Patent application number | Description | Published |
20080199957 | ENHANCED TRANSPORT USING MEMBRANE DISRUPTIVE AGENTS - Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontophoresis, and/or electrophoresis can also be used with the disrupting agents. | 08-21-2008 |
20080220531 | STIMULI-RESPONSIVE MAGNETIC NANOPARTICLES AND RELATED METHODS - Stimuli-responsive magnetic nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles. | 09-11-2008 |
20100150952 | pH-RESPONSIVE POLYMER CARRIER COMPOSITIONS FOR CYTOSOLIC PROTEIN DELIVERY - pH-Responsive polymer-based protein delivery carriers and compositions, methods for making the carriers and compositions, and methods for using the carriers and compositions for intracellular protein antigen delivery, inducing a cytotoxic T-lymphocyte response, introducing a tumor-specific protein antigen to an antigen presenting cell to induce an immune response, and providing tumor protection to a subject. | 06-17-2010 |
20100160216 | ENHANCED TRANSPORT USING MEMBRANE DISRUPTIVE AGENTS - Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes (at physiologic pH, but can become active toward cell membranes if the environment is acidified below ca. pH 6.8), coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontopheresis, and/or electrophereis can also be used with the disrupting agents. | 06-24-2010 |
20100210504 | ENHANCED TRANSPORT USING MEMBRANE DISRUPTIVE AGENTS - Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes (at physiologic pH, but can become active toward cell membranes if the environment is acidified below ca. pH 6.8), coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontopheresis, and/or electrophereis can also be used with the disrupting agents. | 08-19-2010 |
20100215749 | TEMPERATURE- AND pH-RESPONSIVE POLYMER COMPOSITIONS - Temperature- and pH-responsive copolymer compositions, and drug delivery devices, conjugates, nanoparticles, and micelles that include the compositions. | 08-26-2010 |
20110123636 | MICELLIC ASSEMBLIES - Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instances, micellic assemblies provided herein are pH sensitive particles. | 05-26-2011 |
20110129921 | TARGETED POLYMER BIOCONJUGATES - Polymer bioconjugate having a RNAi agent covalently coupled to the alpha or omega end of a pH-dependent membrane-destabilizing polymer. | 06-02-2011 |
20110142951 | MICELLES FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS - Composition comprising a polymeric micelle and an associated polynucleotide. | 06-16-2011 |
20110143434 | DIBLOCK COPOLYMERS AND POLYNUCLEOTIDE COMPLEXES THEREOF FOR DELIVERY INTO CELLS - Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one unit with a group that is anionic at about physiologic pH. The described copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the copolymer is endosomolytic. | 06-16-2011 |
20110143435 | POLYMERIC CARRIER - Provided herein are polymeric carriers suitable for the delivery of polynucleotides (e.g. oligonucleotides) and/or other therapeutic agents into a living cell. | 06-16-2011 |
20110266492 | STIMULI-RESPONSIVE MAGNETIC NANOPARTICLES AND RELATED METHODS - Stimuli-responsive magnetic nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles. | 11-03-2011 |
20110281354 | BISPECIFIC INTRACELLULAR DELIVERY VEHICLES - A composition for delivering an agent to a cell, comprising a bispecific affinity reagent and a pH-responsive, membrane destabilizing polymer. The bispecific affinity reagent may include a first affinity reagent covalently linked to a second affinity reagent, wherein the first affinity reagent binds to a molecule on the surface of a cell, and the second affinity reagent binds to an intracellular target. | 11-17-2011 |
20110281934 | MICELLES OF HYDROPHILICALLY SHIELDED MEMBRANE-DESTABILIZING COPOLYMERS - Provided herein are micelles comprising a plurality of copolymers. In certain instances, micelles provided herein are pH sensitive particles. | 11-17-2011 |
20110286957 | MULTIBLOCK COPOLYMERS - Provided herein are multiblock copolymers, as well as micelles and therapeutic compositions thereof. | 11-24-2011 |
20110288238 | ENHANCED TRANSPORT USING MEMBRANE DISRUPTIVE AGENTS - Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontopheresis, and/or electrophoresis can also be used with the disrupting agents. | 11-24-2011 |
20110305660 | OMEGA-FUNCTIONALIZED POLYMERS, JUNCTION-FUNCTIONALIZED BLOCK COPOLYMERS, POLYMER BIOCONJUGATES, AND RADICAL CHAIN EXTENSION POLYMERIZATION - Polymeric compounds having spatially controlled bioconjugation sites are described. Functionalization is achieved by selective co-terminal chain extension of polymer chains by radical polymerization, such as reversible addition-fragmentation chain transfer (RAFT) polymerization. | 12-15-2011 |
