Harrison, MA
Brian Harrison, Wayland, MA US
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20150294363 | PRIORITIZED LOCATION BASED AD DISPLAY - Systems and methods of displaying content from a vehicle are described. A vehicle location module can determine a vehicle location of the vehicle. A vehicle detection module can detect whether another vehicle is behind the vehicle. The vehicle detection module, responsive to the detection, can identify a vehicle type of the other vehicle and can determine a relative velocity of the other vehicle. A vehicle accelerometer module can measure a vehicle acceleration of the vehicle. A content retrieval module executing on the computing system can access a content based on the vehicle location, the vehicle type, the relative velocity, and the vehicle acceleration. A content prioritization module can select content based on the vehicle location, the vehicle type, the relative velocity, and the vehicle acceleration. An electrophoretic display responsive to the selection can display the selected content. | 10-15-2015 |
Calvin W. Harrison, Franklin, MA US
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20150341812 | VIDEO QUALITY MONITORING - A method for monitoring video quality transmitted over a mobile network, comprising tapping into a mobile network traffic stream organizing the tapped network traffic into at least one individual video session associated with a single user; determining a video quality parameter for the at least one individual video session wherein the video quality parameter is at least one of packet jitter growth, packet loss, instantaneous flow rate balance (IFRB), delay between packets; a jitter statistic; a total time required to receive all packets needed to fully assemble a segment; a statistic of errors in key frames; aggregating context information for the at least one individual video session wherein context information includes at least one of cell tower, smart node, serving gateway node, user, subscriber level, device type, application, and content provider; and transmitting aggregated context information and at least one video quality parameter to a video quality server. | 11-26-2015 |
Christopher Harrison, Newton, MA US
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20150345289 | MICROFLUIDIC OSCILLATING TUBE DENSITOMETER FOR DOWNHOLE APPLICATIONS - Devices, methods and systems for determining one or more properties of at least one fluid sample. A tube configured to receive the at least one fluid sample wherein the tube is placed in a pressure housing. Further, an excitation source configured to generate vibration of the tube whereby a circulation of an electrical current along a portion of the tube is subjected to at least one magnetic field produced by at least one magnet. Further still, at least one vibration sensor that converts vibrations of the tube into a measurement signal. Finally, a processor that receives the measurement signal determines a resonant frequency from the measurement signal using a frequency measuring device to determine a property of the one or more properties of the at least one sample fluid. | 12-03-2015 |
Christopher Harrison, Aubumdale, MA US
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20110104809 | DOWNHOLE SPECTROSCOPIC HYDROGEN SULFIDE DETECTION - Methods and related apparatuses and mixtures are described for detecting hydrogen sulfide in a formation fluid downhole. A detection mixture is combined with the formation fluid downhole. The detection mixture includes metal ions for reacting with hydrogen sulfide forming a metal sulfide, and charged nanoparticles sized so as to inhibit significant aggregation of the metal sulfide so as to enable spectroscopic detection of the metal sulfide downhole. The combined mixture and formation fluid is then spectroscopically interrogated so as to detect the presence of the metal sulfide thereby indicating the presence of hydrogen sulfide in the formation fluid. The mixture also includes chelating ligands for sustaining thermal endurance of the mixture under downhole conditions. | 05-05-2011 |
Cristian Harrison, Beverly, MA US
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20090099230 | Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline- -3-carboxamide - Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide are described herein, including crystalline forms thereof. | 04-16-2009 |
20120165372 | SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE- -3-CARBOXAMIDE - Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide are described herein, including crystalline forms thereof. | 06-28-2012 |
20130116238 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS - Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention. | 05-09-2013 |
20130324743 | PROCESS OF PRODUCING CYCLOALKYLCARBOXAMIDO-INDOLE COMPOUNDS - The present invention features processes for preparing compounds, such as (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1), useful for treating CFTR mediated diseases such as cystic fibrosis. | 12-05-2013 |
20150218122 | Process of Producing Cycloalkylcarboxamido-indole Compounds - The present invention features processes for preparing compounds, such as (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1), useful for treating CFTR mediated diseases such as cystic fibrosis. | 08-06-2015 |
Cristian L. Harrison, Beverly, MA US
