Patent application number | Description | Published |
20110166028 | METHODS FOR PREDICTING TREATMENT RESPONSE BASED ON THE EXPRESSION PROFILES OF BIOMARKER GENES IN NOTCH MEDIATED CANCERS - The invention relates to the identification and use of gene expression profiles with clinical relevance to the treatment of cellular proliferative disorders, especially those mediated by aberrant Notch signaling using a Notch signaling inhibitor. In particular, the invention provides the identities of genes, whose individual or cumulative expression patterns may be useful in various assays. The gene expression profiles, whether embodied in nucleic acid expression, protein expression, or other expression formats, may be used to select subjects afflicted with a Notch mediated cancer who will likely respond to treatment with a gamma-secretase inhibitor or another Notch inhibiting agent. The same markers may be used in the classification of patients being treated with other Notch inhibitors. The methods may further comprise providing diagnostic, prognostic, or predictive information based on the classifying step. The methods may further comprise selecting a treatment based on the classifying step. | 07-07-2011 |
20130178391 | METHODS FOR PREDICTING TREATMENT RESPONSE BASED ON THE EXPRESSION PROFILES OF BIOMARKER GENES IN NOTCH MEDIATED CANCERS - The invention relates to the identification and use of gene expression profiles, or patterns, with clinical relevance to the treatment of cellular proliferative disorders, especially those mediated by aberrant Notch signaling using a Notch signaling inhibitor. In particular, the invention provides the identities of genes, whose individual or cumulative expression patterns may be useful in various assays. The gene expression profiles, whether embodied in nucleic acid expression, protein expression, or other expression formats, may be used to select subjects afflicted with a Notch mediated cancer who will likely respond to treatment with a gamma-secretase inhibitor or another Notch inhibiting agent. It is to be understood and will be appreciated that the same markers may be used in the classification of patients being treated with other Notch inhibitors. The methods may further comprise providing diagnostic, prognostic, or predictive information based on the classifying step. Classifying may include stratifying the tumor (and thus stratifying a subject having the tumor), e.g., for a clinical trial. The methods may further comprise selecting a treatment based on the classifying step. The gene expression profiles may also aid in the early identification of patients who may be failing a therapeutic protocol with a gamma secretase inhibitor and thus provide the basis for early intervention. | 07-11-2013 |
Patent application number | Description | Published |
20090192799 | Breathing Apparatus Speech Enhancement - Speech enhancement in a breathing apparatus is provided using a primary sensor mounted near a breathing mask user's mouth, at least one reference sensor mounted near a noise source, and a processor that combines the signals from these sensors to produce an output signal with an enhanced speech component. The reference sensor signal may be filtered and the result may be subtracted from the primary sensor signal to produce the output signal with an enhanced speech component. A method for detecting the exclusive presence of a low air alarm noise may be used to determine when to update the filter. A triple filter adaptive noise cancellation method may provide improved performance through reduction of filter maladaptation. The speech enhancement techniques may be employed as part of a communication system or a speech recognition system. | 07-30-2009 |
20100088089 | Speech Synthesizer - Synthesizing a set of digital speech samples corresponding to a selected voicing state includes dividing speech model parameters into frames, with a frame of speech model parameters including pitch information, voicing information determining the voicing state in one or more frequency regions, and spectral information. First and second digital filters are computed using, respectively, first and second frames of speech model parameters, with the frequency responses of the digital filters corresponding to the spectral information in frequency regions for which the voicing state equals the selected voicing state. A set of pulse locations are determined, and sets of first and second signal samples are produced using the pulse locations and, respectively, the first and second digital filters. Finally, the sets of first and second signal samples are combined to produce a set of digital speech samples corresponding to the selected voicing state. | 04-08-2010 |