20120021514 | HETEROGENEOUS POLYMERIC MICELLES FOR INTRACELLULAR DELIVERY - Compositions comprising a heterogeneous polymeric micelle and an agent (e.g., a polynucleotide) associated with the micelle are disclosed, together with methods for intracellular delivery of such agent. | 01-26-2012 |
20130011362 | TARGETING MONOMERS AND POLYMERS HAVING TARGETING BLOCKS - Provided herein are monomers incorporating folate or other targeting agent, polymers prepared therefrom, polymers prepared therefrom having a therapeutic agent covalently coupled thereto, as well as micelles and therapeutic compositions thereof. | 01-10-2013 |
20130017167 | HYDROPHOBIC BLOCK CONJUGATED THERAPEUTIC AGENTS - Provided herein are polymers having a therapeutic agent covalently coupled to a hydrophobic block thereof, as well as micelles and therapeutic compositions thereof. | 01-17-2013 |
20140219950 | ENHANCED TRANSPORT USING MEMBRANE DISRUPTIVE AGENTS - Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontophoresis, and/or electrophoresis can also be used with the disrupting agents. | 08-07-2014 |
20150238619 | POLYMERIC CARRIER - Provided herein are polymeric carriers suitable for the delivery of polynucleotides (e.g., oligonucleotides) and/or other therapeutic agents into a living cell. | 08-27-2015 |
20160082121 | BISPECIFIC INTRACELLULAR DELIVERY VEHICLES - A composition for delivering an agent to a cell, comprising a bispecific affinity reagent and a pH-responsive, membrane destabilizing polymer. The bispecific affinity reagent may include a first affinity reagent covalently linked to a second affinity reagent, wherein the first affinity reagent binds to a molecule on the surface of a cell, and the second affinity reagent binds to an intracellular target. | 03-24-2016 |
Patent application number | Description | Published |
20160054774 | PROFILING A JOB POWER AND ENERGY CONSUMPTION FOR A DATA PROCESSING SYSTEM - A process identifier for a job is collected. The job runs on a plurality of nodes. The job is identified using the process identifier. A node for the job is identified. An amount of power consumed by the node to run the job is determined. | 02-25-2016 |
20160054775 | METHODS AND APPARATUS TO ESTIMATE POWER PERFORMANCE OF A JOB THAT RUNS ON MULTIPLE NODES OF A DISTRIBUTED COMPUTER SYSTEM - A non-transitory computer readable storage medium having stored thereon instructions executable by one or more processors to perform operations including: receiving a plurality of input parameters including (i) a workload type, (ii) a list of selected nodes belonging to a distributed computer system, and (iii) a list of frequencies; responsive to receiving the plurality of workload parameters, retrieving calibration data from a calibration database; generating a power estimate based on the plurality of workload parameters and the calibration data; and providing the power estimate to a resource manager is shown. Alternatively, the input parameters may include (i) a workload type, (ii) a list of selected nodes belonging to a distributed computer system, and (iii) an amount of available power, wherein the estimator may provide an estimation of the frequency at which the nodes should operate to utilize as much of the available power without exceeding the available power. | 02-25-2016 |
20160054779 | MANAGING POWER PERFORMANCE OF DISTRIBUTED COMPUTING SYSTEMS - A method of managing power and performance of a High-performance computing (HPC) systems, including: determining a power budget for a HPC system, wherein the HPC system includes a plurality of interconnected HPC nodes operable to execute a job, determining a power and cooling capacity of the HPC system, allocating the power budget to the job to maintain a power consumption of the HPC system within the power budget and the power and cooling capacity of the HPC system, and executing the job on selected HPC nodes is shown. | 02-25-2016 |
20160054780 | POWER AWARE JOB SCHEDULER AND MANAGER FOR A DATA PROCESSING SYSTEM - An indication of a mode for a job is received. An available power for the job is determined based on the mode. A first power for the job is allocated based on the available power. A first frequency for the job is determined based on the available power. The first power is adjusted based on the available power. | 02-25-2016 |
20160054781 | Methods and Apparatus to Manage Jobs that can and Cannot be Suspended When there is a Change in Power Allocation to a Distributed Computer System - A non-transitory computer readable storage medium storing instructions executable by one or more processors of a distributed computer system to perform operations including determining whether a power consumed by the distributed computer system is greater than a power allocated to the distributed computer system, responsive to determining the power consumed by the distributed computer system is greater than the power allocated to the distributed computer system, determining whether all jobs being processed by the distributed computer system are processing at a lowest power state for each job, wherein a job includes one or more calculations performed by the one or more processors of the distributed computer system and responsive to determining all jobs being processed by the distributed computer system are processing at a lowest power state for each job, suspending a job having a lowest priority among all jobs being processed by the distributed computer system is shown. | 02-25-2016 |
