Patent application number | Description | Published |
20150204839 | BIOMARKERS FOR TYPE 2 DIABETES - The present invention relates to a method of identifying a predisposition for developing type 2 diabetes mellitus in a subject, said method comprising the step of assessing in a sample obtained from said subject the amount of one or more metabolite(s) selected from (a) a first group comprising the metabolites glycine, lysoPhosphatidylcholine acyl C18:2, lysoPhosphatidylcholine acyl C17:0, lysoPhosphatidylcholine acyl C18:0, lysoPhosphatidylcholine acyl C18:1, phosphatidylcholine acyl-alkyl C34:2, phosphatidylcholine acyl-alkyl C36:2, phosphatidylcholine acyl-alkyl C36:3 and isobaric metabolites having the same molecular mass as glycine, lysoPhosphatidylcholine acyl C18:2, lysoPhosphatidylcholine acyl C17:0, lysoPhosphatidylcholine acyl C18:0, lysoPhosphatidylcholine acyl C18:1, phosphatidylcholine acyl-alkyl C34:2, phosphatidylcholine acyl-alkyl C36:2 or phosphatidylcholine acyl-alkyl C36:3 but different chemical formula; and/or (b) a second group comprising the metabolite acetylcarnitine C2 and an isobaric metabolite having the same molecular weight as acetylcarnitine C2 but different chemical formula; wherein a decrease in the amount of a metabolite selected from said first group or an increase in the amount of a metabolite selected from said second group as compared to the amount of the corresponding metabolite(s) of a control is indicative of a predisposition to develop type 2 diabetes mellitus. Further, the invention relates to a method of identifying a compound capable of preventing type 2 diabetes mellitus and diseases associated therewith or serving as a lead compound for developing a compound capable of preventing type 2 diabetes mellitus and diseases associated therewith and a method of selecting a therapy to prevent type 2 diabetes mellitus. Also, the invention relates to a kit. | 07-23-2015 |
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20100320430 | Apparatus for Exercising a Force on a Load - An apparatus for exerting a force on a load, comprising at least a first spring system and a second spring system, which two spring systems are coupled with the load and produce forces that are applied to the load, wherein an adjusting device is provided coupled with the load, which is equipped with at least one coupling with which the first spring system and/or the second spring system are/is coupled, and which adjusting device is designed for moving the coupling subject to an adjustment of the load, wherein the first spring system has a linear spring characteristic and is coupled with the load, and wherein the second spring system is coupled with the coupling at a side of the coupling removed from the load, and wherein the coupling is designed for adjusting the second spring system subject to a predetermined spring characteristic of the second spring system such that, at the side of the load, the combination of the coupling with the second spring system possesses a force path diagram having a linear characteristic. | 12-23-2010 |
20120103124 | DELTA ROBOT - A delta robot comprising a stationary base and a movable platform that is connected to the base with three chains of links, and comprising a balancing system incorporating at least one pantograph for balancing the robot's center of mass, wherein the at least one pantograph has a first free extremity at which it supports a countermass which is arranged to balance the center of mass of the robot. | 05-03-2012 |
20120109017 | MECHANICAL DEVICE FOR TISSUE REGENERATION - The invention relates to a mechanical device for tissue-regeneration inside a patient, comprising means ( | 05-03-2012 |
20150183111 | System for Moving a Mobile Tendon Controlled Platform Robot - System for moving a mobile tendon controlled platform robot, comprising a mobile platform, at least one drive means and at least one tendon connected to the mobile platform, wherein the relative position of the at least one tendon with respect to the mobile platform is controllable with the at least one drive means, and wherein the at least one tendon is provided with means to enable the tendon to move without chafing past a surface of an object external to the mobile tendon controlled platform robot. | 07-02-2015 |
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20080210842 | BALANCING DEVICE - A balancing device for a mass, comprising an arm that is adjustable about a pivoting point and with which the mass is coupled, and an adjustable spring system that is coupled with the arm, which spring system comprises at least one spring, wherein the spring system comprises an adjusting mechanism that is connected with the at least one spring, which adjusting mechanism is designed for adjusting the at least one spring so as to aid balancing the mass that is coupled with the arm, wherein a predetermined energy content of the spring system remains substantially the same. | 09-04-2008 |
20150180374 | Energy Harvester - An energy harvester comprising a mass that is subjectable to environmental forces for bringing it into the status of a moving mass, and means linked to the mass for converting and storing of energy embodied in the moving mass, which means are arranged for subsequent release of said energy, wherein the mass is part of a compliant system comprising a frame and first and second elastic beams connecting the mass to the frame, wherein the first and second elastic beams are provided with opposite stiffnesses so as to arrange that in a predefined range of excursions of the moving mass, said mass experiences a preselected stiffness. | 06-25-2015 |
Patent application number | Description | Published |
20140373837 | INHALATION DEVICE FOR POWDERED DRUGS - The invention refers to an inhalation device for powdered drugs to be received by a patient by an inhalation-caused air stream, comprising at least one powder reservoir, metering means for repeatedly metering a powder dose from the reservoir, a transportation mechanism for moving said metering means from a filling position for receiving a powder dose into an emptying position for releasing said powder dose into a powder channel, at least one activating device for manual operation by the patient being operatively connected to said transportation mechanism such that upon operation a single powder dose is being metered, said activating device comprising a dosage key ( | 12-25-2014 |
20140373838 | INHALATION DEVICE FOR POWDERED DRUGS - The invention relates to an inhalation device for powdered drugs to be received by a patient by an inhalation-caused air stream, comprising at least one powder reservoir, metering means for repeatedly metering a powder dose from the reservoir, a transportation mechanism for moving said metering means from a filling position for receiving a powder dose into an emptying position for releasing said powder dose into a powder channel, at least one activating device for manual operation by the patient, said activating device being operatively connected to said transportation mechanism such that upon operation a single powder dose is being metered, said activating device comprising a dosage key ( | 12-25-2014 |
