Hartshorn
Cristina Hartshorn, West Roxbury, MA US
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20140206564 | REAGENTS FOR IMPROVING PCR ACCURACY - Provided herein are reagents for improving PCR accuracy. | 07-24-2014 |
Cristina Hartshorn, Needham, MA US
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20080280292 | Late-PCR - A non-symmetric polymerise chain reaction (PCR) amplification method employing a limiting primer in low concentration whose concentration-adjusted melting point at least equals, and preferably exceeds, that of the excess primer, the latter in turn not being more than 25° C. below the melting temperature of the amplicon. Assays employing such amplification and labeled hybridization probes, including assays that include a detection step following primer extension or a low-temperature probe, or both. Kits for performing such assays and primer or primer-and-probe sets for performing the foregoing amplifications and assays. | 11-13-2008 |
20090111170 | Nucleic acid processing methods, kits and devices - Biological samples containing nucleic acids, RNA and DNA, are freed from bound proteins by incubation with a chaotropic agent such as a guanidium salt, and the mixture is readied for further processing by dilution of such agent to a concentration below 0.05 M without physical isolation of RNA and DNA from one another or from other components of the reaction mixture. Methods include such preparation and further processing, such as amplification and detection, which may be performed in a single container. Chaotropic agent may be supplied as a dried reagent adhered to a container. Kits may include such reagents, alone or with amplification reagents. | 04-30-2009 |
20110311971 | RT-LATE-PCR - An assay comprising more than one primer pair and more than one detection probe, a low copy number synthetic amplicon corresponding to each of the primer pairs. The assay can detect and distinguish between various sub-types and strains of an influenza virus using any suitable nucleic acid amplification technique. Related kits and methods are also described. | 12-22-2011 |
20120040352 | Primers, probes and methods for nucleic acid amplification - Homogenous detection during or following PCR amplification, preferably LATE-PCR, utilizing fluorescent DNA dye and indirectly excitable labeled primers and probes, improves reproducibility and quantification. Low-temperature homogeneous detection during or following non-symmetric PCR amplification, preferably LATE-PCR, utilizing fluorescent DNA dye and indirectly excitable labeled mismatch-tolerant probes permits analysis of complex targets. Sequencing sample preparation methods following LATE-PCR amplifications reduce complexity and permit “single-tube” processing. | 02-16-2012 |
20120198576 | METHODS FOR MAKING EMBRYONIC CELLS, EMBRYOS, AND ANIMALS SENSITIZED TO STRESS - Embodiments of the invention are based upon the discovery that exposure of cleavage-stage embryos to a stress inducer, e.g. heat shock or chemical, renders the exposed embryos more sensitive to a secondary treatment with a stress inducer, e.g. heat shock or chemical inducer. Accordingly, the present invention is directed to methods for making embryos, embryonic cells arising from them, and animals and plants that are sensitized to stress, e.g. physiologic or chemical stressors. Methods of screening for inducers and inhibitors of stress using, as test model systems, embryonic cells, embryos, animals, and plants that are sensitized to stress are also disclosed. | 08-02-2012 |
20130095479 | PRIMERS, PROBES AND METHODS FOR NUCLEIC ACID AMPLIFICATION - Homogenous detection during or following PCR amplification, preferably LATE-PCR, utilizing fluorescent DNA dye and indirectly excitable labeled primers and probes, improves reproducibility and quantification. Low-temperature homogeneous detection during or following non-symmetric PCR amplification, preferably LATE-PCR, utilizing fluorescent DNA dye and indirectly excitable labeled mismatch-tolerant probes permits analysis of complex targets. Sequencing sample preparation methods following LATE-PCR amplifications reduce complexity and permit “single-tube” processing. | 04-18-2013 |
20130210656 | LATE-PCR - A non-symmetric polymerise chain reaction (PCR) amplification method employing a limiting primer in low concentration whose concentration-adjusted melting point at least equals, and preferably exceeds, that of the excess primer, the latter in turn not being more than 25° C. below the melting temperature of the amplicon. Assays employing such amplification and labeled hybridization probes, including assays that include a detection step following primer extension or a low-temperature probe, or both. Kits for performing such assays and primer or primer-and-probe sets for performing the foregoing amplifications and assays. | 08-15-2013 |
Ian Martin Hartshorn, Toronto CA
