Hay, GB
Alan Hay, Belfast GB
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20130132560 | DYNAMIC ADAPTATIONS FOR NETWORK DELAYS DURING COMPLEX EVENT PROCESSING - A message handler may receive a plurality of messages associated with a plurality of events, the events having a temporal relationship to one another. A header inspector may extract latency information from the plurality of messages, the latency information characterizing a transmission duration experienced by each message in traveling from the one or more source nodes through the network. A window manager may correct a disruption in the temporal relationship between at least two events of the plurality of events, the disruption including relative differences in the transmission duration experienced by the at least two events, including relating the at least two events to a time window for processing the at least two events. An event processor may process the at least two events relative to the time window. | 05-23-2013 |
Alan James Hay, London GB
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20090265114 | Influenza virus neuraminidase crystal structure and their use thereof - The invention relates to crystals of the influenza virus neuraminidase protein, their structures and their use. | 10-22-2009 |
Alastair Mackie Hay, Gladsmuir GB
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20130211047 | PURIFICATION TAGS OF SYNTHETIC PEPTIDES AND PROTEINS - The present invention relates to a series of compounds useful for effecting purification, in particular for use in purification of synthetic peptides and proteins. The compounds of the invention are particularly efficient at securely anchoring peptides or proteins to a surface and allowing the peptide or protein to become uniformly orientated, thus ensuring that substantially all of the peptide or protein is available for molecular binding to a substrate. | 08-15-2013 |
David C. Hay, Midlothian GB
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20100086999 | DIFFERENTIATION OF PRIMATE PLURIPOTENT CELLS TO HEPATOCYTE-LINEAGE CELLS - Methods for differentiating primate pluripotent stem cells into hepatocyte-lineage cells are provided. In certain embodiments, the methods utilize sequential culturing of the primate pluripotent stem cells in certain growth factors to produce hepatocyte-lineage cells. In certain embodiments, the population of cells produced by the methods is further enriched for hepatocyte-lineage cells. | 04-08-2010 |
Frances Geralyn Boul Hay, Prestbury GB
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20140195379 | Technology Alternative to Money for Enabling Equitable Trade - Technology, alternative to money, for enabling equitable trade between users. The technology embodies chiralkine money and chiralkine property rights created as vectors through chiralkine contracts made by a recorder that maintains an open register and a trading pair of two users. | 07-10-2014 |
Gareth Ian Hay, Middlesex GB
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20100129710 | LITHOGRAPHICALLY PRINTED CELLS - There are disclosed cells ( | 05-27-2010 |
Gary Hay, Motherwell GB
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20100287443 | PROCESSOR BASED SYSTEM HAVING ECC BASED CHECK AND ACCESS VALIDATION INFORMATION MEANS - A system comprises a first master element; and at least one shared communication element arranged to operably couple the first master element to at least one slave element. The system further comprises at least one validation element located on at least one further validation path located between the first master element and the at least one slave element, wherein the at least one validation element is arranged to validate at least one of: at least one access request by the first master element; and a response to an access request from the at least one slave element. | 11-11-2010 |
20110082970 | SYSTEM FOR DISTRIBUTING AVAILABLE MEMORY RESOURCE - A system for distributing available memory resource comprising at least two random access memory (RAM) elements and RAM routing logic. The RAM routing logic comprises configuration logic to dynamically distribute the available memory resource into a first memory area providing redundant memory storage and a second memory area providing non-redundant memory storage. | 04-07-2011 |
20110083041 | MEMORY SYSTEM WITH REDUNDANT DATA STORAGE AND ERROR CORRECTION - A system comprises at least two random access memory (RAM) elements arranged to store data redundantly. The system further comprises RAM routing logic comprising comparison logic operably coupled to the at least two RAM elements and arranged to compare redundant data read from the at least two RAM elements, and check and validation logic, independent of the RAM routing logic, operably coupled to the at least two RAM elements and arranged to additionally detect an error in the redundant data read from the at least two RAM elements and provide an error indication signal to the RAM routing logic in response thereto. The RAM routing logic further comprises selection logic arranged to dynamically select redundant data from one of the at least two RAM elements based on the comparison of the redundant data and the error indication signal. | 04-07-2011 |
James W. Hay, Cambridge GB