Patent application number | Description | Published |
20120215703 | PROPERTY VALUE ESTIMATION WITH CATEGORICAL LOCATION VARIABLE PROVIDING NEIGHBORHOOD PROXY - Model-based property value estimation with that implements a categorical location variable providing a neighborhood proxy. A regression models the relationship between sale price and a set of explanatory variables. These explanatory variables include a location variable that is defined at a level of granularity such that the location variable acts as a proxy for location within a neighborhood. An infill process remedies the effects of insufficient amounts of location variable data. | 08-23-2012 |
20120323798 | VALUATION OF PROPERTIES BORDERING SPECIFIED GEOGRAPHIC FEATURES - Modeling comparable properties and rendering map images with automatic valuation of properties bordering specified geographic features. A valuation model identifies and accounts for the proximity of properties to geographic features. For example, estimating property value includes accessing property data corresponding to a geographic area and performing a regression based upon the property data. The regression models the relationship between price and explanatory variables, with the explanatory variables including proximity to geographic features. Proximity may be a categorical variable wherein properties bordering the geographic feature are determined to possess the proximity characteristic. Alternative explanatory variables may incorporate different degrees of proximity. | 12-20-2012 |
20130101234 | AUTOMATED VALUATION MODEL WITH CUSTOMIZABLE NEIGHBORHOOD DETERMINATION - Automated valuation model with customizable neighborhood determination. A map image is displayed corresponding to a geographical area, and then user input accommodates definition of a particularly defined geographic area to provide custom identification of a neighborhood to be subject to automated valuation. Once the defined geographic area is established, the automated valuation model is applied to property data corresponding to properties within the defined geographic area. A subject property and corresponding properties within the defined geographic area are then displayed on a map image, preferably with articulation of the defined geographic area as the neighborhood of interest. The neighborhood may be defined by, among other criteria, inclusion within a user-defined shape, as well as exclusion of a user-defined shape from a displayed geographic area. | 04-25-2013 |
20130103595 | SEARCHING REAL ESTATE USING SPATIAL EXCLUSION CONDITIONS - Automated valuation model with customizable neighborhood determination, including spatial exclusion conditions. A map image is displayed corresponding to a geographical area, and then user input accommodates definition of a particularly defined geographic area to provide custom identification of a neighborhood to be subject to automated valuation. Once the defined geographic area is established, the automated valuation model is applied to property data corresponding to properties within the defined geographic area. A subject property and corresponding properties within the defined geographic area are then displayed on a map image, preferably with articulation of the defined geographic area as the neighborhood of interest. The neighborhood may be defined by, among other criteria, inclusion within a user-defined shape, as well as exclusion of a user-defined shape from a displayed geographic area. | 04-25-2013 |
20130179357 | PROPERTY APPRAISAL EVALUATION USING TRAFFIC DATA - A valuation model accounts for traffic features associated with modeled properties, generates listings of model-chosen comparables, and evaluates property appraisals and appraisal-chosen comparables accordingly. In one embodiment, traffic features of homes are used in automated electronic appraising and in the electronic review of appraisals. It first uses GIS techniques to convert traffic features associated with a property into a numeric variable, allowing hedonic price models to measure the price impact of traffic features. This allows traffic features to be used in the automated selection of comparable properties and in the adjusting of comp prices in appraisals. It also allows automated review of appraisals to determine if they fairly accounted for the traffic dimension in the selection of comps and in making any price adjustments. In one example, the automatic valuation uses a regression that models the relationship between price and explanatory variables, with the explanatory variables including traffic feature variables. | 07-11-2013 |
20140074733 | PHOTOGRAPH INITIATED APPRAISAL PROCESS AND APPLICATION - The present invention relates to photograph initiated property assessment. In one example, an electronic device performs a photograph initiated property assessment by accessing a photographic assessment itinerary that includes a plurality of target portions for the subject property and a set of image capture requirements for each of the plurality of target portions. Further, when performing the initiated property assessment the electronic device prompts a plurality of image capture requests according to the photographic assessment itinerary while displaying a menu that permits the addition of information to the set of image captures. | 03-13-2014 |
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20120081169 | Mixer Divider Layout - A symmetrical, balanced, down-conversion mixer is achieved by the coordinated layout of a balanced Local Oscillator (LO) divider circuit and a balanced Radio Frequency (RF) mixer circuit, such that the LO divider is in the center and the RF mixer is arrayed symmetrically around the LO divider. In particular, the LO divider is partitioned into four portions (e.g., Ip, In, Qp, Qn), which are placed in respective quadrants, defined by orthogonal reference axes through the LO divider center. The RF mixer is similarly partitioned into four corresponding portions, which are placed around the LO divider portions in each quadrant. By integrating the LO divider and RF mixer in the layout of the symmetric, balanced, down-conversion mixer, greater component matching and control of current paths are possible, improving operational quality parameters such as IRR, IP | 04-05-2012 |
20130181337 | Power Routing with Integrated Decoupling Capacitance - An integrated circuit chip is disclosed having a semiconductor substrate and a plurality of conduction layers (metalz, metalz+1), disposed on the semiconductor substrate and separated by dielectric layers, for distribution of power and electrical signals on the chip. The integrated circuit chip comprises a power-supply distribution network ( | 07-18-2013 |