Patent application number | Description | Published |
20110041196 | miRNA-Regulated Differentiation-Dependent Self-Deleting Cassette - Targeting constructs and methods of using them are provided for differentiation-dependent modification of nucleic acid sequences in cells and in non-human animals. Targeting constructs comprising a promoter operably linked to a recombinase are provided, wherein the promoter drives transcription of the recombinase in an differentiated cell but not an undifferentiated cell. Promoters include Blimp1, Prm1, Gata6, Gata4, Igf2, Lhx2, Lhx5, and Pax3. Targeting constructs with a cassette flanked on both sides by recombinase sites can be removed using a recombinase gene operably linked to a 3′-UTR that comprises a recognition site for an miRNA that is transcribed in undifferentiated cells but not in differentiated cells. The constructs may be included in targeting vectors, and can be used to automatically modify or excise a selection cassette from an ES cell, a non-human embryo, or a non-human animal. | 02-17-2011 |
20130095565 | miRNA-Regulated Differentiation-Dependent Self-Deleting Cassette - Targeting constructs and methods of using them are provided for differentiation-dependent modification of nucleic acid sequences in cells and in non-human animals. Targeting constructs comprising a promoter operably linked to a recombinase are provided, wherein the promoter drives transcription of the recombinase in an differentiated cell but not an undifferentiated cell. Promoters include Blimp1, Prm1, Gata6, Gata4, Igf2, Lhx2, Lhx5, and Pax3. Targeting constructs with a cassette flanked on both sides by recombinase sites can be removed using a recombinase gene operably linked to a 3′-UTR that comprises a recognition site for an miRNA that is transcribed in undifferentiated cells but not in differentiated cells. The constructs may be included in targeting vectors, and can be used to automatically modify or excise a selection cassette from an ES cell, a non-human embryo, or a non-human animal. | 04-18-2013 |
20140189900 | miRNA-REGULATED DIFFERENTIATION-DEPENDENT SELF-DELETING CASSETTE - Targeting constructs and methods of using them are provided for differentiation-dependent modification of nucleic acid sequences in cells and in non-human animals. Targeting constructs comprising a promoter operably linked to a recombinase are provided, wherein the promoter drives transcription of the recombinase in an differentiated cell but not an undifferentiated cell. Promoters include Blimp1, Prm1, Gata6, Gata4, Igf2, Lhx2, Lhx5, and Pax3. Targeting constructs with a cassette flanked on both sides by recombinase sites can be removed using a recombinase gene operably linked to a 3′-UTR that comprises a recognition site for an miRNA that is transcribed in undifferentiated cells but not in differentiated cells. The constructs may be included in targeting vectors, and can be used to automatically modify or excise a selection cassette from an ES cell, a non-human embryo, or a non-human animal. | 07-03-2014 |
20150291978 | miRNA-REGULATED DIFFERENTIATION-DEPENDENT SELF-DELETING CASSETTE - Targeting constructs and methods of using them are provided for differentiation-dependent modification of nucleic acid sequences in cells and in non-human animals. Targeting constructs comprising a promoter operably linked to a recombinase are provided, wherein the promoter drives transcription of the recombinase in an differentiated cell but not an undifferentiated cell. Promoters include Blimp1, Prm1, Gata6, Gata4, Igf2, Lhx2, Lhx5, and Pax3. Targeting constructs with a cassette flanked on both sides by recombinase sites can be removed using a recombinase gene operably linked to a 3′-UTR that comprises a recognition site for an miRNA that is transcribed in undifferentiated cells but not in differentiated cells. The constructs may be included in targeting vectors, and can be used to automatically modify or excise a selection cassette from an ES cell, a non-human embryo, or a non-human animal. | 10-15-2015 |
Patent application number | Description | Published |
