Hofmeister, US
Christopher Hofmeister, Holderness, NH US
Patent application number | Description | Published |
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20110008136 | REDUCED CAPACITY CARRIER, TRANSPORT LOAD PORT, BUFFER SYSTEM - A load port including a frame defining a load port opening, a substrate carrier interface connected to the frame and configured to removably couple with a substrate carrier shell, a load port door configured to interface with a substrate carrier door, the load port door being movably coupled to frame and having a first position substantially blocking the load port opening, and a second position where the load port opening is substantially unblocked by the load port door, and a door coupling member without moving parts, located on the load port door configured to releasably couple with a corresponding member without moving parts on the substrate carrier door, wherein activation of the door coupling member effects coupling between the load port door and substrate carrier door and a passive release of the substrate carrier door from the substrate carrier shell. | 01-13-2011 |
20110280693 | SUBSTRATE PROCESSING APPARATUS - A substrate processing apparatus including a transport chamber having an end and defining more than one substantially linear substrate transport zone where each transport zone extends longitudinally along the transport chamber between opposing walls of the transport chamber and at least one of the more than one substantially linear substrate transport zones is configured as a supply zone for enabling transport of substrates from the end and at least one of the more than one substantially linear substrate transport zones is configured as a return zone for enabling transport of substrates to the end, and at least one substrate transport located in and movably mounted to the transport chamber for transporting substrates along the more than one substantially linear substrate transport zone, where each substrate transport zone is configured to allow the at least one substrate transport to move from one transport zone to another transport zone. | 11-17-2011 |
20120141235 | DUAL ARM ROBOT - A substrate processing apparatus including a frame, a first arm coupled to the frame at a shoulder axis having a first upper arm, a first forearm and at least one substrate holder serially and rotatably coupled to each other, a second arm coupled to the frame at the shoulder axis where shoulder axes of rotation of the arms are substantially coincident, the second arm having a second upper arm, a second forearm and at least one substrate holder serially and rotatably coupled to each other, and a drive section connected to the frame and coupled to the arms, the drive section being configured to independently extend and rotate each arm where an axis of extension of the first arm is angled relative to an axis of extension of the second arm substantially at each angular position of at least one of the first arm or the second arm. | 06-07-2012 |
20120223597 | MULTIPLE DIMENSION POSITION SENSOR - An apparatus including a controller, a workpiece transport in communication with the controller having a movable portion and a transport path, and a multi-dimensional position measurement device including at least one field generating platen attached to the movable portion and at least one sensor group positioned along the transport path and in communication with the controller, the field generating platen is configured for position measurement and propelling the movable portion, each sensor in the at least one sensor group is configured to provide but one output signal along a single axis corresponding to a sensed field generated by the at least one field generating platen and the controller is configured calculate a multi-dimensional position of the movable portion based on the but one output signal of at least one of the sensors in the at least one sensor group, the multi-dimensional position including a planar position and a gap measurement. | 09-06-2012 |
20130028700 | ROBOT DRIVE WITH MAGNETIC SPINDLE BEARINGS - A drive section for a substrate transport arm including a frame, at least one stator mounted within the frame, the stator including a first motor section and at least one stator bearing section and a coaxial spindle magnetically supported substantially without contact by the at least one stator bearing section, where each drive shaft of the coaxial spindle includes a rotor, the rotor including a second motor section and at least one rotor bearing section configured to interface with the at least one stator bearing section, wherein the first motor section is configured to interface with the second motor section to effect rotation of the spindle about a predetermined axis and the at least one stator bearing section is configured to effect at least leveling of a substrate transport arm end effector connected to the coaxial spindle through an interaction with the at least one rotor bearing section. | 01-31-2013 |
20130078057 | LOAD LOCK FAST PUMP VENT - A semiconductor processing tool is disclosed, the tool having a frame forming at least one chamber with an opening and having a sealing surface around a periphery of the opening, a door configured to interact with the sealing surface for sealing the opening, the door having sides perpendicular to the door sealing surface and perpendicular to a transfer plane of a substrate, and at least one drive located on the frame to a side of at least one of the sides that are substantially perpendicular to the door sealing surface and substantially perpendicular to the transfer plane of the substrate, the drive having actuators located at least partially in front of the sealing surface and the actuators being coupled to one of the sides of the door for moving the door from a sealed position. The at least one drive is located outside of a substrate transfer zone. | 03-28-2013 |
