mass codes produced by ionizing the mass tags are detected and/or quantified using mass spectrometry. The method can be used for multiplexed detection of multiple targets in a particular sample. In some embodiments, a map divided into sections representing sections of the tissue sample may be prepared, with the map sections including data corresponding to quantification data wherein the size of a mass peak is determined and correlated with the amount of a target for the corresponding tissue sample section. | 05-16-2013 |
Hong Wang, Shenzhen CN
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20130125392 | Mounting of Components Using Solder Paste Fiducials - A printed circuit board may have patterned traces. Components may be mounted to the printed circuit board using solder. Solder paste may be printed onto the printed circuit board using a stencil. Following reflow operations, the solder paste may form solder bumps that connect component leads to traces on the printed circuit board. Misalignment between the mounted components and printed circuit board traces can be minimized by forming fiducials from solder paste. During the process of printing solder paste patterns on the printed circuit board, solder paste printing equipment may form the solder paste fiducials. Component mounting equipment may use cameras or other imaging equipment to gather information on the location of the solder paste fiducials. The component mounting equipment may then mount the components on the printed circuit using the information on the location of the solder paste fiducials. | 05-23-2013 |
20150130426 | Digital current equalizing device, analog current equalizing device, current equalizing method and system - Provided are a digital current equalizing device, an analog current equalizing device, a current equalizing method and a system. The digital current equalizing device comprises: an output current sampling amplifying module ( | 05-14-2015 |
20150138231 | Method, device and system for realizing augmented reality information sharing - A method, device and system for realizing augmented reality information sharing are disclosed. The method includes that an intelligent mobile terminal transmits an obtained current image and determined current position information to a cloud end server; the cloud end server sends the received image to a computer related to the intelligent mobile terminal, obtains attribute information of the image according to the received position information, and sends the attribute information to the intelligent mobile terminal and the computer; and the intelligent mobile terminal and the computer respectively overlap the image and the attribute information to form augmented reality information. The disclosure can realize sharing of augmented reality information. | 05-21-2015 |
Hong Wang, Cypress, TX US
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20130143777 | Method for Strengthening a Wellbore of a Well - Method for substantially sealing at least a portion of a wall of a wellbore. Method includes selecting a fracture sealing width defined by the portion of the wellbore wall and the formation, and formulating a fracture sealing composition based on the fracture sealing width. Sealing fluid includes drilling fluid, cementing slurry, completion fluid, and a concentration of particulates forming the fracture sealing composition. The method also includes determining a spurt loss volume of the sealing fluid based at least on the fracture sealing width, determining a fracture volume capacity based at least on the fracture sealing width, and comparing the spurt loss volume of the sealing fluid to the fracture volume capacity. If the sealing fluid has a spurt loss volume less than or equal to the fracture volume capacity, the sealing fluid is pumped into the wellbore, wherein the sealing fluid forms a sealing relationship with the fracture. | 06-06-2013 |
20150233205 | Pumping Fluid To Seal A Subterranean Fracture - The disclosure teaches a method of sealing fractures in a wellbore wherein the steps comprise pumping a first sealing fluid into a wellbore under pressure, monitoring the hydraulic pressure of the sealing fluid in the wellbore for an indicator of seal initialization, stopping the pumping of fluid into the wellbore, monitoring the hydraulic pressure of the sealing fluid in the wellbore, and pumping a second sealing fluid into the wellbore. The disclosure also includes the method wherein the concentration of sealing materials in the first fluid is greater than the concentration of sealing materials in the second fluid and the method wherein the first sealing fluid contains a higher concentration of larger diameter sealing materials than the second sealing fluid. The disclosure also includes a method wherein the pumping rate change between the first pumping of sealing fluid and the pumping of the second sealing fluid. The first and second sealing fluids can be the same. The sealing materials of a sealing fluid are selected such that some of the sealing materials are larger than an estimated original fracture size. | 08-20-2015 |
