Heimberger
Amy Heimberger, Houston, TX US
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20090220551 | CONCURRENT CHEMOTHERAPY AND IMMUNOTHERAPY - The concurrent administration of chemotherapy and immunotherapy has been considered a contraindication because of the concern that the induced lymphopenia would ablate therapeutic efficacy of immunotherapy. Temozolomide has been shown to be an effective chemotherapeutic for patients with malignant gliomas and to deprive patients with glioblastoma (GBM) patients of this agent in order to treat with immunotherapy is controversial. Despite conventional dogma, we demonstrate that both chemotherapy and immunotherapy can be delivered concurrently without negating the effects of immunotherapy, in fact, the temozolomide induced lymphopenia may actually be synergistic with a peptide vaccine. | 09-03-2009 |
20130129675 | INTERFERON THERAPIES IN COMBINATION WITH BLOCKADE OF STAT3 ACTIVATION - Methods of modulating the INF-induced STAT3 activation in a patient in need-thereof are provided for the treatment of disease. The methods comprise the step of administrating to a patient the combination of a therapeutically effective amount of interferon including INF-α and/or INF-β in combination with a STAT3 inhibitor. | 05-23-2013 |
20140377221 | BIOMARKERS AND COMBINATION THERAPIES USING ONCOLYTIC VIRUS AND IMMUNOMODULATION - The invention disclosed herein describes biomarkers useful for prognosis, selection and monitoring of oncolytic virus therapy for patients with various types of cancer. In particular, the present invention provides identification of proteins whose expression patterns are strongly predictive of the outcome of oncolytic virus therapy in a patient with cancer. The present invention provides a method for identifying and selecting cancer patients who are likely to be non-responsive to onocolytic virus therapy. These patients can be co-administered an agent that stimulates a cell-mediated immune response in the patient with the oncolytic virus or can be administered a therapy other than oncolytic virus therapy. | 12-25-2014 |
20150118181 | Concurrent Chemotherapy and Immunotherapy - The concurrent administration of chemotherapy and immunotherapy has been considered a contraindication because of the concern that the induced lymphopenia would ablate therapeutic efficacy of immunotherapy. Temozolomide has been shown to be an effective chemotherapeutic for patients with malignant gliomas and to deprive patients with glioblastoma (GBM) patients of this agent in order to treat with immunotherapy is controversial. Despite conventional dogma, we demonstrate that both chemotherapy and immunotherapy can be delivered concurrently without negating the effects of immunotherapy. In fact, the temozolomide induced lymphopenia may actually be synergistic with a peptide vaccine. | 04-30-2015 |
Amy B. Heimberger, Houston, TX US
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20100144802 | Small Molecule Inhibitors for Immune Modulation - Methods of treating immunosuppression by administering a therapeutic amount of a tryphostin compound of the formula: | 06-10-2010 |
20120021941 | BLOOD TEST FOR THE DETECTION OF CANCER - Methods of detecting cancers are provided. In certain embodiments, a blood test may utilized to identify the presence of a cancer such as, e.g., a melanoma or glioma (e.g., an astrocytoma, a glioblastoma multiforme) in a human patient. In particular, increased p-STAT3 expression by peripheral blood mononuclear cells is selectively associated with the presence of certain cancers. In various embodiments, fluorescence activated cell sorting (FACS) may be used to measure p-STAT3 expression in the peripheral blood of a human patient. | 01-26-2012 |
Hans-Stefan Heimberger, Muehlacker DE
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20100326195 | DEVICE AND METHOD FOR QUALITY TESTING SHEET METAL PARTS - A device and a method are provided for quality testing sheet metal parts, particularly deep-drawn parts. The device has a pulse generator ( | 12-30-2010 |
Markus Heimberger, Besigheim DE
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20150323668 | METHOD FOR THE IMPROVED ACTUATION OF ULTRASONIC SENSORS, DRIVER ASSISTANCE DEVICE AND MOTOR VEHICLE - A method for operating an ultrasonic system having a multiplicity of ultrasonic sensors is disclosed. The sensors are arranged distributed on a motor vehicle and are actuated in measuring cycles for the emission of an ultrasonic signal, where the measuring cycles are repeated. An object in the surroundings of the motor vehicle is detected by a detection device, different from the ultrasonic system, of the motor vehicle, and a relative position of the object relative to the motor vehicle is determined. The number of ultrasonic sensors which are actuated within one measuring cycle is then defined as a function of the current relative position. | 11-12-2015 |