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20110210619 | ADAPTING PORTABLE ELECTRICAL DEVICES TO RECEIVE POWER WIRELESSLY - Wireless power receiving apparatus 150 is retrofitted to a portable electrical device 100 to enable the device to receive power wirelessly. The apparatus comprises a power-receiving element 200 adapted to be attached to the device, e.g. by adhesive 201, and also being adapted to receive power wirelessly from a transmitter of power when the element and transmitter are in proximity with one another. One or more power connectors 203 are connected electrically to the power-receiving element and are adapted to be connected, when the apparatus is in use, to one or more corresponding power connectors 101 of the portable electrical device to deliver power received by the element to the device. The power-receiving element may be in the form of a sticker or may be carried by or incorporated in a replacement cover portion for the portable electrical device. | 09-01-2011 |
20120319500 | ADAPTING PORTABLE ELECTRICAL DEVICES TO RECEIVE POWER WIRELESSLY - Wireless power receiving apparatus | 12-20-2012 |
James Westwood Hay, Cambridge GB
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20090096414 | CONTACT-LESS POWER TRANSFER - A unit for transferring power in an inductive manner to at least one power-receiving device, and a system comprising such a unit and such a device. The unit includes at least one coil structure configured to allow various degrees of translational and rotational freedom of movement of the power-receiving device relative thereto. This provides increased ease of use, since it is not necessary for a user to place the power-receiving device in mechanical or other registration with the unit. | 04-16-2009 |
20090189565 | CONTACT-LESS POWER TRANSFER - There is disclosed a system and method for transferring power without requiring direct electrical conductive contacts. There is provided a primary unit having a power supply and a substantially laminar charging surface having at least one conductor that generates an electromagnetic field when a current flows therethrough and having an charging area defined within a perimeter of the surface, the at least one conductor being arranged such that electromagnetic field lines generated by the at least one conductor are substantially parallel to the plane of the surface or at least subtend an angle of 45° or less to the surface within the charging area; and at least one secondary device including at least one conductor that may be wound about a core. Because the electromagnetic field is spread over the charging area and is generally parallel or near-parallel thereto, coupling with flat secondary devices such as mobile telephones and the like is significantly improved in various orientations thereof. | 07-30-2009 |
20100219791 | CONTACT-LESS POWER TRANSFER - There is disclosed a system and method for transferring power without requiring direct electrical conductive contacts. There is provided a primary unit having a power supply and a substantially laminar charging surface having at least one conductor that generates an electromagnetic field when a current flows therethrough and having an charging area defined within a perimeter of the surface, the at least one conductor being arranged such that electromagnetic field lines generated by the at least one conductor are substantially parallel to the plane of the surface or at least subtend an angle of 45° or less to the surface within the charging area; and at least one secondary device including at least one conductor that may be wound about a core. Because the electromagnetic field is spread over the charging area and is generally parallel or near-parallel thereto, coupling with flat secondary devices such as mobile telephones and the like is significantly improved in various orientations thereof. | 09-02-2010 |
20100320963 | CONTACT-LESS POWER TRANSFER - There is disclosed a system and method for transferring power without requiring direct electrical conductive contacts. There is provided a primary unit having a power supply and a substantially laminar charging surface having at least one conductor that generates an electromagnetic field when a current flows therethrough and having an charging area defined within a perimeter of the surface, the at least one conductor being arranged such that electromagnetic field lines generated by the at least one conductor are substantially parallel to the plane of the surface or at least subtend an angle of 45° or less to the surface within the charging area; and at least one secondary device including at least one conductor that may be wound about a core. Because the electromagnetic field is spread over the charging area and is generally parallel or near-parallel thereto, coupling with flat secondary devices such as mobile telephones and the like is significantly improved in various orientations thereof. | 12-23-2010 |
Jennifer Hay, Glasgow GB
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20110008813 | ASSAY DEVICE AND METHOD - An assay method and device can perform at least one (e.g., at least two) assays on a single aliquot of a sample liquid. The device can mix a sample liquid with assay reagents including magnetically susceptible particles. The device is configured to create a sample liquid-air interface with the sample liquid. The magnetically susceptible particles can be located (via an applied magnetic field) at the liquid-air interface when a second liquid contacts the interface to form a liquid-liquid interface. The magnetic particles travel across the liquid:liquid interface to the second liquid. The magnetically susceptible particles are configured to transport an analyte across the interface into the second liquid. An assay for the analyte is performed in the second liquid. An assay for another analyte can also be performed in the sample liquid. | 01-13-2011 |