20100094620 | Voice Transcoder - First encoded voice bits are transcoded into second encoded voice bits by dividing the first encoded voice bits into one or more received frames, with each received frame containing multiple ones of the first encoded voice bits. First parameter bits for at least one of the received frames are generated by applying error control decoding to one or more of the encoded voice bits contained in the received frame, speech parameters are computed from the first parameter bits, and the speech parameters are quantized to produce second parameter bits. Finally, a transmission frame is formed by applying error control encoding to one or more of the second parameter bits, and the transmission frame is included in the second encoded voice bits. | 04-15-2010 |
20110257965 | INTEROPERABLE VOCODER - Encoding a sequence of digital speech samples into a bit stream includes dividing the digital speech samples into one or more frames and computing a set of model parameters for the frames. The set of model parameters includes at least a first parameter conveying pitch information. The voicing state of a frame is determined and the first parameter conveying pitch information is modified to designate the determined voicing state of the frame, if the determined voicing state of the frame is equal to one of a set of reserved voicing states. The model parameters are quantized to generate quantizer bits which are used to produce the bit stream. | 10-20-2011 |
20130144613 | Half-Rate Vocoder - Encoding a sequence of digital speech samples into a bit stream includes dividing the digital speech samples into one or more frames, computing model parameters for a frame, and quantizing the model parameters to produce pitch bits conveying pitch information, voicing bits conveying voicing information, and gain bits conveying signal level information. One or more of the pitch bits are combined with one or more of the voicing bits and one or more of the gain bits to create a first parameter codeword that is encoded with an error control code to produce a first FEC codeword that is included in a bit stream for the frame. The process may be reversed to decode the bit stream. | 06-06-2013 |
20150340045 | Audio Watermarking via Phase Modification - An audio watermarking system conveys information using an audio channel by modulating an audio signal to produce a modulated signal by embedding additional information into the audio signal. Modulating the audio signal includes segmenting the audio signal into overlapping time segments using a non-rectangular analysis window function produce a windowed audio signal, processing the windowed audio signal for a time segment to produce frequency coefficients representing the windowed time segment and having phase values and magnitude values, selecting one or more of the frequency coefficients, modifying phase values of the selected frequency coefficients using the additional information to map the phase values onto a known phase constellation, and processing the frequency coefficients including the modified phase values to produce the modulated signal. | 11-26-2015 |
Patent application number | Description | Published |
20080262822 | Simulation using resource models - Operational resource modeling is usable to analyze application and computer system performance over a wide range of hypothetical scenarios. Operational resource modeling involves creating and training one or more resource models, and/or simulating hypothetical scenarios using resource models. | 10-23-2008 |
20080262823 | Training of resource models - Operational resource modeling is usable to analyze application and computer system performance over a wide range of hypothetical scenarios. Operational resource modeling involves creating and training one or more resource models, and/or simulating hypothetical scenarios using resource models. | 10-23-2008 |
20080262824 | Creation of resource models - Operational resource modeling is usable to analyze application and computer system performance over a wide range of hypothetical scenarios. Operational resource modeling involves creating and training one or more resource models, and/or simulating hypothetical scenarios using resource models. | 10-23-2008 |
20090006071 | Methods for Definition and Scalable Execution of Performance Models for Distributed Applications - A method and system for defining performance models of distributed applications such as distributed systems or network systems in a way that combines discrete and analytical models and simulating such performance models for analyzing software performance and impacts on devices of the distributed applications is described. Also described is a method for accelerating the simulation process by converting the discrete load into aggregate load dynamically based on the statistical analysis of the simulation results. | 01-01-2009 |
Patent application number | Description | Published |
20080302988 | Trap primer valve assembly with battery pack and timer - A self-contained trap primer valve assembly is housed in a cabinet and includes a conduit for connection to a building's water main to carry water under pressure, a valve is operatively mounted in the conduit and a solenoid is operable for selectively opening and closing the valve, wherein a low voltage battery and a timer mechanism connected to the battery and preset for selectively actuating the solenoid, opens and closes the valve for preselected durations. | 12-11-2008 |