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20110213161 | Preparation of Protected Alpha-Keto Beta-Amino Esters and Amides - The invention provides β-sulfonamide α-keto esters and amides in which the α-keto is protected as a 1,3-dithiolane derivative. Also provided are methods for preparing such esters and amides and for incorporating them into peptides. | 09-01-2011 |
20130109717 | SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE- -3-CARBOXAMIDE | 05-02-2013 |
20130131356 | PREPARATION OF PROTECTED ALPHA-KETO BETA-AMINO ESTERS AND AMIDES - The invention provides β-sulfonamide α-keto esters and amides in which the α-keto is protected as a 1,3-dithiolane derivative. Also provided are methods for preparing such esters and amides and for incorporating them into peptides. | 05-23-2013 |
Grant Robert Harrison, Dover, MA US
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20110307311 | INTERACTIVE, INTERNET SUPPORTED HEALTH AND FITNESS MANAGEMENT SYSTEM - A wellness system monitors the controlled progress of patients under surveillance and includes a server base station which is generally off-site, a web-site interface and a local station at the point-of-use, which is generally a health or fitness center. A unique data base is created for each user and goals and objectives may be set with progress monitored. Typically, the user will respond to a surveyor questionnaire to populate his specific database. This is combined with a professional assessment and an automated measurement of vital statistics such as weight, blood pressure and body composition as measured at the local station. Other data may be entered manually such as height, age and the like. In a more comprehensive system the invention is designed to monitor other data such as cholesterol and blood glucose, as well. The locally input data may be updated at will by the user or on behalf of the user by professional personnel. | 12-15-2011 |
Harvey Harrison, Andover, MA US
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20110079072 | WIND SENSOR - A wind sensor includes first and second elements in an orthogonal axis arrangement and a calibration data array comprising first calibration data associated with the first element and second calibration array data associated with second element. An anemometric processor determines a wind speed (S) and direction (W) for an airflow received by the first and second elements using a first electrical parameter associated with the first element and the first calibration array data and a second electrical parameter associated with the second element and the second calibration array data. A wind sensing probe can have a pair of wind sensing elements, wherein each element has a core formed of a low specific heat, low density, high temperature plastic polymer, with two metal leads extending from the ends of core. A wind sensing element can include a fine Nickel alloy coil wound around an aforementioned core. | 04-07-2011 |
Ian Harrison, Norfolk, MA US
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20150316608 | DEBUGGING SYSTEM AND METHOD - A debugging system for debugging an automated test process used on an automated test platform. The debugging system includes a debugging subsystem and a debugging coupler electrically coupled to the debugging subsystem. The debugging coupler is configured to be releasably electrically coupleable to a test head of the automated test platform. | 11-05-2015 |
20150316609 | DEBUGGING SYSTEM AND METHOD - A debugging system for debugging an automated test process used on an automated test platform. The debugging system includes a debugging coupler configured to be releasably electrically coupleable to a test head of the automated test platform. A debugging subsystem is electrically coupled to the debugging coupler and includes a signal generator configured to apply one or more signals to one or more conductive paths within the debugging coupler. | 11-05-2015 |
20150316610 | DEBUGGING SYSTEM AND METHOD - A method, computer program product, and computing system for electrically coupling a monitoring subsystem to a first group of conductive paths within a debugging coupler that is configured to be releasably electrically coupleable to a test head of an automated test platform. One or more signals present on the first group of conductive paths are monitored while executing at least a portion of an automated test process on the automated test platform. The monitoring subsystem is electrically coupled to a second group of conductive paths within the debugging coupler. One or more signals present on the second group of conductive paths are monitored while executing the at least a portion of the automated test process on the automated test platform. | 11-05-2015 |
20150316611 | DEBUGGING SYSTEM AND METHOD - A method, computer program product, and computing system for defining a first group of transient values for a first group of conductive paths within a debugging coupler that is configured to be releasably electrically coupleable to a test head of an automated test platform. A monitoring subsystem is electrically coupled to the first group of conductive paths. A first group of signals present on the first group of conductive paths is monitored while executing at least a portion of an automated test process on the automated test platform to determine if any of the first group of signals exceeds any of the first group of transient values. | 11-05-2015 |