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20090271711 | AUTOMATED RELATIONSHIP MANAGEMENT FOR DARWIN INFORMATION TYPING ARCHITECTURE - Embodiments of the present invention address deficiencies of the art in respect to relationship management in information architectures and provide a novel and non-obvious method, computer system and computer program product for managing links in a Darwin Information Typing Architecture (DITA). In one embodiment of the invention, a method for managing DITA links can include reading an information unit file comprising a plurality of topics and reading a relationship management file corresponding to the information unit file, wherein the relationship management file comprises at least one link corresponding to at least one of the plurality of topics, wherein a link comprises a reference to or from a second topic. The method can further include displaying in a graphical user interface the plurality of topics and displaying in the graphical user interface a description of each link corresponding to the plurality of topics. | 10-29-2009 |
Jason P. Hartshorn, East Bridgewater, MA US
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20140290346 | MEASUREMENT INSTRUMENT HAVING TOUCHSCREEN USER INTERFACE AND METHOD FOR MEASURING VISCOSITY - The present disclosure provides a viscometer or a rheometer including a touch screen interface. The touch screen interface enables a wider variety of user interface options and functions that would otherwise be cumbersome to implement. These options and functions include a wide variety of settings, security features, and the ability to manipulate test definitions and test data. | 10-02-2014 |
Joe L. Hartshorn, Portsmouth GB
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20150089356 | Text Selection - Mechanisms for selecting text within a displayed document comprises mechanisms for performing the operations of displaying a document comprising continuous text, receiving user input defining a single continuous area of the displayed document, the defined area covering text within the displayed document that is non-continuous, and capturing the text within the defined area. Objects can also be selected with the tool, and multiple areas can also be selected in the same way, all of which can be of any shape that the user desires. | 03-26-2015 |
Matthew B. Hartshorn, Pasadena, CA US
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20090107485 | CALIBRATION AND TRACKING CONTROL OF HELIOSTATS IN A CENTRAL TOWER RECEIVER SOLAR POWER PLANT - A suntracking system for a central receiver solar power plant includes a heliostat field for reflecting sunlight to a receiver, cameras directed toward at least a subset of the heliostats, and a controller. The cameras are configured to produce images of sunlight reflected from multiple heliostats. The heliostats include a mirrored surface having a settable orientation and have a geometry modeled by a set of parameters. A method of estimating heliostat parameters for open-loop suntracking includes acquiring pointing samples by setting the direction of reflection of the heliostats and detecting concurrent sunlight reflections into the cameras. The method uses the acquired pointing samples and surveyed locations of the cameras to estimate the heliostat parameters. The method accurately maintains the sun's reflection directed toward the receiver open-loop utilizing the estimated tracking parameters. | 04-30-2009 |
20120092491 | CALIBRATION AND TRACKING CONTROL OF HELIOSTATS IN A CENTRAL TOWER RECEIVER SOLAR POWER PLANT - A suntracking system for a central receiver solar power plant includes a heliostat field for reflecting sunlight to a receiver, cameras directed toward at least a subset of the heliostats, and a controller. The cameras are configured to produce images of sunlight reflected from multiple heliostats. The heliostats include a mirrored surface having a settable orientation and have a geometry modeled by a set of parameters. A method of estimating heliostat parameters for open-loop suntracking includes acquiring pointing samples by setting the direction of reflection of the heliostats and detecting concurrent sunlight reflections into the cameras. The method uses the acquired pointing samples and surveyed locations of the cameras to estimate the heliostat parameters. The method accurately maintains the sun's reflection directed toward the receiver open-loop utilizing the estimated tracking parameters. | 04-19-2012 |
Richard Hartshorn, London GB
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20110051968 | LOUDSPEAKER ENCLOSURES FOR MOUNTING IN AN APERTURE IN A CAVITY WALL - A loudspeaker enclosure for mounting in an aperture in a cavity wall with a part of the enclosure being located within the wall cavity adjacent the aperture, comprises a main enclosure unit for mounting in the aperture and housing one or more loudspeaker drive units, and a supplementary enclosure unit for location within the wall cavity and being acoustically connected in use to the main unit to increase the effective internal volume of the enclosure beyond that of the main unit. The supplementary unit is connected to the main unit by an articulated connection enabling the main unit to be angled relative to the supplementary unit while the supplementary unit is being inserted through the aperture and into the wall cavity, and enabling the main unit to be aligned with and acoustically coupled to the supplementary unit when the main unit is positioned in the wall aperture. | 03-03-2011 |
Richard A. Hartshorn, London GB
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20090018470 | DEVICE | 01-15-2009 |