20130089396 | REDUCED CAPACITY CARRIER, TRANSPORT, LOAD PORT, BUFFER SYSTEM - In accordance with an exemplary embodiment a semiconductor workpiece processing system having at least one processing tool for processing semiconductor workpieces, a container for holding at least one semiconductor workpiece therein for transport to and from the at least one processing tool and a first transport section elongated and defining a travel direction. The first transport section has parts, that interface the container, supporting and transporting the container along the travel direction to and from the at least one processing tool. The container is in substantially continuous transport at a substantially constant rate in the travel direction, when supported by the first transport section. A second transport section is connected to the at least one process tool for transporting the container to and from the at least one processing tool. | 04-11-2013 |
20130230369 | SUBSTRATE PROCESSING APPARATUS - A substrate processing apparatus including a transport chamber having an end and defining more than one substantially linear substrate transport zone where each transport zone extends longitudinally along the transport chamber between opposing walls of the transport chamber and at least one of the more than one substantially linear substrate transport zones is configured as a supply zone for enabling transport of substrates from the end and at least one of the more than one substantially linear substrate transport zones is configured as a return zone for enabling transport of substrates to the end, and at least one substrate transport located in and movably mounted to the transport chamber for transporting substrates along the more than one substantially linear substrate transport zone, where each substrate transport zone is configured to allow the at least one substrate transport to move from one transport zone to another transport zone. | 09-05-2013 |
20140341679 | ELEVATOR-BASED TOOL LOADING AND BUFFERING SYSTEM - A substrate processing apparatus is provided. The apparatus has a casing, a low port interface and a carrier holding station. The casing has processing devices within for processing substrates. The load port interface is connected to the casing for loading substrates into the processing device. The carrier holding station is connected to the casing. The carrier holding station is adapted for holding at least one substrate transport carrier so the at least one substrate transport carrier is capable of being coupled to the load port interface without lifting the at least one substrate transport carrier off the carrier holding station. The carrier holding station is arranged to provide a substantially simultaneous swap section for substantially simultaneous replacement of the substrate transport carrier from the carrier holding station. | 11-20-2014 |
20150155192 | REDUCED CAPACITY CARRIER AND METHOD OF USE - A substrate transport apparatus is provided. The apparatus has a casing and a door. The casing is adapted to form a controlled environment therein. The casing has supports therein for holding at least one substrate in the casing. The casing defines a substrate transfer opening through which a substrate transport system accesses the substrate in the casing. The door is connected to the casing for closing the substrate transfer opening in the casing. The casing has structure forming a fast swap element allowing replacement of the substrate from the apparatus with another substrate without retraction of the substrate transport system and independent of substrate loading in the casing. | 06-04-2015 |
Christopher Hofmeister, Hempstead, NH US
Patent application number | Description | Published |
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20090003976 | COMPACT SUBSTRATE TRANSPORT SYSTEM - A substrate processing system including a load port module configured to hold at least one substrate container for storing and transporting substrates, a substrate processing chamber, an isolatable transfer chamber capable of holding an isolated atmosphere therein configured to couple the substrate processing chamber and the load port module, and a substrate transport mounted at least partially within the transfer chamber having a drive section fixed to the transfer chamber and having a SCARA arm configured to support at least one substrate, the SCARA arm being configured to transport the at least one substrate between the at least one substrate container and the processing chamber with but one touch of the at least one substrate, wherein the SCARA arm comprises a first arm link, a second arm link, and at least one end effector serially pivotally coupled to each other, where the first and second arm links have unequal lengths. | 01-01-2009 |
Christopher A. Hofmeister, Hampstead, NH US
Patent application number | Description | Published |
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20100119349 | SUBSTRATE ALIGNMENT SYSTEM - A system for aligning an end effector with a substrate in a substrate transport apparatus. The system comprises a first sensor connected to the end effector and a controller for moving the substrate transport apparatus. The sensor has a sensing path pointed in an outward direction. The sensing path does not intersect the substrate when the substrate is located on the end effector. The controller for moving the substrate transport apparatus moves the substrate transport apparatus, based at least partially upon input from the sensor, to position the end effector at a predetermined position relative to the substrate to pick up the substrate onto the end effector. | 05-13-2010 |
Craig Hofmeister, Columbus, OH US
Patent application number | Description | Published |