20150316614 | DEBUGGING SYSTEM AND METHOD - A method, computer program product, and computing system for monitoring a first group of signals present on a first group of conductive paths within a debugging coupler that is configured to be releasably electrically coupleable to a test head of an automated test platform while executing at least a portion of an automated test process on the automated test platform. A second group of signals present on a second group of conductive paths is monitored while executing the at least a portion of the automated test process on the automated test platform. The first group of signals and the second group of signals are temporally aligned, thus defining a group of temporally aligned signals. | 11-05-2015 |
Jacob C. Harrison, W. Newton, MA US
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20110039327 | ORGANIC ACID PRODUCTION BY FUNGAL CELLS - Improved systems for the biological production of organic acids are described. | 02-17-2011 |
20150104543 | ORGANIC ACID PRODUCTION BY FUNGAL CELLS - Improved systems for the biological production of organic acids are described. | 04-16-2015 |
Jacob C. Harrison, Newton, MA US
Patent application number | Description | Published |
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20110045559 | MALIC ACID PRODUCTION IN RECOMBINANT YEAST - The present disclosure relates to modified yeast, wherein the yeast has reduced pyruvate decarboxylase polypeptide (PDC) activity and methods of using such yeast to produce malic and/or succinic acid. | 02-24-2011 |
20120077273 | Methods and Compositions for Limiting Viability of a Modified Host Cell Outside of Designated Process Conditions - The invention provides methods and compositions for inhibiting proliferation of a modified host cell outside of a designated process condition. Compositions and methods for providing a host cell having reduced viability when exposed to natural conditions external to a controlled environment are disclosed. | 03-29-2012 |
20150232864 | Methods and Compositions for Limiting Viability of a Modified Host Cell Outside of Designated Process Conditions - The invention provides methods and compositions for inhibiting proliferation of a modified host cell outside of a designated process condition. Compositions and methods for providing a host cell having reduced viability when exposed to natural conditions external to a controlled environment are disclosed. | 08-20-2015 |
Jacob Carter Harrison, Newton, MA US
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20120244589 | Photoalkanogens with Increased Productivity - The present disclosure identifies methods and compositions for modifying photoautotrophic organisms as hosts, such that the organisms efficiently convert inorganic carbon and light into n-alkanes, and in particular the use of such organisms for the commercial production of n-alkanes and related molecules. | 09-27-2012 |
Jose Harrison, North Andover, MA US
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20100231236 | Integrated VSWR Detector for Monolithic Microwave Integrated Circuits - An integrated RF circuit is disclosed having an RF input port and an RF output port. The RF output port is for being coupled with a known impedance to an external circuit element such as an antenna. At least an RF circuit element is disposed along a propagation path between the RF input port and the RF output port. The RF circuit element has a first input port and a first output port and is for affecting a signal received at the first input port and providing the affected signal to the first output port. The integrated RF circuit also has a VSWR detector circuit for measuring a ratio of a characteristic of RF signals at the first input port and a same characteristic of the RF signals at the first output port and for providing an indication of the ratio at a VSWR output port. The measured ratio of the characteristic is affected by an impedance of the coupling thereby providing an indication relating to the coupling. | 09-16-2010 |
Kate Harrison, Arlington, MA US
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20160049656 | THREE-DIMENSIONAL, POROUS ANODE FOR USE IN LITHIUM-ION BATTERIES AND METHOD OF FABRICATION THEREOF - A three-dimensional, porous anode material suitable for use in a lithium-ion cell. The three-dimensional, porous anode material includes active anode particles embedded within a carbon matrix. The porous structure of this novel anode material allows for the expansion and contraction of the anode without the anode delaminating or breaking apart, thus improving the life-cycle of the lithium-ion cell. An example of this three-dimensional porous anode material is a porous silicon-carbon composite formed using a bi-continuous micro-emulsion (BME) template. | 02-18-2016 |
Katherine E. Harrison, North Cambridge, MA US
Patent application number | Description | Published |
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20090218235 | Gas sensor - Metal-oxide gas sensor. According to one embodiment, the sensor includes a layer or pellet of tungsten trioxide (WO | 09-03-2009 |
