Harbottle
Andrew Harbottle, Newcastle Upon Tyne UK
Patent application number | Description | Published |
---|---|---|
20110201011 | METHODS FOR ASSAYING MC1R VARIANTS AND MITOCHONDRIAL MARKERS IN SKIN SAMPLES - The present invention relates to methods for predicting, diagnosing and monitoring skin states and skin diseases. The methods combine the use of non-invasive skin collecting techniques with one or more assays for determining mitochondrial DNA (mtDNA) aberrations and Melanocortin 1 Receptor (MC1R) variants, thereby providing a comprehensive tool for identifying, predicting and/or monitoring photoageing, ultraviolet radiation (UVR) damage or skin disease. The methods of the invention may also be effective in screening for new therapeutic agents, skin care products and treatment regimes, and may also be useful for monitoring the response of a subject to a preventative or therapeutic treatment. | 08-18-2011 |
Andrew Harbottle, Tyne And Wear GB
Patent application number | Description | Published |
---|---|---|
20100311057 | Mitochondrial DNA Deletion Between About Residues 12317-16254 for Use in the Detection of Cancer - The present invention relates to methods for predicting, diagnosing and monitoring cancer. The methods comprise obtaining biological samples, extracting mitochondrial DNA (mtDNA) from the samples, quantifying mitochondrial DNA mutation in the sample and comparing the level of mtDNA mutation with a reference value. The methods of the invention may also be effective in screening for new therapeutic agents and treatment regimes, and may also be useful for monitoring the response of a subject to a preventative or therapeutic treatment. | 12-09-2010 |
20110045471 | Methods for Assaying MC1R Variants and Mitochondrial Markers in Skin Samples - The present invention relates to methods for predicting, diagnosing and monitoring skin states and skin diseases. The methods combine the use of non-invasive skin collecting techniques with one or more assays for determining mitochondrial DNA (mtDNA) aberrations and Melanocortin 1 Receptor (MC1R) variants, thereby providing a comprehensive tool for identifying, predicting and/or monitoring photoageing, ultraviolet radiation (UVR) damage or skin disease. The methods of the invention may also be effective in screening for new therapeutic agents, skin care products and treatment regimes, and may also be useful for monitoring the response of a subject to a preventative or therapeutic treatment. | 02-24-2011 |
20130059299 | ABERRANT MITOCHONDRIAL DNA, ASSOCIATED FUSION TRANSCRIPTS AND TRANSLATION PRODUCTS AND HYBRIDIZATION PROBES THEREFORE - The present invention provides novel mitochondrial fusion transcripts, the parent mutated mtDNA molecules, and the resulting translation products (proteins) for predicting, diagnosing and/or monitoring cancer. Hybridization probes complementary thereto for use in the methods of the invention are also provided. | 03-07-2013 |
20130288243 | Mitochondrial DNA deletion between about residues 12317-16254 for use in the detection of cancer - The present invention relates to methods for predicting, diagnosing and monitoring cancer. The methods comprise obtaining biological samples, extracting mitochondrial DNA (mtDNA) from the samples, quantifying a mtDNA mutation in the sample and comparing the level of the mtDNA mutation present in the sample with a reference value The methods of the invention may also be effective in screening for new therapeutic agents and treatment regimes Further, said methods may be also be useful for monitoring the response of a subject to a preventative or therapeutic treatment. | 10-31-2013 |
20140024025 | UV ASSOCIATED MTDNA FUSION TRANSCRIPTS AND METHODS AND USES THEREOF - The present invention provides novel mitochondrial fusion transcripts and related deletion molecules that are associated with UV exposure. Methods for in vivo and in vitro detection of mtDNA molecules and associated fusion transcripts is also provided, as is their use in the screening and testing of skin care products. | 01-23-2014 |
Andrew Harbottle, Newcastle Upon Tyne GB
Patent application number | Description | Published |
---|---|---|
