Patent application number | Description | Published |
20090267354 | UNITARY LATCH, BLAST LOCK, AND RELEASE HANDLE ASSEMBLY FOR VEHICLE DOOR - An assembly is provided for opening a heavy weight door, such as on a military vehicle, by an occupant in the vehicle. The assembly includes a latch module with a catch and rotor adapted to engage and disengage the striker on the door frame, a blast lock module including a pawl adapted to engage and disengage the door frame, and a release handle module with a single interior handle for controlling the engagement and disengagement of the latch and blast lock modules. The three modules are pre-assembled on a carrier plate so as to form a rigid, unitary assembly for mounting on the inside of the door. When a person chooses to exit the vehicle, the handle is actuated so as to retract the blast lock and then release the latch. When the door is closed, a person inside the vehicle can actuate the handle so as to engage the blast lock for safety. | 10-29-2009 |
20110204675 | INTUITIVE CONTROL SYSTEM FOR POWER ASSISTED VEHICLE DOORS - A heavy vehicle door or ramp is opened and closed using an intuitive control system. The door includes a latch assembly, a lock assembly, and a power unit to assist in opening and closing the door. The door includes an interior joy stick handle and an exterior lever handle. From outside the vehicle, the door is opened and closed by pivoting the lever handle downwardly and upwardly, respectively. From the interior of the vehicle, the joy stick handle is pulled inwardly to close the door and push outwardly to open the door. Pivoting the joystick handle forwardly engages the blast locks, while pivoting the joystick handle rearwardly unlatches the latch assembly and disengages the blast locks. The power assist unit is actuated by pivotal movement of the outside door handle and lateral pivotal movement of the interior joystick handle. Perimeter bump strips offer safety functions to prevent injuries when remote function is active. | 08-25-2011 |
20120174489 | INTUITIVE CONTROL SYSTEM FOR POWER ASSISTED VEHICLE DOORS - A heavy vehicle door or ramp is opened and closed using an intuitive control system. The door includes a latch assembly, a lock assembly, and a power unit to assist in opening and closing the door. The door includes an interior joy stick handle and an exterior lever handle. From outside the vehicle, the door is opened and closed by pivoting the lever handle downwardly and upwardly, respectively. From the interior of the vehicle, the joy stick handle is pulled inwardly to close the door and pushed outwardly to open the door. Pivoting the joystick handle forwardly engages the blast locks, while pivoting the joystick handle rearwardly unlatches the latch assembly and disengages the blast locks. The power assist unit is actuated by pivotal movement of the outside door handle and lateral pivotal movement of the interior joystick handle. | 07-12-2012 |
20120175893 | INTUITIVE CONTROL SYSTEM FOR POWER ASSISTED VEHICLE DOORS - A heavy vehicle door or ramp is opened and closed using an intuitive control system. The door includes a latch assembly, a lock assembly, and a power unit to assist in opening and closing the door. The door includes an interior joy stick handle and an exterior lever handle. From outside the vehicle, the door is opened and closed by pivoting the lever handle downwardly and upwardly, respectively. From the interior of the vehicle, the joy stick handle is pulled inwardly to close the door and pushed outwardly to open the door. Pivoting the joystick handle forwardly engages the blast locks, while pivoting the joystick handle rearwardly unlatches the latch assembly and disengages the blast locks. The power assist unit is actuated by pivotal movement of the outside door handle and lateral pivotal movement of the interior joystick handle. | 07-12-2012 |
Patent application number | Description | Published |
20080242622 | Identification of genetic alterations that modulate drug sensitivity in cancer treatments - This invention features methods of identifying genetic alterations that can modulate cancer cells' sensitivity to an anti-cancer drug. Information on such genetic alterations can be used to predict cancer therapeutic outcomes and to stratify patient populations to maximize therapeutic efficacy. | 10-02-2008 |
20090217404 | Cell-based RNA interference and related methods and compositions - The invention provides, among other things, methods for performing RNA interference (RNAi) in stem cells (such as embryonic stem cells) and methods for using such stem cells in vivo. The invention also provides various animal models based on conditional/inducible, reversible, tissue-specific/spacial, and/or developmental stage-specific/temporal RNAi of certain target genes, which animal model may be useful for, e.g., drug target identification and/or validation. | 08-27-2009 |
20100186097 | CELL-BASED RNA INTERFERENCE AND RELATED METHODS AND COMPOSITIONS - The invention provides, among other things, methods for performing RNA interference in stem cells and methods for using the stem cells in vivo. | 07-22-2010 |
20120251528 | Non-Human Mammal Model Of Human Hematopoietic Cancer - The present invention describes Photolabile Compounds methods for use of the compounds. The Photolabile Compounds have a photoreleasable ligand, which can be biologically active, and which is photoreleased from the compound upon exposure to light. In some embodiments, the Photolabile Compounds comprise a light antenna, such as a labeling molecule or an active derivative thereof. In one embodiment, the light is visible light, which is not detrimental to the viability of biological samples, such as cells and tissues, in which the released organic molecule is bioactive and can have a therapeutic effect. In another embodiment, the photoreleasable ligand can be a labeling molecule, such as a fluorescent molecule. | 10-04-2012 |
20140134635 | RNAi-Based Method of Drug Screening and Characterization - The invention is directed to a method of characterizing a mechanism of action of an agent (e.g., a chemotherapeutic agent, a genotoxic agent). The method comprises contacting a plurality of populations of cells with an agent to be assessed, wherein each population of cells have one gene of interest targeted by a small hairpin RNA (shRNA) and wherein said gene of interest regulates cell death and a plurality of genes that regulate cell death are targeted in the plurality of populations of cells. A responsiveness of each population of cells to the agent is determined, thereby obtaining an shRNA signature of the agent, so as to identify one or more genes that mediate a response to the agent, thereby characterizing the mechanism of action of the agent. The invention is also directed an article of manufacture for characterizing a mechanism of action of a chemotherapeutic or genotoxic agent. | 05-15-2014 |
20140206544 | RNAi-Based Method of Screening and Characterizing Drug Combinations - In one aspect, the invention is directed to a method of characterizing a mechanism of action of a combination of agents. The method comprises contacting a plurality of populations of cells with a combination of agents to be assessed, wherein each population of cells have one gene of interest targeted by a small hairpin RNA (shRNA) and wherein the gene of interest regulates cell death and a plurality of genes that regulate cell death are targeted in the plurality of populations of cells. A responsiveness of each population of cells to the combination of agents is determined, thereby obtaining an shRNA signature of the combination of agents so as to identify one or more genes that mediate a response to the combination of agents, thereby characterizing the mechanism of action of the combination of agents. In another aspect, the invention is directed to a method of determining whether a patient population treated with a first agent would benefit from a treatment using the first agent in combination with one or more additional agents. In yet another aspect, the invention is directed to method of determining whether a formulation of one or more agents maintains a mechanism of action of the one or more agents when unformulated. | 07-24-2014 |