20100255353 | Thermal switch material suitable for use in controlling short circuits in lithium-ion batteries and method of making the thermal switch material - A composite thermal switch material suitable for use in controlling short circuits in lithium ion batteries. The switch material comprises a substantially homogeneous matrix of metallic nanoparticles and non-electrically conductive polymeric nanoparticles, the non-electrically conductive polymeric nanoparticles being fused to one another and having a greater thermal expansion coefficient than the metallic nanoparticles, the metallic nanoparticles and the non-electrically conductive polymeric nanoparticles being present in said substantially homogeneous matrix in relative proportions such that the composite thermal switch material is electrically conductive below a switching temperature and is substantially non-electrically conductive at or above the switching temperature. | 10-07-2010 |
20120237848 | Electrochemical device comprising an electrically-conductive, selectively-permeable membrane - An electrochemical device, such as a fuel cell or an electrolyzer. In one embodiment, the electrochemical device includes a membrane electrode assembly (MEA), an anodic gas diffusion medium in contact with the anode of the MEA, a cathodic gas diffusion medium in contact with the cathode, a first bipolar plate in contact with the anodic gas diffusion medium, and a second bipolar plate in contact with the cathodic gas diffusion medium. Each of the bipolar plates includes an electrically-conductive, non-porous, liquid-permeable, substantially gas-impermeable membrane in contact with its respective gas diffusion medium, the membrane including a solid polymer electrolyte and a non-particulate, electrically-conductive material, such as carbon nanotubes, carbon nanofibers, and/or metal nanowires. In addition, each bipolar plate also includes an electrically-conductive fluid chamber in contact with the electrically-conductive, selectively-permeable membrane and further includes a non-porous and electrically-conductive plate in contact with the fluid chamber. | 09-20-2012 |
Katherine E. Harrison, Arlington, MA US
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20130130126 | ELECTROCHEMICAL CELL FOR HIGH-VOLTAGE OPERATION AND ELECTRODE COATINGS FOR USE IN THE SAME - Electrochemical cell for high-voltage operation and electrode coatings for the same. The electrochemical cell and electrode coatings of the present invention can preferably withstand charging voltages to at least 5-Volts. In one embodiment, the electrochemical cell can include an anode, a cathode, a separator, and an electrolyte, wherein the anode, the cathode, and the separator are operatively associated with the electrolyte. The cathode can include, for example, a mixture of a metal oxide, an elongated carbon structure, and a conductive material. The metal oxide can be, for example, a lithium-nickel-manganese oxide, such as LiNi | 05-23-2013 |
Lane T. Harrison, Boston, MA US
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20150106927 | REAL-TIME DETECTION AND CLASSIFICATION OF ANOMALOUS EVENTS IN STREAMING DATA - A system is described for receiving a stream of events and scoring the events based on anomalousness and maliciousness (or other classification). The events can be displayed to a user in user-defined groupings in an animated fashion. The system can include a plurality of anomaly detectors that together implement an algorithm to identify low probability events and detect atypical traffic patterns. The atypical traffic patterns can then be classified as being of interest or not. In one particular example, in a network environment, the classification can be whether the network traffic is malicious or not. | 04-16-2015 |
Luddy Harrison, Chestnut, MA US
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20100223605 | APPARATUS AND METHOD FOR AUTOMATICALLY PARALLELIZING NETWORK APPLICATIONS THROUGH PIPELINING TRANSFORMATION - In some embodiments, a method and apparatus for automatically parallelizing a sequential network application through pipeline transformation are described. In one embodiment, the method includes the configuration of a network processor into a D-stage processor pipeline. Once configured, a sequential network application program is transformed into D-pipeline stages. Once transformed, the D-pipeline stages are executed in parallel within the D-stage processor pipeline. In one embodiment, transformation of a sequential application program is performed by modeling the sequential network program as a flow network model and selecting from the flow network model into a plurality of preliminary pipeline stages. Other embodiments are described and claimed. | 09-02-2010 |
Nathan Harrison, Cambridge, MA US
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20140118831 | LIGHT DIFFUSER AND METHOD OF MANUFACTURING THE SAME - A light diffuser including a transparent substrate having a top surface and a bottom surface. The top surface having formed thereon a plurality of tilted plane portions including a first tilted plane portion and a second tilted plane portion. The first tilted plane portion being tilted in a first direction and the second tilted plane portion being tilted in a second direction. The first direction of the first tilted plane portion being different from the second direction of the second tilted plane portion. | 05-01-2014 |
Nathan Harrison, Brookline, MA US