20120058483 | MITOCHONDRIAL MUTATIONS AND REARRANGEMENTS AS A DIAGNOSTIC TOOL FOR THE DETECTION OF SUN EXPOSURE, PROSTATE CANCER AND OTHER CANCERS - Mitochondrial DNA deletions useful for the detection of cancers and sun exposure are provided. In particular, methods and kits for detecting mitochondrial DNA deletions for the early detection, diagnosis and progression of prostate cancer, sun exposure and non-melonoma skin cancer are provided. | 03-08-2012 |
Andrew Harbottle, Pandon Quays GB
Patent application number | Description | Published |
---|---|---|
20090192047 | Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers - Mitochondrial DNA deletions useful for the detection of cancers and sun exposure are provided. In particular, methods and kits for detecting mitochondrial DNA deletions for the early detection, diagnosis and progression of prostate cancer, sun exposure and non-melonoma skin cancer are provided. | 07-30-2009 |
Bruce David Harbottle, Robindale ZA
Patent application number | Description | Published |
---|---|---|
20140310894 | OMNIDIRECTIONAL AUTOMATIC SWIMMING POOL CLEANERS - Automatic pool cleaners (APCs) and components thereof are detailed. The APCs may turn feet, rather than entire bodies, to change direction and may provide water-flow paths through the bodies that are oriented vertically. Thus, unlike existing disc-based cleaners, the APCs may reduce influence of connected hoses on their movements within pools. | 10-23-2014 |
Bruce David Harbottle, Johannesburg ZA
Patent application number | Description | Published |
---|---|---|
20110226361 | IDLER MECHANISMS FOR HYDRAULIC DEVICES - Devices and methods for inhibiting movement of automatic pool cleaners (APCs) are described. Versions of the devices may cause pool water to bypass flowing through bodies of APCs. Alternatively, they may cause water flowing though bodies of APCs to bypass the associated motive force creators. The devices thus may constitute idler mechanisms, as they effectively prevent movement without requiring operation of the ultimate driver (i.e. the pump) to cease. | 09-22-2011 |
Bruce David Harbottle, Douglasdale ZA
Patent application number | Description | Published |
---|---|---|
20110314617 | AUTOMATIC POOL CLEANERS AND COMPONENTS THEREOF - Automatic pool cleaners (APCs) and components thereof are detailed. The APCs may include tracks for movement, with the tracks having teethed internal surfaces. The APCs additionally may supply shift mechanisms for purposes of changing direction of their movement and incorporate bladed scrubbers and easily-opening bodies. | 12-29-2011 |
David Harbottle, Hasland GB
Patent application number | Description | Published |
---|---|---|
20110000285 | Apparatus for Inspection of a Fluid and Method - Apparatus for inspection of a fluid comprising: a channel portion, the channel portion having a channel inlet and a channel outlet separate from the channel inlet; a piezoelectric sensor element provided at a sensor position of the channel and arranged to contact fluid flowing through the channel portion from said channel inlet to said channel outlet, the apparatus being configured to determine a difference value being a value corresponding to a difference between a resonant frequency of oscillation of said piezoelectric element at a given moment in time and a reference resonant frequency. | 01-06-2011 |
Gareth William Harbottle, Nottingham GB
Patent application number | Description | Published |
---|---|---|
20140296208 | KINASE INHIBITORS - There are provided compounds of formula I, | 10-02-2014 |
Stephen Harbottle, Cambridge GB
Patent application number | Description | Published |
---|---|---|
20100291664 | Laboratory Apparatus with Incubator - Laboratory apparatus comprises at least one cabinet; at least one incubator; at least one transfer hatch; and means for circulating air within the apparatus, wherein the at least one cabinet is connected to an incubator and a transfer hatch; wherein the at least one incubator comprises at least two discrete compartments each accessible by independent openings; and wherein the apparatus is substantially sealed against exchange of air between the cabinet and the external environment. | 11-18-2010 |