20150275600 | METHOD FOR SWEEPING SOLIDS OR DISPLACING A FLUID IN A WELLBORE - A method and system for removing solids or displacing a fluid from a wellbore wherein a plurality of resilient rubber-like flexible reticulated open cell foam elements are dispersed in a fluid and pumped through drill pipe and into the annulus between the wellbore and the drill pipe. In the annulus, the foam elements impact and dislodge solids such as proppants, gravels, drilled cuttings and other solids or a fluid to be displaced and the proppants, etc. or the fluid are carried by the fluid containing the foam elements back to the surface or a different location in the wellbore. At the surface, the fluid containing the foam elements and the proppants, etc., is carried to a shale shaker where the solids and the foam elements are separated from the fluid. The separated solids and foam are collected for disposal and, after adding new foam elements, the fluid can be recirculated down hole. | 10-01-2015 |
20150292278 | Method of Stopping Lost Circulation - A method for forming a seal to subterranean fractures or other voids penetrated by a wellbore comprises a particulate sealing formulation of fast sealing and fast strengthening. To achieve fast sealing, the particulate formulation is comprised of particulates of a wide and continuous particle size distribution. Furthermore, the method comprises minimizing the spurt loss of a formulation by adjusting its particulates larger than D30, based on evaluation with a slot disk test method. The fast strengthening of the formulation is achieved by fast accumulation of particulates onto the initially formed seal. Furthermore, the method comprises maximizing the fluid loss after spurt of a formulation by adjusting its particulates smaller than D30 or adding some diatomaceous earth. At least 5% of the sealing particulates by volume of the total particulates are smaller than 200 micron and acid soluble. | 10-15-2015 |
20150292279 | Method of Stopping Lost Circulation - A method for forming a seal to subterranean fractures or other voids penetrated by a wellbore comprises a particulate sealing formulation of fast sealing and/or fast strengthening. To achieve fast sealing, the particulate formulation is comprised of multiple groups of particulates of a narrow particle size distribution. Furthermore, the method comprises minimizing the spurt loss of a formulation by adjusting its particulates larger than D30, based on evaluation with a slot disk test method. The fast strengthening of the formulation is achieved by fast accumulation of particulates. Furthermore, the method comprises maximizing the fluid loss after spurt of a formulation by adjusting its particulates smaller than D30 or adding some diatomaceous earth or selecting particulates of a D75 larger than 75 microns and with a narrow particle size distribution. At least 5% of the sealing particulates by weight of the total particulates are smaller than 200 micron and acid soluble. | 10-15-2015 |
20160002998 | Method of Supporting a Subterranean Conduit - A method and apparatus for consolidating a formation penetrated by a wellbore utilize radial stress. The radial stress is created by loading the wellbore, wellbore casing or production pipe with preferably round, dense bead like materials. The shape and density of the bead like material transfers the axial direction of stress created by the vertical height of the bead like materials to a radial direction. The radial stress can also be generated by inflating an inflatable device. The radially directed stress can compact the geologic formation. This can include compaction of loose sand which otherwise may enter the production flow of hydrocarbon. The bead like materials can also support the wellbore casing or production piping from point loading. This can include point loading created by the movement of salt or other subterranean formations. The bead like materials can include barite, hematite, iron oxide, ilmenite, metal, alloy and combinations thereof. | 01-07-2016 |
Hong Wang, Oak Ridge, TN US
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20130205911 | REVERSAL BENDING FATIGUE TESTING - Embodiments for apparatuses for testing reversal bending fatigue in an elongated beam are disclosed. Embodiments are configured to be coupled to first and second end portions of the beam and to apply a bending moment to the beam and create a pure bending condition in an intermediate portion of the beam. Embodiments are further configured to cyclically alternate the direction of the bending moment applied to the beam such that the intermediate portion of the beam cyclically bends in opposite directions in a pure bending condition. | 08-15-2013 |
20150275638 | CAVITATION-BASED HYDRO-FRACTURING TECHNIQUE FOR GEOTHERMAL RESERVOIR STIMULATION - A rotary shutter valve | 10-01-2015 |
20150275639 | CAVITATION-BASED HYDRO-FRACTURING SIMULATOR - An apparatus | 10-01-2015 |