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20140268879 | TRANSPARENT WAVEGUIDE DIFFUSER FOR LIGHTING AND METHODS OF MANUFACTURING TRANSPARENT WAVEGUIDE DIFFUSER - A waveguide light diffuser panel is disclosed that diffuses source lights and transmits ambient light. Conventional waveguide light diffusers diffuse all light and therefore provide a hazy outcome. In manufacturing a waveguide transparent diffuser, a printing method, such as inkjet printing, may be used. In this method, dot micro-lenses are formed on one side of a panel, which cover a portion of the panel in a staggered or random arrangement. The other side of the panel is coated with an anti-reflective material, or the shape of the panel may be concave. The dot shape is designed for efficient reflection of the incident light, as opposed to conventional hazy diffusers in which the reflection efficiency is low. High reflection efficiency in this case compensates for the reduced dot coverage. | 09-18-2014 |
Robert J. Harrison, Medfield, MA US
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20080249023 | Antibacterial Peptide with Activity Against B. Anthracis - Disclosed is a therapeutic peptide useful in the treatment or prevention of infection caused by Gram-positive bacteria such as | 10-09-2008 |
20090156502 | DIPHTHERIA TOXIN VARIANT - The present invention relates to methods and compositions of modified variants of diphtheria toxin (DT) that reduce binding to vascular endothelium or vascular endothelial cells, and therefore, reduce the incidence of Vascular Leak Syndrome. One aspect of the present invention relates to a polypeptide toxophore from a modified DT, wherein the mutation is the substitution or deletion at least one amino acid residue at the amino acid residues 6-8, 28-30 or 289-291 of native DT. Another aspect of the present invention relates to a fusion protein which comprises a modified DT and a non-DT fragment. Another aspect of the present invention relates to the use of modified DT for the treatment of cancer. | 06-18-2009 |
20120149650 | Diphtheria Toxin Variant - The present invention relates to methods and compositions of modified variants of diphtheria toxin (DT) that reduce binding to vascular endothelium or vascular endothelial cells, and therefore, reduce the incidence of Vascular Leak Syndrome. One aspect of the present invention relates to a polypeptide toxophore from a modified DT, wherein the mutation is the substitution or deletion at least one amino acid residue at the amino acid residues 6-8, 28-30 or 289-291 of native DT. Another aspect of the present invention relates to a fusion protein which comprises a modified DT and a non-DT fragment. Another aspect of the present invention relates to the use of modified DT for the treatment of cancer. | 06-14-2012 |
Sean J. Harrison, Belmont, MA US
Patent application number | Description | Published |
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20090181966 | PGD2 receptor antagonists for the treatment of inflammatory diseases - Disclosed herein are compounds represented by Structural Formula (I) and (I-A): | 07-16-2009 |
20100197924 | PREPARATION OF AMINOTETRALIN COMPOUNDS - The present invention relates to synthetic processes for preparation of aminotetralin compounds with kinase inhibitory activity. The invention also provides synthetic intermediates useful in the processes of the invention. | 08-05-2010 |
20110212969 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF - This invention provides compounds of formula (I): | 09-01-2011 |
20110288117 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF - This invention provides compounds of formula (I): | 11-24-2011 |
20120015942 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF - This invention provides compounds of formula (I): | 01-19-2012 |
20120015943 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF - This invention provides compounds of formula (I): | 01-19-2012 |
20140243334 | SUBSTITUTED HYDOXAMIC ACIDS AND USES THEREOF - This invention provides compounds of formula (I): | 08-28-2014 |
20140243335 | SUBSTITUTED HYDOXAMIC ACIDS AND USES THEREOF - This invention provides compounds of formula (I): | 08-28-2014 |
20140256947 | PREPARATION OF AMINOTETRALIN COMPOUNDS - The present invention relates to synthetic processes for preparation of aminotetralin compounds with kinase inhibitory activity. The invention also provides synthetic intermediates useful in the processes of the invention. | 09-11-2014 |
20140275093 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF - This invention provides compounds of formula (I): | 09-18-2014 |
20150112071 | PREPARATION OF AMINOTETRALIN COMPOUNDS - The present invention relates to synthetic processes for preparation of aminotetralin compounds with kinase inhibitory activity. The invention also provides synthetic intermediates useful in the processes of the invention. | 04-23-2015 |
20150210700 | INDOLE-SUBSTITUTED PYRROLOPYRIMIDINYL INHIBITORS OF UBA6 - Disclosed are chemical entities that inhibit Uba6, each of which is a compound of Formula /: Formula (I) or a pharmaceutically acceptable salt thereof, wherein R* | 07-30-2015 |
Soren Harrison, Somerville, MA US