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20160075784 | CS1-SPECIFIC CHIMERIC ANTIGEN RECEPTOR ENGINEERED IMMUNE EFFECTOR CELLS - Disclosed herein are chimeric antigen receptors (CAR) that can specifically recognize tumor-associated antigens (TAA) on multiple myeloma (MM) cells. Also disclosed are immune effector cells, such as T cells or Natural Killer (NK) cells, that are engineered to express these CARs. Therefore, also disclosed are methods of providing an anti-tumor immunity in a subject with MM that involves adoptive transfer of the disclosed immune effector cells engineered to express the disclosed CARs. | 03-17-2016 |
Dane Hofmeister, Racine, WI US
Patent application number | Description | Published |
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20130015277 | FOOD WASTE DISPOSER WITH PUMPING VANE - A food waste disposer has a food conveying section that receives food waste and water; a grind section including a grind mechanism, and a motor section including a motor. The grind mechanism includes a rotating shredder plate assembly that is rotated in a grind ring to grind food waste to form a slurry of ground food waste and water. The upper end bell has a flat floor and a shredder plate of the rotating shredder plate assembly includes a pumping vane that extends into the discharge channel and occupies at least twenty-percent of a cross-sectional area of the discharge channel. In an aspect, the motor is an induction motor. | 01-17-2013 |
20130175375 | FOOD WASTE DISPOSER WITH FOOD DEFLECTING HOUSING - A food waste disposer has a food conveying section that receives food waste and water; a grinding section including a grinding mechanism, and a motor section including a motor. The grinding section is disposed between the food conveying section and the motor section. The grinding mechanism includes a stationary grind ring and a rotating shredder plate assembly that rotates in the grind ring to grind food waste to form ground matter that combines with the water to form a slurry. The slurry passes into a discharge area in an upper end bell below the shredder plate assembly. The food conveying section includes a housing having a food waste deflecting band with an angular profile at a lower end of the housing. | 07-11-2013 |
Douglas F. Hofmeister, Evanston, IL US
Patent application number | Description | Published |
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20080262895 | BUSINESS RESILIENCE SYSTEMS AND METHODS - Systems and methods are provided as pieces of the end-to-end resilience capability such as impact assessments, continuity plans and monitoring/alert technologies. Various disclosed systems and methods may be used to leverage technology in conjunction with consulting services to optimize the creation, maintenance and execution of business resilience. Select systems and methods utilize a diagnostic risk atom tool to connect an enterprise risk assessment that can be associated with a risk mitigation strategy and action plans that are triggered based on alerts and notification methods tied to an individual's role, responsibility and assets that they manage. | 10-23-2008 |
Frank M. Hofmeister, Simpsonville, SC US
Patent application number | Description | Published |
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20080260305 | Easy-open/reclosable bag and package - An easy-open/reclosable bag includes a first wall having an outer and inner surface; a second wall having an outer and inner surface; a bottom portion connecting the first and second walls; a first and second side seal; and a bag mouth; the first wall including a first folded edge portion including a first and second segment, a fold, and a PSA between the first and second segments; the outer surface of the first wall including an easy-open sealant; the outer surface of the second wall including an easy-open or regular sealant; and the inner surface of the first and second walls each including a regular sealant. A method of making an easy-open/reclosable bag, and a package, are also disclosed. | 10-23-2008 |
20110236540 | Ovenable cook-in film with reduced protein adhesion - The presently disclosed subject matter relates generally to packaging films that exhibit favorable sealing characteristics and reduced adhesion to meat at high temperatures. The presently disclosed subject matter also relates to packages constructed from such films and methods of using the films in high temperature applications. | 09-29-2011 |
James P. Hofmeister, Tombstone, AZ US
Patent application number | Description | Published |
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20120232814 | FREQUENCY-SAMPLING CIRCUIT AND METHOD FOR HEALTH PROGNOSTICS - The present invention provides a frequency-sampling circuit and method for characterizing a health condition of a test unit attached to a power supply. The frequency-sampling circuit is connected externally to the test unit. The circuit comprises an inductor and a capacitor connected in series at an output. When switched, the circuit resonates with an AC loop current to produce a damped-frequency response at the output. Frequency measurements of this response are processed to generate SoH or RUL estimates for the test unit. The voltages applied within the frequency-sampling circuit are limited, which in turn limits the AC loop current to avoid loading the power supply. Incorporating the inductance and capacitance with in the frequency-sampling circuit allows the circuit to be configured for different classes of test units having a wide range of characteristic impedances. | 09-13-2012 |
James P. Hofmeister, Tucson, AZ US
Patent application number | Description | Published |
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20090160457 | CIRCUIT FOR THE DETECTION OF SOLDER-JOINT FAILURES IN A DIGITAL ELECTRONIC PACKAGE - The solder-joint integrity of digital electronic packages, such as FPGAs or microcontrollers that have internally connected input/output buffers, is evaluated by applying a time-varying voltage through one or more solder-joint networks to charge a charge-storage component. Each network includes an I/O buffer on the die in the package and a solder-joint connection, typically one or more such connections inside the package and between the package and a board. The time constant for charging the component is proportional to the resistance of the solder-joint network, hence the voltage across the charge-storage component is a measurement of the integrity of the solder-joint network. | 06-25-2009 |
