Patent application number | Description | Published |
20130265585 | SYSTEMS AND METHODS FOR PHASE MEASUREMENTS - Preferred embodiments of the present invention are directed to systems for phase measurement such as for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. Light based techniques with nanometer resolution enable the cellular machinery to be studied in its native state. Thus, preferred embodiments of the present invention include systems based on principles of interferometry and/or phase measurements and are used to study cellular physiology. These systems include principles of low coherence interferometry (LCI) using optical interferometers to measure phase, or light scattering spectroscopy (LSS) wherein interference within the cellular components themselves is used, or in the alternative the principles of LCI and LSS can be combined to result in systems of the present invention. | 10-10-2013 |
20140361148 | SYSTEM AND METHOD FOR HILBERT PHASE IMAGING - Hilbert phase microscopy (HPM) as an optical technique for measuring high transverse resolution quantitative phase images associated with optically transparent objects. Due to its single-shot nature, HPM is suitable for investigating rapid phenomena that take place in transparent structures such as biological cells. A preferred embodiment is used for measuring biological systems including measurements on red blood cells, while its ability to quantify dynamic processes on the millisecond scale, for example, can be illustrated with measurements on evaporating micron-size water droplets. | 12-11-2014 |
Patent application number | Description | Published |
20120035442 | PORTABLE RAMAN DIAGNOSTIC SYSTEM - The present invention further relates to the selection of the specific filter combinations, which can provide sufficient information for multivariate calibration to extract accurate analyte concentrations in complex biological systems. The present invention also describes wavelength interval selection methods that give rise to the miniaturized designs. Finally, this invention presents a plurality of wavelength selection methods and miniaturized spectroscopic apparatus designs and the necessary tools to map from one domain (wavelength selection) to the other (design parameters). Such selection of informative spectral bands has a broad scope in miniaturizing any clinical diagnostic instruments which employ Raman spectroscopy in particular and other spectroscopic techniques in general. | 02-09-2012 |
20120259228 | TRI MODAL SPECTROSCOPIC IMAGING - The present invention relates to a spectroscopic imaging system using autofluorescence and reflectance images to diagnose tissue. A preferred embodiment of the invention uses a plurality of light sources to illuminate a tissue region to provide the fluorescence and reflectance images, respectively. | 10-11-2012 |
20120302892 | PORTABLE OPTICAL FIBER PROBE-BASED SPECTROSCOPIC SCANNER FOR RAPID CANCER DIAGNOSIS - A multimodal probe system for spectroscopic scanning of tissue for disease diagnosis. The system can use diffuse reflectance spectroscopy, fluorescence spectroscopy and Raman spectroscopy for the detection of cancerous tissue, such as tissue margin assessment. | 11-29-2012 |
20120307035 | SINGLE-SHOT FULL-FIELD REFLECTION PHASE MICROSCOPY - The present invention relates to a full-field reflection phase microscope. In a preferred embodiment, the invention can combine low-coherence interferometry and off-axis digital holographic microscopy (DHM). The reflection-based DHM provides highly sensitive and a single-shot imaging of cellular dynamics while the use of low coherence source provides a depth-selective measurement. A preferred embodiment of the system uses a diffraction grating in the reference arm to generate an interference image of uniform contrast over the entire field-of-view albeit low-coherence light source. With improved path-length sensitivity, the present invention is suitable for full-field measurement of membrane dynamics in live cells with sub-nanometer-scale sensitivity. | 12-06-2012 |
20150177133 | TOMOGRAPHIC PHASE MICROSCOPY - The present invention relates to systems and methods for quantitative three-dimensional mapping of refractive index in living or non-living cells, tissues, or organisms using a phase-shifting laser interferometric microscope with variable illumination angle. A preferred embodiment provides tomographic imaging of cells and multicellular organisms, and time-dependent changes in cell structure and the quantitative characterization of specimen-induced aberrations in high-resolution microscopy with multiple applications in tissue light scattering. | 06-25-2015 |
Patent application number | Description | Published |
