Patent application number | Description | Published |
20090107003 | Technology for Cleaning Thermal Fatigue Cracks in Nickel-Based Superalloys With a High Chromium Content - There is described a method for cleaning components that comprise cracks that are polluted with oxides, in particular gas turbine part. In said method, the components to be cleaned are exposed in a cleaning chamber at high temperature to a cleaning gas containing gaseous halogen compounds, which ionize to form halide ions. A cleaning gas is used containing 18 to 30% by volume hydrogen halide. | 04-30-2009 |
20100032472 | Brazing composition and brazing method for superalloys - A brazing composition for the brazing of superalloys including a base material with at least one initial phase is provided. The initial phase has a solidus temperature that is below the solidus temperature of the base material and, above a certain temperature, forms with the base material and/or with at least one further initial phase at least one resultant phase, the solidus temperature of which is higher that the solidus temperature of the initial phases. Heat treatment takes place in two stages, wherein the temperature of the second heat treatment is preferably 800-1200° C. The brazing composition may likewise be of the type MCrAlX, and the power particles of the initial phase may be in the form of nanoparticles. | 02-11-2010 |
20100192589 | Method for Production of a Coating System - Conventionally, cavities and cracks are filled with a solder metal which forms brittle phases with a subsequently applied coating, which have a negative effect on the mechanical properties. According to the invention, the components which form brittle phases are removed from the solder metal. The above is achieved, whereby a second material is applied which reacts with said component and which is removed again with the brittle phases, before the coating. | 08-05-2010 |
20100224600 | TWO-STEP WELDING PROCESS - A welding process is provided. The welding process includes two steps. First, the welding material is applied over a large area of the substrate in the region without melting or partially melting the welding material. Then, a welding device is used to melt the applied welding material. In addition the welding material may be applied in two applications where the second application of the welding material is applied over a large area of the first application of molten and solidified welding material. Then, the second application of the welding material is melted. | 09-09-2010 |
20110154947 | Brazing Composition and Brazing Method for Superalloys - A brazing composition for the brazing of superalloys including a base material with at least one initial phase is provided. The initial phase has a solidus temperature that is below the solidus temperature of the base material and, above a certain temperature, forms with the base material and/or with at least one further initial phase at least one resultant phase, the solidus temperature of which is higher that the solidus temperature of the initial phases. Heat treatment takes place in two stages, wherein the temperature of the second heat treatment is preferably 800-1200° C. The brazing composition may likewise be of the type MCrAlX, and the power particles of the initial phase may be in the form of nanoparticles. | 06-30-2011 |
20110174867 | PROCESS FOR BRAZING WIDE GAPS - A method for repairing wider gaps in a substrate of a component by brazing at a brazing temperature is provided. Filler material and solder are prevented from separating in that, in a two-stage process, first the filler material and then the solder are applied to the wider gap. The powder does not melt at the brazing temperature and the filler metal does melt at the brazing temperature. | 07-21-2011 |
Patent application number | Description | Published |
20080234192 | COMPOSITIONS AND METHODS OF USE FOR TREATING CARDIOVASCULAR DISEASE - In one aspect, the present invention provides isolated oxidation resistant mutant apoA-I polypeptides comprising an amino acid sequence substantially homologous to SEQ ID NO:4, the mutant apoA-I polypeptide comprising a combination of: (1) a conservative amino acid substitution at residue Tyr192; and (2) at least one conservative amino acid substitution at residue Met86, Met112, or Met148, wherein the mutant apoA-I polypeptide is resistant to modification by an oxidizing agent. In another aspect, the invention provides a method of promoting cholesterol efflux activity in a mammalian subject in need thereof, the method comprising the step of administering an effective amount of an oxidation resistant apoA-I agonist to the subject to promote cholesterol efflux. | 09-25-2008 |
20080261250 | Methods for Assessing the Risk for Development of Cardiovascular Disease - The present invention relates to diagnostic tests, methods and kits that are useful to assess a subject's risk of developing a pathologic condition related in part to the presence of HDL oxidation product. Measuring the quantity of one or more HDL oxidation products present in the blood is useful in evaluating risk for developing or evaluating the severity of a disease or evaluating response to treatment for such a disease as, for instance, cardiovascular disease. | 10-23-2008 |
20100297680 | METHODS FOR ASSESSING THE RISK FOR DEVELOPMENT OF CARDIOVASCULAR DISEASE - The present invention relates to diagnostic tests, methods and kits that are useful to assess a subject's risk of developing a pathologic condition related in part to the presence of HDL oxidation product. Measuring the quantity of one or more HDL oxidation products present in the blood is useful in evaluating risk for developing or evaluating the severity of a disease or evaluating response to treatment for such a disease as, for instance, cardiovascular disease. | 11-25-2010 |
20110212477 | LIPOPROTEIN-ASSOCIATED MARKERS FOR CARDIOVASCULAR DISEASE - The invention provides methods of screening a mammalian subject to determine if the subject is at risk to develop, or is suffering from, cardiovascular disease. The methods comprise detecting an amount of at least one biomarker in a biological sample, or HDL subfraction thereof, from the subject, and comparing the detected amount of the biomarker to a predetermined value, where a difference between the detected amount and the predetermined value is indicative of the presence or risk of cardiovascular disease in the subject. In some embodiments, the biomarker comprises at least one of ApoC-IV, Paraoxonase 1, C3, C4, ApoA-IV, ApoE, ApoL1, C4B1, Histone H2A, ApoC-II, ApoM, Vitronectin, Haptoglobin-related protein, and Clusterin, or combinations thereof. | 09-01-2011 |
