Holtman
Bettina Holtman, Wuerzburg DE
Patent application number | Description | Published |
---|---|---|
20140073567 | USE OF PEGYLATED IGF-1 VARIANTS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS - The present invention relates to a pharmaceutical composition containing a PEGylated IGF-I variant derived from the wild-type human IGF-I amino acid sequence where one or two of the lysine amino acids at positions 27, 65, and 68 are altered to be a polar amino acid other than lysine and where the PEG is attached to at least one lysine residue. The invention also relates to methods for the treatment, prevention and/or delay of progression of neuromuscular disorders, in particular amyotrophic lateral sclerosis (ALS) by administering a therapeutically effective amount of the pharmaceutical composition of the invention. | 03-13-2014 |
John M. Holtman, Raleigh, NC US
Patent application number | Description | Published |
---|---|---|
20090327189 | DYNAMIC ONTOLOGY-DRIVEN TEMPLATE SELECTION - One aspect of the present invention includes dynamically selecting templates through the use of an ontology. In one embodiment, an ontology is defined to structure information system content, and an ontology classification is then assigned when content is provided to the information system. Based on this classification, the most appropriate template classified in the ontology is applied to the content. If a template exists at the content item's ontology level, this template is applied to the content. If no template exists, then the ontology tree is navigated upward to locate a template at the nearest ancestor ontology level. If a template was found by navigating the ontology tree, then this template is applied to the content item. | 12-31-2009 |
20090327337 | DYNAMIC ONTOLOGY-DRIVEN TEMPLATE SELECTION - One aspect of the present invention includes dynamically selecting templates through the use of an ontology. In one embodiment, an ontology is defined to structure information system content, and an ontology classification is then assigned when content is provided to the information system. Based on this classification, the most appropriate template classified in the ontology is applied to the content. If a template exists at the content item's ontology level, this template is applied to the content. If no template exists, then the ontology tree is navigated upward to locate a template at the nearest ancestor ontology level. If a template was found by navigating the ontology tree, then this template is applied to the content item. | 12-31-2009 |
Joseph R. Holtman, Lexington, KY US
Patent application number | Description | Published |
---|---|---|
20100120857 | USE OF TRIS-QUATERNARY AMMONIUM SALTS AS PAIN MODULATING AGENTS - Provided are tris-quaternary ammonium compounds which are modulators of nociception and pain. | 05-13-2010 |
20100173937 | USE OF TETRAKIS-QUATERNARY AMMONIUM SALTS AS PAIN MODULATING AGENTS - Provided are methods of modulating, treating, reversing and/or preventing pain using tetrakis quaternary ammonium compounds, especially regarding pain of central and/or peripheral origin and/or pain which is nociceptive, neuropathic, somatic, visceral, and/or inflammatory in nature. | 07-08-2010 |
20110166177 | BIS-QUATERNARY AMMONIUM SALTS AS PAIN MODULATING AGENTS - Provided are methods for using bis-quaternary ammonium compounds to treat inflammatory pain, neuropathic pain and nociceptive pain. | 07-07-2011 |
Joseph R. Holtman, Lisle, IL US
Patent application number | Description | Published |
---|---|---|
20140011836 | METHOD OF TREATING NEUROPATHIC PAIN - Provided are methods for using bis-quaternary ammonium compounds to treat inflammatory pain, neuropathic pain and nociceptive pain. | 01-09-2014 |
Karen S. Holtman, Grayslake, IL US
Patent application number | Description | Published |
---|---|---|
20110040651 | SYSTEMS AND METHODS FOR MANAGING ORDERS MADE VIA A COMPUTER NETWORK - A system and method for allowing a user to schedule pickup of an ordered item provides a user interface having user interface elements for allowing a user to specify a frequency with which an order is it to be picked up, for informing a user as to availability of the item for pickup, and/or for allowing a user to request that an item be held in reserve for pickup within a given period of time, such as 24 hours. Frequency options provided to the user for selection when scheduling an order for pickup may include a one-time frequency, a daily frequency, a weekly frequency, a monthly frequency, and user specified dates. The information as to availability of the item for pickup is determined considering a time of order and real-time stocking information for the item. | 02-17-2011 |
20110320309 | SYSTEMS AND METHODS FOR MANAGING ORDERS MADE VIA A COMPUTER NETWORK - A system and method for allowing a user to schedule pickup of an ordered item provides a user interface having user interface elements for allowing a user to specify a frequency with which an order is it to be picked up, for informing a user as to availability of the item for pickup, and/or for allowing a user to request that an item be held in reserve for pickup within a given period of time, such as 24 hours. Frequency options provided to the user for selection when scheduling an order for pickup may include a one-time frequency, a daily frequency, a weekly frequency, a monthly frequency, and user specified dates. The information as to availability of the item for pickup is determined considering a time of order and real-time stocking information for the item. | 12-29-2011 |
Matthew W. Holtman, Conception Jct., MO US
Patent application number | Description | Published |
---|---|---|
20140219768 | PORTABLE INDPENDENT VEHICLE LIFT AND SUPPORT SYSTEM - An improved vehicle lift system is provided for lifting and supporting a vehicle. The vehicle lift system includes a portable front lift for lifting and supporting a front end of the vehicle, a portable rear lift for lifting and supporting a rear end of the vehicle, and a portable control station for remotely controlling the front lift and the rear lift from a safe and convenient location. The vehicle lift system may include hydraulics, pneumatics, electronics, and/or mechanical linkages for distributing and providing lifting power to the front lift and the rear lift. | 08-07-2014 |
Richard Holtman, Dunlap, IL US
Patent application number | Description | Published |
---|---|---|
20140203112 | FUEL INJECTOR - A common rail fuel injector includes a control valve member unattached to, but trapped between, a push pin and a seat of an injector body. The push pin has a head that includes a contact surface and a crown that includes a stop surface. An air gap surface of an armature is located between a top of the head and the stop surface of the crown when the contact surface of the push pin is in contact with the armature. The stop surface of the crown is located between an air gap plane of a stator assembly and the air gap surface of the armature. The push pin, the armature and the control valve member are movable among a rest configuration, an injection configuration, and an over travel configuration. | 07-24-2014 |