Hong Wang, Hamilton, CA US
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20140024065 | EX VIVO METHOD FOR DETERMINING POTENTIAL GLP-2 RECEPTOR MODULATORS - Disclosed herein is a method for measuring the contractility of intestinal tissue upon treatment with GLP-2 or a GLP-2 ligand. Also disclosed is an assay which directly measures the activity of GLP-2 or GLP-2 ligands ex vivo and permits the screening of putative GLP-2 ligands in native tissue. | 01-23-2014 |
Hong Wang, Des Plaines, IL US
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20130252232 | HEPATITIS B VIRUS TYPING AND RESISTANCE ASSAY - The present invention provides methods, kits, and oligonucleotides for detecting and analyzing the nucleotide sequence of a reverse transcriptase (RT) region of the polymerase (Pol) gene of Hepatitis B Virus (HBV). In certain embodiments, a target RT region is amplified and subjected to DNA sequencing. The sequence obtained is compared to one or more DNA sequences characteristic of an HBV genotype or serotype, and/or one or more DNA sequences characteristic of an HBV mutation that confers resistance to a drug or vaccine, to determine the HBV genotype or serotype of the amplified product and/or the presence or absence of one or more DNA sequences characteristic of an HBV mutation that confers resistance to a drug or vaccine. | 09-26-2013 |
20150259755 | HEPATITIS B VIRUS TYPING AND RESISTANCE ASSAY - The present invention provides methods, kits, and oligonucleotides for detecting and analyzing the nucleotide sequence of a reverse transcriptase (RT) region of the polymerase (Pol) gene of Hepatitis B Virus (HBV). In certain embodiments, a target RT region is amplified and subjected to DNA sequencing. The sequence obtained is compared to one or more DNA sequences characteristic of an HBV genotype or serotype, and/or one or more DNA sequences characteristic of an HBV mutation that confers resistance to a drug or vaccine, to determine the HBV genotype or serotype of the amplified product and/or the presence or absence of one or more DNA sequences characteristic of an HBV mutation that confers resistance to a drug or vaccine. | 09-17-2015 |
Hong Wang, Newton, MA US
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20140178475 | Therapeutic Nanoparticles Comprising a Therapeutic Agent and Methods of Making and Using Same - The present disclosure generally relates to nanoparticles comprising a substantially hydrophobic acid, a basic therapeutic agent having a protonatable nitrogen, and a polymer. Other aspects include methods of making and using such nanoparticles. | 06-26-2014 |
20140186452 | Process for Preparing Therapeutic Nanoparticles - The present disclosure generally relates to a process for preparing therapeutic nanoparticles, where the process includes combining a therapeutic agent with an organic acid. The therapeutic nanoparticles may have, for example, improved drug loading and/or drug release properties. | 07-03-2014 |
20140248358 | Therapeutic Nanoparticles Comprising a Therapeutic Agent and Methods of Making and Using Same - The present disclosure generally relates to nanoparticles comprising a substantially hydrophobic acid, a basic therapeutic agent having a protonatable nitrogen, and a polymer. Other aspects include methods of making and using such nanoparticles. | 09-04-2014 |
20140249158 | Therapeutic Nanoparticles Comprising a Therapeutic Agent and Methods of Making and Using Same - The present disclosure generally relates to nanoparticles comprising a substantially hydrophobic acid, a basic therapeutic agent having a protonatable nitrogen, and a polymer. Other aspects include methods of making and using such nanoparticles. | 09-04-2014 |
20150056300 | THERAPEUTIC NANOPARTICLES WITH HIGH MOLECULAR WEIGHT COPOLYMERS - The present disclosure generally relates to therapeutic nanoparticles. Exemplary nanoparticles disclosed herein may include about 0.1 to about 40 weight percent of a therapeutic agent and about 10 to about 90 weight percent a diblock poly(lactic) acid-poly(ethylene)glycol copolymer or a diblock poly(lactic)-co-poly(glycolic) acid-poly(ethylene)glycol copolymer, wherein the diblock poly(lactic) acid-poly(ethylene)glycol copolymer comprises poly(lactic) acid having a number average molecule weight of about 30 kDa to about 90 kDa or the diblock poly(lactic)-co-poly(glycolic) acid-poly(ethylene)glycol copolymer comprises poly(lactic)-co-poly(glycolic) acid having a number average molecule weight of about 30 kDa to about 90 kDa. | 02-26-2015 |
20150258102 | THERAPEUTIC NANOPARTICLES COMPRISING A THERAPEUTIC AGENT AND METHODS OF MAKING AND USING SAME - The present disclosure generally relates to nanoparticles comprising a substantially hydrophobic acid and a therapeutic agent (1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea), or pharmaceutically acceptable salts thereof, and a polymer. Other aspects include methods of making and using such nanoparticles. | 09-17-2015 |