20080308708 | ACCESSORY MOUNTING SYSTEM SUITABLE FOR USE IN A VEHICLE - An accessory mounting system suitable for use in a vehicle includes an assembly adapted for releasable mounting to a receiving structure on the interior surface at a portion of the windshield of the vehicle. A light absorbing layer is at that portion of the windshield and at least partially hides the assembly from view by a viewer external the vehicle who is viewing through the windshield when the assembly is normally mounted to the receiving structure. The light absorbing layer includes a light transmitting portion. At least two accessories are housed by the assembly and one of the two accessories includes a forwardly-viewing camera that views through the light transmitting portion of the light absorbing layer at that portion of the windshield of the vehicle when the assembly is mounted to the receiving structure, and wherein the light absorbing layer comprises a ceramic frit layer. | 12-18-2008 |
20090219394 | ACCESSORY MOUNTING SYSTEM SUITABLE FOR USE IN A VEHICLE - An accessory mounting system includes an assembly adapted for mounting or attachment at a portion of the windshield of a vehicle. A light absorbing layer at the portion of the windshield of the vehicle at least partially hides the assembly from view by a viewer external the vehicle when the viewer is viewing through the windshield with the assembly at the portion of the windshield. The light absorbing layer includes a light transmitting portion, and a forwardly-viewing camera disposed at the assembly views through the light transmitting portion of the light absorbing layer at the portion of the windshield of the vehicle when the assembly is at the portion of the windshield. The assembly may comprise a pivot element for connecting to an interior mirror or the assembly may comprise a mirror assembly mount button received by a mirror mount of a single-pivot or double-pivot interior rearview mirror assembly. | 09-03-2009 |
20100195226 | ACCESSORY SYSTEM SUITABLE FOR USE IN A VEHICLE - A vehicular accessory system includes an attachment element at an in-cabin surface of a vehicle windshield. The attachment element accommodates a rain sensor, which has a field of view through an aperture of the attachment element towards the vehicle windshield. An interior rearview mirror assembly has a case that houses a reflective mirror element, and includes a base portion with a mirror mount for attaching the mirror assembly to the attachment element. The base portion encompasses the rain sensor when the mirror mount is attached to the attachment element at the vehicle windshield. The mirror assembly includes a video camera disposed at the base portion. Electrical wiring may, at least in part, connect the video camera in the base portion with circuitry in the case, and the electrical wiring may be routed through a pivot joint of the mirror assembly. | 08-05-2010 |
20110134553 | INTERIOR REARVIEW MIRROR SYSTEM WITH FORWARDLY-VIEWING CAMERA - A vehicular interior rearview mirror system includes an attachment element attached at an in-cabin surface of a vehicle windshield and an interior rearview mirror assembly that includes a structure that includes a mount for attaching the mirror assembly to the attachment element, a pivot element, and an interior rearview mirror head pivotally attached at the pivot element. The interior rearview mirror head is adjustable by a driver of the vehicle about the pivot element to adjust a rearward field of view. At least one accessory is encompassed by the structure of the mirror assembly. The structure covers the at least one accessory from view by the driver operating the vehicle. One of the accessories is a forwardly-viewing camera and, with the interior rearview mirror assembly attached to the attachment element, the forwardly-viewing camera views through the vehicle windshield. | 06-09-2011 |
20110278439 | INTERIOR REARVIEW MIRROR SYSTEM WITH FORWARDLY-VIEWING CAMERA - A vehicular interior rearview mirror system includes an attachment element attached at an in-cabin surface of a vehicle windshield and an interior rearview mirror assembly that includes a mount for attaching the mirror assembly to the attachment element, a housing, a single ball and socket pivot joint, and an interior rearview mirror head adjustable by a driver of the vehicle about the single pivot joint to adjust a rearward field of view. The housing houses a forwardly-viewing camera and, with the interior rearview mirror assembly attached at the attachment element, the forwardly-viewing camera views through the vehicle windshield. The attachment element is a mirror mounting button and a rain sensor is disposed at an inner open central portion of the mirror mounting button and views, via the inner open central portion of the mirror mounting button, through the vehicle windshield. | 11-17-2011 |