20090203017 | Use of Nucleic Acid Probes to Detect Nucleotide Sequences of Interest in a Sample - The invention relates to methods for the determination and detection of nucleic acids sequences in a sample. The nucleic acid may be RNA or DNA or both. The invention also relates to methods for the determination of the presence and species of various microorganisms in a sample. We have also identified a set of oligonucleotide nucleic acid sequences within the rRNAs of Gram-negative organisms that facilitates both the broad identification of Gram-negative organisms as a class when used as a pool, or in combination, for example in a hybridization assay. This set of oligonucleotides may detect sequences that are indicative of the presence of organisms of the broad class of Gram-negative organisms while exhibiting little or no false identification of Gram-positive organisms, and fungi, or other microorganisms. The assay includes concurrent incubation with at least one nucleotide sequence of interest, at least one nucleic acid probe, a fluorosurfactant, and a nuclease. The assay may further be employed to detect the presence of bacteria, fungi, or other microorganisms by use of additional specific probes, or to detect and/or identify target nucleic acid sequences in a sample. Further, the invention also relates to methods of reducing non-specific binding and facilitating complex formation in a binding assay. The binding assay may be, but is not limited to, a nucleic acid hybridization assay or an immunoassay. The invention also relates to methods of detection that employ at least one target of interest, which may be a nucleotide sequence, at least one probe, which may be a nucleic acid probe and a nuclease. | 08-13-2009 |
20120301907 | METHODS, DEVICES, AND SYSTEMS OF DETECTING MICROORGANISMS - A rapid, sensitive method of separating and detecting microorganisms from a sample potentially containing microorganisms, such as but not limited to bacteria, fungi, yeast, viruses, and the like. The method relies on separation techniques to separate and concentrate the cells from the sample, together with chemical techniques to amplify the amount of detectable signal from low numbers of cells to provide a rapid and sensitive method of detecting microorganisms. This detection method may utilize: a filtration device; a centrifugation device; a system; a swab device; and kit comprising one or more of the devices and components to perform the present method of separating and detecting microorganisms in a sample potentially containing microorganisms. The sample may be a chemical, cosmetic, personal care, pharmaceutical, or consumable good in its raw material, in-process, and/or finished product states that needs to be tested for any contaminating microorganisms prior to shipment to the consumer. | 11-29-2012 |
20130309700 | METHODS, DEVICES, AND SYSTEMS OF DETECTING MICROORGANISMS - A rapid, sensitive method of separating and detecting microorganisms from a sample containing microorganisms, such as but not limited to bacteria, fungi, yeast, viruses, and the like. The method relies on separation techniques to separate and concentrate the cells from the sample, together with chemical techniques to amplify the amount of detectable signal from low numbers of cells to provide a rapid and sensitive method of detecting microorganisms. This detection method may utilize: a filtration device; a centrifugation device; a system; a swab device; and kit comprising one or more of the devices and components to perform the present method of separating and detecting microorganisms in a sample containing microorganisms. The sample may be a chemical, cosmetic, personal care, pharmaceutical, or consumable good in its raw material, in-process, and/or finished product states that needs to be tested for any contaminating microorganisms prior to shipment to the consumer. | 11-21-2013 |
20150140583 | METHODS, DEVICES, AND SYSTEMS OF DETECTING MICROORGANISMS - A rapid, sensitive method of separating and detecting microorganisms from a sample containing microorganisms, such as but not limited to bacteria, fungi, yeast, viruses, and the like. The method relies on separation techniques to separate and concentrate the cells from the sample, together with chemical techniques to amplify the amount of detectable signal from low numbers of cells to provide a rapid and sensitive method of detecting microorganisms. This detection method may utilize: a filtration device; a centrifugation device; a system; a swab device; and kit comprising one or more of the devices and components to perform the present method of separating and detecting microorganisms in a sample containing microorganisms. The sample may be a chemical, cosmetic, personal care, pharmaceutical, or consumable good in its raw material, in-process, and/or finished product states that needs to be tested for any contaminating microorganisms prior to shipment to the consumer. | 05-21-2015 |