20120288880 | METHODS AND COMPOSITIONS FOR DIAGNOSIS OR PROGNOSIS OF CARDIOVASCULAR DISEASE - The invention provides methods of screening a mammalian subject to determine if the subject is at risk to develop or is suffering from, cardiovascular disease. In one embodiment, the method comprises detecting a measurable feature of at least two biomarkers in an EMT subfraction, or in a complex containing apoA-I or apoA-III isolated from a biological sample obtained from the subject, wherein the at least two biomarkers are selected from the group consisting of apoA-I, apoA-II, apoB-100, Lp(a), apoC-I, and apoC-III, combinations or portions and/or derivatives thereof, and comparing the measurable features of the at least two biomarkers from the biological sample to a reference standard, wherein a difference in the measurable features of the at least two biomarkers from the biological sample and the reference standard is indicative of the presence or risk of cardiovascular disease in the subject. | 11-15-2012 |
Patent application number | Description | Published |
20090187130 | HYDROGELS WITH TAPERED EDGE - An adhesive hydrogel dressing as well as to methods of applying the dressing to a patient is described. The dressing generally comprises an adhesive hydrogel pad, a backing layer, and an adhesive layer on the backing layer facing the hydrogel pad. The adhesive layer and backing layer form a perimeter around the hydrogel pad and hold the hydrogel pad in place on an application surface. The adhesive hydrogel pad is formed with at least a portion of the perimeter of the hydrogel pad tapered proximate the area that the hydrogel pad and release liner separate during liner removal. | 07-23-2009 |
20100106113 | THIN FILM DELIVERY SYSTEM AND METHOD OF MANUFACTURE - A carrier delivered dressing is disclosed which has a conformable backing with a pressure sensitive adhesive coated on a bottom face and removable carrier attached to the top face of the backing. A bond block material is positioned between the backing and the carrier. A cut line traverses both the carrier and the bond block material to form a tab. | 04-29-2010 |
20100318072 | MEDICAL ARTICLE HAVING FLUID CONTROL FILM - The present invention provides medical articles having a fluid control film component which comprise a sheet having microchannels that permit directional flow of a liquid. Articles incorporating the fluid control film include: wound dressings, wound drains, tympanostomy fluid wicks, intravenous access site dressings, drug delivery dressings, and sweat collection patches. | 12-16-2010 |
20130274667 | MEDICAL DRESSING COMPRISING AN APERTURED HYDROGEL - Disclosed is an apertured hydrogel that is used in connection with an insertion device to provide comfort at the site of entry into the skin. In one embodiment, the hydrogel contains antimicrobial properties to help inhibit microbial growth at the site of insertion of the device into the skin. In the invention the apertured hydrogel is provided with a medical dressing and comprises a hydrogel having an upper surface and a lower surface, a film covering the upper surface of the hydrogel, a base sheet releasably covering to the lower surface of the hydrogel, an aperture in the film and hydrogel from the upper surface to the lower surface of the hydrogel, wherein the base sheet extends beyond the hydrogel to form a tab. | 10-17-2013 |
20140061408 | MEDICAL ARTICLE SECUREMENT SYSTEMS AND METHODS OF USING SAME - Brackets, systems comprising a bracket, and methods for securing medical articles. The bracket can include a base, a post coupled to the base and extending upwardly from the base in a direction generally normal to a first major surface of the base, and an arm coupled to the base and extending generally parallel to the first major surface of the base. The arm can be spaced a distance from the first major surface of the base to define a channel under the arm that is dimensioned to receive at least a portion of the medical article. The arm can be cantilevered, and the post and the arm can each be fixed with respect to the base. Methods can include abutting an external surface of the medical article against the post; and moving a portion of the medical article into the channel defined by the arm. | 03-06-2014 |
20140066856 | MEDICAL ARTICLE SECUREMENT SYSTEMS COMPRISING A BRACKET AND A FLAP - A medical article securement system comprising a bracket and a flap for securing a medical article. The bracket can include a base, and an arm coupled to the base and extending generally parallel to the first major surface of the base. The arm can be spaced a distance from the first major surface of the base to define a channel under the arm that can be dimensioned to receive at least a portion of the medical article. The flap can include a fixed end, and a free end that is movable with respect to the bracket between a first position in which the flap is not positioned over the bracket, and a second position in which at least a portion of the flap is positioned over the bracket to further inhibit movement of the medical article. The fixed end of the flap can be coupled to the bracket. | 03-06-2014 |
20140066882 | MEDICAL ARTICLE SECUREMENT SYSTEMS COMPRISING INDICIA AND METHODS OF USING SAME - A medical article securement system comprising indicia and methods of using same. The indicia can include a representation of a medical article, such that the indicia mimics the appearance of the medical article and provides a visual cue for coupling the medical article to the medical article securement system. The systems can further include a bracket that can comprise the indicia. Methods can include orienting the medical article relative to the medical article securement system in an orientation that matches the indicia, and coupling the medical article to the medical article securement system. | 03-06-2014 |
20150141949 | MEDICAL DRESSING WITH MULTIPLE ADHESIVES - The disclosed medical dressing includes multiple adhesives. A first adhesive can strongly secure to the medical device, while a gentle adhesive secures to skin. Therefore, the medical device is secure, while the skin is in contact with a gentle adhesive. Selection of the adhesive, as well as the positioning of the adhesive on the medical dressing disclosed result in a medical dressing that effectively secures a medical device to a patient, while gently securing to skin. | 05-21-2015 |