Joanna Hay, Devon GB
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20120059155 | Method of Controlling O-Linked Glycosylation of Antibodies - A method for producing antibodies in fungal host cells is provided where the produced antibodies has a low degree of glycosylation. | 03-08-2012 |
Joanna Hay, Leicestershire GB
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20100222267 | RECOMBINANT TRANSFERRIN MUTANTS - The present invention provides a recombinant protein comprising the sequence of a transferrin mutant, wherein Ser415 is mutated to an amino acid which does not allow glycosylation at Asn413 and/or wherein Thr613 is mutated to an amino acid which does not allow glycosylation as Asn611. It also provides polynucleotides encoding the same and methods of making and using said recombinant protein. | 09-02-2010 |
20140031294 | RECOMBINANT TRANSFERRIN MUTANTS - The present invention provides a recombinant protein comprising the sequence of a transferrin mutant, wherein Ser415 is mutated to an amino acid which does not allow glycosylation at Asn413 and/or wherein Thr613 is mutated to an amino acid which does not allow glycosylation as Asn611. It also provides polynucleotides encoding the same and methods of making and using said recombinant protein. | 01-30-2014 |
Joanna Hay, Colyton GB
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20090175893 | Albumin-Fused Anti-Angiogenesis Peptides - The invention relates to proteins comprising angiogenesis inhibiting peptides, such as endostatin peptides (including, but not limited to, fragments and variants thereof), which exhibit anti-retroviral activity, fused or conjugated to albumin (including, but not limited to fragments or variants of albumin). These fusion proteins are herein collectively referred to as “albumin fusion proteins of the invention.” These fusion proteins are herein collectively referred to as “albumin fusion proteins of the invention.” These fusion proteins exhibit extended shelf-life and/or extended or therapeutic activity in solution. The invention encompasses therapeutic albumin fusion proteins, compositions, pharmaceutical compositions, formulations and kits. The invention also encompasses nucleic acid molecules encoding the albumin fusion proteins of the invention, as well as vectors containing these nucleic acids, host cells transformed with these nucleic acids and vectors, and methods of making the albumin fusion proteins of the invention using these nucleic acids, vectors, and/or host cells. The invention also relates to compositions and methods for inhibiting proliferation of vascular endothelial cells and tumor angiogenesis induced cell fusion. The invention further relates to compositions and methods preventing growth of, or promoting regression of, primary tumors and metastases; and for treating cancer, diabetic retinopathy, progressive macular degeneration or rheumatoid arthritis. | 07-09-2009 |
20120263747 | Albumin-Fused Anti-Angiogenesis Peptides - The invention relates to proteins comprising angiogenesis inhibiting peptides, such as endostatin peptides (including, but not limited to, fragments and variants thereof), which exhibit anti-retroviral activity, fused or conjugated to albumin (including, but not limited to fragments or variants of albumin). These fusion proteins are herein collectively referred to as ‘albumin fusion proteins of the invention.’ These fusion proteins are herein collectively referred to as ‘albumin fusion proteins of the invention.’ These fusion proteins exhibit extended shelf-life and/or extended or therapeutic activity in solution. The invention encompasses therapeutic albumin fusion proteins, compositions, pharmaceutical compositions, formulations and kits. The invention also encompasses nucleic acid molecules encoding the albumin fusion proteins of the invention, as well as vectors containing these nucleic acids, host cells transformed with these nucleic acids and vectors, and methods of making the albumin fusion proteins of the invention using these nucleic acids, vectors, and/or host cells. The invention also relates to compositions and methods for inhibiting proliferation of vascular endothelial cells and tumor aniogenesis induced cell fusion. The invention further relates to compositions and methods preventing growth of, or promoting regression of, primary tumors and metastases; and for treating cancer, diabetic retinophathy, progressive macular degeneration or rheumatoid arthritis. | 10-18-2012 |
Joanna Mary Hay, Devon GB
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20110313133 | Albumin variants and conjugates - Based on the three-dimensional structure of albumin, the inventors have designed variant polypeptides (muteins) which have one or more cysteine residues with a free thiol group (hereinafter referred to as “thio-albumin”). The variant polypeptide may be conjugated through the sulphur atom of the cysteine residue to a conjugation partner such as a bioactive compound. | 12-22-2011 |
Joanne Hay, Leicestershire GB