Jean Hofmeister, White Hall, MD US
Patent application number | Description | Published |
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20140123614 | FLOATING TRIMMER ATTACHMENT FOR LAWNMOWERS - A trimmer attachment for installation on a lawnmower is disclosed that includes a floating trimmer head driven by a trimmer drive pulley. The trimmer drive pulley is connected by a belt to a mower trimmer pulley, which is attached to an existing mower blade pulley. The trimmer attachment is easily removed from the lawnmower when not in use or when it is not needed. The lawnmower further includes a foot pedal which allows the user to raise the trimmer attachment when necessary, and a hand lever which can be used to both raise and lower the attachment for purposes of clearing obstacles and operating bump-feed type trimmer head, when installed. | 05-08-2014 |
Joseph Haydn Hofmeister, Minneapolis, MN US
Patent application number | Description | Published |
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20130274561 | VAGINAL MANIPULATOR INCLUDING LIGHT SOURCE - A vaginal manipulator includes a shaft, a handle connected to a first end of the shaft, and a head connected to a second end of the shaft. The head includes a rigid anterior surface that moves independently from a rigid posterior surface of the head. When the vaginal manipulator is inserted into a vagina, the rigid anterior surface is movable to displace an anterior wall of the vagina and the rigid posterior surface is movable to displace a posterior wall of the vagina. A light source is provided on the head. | 10-17-2013 |
Kenton K. Hofmeister, Portland, OR US
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20150199113 | ELECTRONIC CONTENT VISUAL COMPARISON APPARATUS AND METHOD - Methods and apparatus are presented for visual comparison of different portions of one or more source documents to emulate a paper folding gesture experience in a user device, in which the user uses a mouse or finger in a touchscreen device to circle two or more portions of interest in the same or separate source documents, and provides a different user input such as a pinch motion or zoom in feature to display the selected regions proximate one another for visual comparison. | 07-16-2015 |
Lucas L. Hofmeister, Nashville, TN US
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20140107292 | COPOLYMERS AND METHODS OF USE THEREOF - Copolymers, such as block copolymers, having at least one block that is a random copolymer of ε-caprolactone and a-carboxy-s-caprolactone are disclosed. Also described are methods of using such copolymers, such as, for example, in medical devices. | 04-17-2014 |
Michael Hofmeister, Midland, MI US
Patent application number | Description | Published |
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20120114860 | METHOD OF INHIBITING FORMATION OF DEPOSITS IN A MANUFACTURING SYSTEM - A method inhibits formation of deposits on a cooling surface of an electrode. The electrode is used in a manufacturing system that deposits a material on a carrier body. The cooling surface comprises copper. The system includes a reactor defining a chamber. The electrode is at least partially disposed within the chamber and supports the carrier body. A circulation system, in fluid communication with the electrode, transports a coolant composition to and from the cooling surface. The coolant composition comprises a coolant and dissolved copper from the cooling surface. A filtration system is in fluid communication with the circulation system. The method heats the electrode. The cooling surface of the electrode is contacted with the coolant composition. The material is deposited on the carrier body, and the coolant composition is filtered with the filtration system to remove at least a portion of the dissolved copper therefrom. | 05-10-2012 |
Michael K. Hofmeister, Clover, SC US
Patent application number | Description | Published |
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20160140361 | METHODS FOR ANTI-FRAUD MASKING OF A UNIVERSAL RESOURCE INDENTIFIER ("URI') - Methods may display a URI of a resource. Methods may determine the presence of a non-public data element in the URI. Methods may generate a random number in response to the determination of the presence of the non-public data element. Methods may compute a resultant number based on the exclusive or of the random number and the non-public data element. Methods may substitute the resultant number for the non-public data element in the URI. Methods may transmit the URI and the random number to a server. Methods may receive a resource from the server, in response to the transmission of the URI and the random number to the server. Methods may compute the non-public data element using the random number and the resultant number. Methods may substitute the non-public data element for the resultant number in the URI. Methods may re-determine the URI of the resource. | 05-19-2016 |
Michael K. Hofmeister, Lake Wylie, SC US
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20140114902 | Intelligent Data Agent for a Knowledge Management System - A system includes a memory operable to store one or more classification rules. The system also includes a processor communicatively coupled to the memory. The processor is operable to retrieve one or more data elements from a data source. The processor is further operable to identify a structured data element among the one or more data elements. The processor is further operable to parse the structured data element using one or more filter processes to produce a plurality of tokens. The processor is further operable to classify the plurality of tokens based at least in part on the one or more classification rules and an ontology, which includes a plurality of concepts and a plurality of relationships between the concepts. The processor is further operable to generate a knowledge assertion, which includes the plurality of classified tokens and one or more relationships between the classified tokens. | 04-24-2014 |