20120162430 | INTERIOR REARVIEW MIRROR SYSTEM WITH FORWARDLY-VIEWING CAMERA - A vehicular interior rearview mirror system includes an attachment element at an in-cabin surface of a vehicle windshield and an interior rearview mirror assembly that includes a housing having a mount for attaching the mirror assembly to the attachment element. An interior rearview mirror head is pivotable about the housing by a single ball and socket pivot joint and is adjustable by a driver of the vehicle about the single pivot joint to adjust a rearward field of view. The housing houses a forwardly-viewing camera and, with the interior rearview mirror assembly attached at the attachment element, the forwardly-viewing camera views through the vehicle windshield. The interior rearview mirror assembly includes a control that may receive an input and/or deliver an output via a bus communication, and that may at least partially control a braking system and/or a traction control system of the equipped vehicle. | 06-28-2012 |
20130037589 | ACCESSORY SYSTEM FOR VEHICLE - An accessory system for a vehicle includes a windshield of a vehicle and a receiving structure attached at an in-cabin surface of the windshield. A structure is attached at the receiving structure. With the structure attached at the receiving structure, a cluster of individual sensors resides on or near the in-cabin surface of the vehicle windshield, and the cluster of individual sensors includes a forwardly-viewing camera. At least one of the individual sensors may (a) receive an input via a bus communication and/or (b) deliver an output via a bus communication. With the structure attached at the receiving structure, at least one of the individual sensors may be removable from the structure for service. At least one of the sensors may view through the windshield via a light transmitting aperture established in a light absorbing hiding layer at the windshield. | 02-14-2013 |
20130076904 | ACCESSORY MOUNTING SYSTEM FOR A VEHICLE - A vehicular accessory mounting system includes a structure adhesively attached at a region of an interior surface of the vehicle windshield. The structure is configured to accommodate an accessory. A light absorbing layer at the region of the interior surface of the vehicle windshield at least partially hides the structure from view by a viewer, who is external the vehicle, viewing through the windshield. The accessory views through a light transmitting portion of the light absorbing layer and through the windshield to the exterior of the vehicle when the structure is attached at the region of the interior surface of the windshield and when the accessory is accommodated thereat. The structure may include a mirror assembly mount button and the mirror assembly mount button may be configured to be received by a mirror mount of an interior rearview mirror assembly. | 03-28-2013 |
20130135477 | ACCESSORY MOUNTING SYSTEM FOR A VEHICLE - An accessory mounting system for mounting an electronic device at a windshield of a vehicle includes a bracket. The bracket is configured to mount at an interior surface of the vehicle windshield. The bracket includes an attaching structure configured to attach the bracket at the interior surface of the vehicle windshield. The bracket may include a support frame coupled to an attaching structure and to an adjustable support of an interior rearview mirror assembly. The support frame may have a set off portion set off from the interior surface of the windshield to accommodate an electronic device between the windshield and the set off portion. | 05-30-2013 |
20150266424 | ACCESSORY MOUNTING SYSTEM FOR A VEHICLE - An accessory mounting system for mounting an accessory at a windshield of a vehicle includes an accessory adapted for mounting at and demounting from a receiving structure adhesively attached by an adhesive to an interior surface of a vehicle windshield. The accessory includes a camera and circuitry. With the accessory received and supported by the receiving structure and with the receiving structure adhesively attached by an adhesive to an interior surface of a vehicle windshield, (i) the accessory receives an input from the equipped vehicle via a CAN bus communication and delivers an output to the equipped vehicle via a CAN bus communication, and (ii) the camera views forwardly through the windshield via a light transmitting portion of a light absorbing layer of the windshield of the equipped vehicle, with the light absorbing layer otherwise hiding the accessory from view through the windshield from external the equipped vehicle. | 09-24-2015 |