Roland Heimberger, Haidershofen AT
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20140041483 | DRIVE UNIT FOR A HYBRID VEHICLE - A drive unit for a motor vehicle with hybrid drive. The drive unit includes an input shaft which may be connected to the crankshaft of an internal combustion engine of the motor vehicle, a gearbox shaft which may be connected via a toothed hub of a clutch plate as an input shaft of the downstream gearbox, and an electric machine, the rotor of which is connected rotationally fixedly to the clutches. The components are accommodated in a housing having a radially extending housing wall as a bearing wall which forms a physical separation of a chamber of the electric machine and a chamber of the clutches. | 02-13-2014 |
Rudolf Heimberger, Oberderdingen DE
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20090292170 | STEREO-ENDOSCOPE - A stereo-endoscope is provided having a hollow shank with two axially parallel optical channels, which channels run through the hollow shank and respectively form at least a section of an image path to respective oculars of a binocular observation device arranged on the proximal end of the hollow shank. Moreover, the stereo-endoscope includes a camera connection, and one of the optical channels also forms at least one section of an image path to the camera connection. | 11-26-2009 |
20100240950 | Uretero-Renoscope - A uretero-renoscope includes a shaft, on whose distal end an instrument head is arranged. The instrument head tapers continuously in the distal direction. | 09-23-2010 |
20110092772 | ENDOSCOPIC INSTUMENT WITH AN LED ILLUMINATION MODULE - An endoscopic instrument is provided with an LED illumination module having at least one LED arranged at the distal end of the instrument and having an electrical connection lead attached to this LED. The connection lead is a coaxial cable, which extends from the distal end to the proximal end of the instrument, and is designed for leading away the waste heat produced by the LED. At least one electrical conductor of the coaxial cable is connected to the LED in a heat-conducting manner. | 04-21-2011 |
20110160532 | ENDOSCOPIC INSTRUMENT - An endoscopic instrument includes an elongate guide element having at least one guide rail extending from a proximal to a distal end of the guide element. At least one working instrument, which is provided with an engagement element which fits with the at least one guide rail, engages with the at least one guide rail in a manner such that the working instrument is displaceable along the at least one guide rail. | 06-30-2011 |
Tanja Heimberger, Wurzburg DE
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20110020287 | Parvovirus Cancer Therapy and Combination with Chemotherapy - Described is a pharmaceutical composition containing (a) a parvovirus and (b) a chemotherapeutic agent, preferably as separate entities. The parvovirus might be based on parvovirus H1, LuIII, Mouse minute virus (MMV), Mouse parvovirus (MPV), Rat minute virus (RMV), Rat parvovirus (RPV), Rat virus (RV), vectors based on the foregoing viral species, and/or cells capable of actively producing the foregoing viral species. The pharmaceutical composition is beneficial for the treatment of a tumor. Tumors for which a parvovirus or the adjunction of the invention has particular utility include glioma, medulloblastoma, meningioma and pancreatic cancer. Preferred chemotherapeutic agents are gemcitabine and Temozolodine. | 01-27-2011 |
Tanja Heimberger, Wuerzburg DE
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20140234261 | Parvovirus Cancer Therapy and Combination with Chemotherapy - Described is a pharmaceutical composition containing (a) a parvovirus and (b) a chemotherapeutic agent, preferably as separate entities. The parvovirus might be based on parvovirus H1, LuIII, Mouse minute virus (MMV), Mouse parvovirus (MPV), Rat minute virus (RMV), Rat parvovirus (RPV), Rat virus (RV), vectors based on the foregoing viral species, and/or cells capable of actively producing the foregoing viral species. The pharmaceutical composition is beneficial for the treatment of a tumor. Tumors for which a parvovirus or the adjunction of the invention has particular utility include glioma, medulloblastoma, meningioma and pancreatic cancer. Preferred chemotherapeutic agents are gemcitabine and Temozolodine. | 08-21-2014 |