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20110315883 | THIN FILM MEASUREMENT TECHNIQUE - A thin film measurement technique is disclosed. The thin film measurement technique comprises radioisotopes, radiation detectors, mechanical hardware, electronics and/or circuitry, wires, cables, connectors, measurement software, and a computer. One aspect of the thin film measurement technique pertains to measurement sensors, which measure radiation emerging from material surfaces. Another aspect of the disclosure pertains to mechanical hardware that enables the thin film measurement to be made. Another aspect of the disclosure pertains to filter housings. Another aspect of the disclosure pertains to measurement software, for quantifying the measurement from the sensor, and/or controlling and optimizing processes based on said measurements. Another aspect of the disclosure pertains to hardware and equipment utilizing the thin film measurement technique. All aspects can be utilized alone or in combination with one another. | 12-29-2011 |
Soren David Harrison, Somerville, MA US
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20090058354 | SOLAR-POWERED MEDIA SYSTEM AND APPARATUS - Solar-powered media systems and apparatuses are disclosed. The solar-powered media systems and apparatuses comprise shade structures, solar cells, energy storage devices, electronics and/or circuitry, docking stations, wireless communications devices, and audio and/or visual components capable of outputting media content. One aspect of the solar-powered media system and apparatus pertains to shade structures, which provide shade for one or more users. Another aspect of the disclosure pertains to energy storage devices, which store electrical energy to power the solar-powered media system. Another aspect of the disclosure pertains to docking stations, which allow communication and electrical energy transfer between various devices. Another aspect of the disclosure pertains to audio & visual components capable of outputting media content for one or more users. Another aspect of the disclosure pertains to solar cells integrated into or attached to the said shade structure. All aspects can be utilized alone or in combination with one another. | 03-05-2009 |
Stephen C. Harrison, Cambridge, MA US
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20100105151 | Novel Druggable Regions in the Dengue Virus Envelope Glycoprotein and Methods of Using the Same - The present invention relates to novel druggable regions discovered in dengue virus envelope glycoprotein, or dengue virus E protein, which is a class II viral E protein. The present invention further relates to methods of using the druggable regions to screen potential candidate therapeutics for diseases caused by viruses having class II E proteins, e.g. viral fusion inhibitors. | 04-29-2010 |
Stephen C. Harrison, Brighton, MA US
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20110086041 | Fusion-Intermediate State of HIV-1 gP41 Targeted by Broadly Neutralizing Antibodies - Isolated, antigenic polypeptides including a prehairpin intermediate conformation of gp41 and vectors encoding such polypeptides are provided. Antibodies that bind to a prehairpin intermediate conformation of gp41 and methods of making antibodies a that bind to prehairpin intermediate conformation of gp41 are also provided. Vaccines against a prehairpin intermediate conformation of gp41, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided. Methods of screening compounds that bind to an isolated, prehairpin intermediate conformation of gp41 are further provided. | 04-14-2011 |
20120045472 | Biochemically Stabilized HIV-1 ENV Trimer Vaccine - Stabilized trimers of a clade A strain and a clade C strain of HIV-1 are provided. Broadly neutralizing antisera against HIV-1, methods of making broadly neutralizing antisera against HIV-1, broadly neutralizing vaccines against HIV-1, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided. | 02-23-2012 |
20140302043 | BROADLY NEUTRALIZING HUMAN ANTIBODY THAT RECOGNIZES THE RECEPTOR-BINDING POCKET OF INFLUENZA HEMAGGLUTININ - The invention features a novel influenza antibody that specifically binds to influenza hemagglutinin and reduces or inhibits hemagglutinin binding to sialic acid. The invention also provides methods, compositions, and kits featuring the novel antibody and its use in preventing or treating influenza infection. | 10-09-2014 |
Tom Harrison, Newton, MA US
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20080263019 | NATURAL LANGUAGE QUERY PROCESSING - An enhanced natural language information retrieval technique tokenizes an incoming query, comparing the tokenized representation against a collection of query templates. Query templates include a first portion having one or more query patterns representative of a query and in a form suitable for matching the tokenized representation of an incoming query. Query templates also include one or more information retrieval commands that are designed to return information relevant to those query patterns in its first portion. The enhanced natural language information retrieval technique selects those query templates that are determined to be most relevant to the incoming query (via its tokenized representation) and initiates one or more information retrieval commands associated with the selected query templates. | 10-23-2008 |
Tyler Harrison, Somerville, MA US
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20130289058 | CYCLIC BRIDGEHEAD ETHER DGAT1 INHIBITORS - The invention relates to compounds of formula (I): | 10-31-2013 |
20150141474 | CYCLIC ETHER DGAT1 INHIBITORSCYCLIC ETHER DGAT1 INHIBITORS - The invention relates to compounds of formula (I): useful for treating disorders mediated by acyl coA-diacylglycerol acyl transferase 1 (DGAT1), e.g. metabolic disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment. | 05-21-2015 |