20150322476 | METHODS, DEVICES, AND SYSTEMS OF DETECTING MICROORGANISMS - A rapid, sensitive method of separating and detecting microorganisms from a sample potentially containing microorganisms, such as but not limited to bacteria, fungi, yeast, viruses, and the like. The method relies on separation techniques to separate and concentrate the cells from the sample, together with chemical techniques to amplify the amount of detectable signal from low numbers of cells to provide a rapid and sensitive method of detecting microorganisms. This detection method may utilize: a filtration device; a centrifugation device; a system; a swab device; and kit comprising one or more of the devices and components to perform the present method of separating and detecting microorganisms in a sample potentially containing microorganisms. The sample may be a chemical (e.g., household cleaners), cosmetic, personal care, pharmaceutical, or consumable (e.g., food or beverage) good in its raw material, in-process, and/or finished product states that needs to be tested for any contaminating microorganisms prior to shipment to the consumer. | 11-12-2015 |
Patent application number | Description | Published |
20140042135 | SYSTEM AND METHOD OF RECEIVING OR USING DATA FROM EXTERNAL SOURCES FOR A WELDING SEQUENCE - The invention described herein generally pertains to a system and method for performing a welding operation that is controlled in part by a welding sequence. An input component is provided that receives an input from an operator during a performance of a welding operation in which the input allows control of the welding operation or feedback from the welding operation. In an embodiment, the input component is incorporated or affixed to equipment of the operator. An Radio Frequency Identification (RFID) tag is further utilized to control use of a welding sequence based on wireless data communicated between the RFID tag and an RFID component. | 02-13-2014 |
20140042136 | SYSTEM AND METHOD OF EXPORTING OR USING WELDING SEQUENCER DATA FOR EXTERNAL SYSTEMS - The invention described herein generally pertains to a system and method for collecting one or more welding parameters in real time during creation of one or more welds using a welding sequence. The one or more welding parameters can be associated with a particular welding sequence. Moreover, based on the one or more welding parameters collected, a modeled welding parameter can be generated to increase quality, efficiency, and the like. A collection component collects real time welding parameter data from which a quality manager component creates a modeled welding parameter. The modeled welding parameter can be employed for the welding sequence to monitor or track the welding parameter during a subsequent weld. | 02-13-2014 |
20140263226 | SYSTEM AND METHOD FOR CREATING OR MODIFYING A WELDING SEQUENCE - The invention described herein generally pertains to a system and method for welder system that relates to creating a welding sequence for a welding environment in which the welding sequence is based upon non-real time data collected from a welding procedure. Welding procedure information is collected and utilized to create a welding sequence to perform two or more welds in which at least one parameter is based on the collected welding procedure information (e.g., non-real world welding procedure). | 09-18-2014 |
20140263227 | SYSTEM AND METHOD OF RECEIVING OR USING DATA FROM EXTERNAL SOURCES FOR A WELDING SEQUENCE - The invention described herein generally pertains to a system and method for evaluating one or more conditions or preliminary weld condition related to a welding system and/or method that utilizes a welding sequence to perform two or more welds with respective welding schedules. In an embodiment, an operator registration is provided that verifies the operator and identifies welding sequences to which the operator is authorized to perform. In another embodiment, one or more fixture locations are monitored to determine whether a workpiece is accurately configured prior to a welding operation. In still another embodiment, locations on a workpiece can be displayed to assist an operator in performing two or more welds utilizing a welding sequence. Moreover, a wireless system communications a data signal to a welding work cell in which such data is used to identify a welding sequence. | 09-18-2014 |
Patent application number | Description | Published |
20100176104 | METHOD AND APPARATUS FOR ADAPTIVE GMAW SHORT CIRCUIT FREQUENCY CONTROL AND METHOD OF HIGH DEPOSITION ARC WELDING - An electric arc welding device for performing a pulse welding process by a current between an advancing electrode and workpiece where the welder comprises a short detecting circuit for creating a short signal upon occurrence of a short circuit between the advancing electrode and the workpiece and a boost circuit to create a plasma boost pulse after the short circuit is cleared during the time period when the welder is not outputting the peak pulse current. The peak pulse current to background current ratio is high and the duration of the peak pulse is short. | 07-15-2010 |