20140114903 | Knowledge Management Engine for a Knowledge Management System - A system includes a memory operable to store an ontology. The ontology includes a plurality of instances, and a plurality of relationships between the instances. The system also includes a processor communicatively coupled to the memory. The processor is operable to receive a proposed knowledge assertion. The proposed knowledge assertion includes a plurality of classified tokens and a plurality of relationships between the classified tokens. The processor is further operable to determine whether the classified tokens correspond to instances in the ontology. The processor is further operable to validate the proposed knowledge assertion based on the ontology. The processor is further operable to determine whether to update the ontology with the proposed knowledge assertion. | 04-24-2014 |
20140114948 | Search Engine for a Knowledge Management System - A system includes a memory operable to store a search index. The system also includes a processor communicatively coupled to the memory. The processor is operable to receive a search request relating to information stored in an ontology. The processor is further operable to parse the search request to determine a search type. The processor is further operable to query, based at least in part on the search type, one or more of the search index and the ontology. | 04-24-2014 |
20140114949 | Knowledge Management System - A system includes a memory operable to store an ontology and a search index. The system also includes a data agent operable to generate a knowledge assertion by parsing one or more data elements retrieved from a data source. The system also includes a knowledge management engine comprising a processor. The knowledge management engine is operable to validate the knowledge assertion based on the ontology. The knowledge management engine is further operable to determine whether to update the ontology with the knowledge assertion. The system also includes a search engine operable to generate the search index at least in part by indexing data stored in the ontology. | 04-24-2014 |
20140114953 | Visualization Engine for a Knowledge Management System - A system includes a memory operable to store visualization rules. The system also includes a processor communicatively coupled to the memory. The processor is operable to receive a visualization request relating to information stored in an ontology. The processor is further operable to parse the visualization request to generate a search query. The processor is further operable to submit the search query to the ontology. The processor is further operable to receive, in response to the query, a result. The result includes a plurality of instances and a plurality of relationships between the instances. The processor is further operable to generate a visual representation of the result using the visualization rules. | 04-24-2014 |
Nicholas M. Hofmeister, San Diego, CA US
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20140108154 | DISPLAY OF CROSS-SELL ADVERTISEMENTS TO A USER BASED ON GENETICS - Display of cross-sell advertisements to a user, including, but not limited to, in a social genetics network includes: associating genetic data with product and service categories; accessing specific genetic data of a user to obtain a set of product and service categories associated with the genetic data of the user; analyzing non-genetic data of the user, including past purchase history, and analyzing the genetic data of the user to discover correlations in preferences of the user; selecting one or more desired product and service categories from the set of the product and service categories that match the correlations in the preferences of the user; sending a product or service request to at least one advertiser for a cross-sell advertisement relating to the desired product and service categories; and responsive to receiving the cross-sell advertisement from the advertiser, displaying the cross-sell advertisement on an electronic device of the user. | 04-17-2014 |
20140108527 | SOCIAL GENETICS NETWORK FOR PROVIDING PERSONAL AND BUSINESS SERVICES - Creation of a social genetics network that provides personal and business services includes: receiving non-genetic data and genetic data about a user and storing the non-genetic data and genetic data in a database; analyzing the genetic data and the non-genetic data to i) assign traits to the user based at least in part on phenotypic and/or genotypic relationships found in the genetic data and the non-genetic data, and ii) determine trait connections between the user and other users in the network based on a similarity of the traits that are common to the user and the other users; and generating and displaying on an electronic device a social genetics profile that includes at least a portion of the non-genetic data, at least a portion of the traits assigned to the user, and at least a portion of the trait connections of the user to the other users. | 04-17-2014 |
R. Jon Hofmeister, Portland, OR US