Hong Wang, Chaoyang District CN
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20140179325 | METHOD AND SYSTEM FOR SUPPORTING FAST RECOVERY OF USER EQUIPMENT - A method for supporting fast recovery of a User Equipment (UE) includes performing, by a serving base station, UE context synchronization for one or more other base stations in a related small cell cluster when a UE accesses the serving base station, performing, by a base station that the UE performs a radio resource control (RRC) connection re-establishment, the RRC connection re-establishment for the UE according to UE context saved in a synchronization process. The present also discloses another method and system for supporting UE fast recovery. By applying the technical solution disclosed by the present disclosure, when the UE moves in a small cell scenario, the UE can be recovered quickly in the case of a failure, so as to avoid the UE returns to an idle mode, avoid data loss, guarantee business continuity, and improve UE experience. | 06-26-2014 |
20150282152 | METHOD FOR ALLOCATING AGGREGATE MAXIMUM BIT RATE OF UE, METHOD FOR ALLOCATING AGGREGATE BIT RATES OF NON-GBR SERVICES AND BASE STATIONS - A method for allocating an aggregate maximum bit rate (AMBR) of a user equipment (UE) includes obtaining, by a master base station (MeNB), the AMBR of the UE (UE-AMBR), and obtaining, by the MeNB, information for allocating an AMBR of a secondary base station (SeNB), and allocating, the AMBR of the SeNB according to the information, wherein a sum of the AMBRs of the MeNB and the SeNB is not greater than the UE-AMBR. A method for coordinating aggregate bit rates of non-GBR services between base stations includes sending, by an SeNB, information for allocating an aggregate maximum bit rate (AMBR) of the SeNB to an MeNB, and receiving, by the SeNB, the AMBR allocated by the MeNB. | 10-01-2015 |
Hong Wang, Troy, MI US
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20140255785 | SILICON-GRAPHENE NANOCOMPOSITES FOR ELECTROCHEMICAL APPLICATIONS - A nanographitic composite for use as an anode in a lithium ion battery includes nanoscale particles of an electroactive material; and a plurality of graphene nanoplatelets having a thickness of 0.34 nm to 5 nm and lateral dimensions of less than 900 nm, wherein the electroactive particle has an average particle size that is larger than the average lateral dimension of the graphene nanoplatelets, and the graphene nanoplatelets coat at least a portion of the nanoscale particles to form a porous nanographitic layer made up of overlapping graphene nanoplatelets. | 09-11-2014 |
Hong Wang, Wuxi City CN
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20140276003 | Systems and Methods to Detect and Present Interventional Devices via Ultrasound Imaging - The present disclosure includes a method for providing real-time guidance to an interventional device coupled to an ultrasound imaging system operating in a first mode and a second mode. The method includes, in the first mode, stopping transmission of ultrasound signals from a transducer of the ultrasound imaging apparatus, and transmitting, via an acoustic sensor mounted on a head portion of an interventional device, an ultrasound signal that is then received by the transducer to generate a first image of a location of the head portion; in a second mode, stopping transmitting ultrasound signals from the acoustic sensor, transmitting ultrasound signals via the transducer, and receiving echoes of the transmitted ultrasound signals to generate a second image of an object structure; and combining the first image with the second image to derive a third image displaying and highlighting a relative location of the head portion in the object structure. | 09-18-2014 |
Hong Wang, Zibo CN
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20140309480 | Electromagnetic therapy apparatus and auxiliary physiotherapy liquid thereof - An electromagnetic therapy apparatus includes: upper magnetic heads mounted on a frame; lower magnetic heads mounted in a treatment bed, wherein each of the lower magnetic heads is connected to a rotary power supplier and is driven to rotate individually thereby, the lower magnetic heads drive the upper magnetic heads to rotate by magnetic force coupling; therapy clothes provided on a treatment bed and connected to a physiotherapy liquid collection tank through a circulation pump; self-heating tourmaline slices or metal clamps mounted in the therapy clothes; and a high-frequency heating induction coil mounted in the treatment bed and connected to a high-frequency power supplier. Auxiliary physiotherapy liquid includes: basic liquid; and a traditional Chinese medicine additive. By applying a magnetic principle of Western medicine on human bodies, anti-cancer and blood-thinning effects can be achieved. With high-speed metabolism, utilizing the traditional Chinese medicine can accelerate a recovery process. | 10-16-2014 |
Hong Wang, Zhuzhou City CN