20100108924 | TRAP PRIMER VALVE ASSEMBLY WITH BATTERY PACK AND TIMER - A self-contained trap primer valve assembly is housed in a cabinet and includes a conduit for connection to a building's water main to carry water under pressure, a valve is operatively mounted in the conduit and a solenoid is operable for selectively opening and closing the valve, wherein a low voltage battery and a timer mechanism connected to the battery and preset for selectively actuating the solenoid, opens and closes the valve for preselected durations. | 05-06-2010 |
20110284780 | TRAP PRIMER VALVE ASSEMBLY WITH BATTERY PACK AND TIMER - A self-contained trap primer valve assembly is housed in a cabinet and includes a conduit for connection to a building's water main to carry water under pressure, a valve is operatively mounted in the conduit and a solenoid is operable for selectively opening and closing the valve, wherein a low voltage battery and a timer mechanism connected to the battery and preset for selectively actuating the solenoid, opens and closes the valve for preselected durations. | 11-24-2011 |
20120174991 | FLOW-THROUGH TRAP PRIMER VALVE ASSEMBLY - A flow meter trap primer valve assembly for regulating flow includes an inlet for receiving water from a supply, a check valve mounted within an adaptor having an elongate bore forming a jet, and the check valve includes a piston mounted within a cartridge. A biasing element normally urges the piston against a trap seat. | 07-12-2012 |
20120280156 | TRAP PRIMER VALVE ASSEMBLY WITH BATTERY PACK AND TIMER - A self-contained trap primer valve assembly is housed in a cabinet and includes a conduit for connection to a building's water main to carry water under pressure, a valve is operatively mounted in the conduit and a solenoid is operable for selectively opening and closing the valve, wherein a low voltage battery and a timer mechanism connected to the battery and preset for selectively actuating the solenoid, opens and closes the valve for preselected durations. | 11-08-2012 |
20140048150 | FLOW-THROUGH TRAP PRIMER VALVE ASSEMBLY - A flow meter trap primer valve assembly for regulating flow includes an inlet for receiving water from a supply, a check valve mounted within an adaptor having an elongate bore forming a jet, and the check valve includes a piston mounted within a cartridge. A biasing element normally urges the piston against a trap seat. | 02-20-2014 |
Patent application number | Description | Published |
20080229480 | Heat deflector for use with a hood-type hair dryer - An air flow deflector for use with a hood-type hair dryer is a thick, resiliently compressible, unitary halo with an inner perimeter of length suited to surround and abut, preferably with tension, against the subject's head when the halo's inner perimeter is contoured approximately immediately below the subject's hair line. The halo deflects the flow of warm air away from exposed skin portions of the head, neck and shoulders and has an arcuate upturned extension on its front portion for deflecting air flow back to the interior of the hood of the dryer. In use, the halo is slid downwardly against tension over the top of the head of the subject to a position at least below the hairline and preferably resting around the neck and on the shoulders of the subject. After setting, the halo is slid upwardly and contoured to approximately immediately below the subject's hairline. | 09-25-2008 |
20080229607 | Heat deflector for use with a hood-type hair dryer - An air flow deflector for use with a hood-type hair dryer is a thick, resiliently compressible, unitary halo with an inner perimeter of length suited to surround and abut, preferably with tension, against the subject's head when the halo's inner perimeter is contoured approximately immediately below the subject's hair line. The halo deflects the flow of warm air away from exposed skin portions of the head, neck and shoulders. An arcuate upturned extension on its front portion deflects air flow back to the interior of the hood of the dryer. The unitary halo may be continuous or split for adjustability and hinged for increased manipulability. | 09-25-2008 |
20120167407 | Heat Deflector For Use With A Hood-Type Hair Dryer - An air flow deflector for use with a hood-type hair dryer is a thick, resiliently compressible, unitary halo with an inner perimeter of length suited to surround and abut, preferably with tension, against the subject's head when the halo's inner perimeter is contoured approximately immediately below the subject's hair line. The halo deflects the flow of warm air away from exposed skin portions of the head, neck and shoulders. An arcuate upturned extension on its front portion deflects air flow back to the interior of the hood of the dryer. The unitary halo may be continuous or split for adjustability and hinged for increased manipulability. | 07-05-2012 |