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20100139291 | Field-deployable electronics platform having thermoelectric power source and interchangeable power management electronics and application modules - A wrapped thermoelectric power source having an inner and an outer insulator is provided within a housing formed, at least partially, by an upper and lower thermal transfer elements. The thermoelectric power source including a plurality of coupled pairs of thin film materials possessing thermoelectric properties, the pairs disposed on a flexible substrate and electrically coupled in any series/parallel combination, with the flexible substrate wrapped around an inner thermal insulator. The thermoelectric power source may be sized such that at least a portion of an electronics module may be disposed at least partly within the inner thermal insulator. The electronics module is electrically coupled to the thermoelectric power source, and includes components for voltage regulation and/or power conditioning. A mechanical means, connected to both the upper and the lower thermal transfer elements, holds those elements substantially adjacent opposite sides of the thermoelectric power source while preventing thermal shorting between the upper and lower thermal transfer elements. In one aspect, the electronics module further includes applications circuitry such as, but not limited to, one or more of sensors, data storage, signal processing, computational resources and wireless communication circuitry. | 06-10-2010 |
Robert Hofmeister, Hingham, MA US
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20090022738 | Multispecific deimmunized CD3-binders - The present invention provides a cytotoxically active CD3 specific binding construct comprising a first domain specifically binding to human CD3 and an Ig-derived second binding domain. Furthermore, a nucleic acid sequence encoding a CD3 specific binding construct of the invention is provided. Further aspects of the invention are vectors and host cells comprising said nucleic acid sequence, a process for the production of the construct of the invention and composition comprising said construct. The invention also provides the use of said constructs for the preparation of pharmacutical compositions for the treatment of particular diseases, a method for the treatment of particular diseases and a kit comprising the binding construct of the invention. | 01-22-2009 |
20130224205 | MULTISPECIFIC DEIMMUNIZED CD3-BINDERS - The present invention provides a cytotoxically active CD3 specific binding construct comprising a first domain specifically binding to human CD3 and an Ig-derived second binding domain. Furthermore, a nucleic acid sequence encoding a CD3 specific binding construct of the invention is provided. Further aspects of the invention are vectors and host cells comprising said nucleic acid sequence, a process for the production of the construct of the invention and composition comprising said construct. The invention also provides the use of said constructs for the preparation of pharmaceutical compositions for the treatment of particular diseases, a method for the treatment of particular diseases and a kit comprising the binding construct of the invention. | 08-29-2013 |
Robert Hofmeister, Scituate, MA US
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20090241202 | DOMAIN-GRAFTED ANTIBODIES - The present invention relates to antibodies. Specifically, the present invention relates to antibodies composed of novel combinations of inter-species antibody domains (“domain-grafted antibodies”). The present invention further relates to compositions comprising such domain-grafted antibodies, as well as methods for producing such domain-grafted antibodies. Finally, the present invention relates to methods of evaluating the in vivo biological effect of such domain-grafted antibodies as well as uses of such domain-grafted antibodies for cross-species evaluation of the in vivo activity antibodies intended for human therapy. | 09-24-2009 |
20130136748 | BIOLOGICAL MATERIALS RELATED TO HER3 - The present disclosure relates to amino acid sequences that are directed against (as defined herein) HER3, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences (also referred to herein as “amino acid sequences of the invention”, “compounds of the invention”, and “polypeptides of the invention”, respectively). The disclosure also relates to nucleic acids encoding such amino acid sequences and polypeptides (also referred to herein as “nucleic acids of the invention” or “nucleotide sequences of the invention”); to methods for 10 preparing such amino acid sequences and polypeptides; to host cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes, such as the prophylactic, therapeutic or diagnostic purposes mentioned herein. | 05-30-2013 |
Rudolf J. Hofmeister, Sunnyvale, CA US
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20090041469 | AUTOMATIC SELECTION OF DATA RATE FOR OPTOELECTRONIC DEVICES - Automatic selection and setting an operational data rate of an optoelectronic device. In particular, an integrated circuit includes a data rate select input for the selection and setting of the operational data rate. The integrated circuit internally generates a loss of lock signal if an input data rate does not match the operational data rate. The integrated circuit then automatically sets and selects operational data rates within a predetermined range of operational data rates until the loss of lock signal is deasserted or until all of the rates within the predetermined range of operational data rates have been attempted. | 02-12-2009 |
Rudolf J. Hofmeister, San Jose, CA US
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20110194183 | Apparatus For Enhancing Scattered Light Detection By Re-Directing Scattered Light Outside The Angular Range Of Collection Optics Back To The Sample And Method Of Fabricating Same - An apparatus comprising an optical window transmits both an excitation beam to a sample and scattered light from the sample which is within the angular range of the collection optics. Scattered light from the sample outside the angular range of the collection optics is re-directed back to the sample by reflection from one or more surfaces of the apparatus. As a result, the magnitude of scattered light collected is increased. | 08-11-2011 |