20120078261 | PATELLA RESECTIONING GUIDE AND ASSEMBLY - A patella resection assembly comprises a patella resection guide and a stylus. The patella resection guide has bone-gripping members on two movable arms and a saw guide surface. The stylus is pivotably mounted to the arms of the resection guide and has a free end received in the slot in the resection guide. The arms of the patella resection guide are movable to a variety of positions with different distances between the bone-gripping members while the stylus is in place. | 03-29-2012 |
20130023890 | PATELLA CLAMP AND DRILL GUIDE SURGICAL INSTRUMENT - An orthopaedic surgical instrument includes a patella drill guide having a first bracket, a second bracket coupled to the first bracket and moveable relative to the first bracket. The second bracket includes a drill plate having a plurality of guide holes defined therein. | 01-24-2013 |
Richard Andrew Hartshorn, London GB
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20140253872 | SEALING SYSTEM FOR USE IN VARIABLE FOCUS LENSES - The present disclosure provides a sealing device for use in variable focus lenses that includes a guide member having at least one internal cavity and a passageway intersecting the internal cavity. A pinch member is slidably engaged within the internal cavity of the guide member and a portion of the pinch member slides across the passageway and into a portion of the internal cavity to deform and seal a fluid tube extending through the passageway. A set of adjustable eyeglasses employing the sealing device is also provided. | 09-11-2014 |
Richard Timothy Hartshorn, Lawrenceburg, IN US
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20080242570 | LIQUID COMPOSITION SYSTEM HAVING A VISUAL INDICATION CHANGE - A detergent composition having a pH dye and an amphoteric surfactant that changes color when added to a volume of water. | 10-02-2008 |
Scott Hartshorn, Everett, WA US
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20100147996 | FAIL SAFE EXTENDED TORQUE BOX STRUT-TO-WING MOUNT - An apparatus for mounting an aircraft engine to a wing includes a torque box strut for supporting the engine and a mounting system for attaching the torque box strut to the wing. The mounting system has an aft mounting system for attaching the torque box strut to the wing and that has at least one active aft link for attaching the torque box strut to the wing during normal aircraft operation, and at least one aft link catcher for attaching the torque box strut to the wing upon a failure of one of the at least one active aft link. The mounting system has a forward mounting system for attaching the torque box strut to the wing and that has at least one active forward link for attaching the torque box strut to the wing during normal aircraft operation, and at least one forward link catcher for attaching the torque box strut to the wing upon a failure of one of the at least one active forward link. | 06-17-2010 |
Scott D. Hartshorn, Everett, WA US
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20090089019 | APPARATUS AND METHODS FOR GENERATING A POINT REPRESENTATION OF A STRUCTURE - A computer-performed method of modeling a physical structure. A plurality of geometric parameters specific to a type of the structure are applied to aerodynamic surface data in accordance with rules predefined for the structure type to geometrically describe a plurality of structural features. Based on the geometric describing, a plurality of points representing the structure are obtained. The points are used to model the structure. | 04-02-2009 |
Stephen Richard Hartshorn, St. Paul, MN US
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20110077358 | Functional Polymer With Pendant Color Changing Indicator - A functionalized polymer is disclosed that comprises the reaction product of a polymer having one or more pendant reactive functional groups and a color changing indictor having a co-reactive functional group. The co-reactive functional group of the color changing is able to react with the reactive functional group of the polymer to form a covalent bond. Therefore, the color changing indicator is pendant from the polymer. The color changing indicator maintains its ability to produce a visually discernable color change in the presence of an associated stimulus. | 03-31-2011 |
Steven Jon Hartshorn, Henderson, NV US
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20140017919 | Distribution Tap Security Cover - A security cover for a distribution tap that is mounted over the top of the tap preventing access to the service drop ports on top of the tap. The security cover includes one or more walls, a lid allowing access through the security cover to the tap, a base plate attachable to the tap and notches in at least one wall for cable access. The lid and walls fit over and substantially enclose the service drop ports of the tap. The lid is attachable to at least one of the walls via a z-hinge and a barrel and plunger lock is used to secure the lid to the walls. One side of the base plate is attachable to the walls and the opposite side of the base plate is attachable to the tap. The base plate is substantially open to the top surface of the tap and is attachable to the tap via the tap's existing mounting points. | 01-16-2014 |