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20140331891 | RAILWAY WAGON BOGIE AND AXLE BOX RUBBER SPRING THEREOF - The present application provides an axle box rubber spring including an upper end plate, a lower end plate and a rubber member filled between the upper end plate and the lower end plate, wherein a surface, connected with the rubber member, of at least one of the upper end plate and the lower end plate is provided with a projection and a recess which are distributed alternately, and each of the projection and the recess is in a strip shape. Due to the projection and the recess which are distributed alternatively and both in a strip shape, the axle box rubber spring according to the present application has an increased rigidity, and a reliable positioning is ensured, and further the operating requirement of a heavy-haul railway wagon may be met. The present application further provides a railway wagon bogie having the axle box rubber spring. | 11-13-2014 |
Hong Wang, Beijing CH
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20150036665 | METHOD FOR TRANSMITTING SHORT LANGUAGE SIGNALING IN MAC-E PDU - Disclosed is a method for transmitting control information in a media access control-enhanced packet data unit (MAC-e PDU), including determining a data size of a transport format combination (TFC) selected by a user equipment (UE), including control information into the MAC-e PDU when a size of data and a header for the MAC-e PDU is shorter than the data size of the TFC, padding data of the MAC-e PDU with padding bits if a size of data including a corresponding header is shorter than the data size of the TFC, including the control information into the padding bits if the length of the padding bits is suitable for the transmission of the control information, and sending, by the UE, the MAC-e PDU including the control information to a node B. | 02-05-2015 |
Hong Wang, Tempe, AZ US
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20150087007 | MICROFLUIDIC ELECTROCAGE DEVICE AND CELL MEDIUM FOR TRAPPING AND ROTATING CELLS FOR LIVE-CELL COMPUTED TOMOGRAPHY (CT) - A microfluidic device useable for performing live cell computed tomography imaging is fabricated with a cover portion including a first wafer with at least one metal patterned thereon, a base portion including a second wafer with at least one metal patterned thereon and negative photoresist defining recesses therein, and a diffusive bonding layer including a negative photoresist arranged to join the cover portion and the base portion. A composition useful in live cell computer topography includes a long-chain polysaccharide at a concentration of from about 0.01% to about 10.0% in cell culture medium for supporting cell life while enabling cell rotation rate to be slowed to a speed commensurate with low light level imaging. | 03-26-2015 |
20160084750 | MICROFLUIDIC SYSTEMS AND METHODS FOR HYDRODYNAMIC MICROVORTICAL CELL ROTATION IN LIVE-CELL COMPUTED TOMOGRAPHY - Microfluidic devices for 3D hydrodynamic microvortical rotation of at least one live single cell or cell cluster, systems incorporating the devices, and methods of fabricating and using the devices and systems, are provided. A microfluidic chip rotates at least one live single cell or cell cluster in a microvortex about a stable rotation axis perpendicular to an optical axis within a chamber having a trapezoidal cross-sectional shape located below a flow channel. An optical trap may be used to position the cell or cells with the microvortex, and the cell or cells may be subject to live-cell or cell cluster computer tomography imaging. | 03-24-2016 |
Hong Wang, Cambridge, MA US
Patent application number | Description | Published |
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20150140104 | THERAPEUTIC POLYMERIC NANOPARTICLES AND METHODS OF MAKING AND USING SAME - Described herein are polymeric nanoparticles that include a therapeutic agent which is 2-(3-((7-(3-(ethyl(2-hydroxyethyl)amino)propoxy)quinazolin-4-yl)amino)-1H-pyrazol-5-yl)-N-(3-fluorophenyl)acetamide (also known as AZD1152 hqpa) or a pharmaceutically acceptable salt thereof, and methods of making and using such therapeutic nanoparticles. | 05-21-2015 |
Hong Wang, Huntingdon Valley, PA US
Patent application number | Description | Published |
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20160089391 | Molecular Targets for Cardiovascular Disease - The invention relates to methods and compositions for treating and preventing cardiovascular disease, including but not limited to treating and preventing endothelial dysfunction in subjects having hyperhomocysteinemia, hyperglycemia, or a combination of hyperhomocysteinemia and hyperglycemia. As endothelial dysfunction is an indicator for atherosclerosis and cardiovascular disease, this treatment has general impact for early prevention and treatment for all cardiovascular disease. In particular, the present invention relates to methods and compositions for inhibiting calpain activity. | 03-31-2016 |