20120320375 | Apparatus for Stabilizing Mechanical, Thermal, and Optical Properties and for Reducing the Fluorescence of Biological Samples for Optical Evaluation - An apparatus is presented for stabilizing an optical, thermal, and mechanical interface between a spectroscopic and/or imaging system and a biological sample. The apparatus includes a window retainer having a retainer surface and a well. The retainer surface surrounds the well. Further, the retainer surface is substantially planar. An optical window is located in the well. The optical window comprises a first and second surface. The second surface is in contact with the window retainer. The first surface is substantially flush with the retainer surface. The apparatus further includes an attachment mechanism coupling the window retainer to the biological sample such that a fluid, gel, adhesive or elastomer interposed between the optical window and the biological sample is trapped in the well. | 12-20-2012 |
20130301046 | SYSTEMS HAVING A REFLECTED LIGHT SENSOR AND METHODS OF USE - Various systems and methods of monitoring laser safety by sensing contact of the system with a sample are provided. The system includes a focusing element for focusing an incident light from a laser light source onto a sample, an optical element having a collection zone for collecting a signal from the sample, a reflected light sensor for sensing a reflected light from the sample, wherein the reflected light sensor is located outside the collection zone of the optical element and on an inner surface of a housing of the system, an electrical circuit operably connected to the reflected light sensor and the laser light source and configured to control power to the laser light source in accordance with the reflected light sensed by the reflected light sensor and a spectral analyzer for processing the signal. Methods and other systems are also described and illustrated. | 11-14-2013 |
20160041087 | ANALYSIS AND PURGING OF MATERIALS IN MANUFACTURING PROCESSES - Various systems and methods of analyzing one or more properties of a sample are provided. The system includes a self-contained purging device having a sample holder and one or more analyzers for analyzing one or more properties of the sample. The purging device is configured to remove sample contained within the sample holder when an analysis is complete. In one embodiment the purging device is configured via an air pump having a tube in fluid communication with an air inlet of the sample holder, wherein the air pump is configured to deliver pressurized air to the air inlet and thereby purge the sample. The pressurized air is localized ambient air, and substantially free of contaminants. Methods and other systems are also described and illustrated. | 02-11-2016 |
Rudy Hofmeister, San Jose, CA US
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20160069805 | OPTICAL AND CHEMICAL ANALYTICAL SYSTEMS AND METHODS - Optical and chemical analytical systems and methods are provided herein. In one embodiment, a method includes exposing a mixture sample to electromagnetic radiation, the mixture sample including analytes, detecting responsiveness of one or more of the analytes to the electromagnetic radiation, calculating average responsiveness of the one or more of the analytes, and calculating a concentration of the one or more of the analytes in the mixture sample using the average responsiveness. | 03-10-2016 |
Rudy Hofmeister, Los Altos, CA US
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20100111539 | TRANSCEIVER MODULE AND INTEGRATED CIRCUIT WITH DUAL EYE OPENERS - A transceiver module having integrated eye diagram opening functionality for reducing jitter is described. The transceiver module may include a transmitter eye opener and a receiver eye opener integrated in a single circuit. The transceiver module may also include serial control and various other integrated components. Other functionalities that may be integrated on the transceiver module include loopback modes, bypass features, bit error rate testing, and power down modes. | 05-06-2010 |
20110293285 | TRANSCEIVER MODULE AND INTEGRATED CIRCUIT WITH DUAL EYE OPENERS - A transceiver module having integrated eye diagram opening functionality for reducing jitter is described. The transceiver module may include a transmitter eye opener and a receiver eye opener integrated in a single circuit. The transceiver module may also include serial control and various other integrated components. Other functionalities that may be integrated on the transceiver module include loopback modes, bypass features, bit error rate testing, and power down modes. | 12-01-2011 |
Ryan J. Hofmeister, Portland, OR US
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20140326287 | WEARABLE THERMOELECTRIC GENERATOR ASSEMBLY AND METHOD OF MANUFACTURING SAME - A thermoelectric generator module for a wearable thermoelectric generator assembly may include a top heat coupling plate and a bottom heat coupling plate each having a head formed on an outer surface of the heat coupling plate and thermally conductive strips formed on an inner surface. At least one thermoelectric foil may be interposed between the top and bottom heat coupling plate. A perimeter band may circumscribe the perimeter edges of the top and bottom heat coupling plate and encapsulate the thermoelectric foil. The head of at least one of the top and bottom heat coupling plate may protrude beyond upper and/or lower surfaces of the perimeter band. | 11-06-2014 |
William H. Hofmeister, Nashville, TN US
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20090215654 | Capillary Perfused Bioreactors with Multiple Chambers - A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, where the bottom surface is located therebetween the first surface and the second surface. The first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a channel for receiving cells and a liquid medium. In forming the bioreactor, the channel is sized to allow the growth of a layer of cells on a biocompatible coating layer and a flow of liquid in the channel. The flow of liquid is controlled so as to provide a known shear force to the layer of cells. The flow of liquid can be further controlled so as to provide an environment that simulates a vascular space in the channel. | 08-27-2009 |