20100237052 | METHOD AND APPARATUS FOR ADAPTIVE GMAW SHORT CIRCUIT FREQUENCY CONTROL - A welding apparatus having a waveform compensation device, a power section coupled to the waveform compensation device which generates a welding waveform in accordance with a signal from the waveform compensation device, and a frequency detection device which detects at least one of a voltage, current and power of a welding arc and determines a shorting frequency of the arc. The waveform compensation device adjusts at least a portion of the welding waveform based on an output from the frequency detection device. | 09-23-2010 |
20120325791 | WELDING SYSTEM WITH CONTROLLED WIRE FEED SPEED DURING ARC INITATION - A welding system including a power supply, a torch electrically connected to said power supply, a wire feeder that provides a welding consumable to the torch, a controller that communicates with a motor associated the wire feeder and the power supply. The controller obtains a wire feed speed of said motor as it accelerates from a run-in speed to a pre-set speed and controls the power supplied to the torch based on this wire feed speed to reduce stubbing or spattering during arc initiation. | 12-27-2012 |
20140110385 | SYSTEM AND METHODS PROVIDING MODULATION SCHEMES FOR ACHIEVING A WELD BEAD APPEARANCE - Systems and methods for affecting an appearance of a deposited weld bead by modulating one or more welding parameters. For example, an electrode negative portion of a welding output current may be modulated to affect the appearance of a deposited weld bead. Furthermore, a wire feed speed of a welding electrode may be synergistically modulated with an electrode negative portion of a welding output current to affect a deposited weld bead appearance. Two or more welding processes may be interleaved with each other at a specified modulation frequency to affect a deposited weld bead appearance. One or more welding parameters may be modulated based on a welding travel speed to provide a consistent appearance of a deposited weld bead. | 04-24-2014 |
20140131320 | SYSTEM AND METHOD TO DETECT DROPLET DETACHMENT - The invention described herein generally pertains to a method for improved droplet detachment detection in a welding process in which a derivative of at least one welding parameter over time is used to detect droplet detachment from the wire during a welding operation based identification of a peak signature. | 05-15-2014 |
20140131322 | SYSTEM AND METHODS PROVIDING MODULATION SCHEMES TO AFFECT HEAT INPUT TO A WELD - Systems and methods to affect heat input to a weld and, therefore, an appearance of a deposited weld bead by modulating a mixing ratio of shielding gases and/or one or more welding parameters. For example, a mixing ratio of two different shielding gases from two sources of shielding gases may be modulated to affect the appearance of a deposited weld bead. The modulation frequency may be based on a selected travel speed of a welding tool. Furthermore, a wire feed speed of a welding electrode may be synergistically modulated with the shielding gases to affect a deposited weld bead appearance. Other welding parameters may be synergistically modulated with the shielding gases to affect a deposited weld bead appearance. | 05-15-2014 |
20140131332 | SYSTEMS AND METHODS TO FACILITATE THE STARTING AND STOPPING OF ARC WELDING PROCESSES - Systems and methods for facilitating the starting and stopping of arc welding processes, as well as for responding to events in mid-weld. Specially designed signals may be briefly applied between a welding electrode and a welding workpiece at the start and end of a welding process to gracefully and properly start and stop a weld. Furthermore, specially designed signals may be briefly applied in the middle of a welding process, if determined events occur, to counter the undesirable effects of the events. | 05-15-2014 |
20140251971 | ELECTRIC ARC WELDER USING HIGH FREQUENCY PULSES AND NEGATIVE POLARITY - An electric arc welder including a high speed switching power supply with a controller for creating high frequency current pulses with negative polarity components through the gap between a workpiece and a welding wire advancing toward the workpiece, where the pulses and a background current defining a series of weld cycles. A wave shape generator defines the shape of the pulses and the background current including a controlled ramp up and/or ramp down in each of said cycles, and a circuit to change the shapes of the pulses and/or background current in a repeating pattern in each of the weld cycles, including a negative current in at one of said pulses. The shape change in a cycle can be between first and second shapes or by a rhythmic AC modulation. | 09-11-2014 |