20160054783 | METHOD AND APPARATUS TO GENERATE AND USE POWER, THERMAL AND PERFORMANCE CHARACTERISTICS OF NODES TO IMPROVE ENERGY EFFICIENCY AND REDUCING WAIT TIME FOR JOBS IN THE QUEUE - A non-transitory computer readable storage medium having stored thereon instructions, the instructions being executable by one or more processors to perform operations including: receiving, by a calibration module executed by the one or more processors, a calibration request including (i) a workload type, (ii) a list of compute nodes belonging to a distributed computer system, and (iii) one or more frequencies; responsive to identifying the workload type as a clustered workload type, instructing a plurality of compute nodes on the list of compute nodes to begin processing a workload of the workload type; and responsive to identifying the workload type as a clustered workload type, instructing a compute node on the list of compute nodes to begin processing the workload of the workload type is shown. | 02-25-2016 |
Patent application number | Description | Published |
20090078820 | WING-TO-BODY FAIRING - In one embodiment, a wing-to-body fairing for reducing noise due to wing-to-body fairing vibrations in at least one of an aircraft and a spacecraft comprises a honeycomb center comprising a cavity which is substantially filled with foam material. | 03-26-2009 |
20090184200 | VIBRATION DAMPING FOR WING-TO-BODY AIRCRAFT FAIRING - A wing-to-body fairing for aircraft is formed from a sandwich structure having integrated vibration damping. | 07-23-2009 |
20090184206 | PARTICLE-FILLED WING-TO-BODY FAIRING - A wing-to-body fairing for reducing noise due to wing-to-body fairing vibrations in an aircraft, spacecraft, or vehicle may include a honeycomb center having a cavity which is at least partially filled with particle material. | 07-23-2009 |
20120032024 | WING-TO-BODY FAIRING WITH SPRAY-ON FOAM AND NOISE REDUCTION METHOD - A fairing includes a fairing body having a fairing interior and an interior surface and a spray-on insulation foam layer provided on the interior surface of the fairing body. | 02-09-2012 |
20120325966 | Flight Vehicle Fairing Having Vibration-Damping Blankets - Vibration-damping blankets are attached to the back surfaces of fairing panels of a flight vehicle (e.g., an aircraft or spacecraft) to reduce vibration, fatigue, structure and airborne transmitted energy, and cabin noise. In one case, the flight vehicle fairing has an exterior comprising exterior surfaces of a multiplicity of removable panels. A method of retrofitting the flight vehicle with vibration-damping blankets comprises: removing a panel from the flight vehicle exterior; attaching a vibration-damping blanket to a back surface of the removed panel; and installing the panel with attached vibration-damping blanket on the flight vehicle with the exterior surface of the panel forming part of the flight vehicle exterior. In one embodiment, the vibration-damping blanket comprises polymeric (e.g., aromatic polyamide) fibers in a nonwoven structure. | 12-27-2012 |
20130327588 | METHODS AND APPARATUS FOR REDUCING NOISE IN REINFORCED SKIN STRUCTURES - Assemblies, methods, and an apparatus for damping vibrational energy induced to a reinforced skin structure are disclosed. The reinforced skin structure includes an outer wall and at least one stringer coupled to the outer wall. The method includes providing a damping apparatus that includes a stiffening member configured to adjust at least one of a bending mode and a torsional twisting mode of the stringer and an energy dissipation member configured to dissipate vibrational energy of the stringer. The stiffening member includes at least two elongated members that are spaced a distance apart and at least one truss member that extends obliquely between the at least two elongated members. The damping apparatus is attached to the at least one stringer. The damping apparatus may be configured to dampen vibration in the range of between about 200-600 Hz. | 12-12-2013 |
20140027569 | WING-TO-BODY FARING WITH SPRAY-ON FOAM AND NOISE REDUCTION METHOD - A fairing includes a fairing body having a fairing interior and an interior surface and a spray-on insulation foam layer provided on the interior surface of the fairing body. | 01-30-2014 |