20100260410 | Closed-Loop Process Control for Electron Beam Freeform Fabrication and Deposition Processes - A closed-loop control method for an electron beam freeform fabrication (EBF | 10-14-2010 |
20100270274 | Use of Beam Deflection to Control an Electron Beam Wire Deposition Process - A method for controlling an electron beam process wherein a wire is melted and deposited on a substrate as a molten pool comprises generating the electron beam with a complex raster pattern, and directing the beam onto an outer surface of the wire to thereby control a location of the wire with respect to the molten pool. Directing the beam selectively heats the outer surface of the wire and maintains the position of the wire with respect to the molten pool. An apparatus for controlling an electron beam process includes a beam gun adapted for generating the electron beam, and a controller adapted for providing the electron beam with a complex raster pattern and for directing the electron beam onto an outer surface of the wire to control a location of the wire with respect to the molten pool. | 10-28-2010 |
20120003729 | CAPILLARY PERFUSED BIOREACTORS WITH MULTIPLE CHAMBERS - A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining a cavity with a bottom surface, where the bottom surface is located therebetween the first surface and the second surface. The first surface of the first substrate is received by the second surface of the second substrate to cover the cavity so as to form a channel for receiving cells and a liquid medium. In forming the bioreactor, the channel is sized to allow the growth of a layer of cells on a biocompatible coating layer and a flow of liquid in the channel. The flow of liquid is controlled so as to provide a known shear force to the layer of cells. The flow of liquid can be further controlled so as to provide an environment that simulates a vascular space in the channel. | 01-05-2012 |
William Hudson Hofmeister, Nashville, TN US
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20130216779 | Nanostructures from Laser-Ablated Nanohole Templates - Solution casting a nanostructure. Preparing a template by ablating nanoholes in a substrate using single-femtosecond laser machining. Replicating the nanoholes by applying a solution of a polymer and a solvent into the template. After the solvent has substantially dissipated, removing the replica from the substrate. | 08-22-2013 |
20140308207 | OPEN MICROFLUIDIC DEVICES FOR CHEMOTAXIS, METHODS OF USING SAME, AND APPLICATIONS OF SAME - In one aspect, an on-chip microfluidic device (OMD) is provided for microscopic observation. In one embodiment, an on-chip gradient generating device has a silica chip having a cell loading portion configured to load the tissue. A microfluidic channel is formed in the silica chip for a chemoattractant solution having the chemoattractant to flow through, and a plurality of gradient generating ports is formed to connect to the microfluidic channel to the cell loading portion. A chemoattractant supply device is connected to an inlet of the at least one microfluidic channel for supplying the chemoattractant with a constant positive pressure to the chemoattractant solution flowing in the microfluidic channel to create the passive gradient of the chemoattractant in the chemoattractant solution such that the tissue is exposed to the chemoattractant solution having different concentration of the chemoattractant at each gradient generating port. | 10-16-2014 |
20150093550 | Nanostructures from Laser-Ablated Nanohole Templates - Solution casting a nanostructure. Preparing a template by ablating nanoholes in a substrate using single-femtosecond laser machining. Replicating the nanoholes by applying a solution of a polymer and a solvent into the template. After the solvent has substantially dissipated, removing the replica from the substrate. | 04-02-2015 |
William T. Hofmeister, Flower Mound, TX US
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20150216409 | Methods And Apparatuses For Providing Laser Scanning Applications - An autorefractor-keratometer device including a first laser scanning device that emits a plurality of laser scans, a second laser device that emits a laser pulse, a first detector that detects the plurality of emitted laser line scans to determine corneal topography, and a second detector that detects a reflection of the emitted laser pulse to determine sphero-cylinder refraction. | 08-06-2015 |
20150277154 | 3D Laser Tracer And Methods Of Tracing In 3D - A method for providing eyewear to a customer includes touchlessly scanning eyewear selected by a customer with a laser tracer having a laser-camera assembly, producing from the laser-camera scan an electronic 3D representation of at least a portion of the eyewear, electronically transmitting the 3D representation to an eyewear part manufacturer, and, based upon the 3D representation received, manufacturing a finished eyewear product having the eyeglass prescription of the customer. An eyewear scanning system as the laser tracer employs the method by holding the eyewear within a housing. A scanner subassembly has the laser-camera assembly with the camera positioned at a fixed angle to the laser and sighted toward the eyewear. A scanner movement assembly moves the scanner subassembly with respect to the eyewear. A computer is programmed to conduct a scan of the eyewear with the laser and the camera and to produce the three-dimensional representation. | 10-01-2015 |
William Todd Hofmeister, Flower Mound, TX US
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20140240460 | LASER FRAME TRACER - A laser frame tracer ( | 08-28-2014 |