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20110124576 | Transferrin Variants and Conjugates - Based on the three-dimensional structure of transferrin, the inventors have designed variant polypeptides (muteins) which have one or more Cysteine residues with a free thiol group (hereinafter referred to as thiotransferrin). The variant polypeptide may be conjugated through the sulphur atom of the Cysteine residue to a bioactive compound. | 05-26-2011 |
Johanna Hay, Colyton GB
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20140017273 | Albumin-Fused Anti-Angiogenesis Peptides - The present disclosure relates to albumin fusion protein including an angiogenesis inhibiting peptide, or a fragment or variant thereof, and albumin, or a fragment or variant thereof. The fusion proteins exhibit extended shelf-life and/or extended or therapeutic activity in solution. The disclosure includes therapeutic albumin fusion proteins, compositions, pharmaceutical compositions, formulations and kits, as well as nucleic acid molecules encoding the albumin fusion proteins, vectors containing these nucleic acids, host cells transformed with these nucleic acids and vectors, and methods of making the albumin fusion proteins using these nucleic acids, vectors, and/or host cells. The disclosure further relates to compositions and methods for inhibiting proliferation of vascular endothelial cells and tumor angiogenesis induced cell fusion. The disclosure further relates to compositions and methods preventing growth of, or promoting regression of, primary tumors and metastases; and for treating cancer, diabetic retinophathy, progressive macular degeneration or rheumatoid arthritis. | 01-16-2014 |
Laura Anne Hay, Banchory GB
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20140239011 | CONTAINER FOR USE WITH A COUNTER MOUNTED DISPENSING SYSTEM - The present disclosure relates to a container for flowable material configured to be installed in a counter below an access hole. The container includes a first deformable portion and a second deformable portion. The first deformable portion defines a first cavity and has a sealable first cavity inlet. The second deformable portion defines a second cavity and is in flow communication with the first cavity. The first deformable portion is configured to deform to fit into the access hole when substantially no flowable material is therein and the second deformable portion configured to deform to fit through the access hole when substantially no flowable material is therein. The disclosure also includes a method of installing a container of flowable material in a counter below an access hole. | 08-28-2014 |
Martin Alexander Hay, Prestbury GB
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20110082805 | METHOD FOR DISCOVERING DRUGS - A method of creating patent rights for a business entity in a drug candidate for clinical development, in which an expert in pharmaceutical science and an expert in pharmaceutical patent law collaborate in a risk-free environment to identify and protect drug candidates, and a kit useful in the method. | 04-07-2011 |
20130221616 | Chiralkine - A game in which the moves players can make simulate both the symmetric and antisymmetric couplings of muscle pairs that accompany co-ordinated movement of the two sides of the human body, and in which each player's move comprises two components, one beneficial to the player and the other beneficial to the player(s) opponents (herein called chiralkines); a kit for playing the game; an electronic gaming device for use in playing the game; left- and right handed money and left- and right-handed property rights for use in a game or commerce; and apparatuses adapted for use with these. | 08-29-2013 |
20140195379 | Technology Alternative to Money for Enabling Equitable Trade - Technology, alternative to money, for enabling equitable trade between users. The technology embodies chiralkine money and chiralkine property rights created as vectors through chiralkine contracts made by a recorder that maintains an open register and a trading pair of two users. | 07-10-2014 |
Philip Andrew Hay, Scarborough GB
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20100330077 | 1-ACETIC ACID-INDOLE DERIVATIVES WITH PGD2 ANTAGONIST ACTIVITY - Compounds of general formula (I) | 12-30-2010 |
Timothy Nicholas Hay, Cambridge GB
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20110116337 | Synchronising between clock domains - An integrated circuit | 05-19-2011 |
Timothy Nicholas Hay, Cherry Hinton GB
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20140156949 | FAULT HANDLING IN ADDRESS TRANSLATION TRANSACTIONS - A data processing apparatus having a memory configured to store tables having virtual to physical address translations, a cache configured to store a subset of the virtual to physical address translations and cache management circuitry configured to control transactions received from the processor requesting virtual address to physical address translations. The data processing apparatus identifies where a faulting transaction has occurred during execution of a context and whether the faulting transaction has a transaction stall or transaction terminate fault. The cache management circuitry is responsive to identification of the faulting transaction having a transaction terminate fault to invalidate all address translations in the cache that relate to the context of the faulting transaction such that a valid bit associated with each entry in the cache is set to invalid for the address translations. | 06-05-2014 |