20140361120 | Flight Vehicle Fairing Having Vibration-Damping Blankets - Vibration-damping blankets are attached to the back surfaces of fairing panels of a flight vehicle (e.g., an aircraft or spacecraft) to reduce vibration, fatigue, structure and airborne transmitted energy, and cabin noise. In one case, the flight vehicle fairing has an exterior comprising exterior surfaces of a multiplicity of removable panels. A method of retrofitting the flight vehicle with vibration-damping blankets comprises: removing a panel from the flight vehicle exterior; attaching a vibration-damping blanket to a back surface of the removed panel; and installing the panel with attached vibration-damping blanket on the flight vehicle with the exterior surface of the panel forming part of the flight vehicle exterior. In one embodiment, the vibration-damping blanket comprises polymeric (e.g., aromatic polyamide) fibers in a nonwoven structure. | 12-11-2014 |
Patent application number | Description | Published |
20130225996 | LUNG BIOPSY NEEDLE - Systems, methods, and devices for biopsying tissue, in particular lung nodules, with a flexible needle are described herein. Preferably, the flexible needle is able to articulate or bend so as to provide access to areas previously difficult or impossible to biopsy. Further embodiments provide for steering and navigating the flexible needle to a region to be biopsied. | 08-29-2013 |
20130225997 | LUNG BIOPSY NEEDLE - Systems, methods, and devices for biopsying tissue, in particular lung nodules, with a flexible needle are described herein. Preferably, the flexible needle is able to articulate or bend so as to provide access to areas previously difficult or impossible to biopsy. Further embodiments provide for steering and navigating the flexible needle to a region to be biopsied. | 08-29-2013 |
20130226026 | PULMONARY NODULE ACCESS DEVICES AND METHODS OF USING THE SAME - In certain embodiments, a device is configured to be delivered to the site of a nodule in the lung or other body organ or lumen. The device can be configured to attach directly to the target nodule or to tissue adjacent the target nodule. The device can be configured to provide repeatable access to the site of the target nodule. In some embodiments, the device includes a guide wire that can extend proximal the device. The guide wire can be configured to engage with a catheter or other medical device to provided repeatable and dependable navigation to the site of the target nodule. In some embodiments, the device can include a channel portion through which medical devices and/or instruments can be navigated. In some embodiments, the device can be deployed in the wall of an airway or other body lumen to provide transluminal access to a nodule outside of the lumen. | 08-29-2013 |
20140276051 | Device for Minimally Invasive Delivery of Treatment Substance - Systems, methods, and devices for delivering ablation fluid to a location of interest within a body (e.g., a location with the lung) are described herein. Ablation fluid delivery systems and devices can include flexible delivery needles within which a plurality of smaller flexible needles is housed. The smaller flexible needles can be configured to articulate or bend with respect to the flexible delivery needle to increase an effective delivery area for the ablation fluid. The smaller flexible needles can include apertures or other openings to facilitate delivery of the ablation fluid to the location of interest. | 09-18-2014 |
20140276764 | Flexible RF Ablation Needle - Embodiments disclosed herein are directed to devices, methods, and systems for the treatment of tissue using energy delivery. Specifically, certain embodiments may be used for the treatment of lung tissue, such as lung nodules, using RF ablation, via a catheter provided with a first electrode attached to a distal end of the catheter, wherein the first electrode is hollow, wherein the first electrode comprises a piercing tip configured to pierce through an airway all and a second electrode received in a movable manner within the first electrode, wherein the second electrode is extendable from the first electrode to form a first extended configuration. | 09-18-2014 |
20150080714 | APPARATUSES, METHODS, AND SYSTEMS FOR THE IDENTIFICATION AND TREATMENT OF PULMONARY TISSUE - Embodiments of the present invention include devices, systems, and methods for implanting and locating traceable markers in a region of a patient's body such as a lung, and in particular lung nodules which may be difficult to locate using traditional means. Further embodiments describe devices, systems, and methods that may be used to treat regions in the lung such as lung nodules with various treatment modalities including heating, microwave irradiation, chemical treatment, and which may be used in conjunction with embodiments of the traceable markers described herein. | 03-19-2015 |