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Hao Wu

Hao Wu, Brookline, MA US

Patent application numberDescriptionPublished
20150297570SMALL MOLECULE INHIBITORS OF MALT1 - MALT1 cleavage activity is linked to the pathogenesis of activated B-cell-like diffuse large B-cell lymphoma (ABC-DLBCL), a chemo-resistant form of DLBCL. We developed a MALT1 activity assay and identified chemically diverse MALT1 inhibitors. A selected lead compound MI-2 featured direct binding to MALT1 and suppression of its protease function. MI-2 concentrated within human ABC-DLBCL cells and irreversibly inhibited cleavage of MALT1 substrates. This was accompanied by suppression of NF-10-22-2015

Hao Wu, Pittsford, NY US

Patent application numberDescriptionPublished
20150302611VEHICLE DIMENSION ESTIMATION FROM VEHICLE IMAGES - A method and system for determining one or more dimension estimations for a vehicle. A sequence of image frames of a vehicle is received, and a digital representation of the vehicle is extracted from each image in the sequence of image frames. A bounding box is determined for the vehicle based upon the extracted digital representation for each digital representation of the vehicle and at least one dimension of the vehicle is estimated based upon the determined bounding box. An indication of the at least one estimated dimension is output. The indication of at least one estimated dimension is transferred as an input to a comparison technique for further processing the indication of the at least one estimated dimension. The comparison technique can include a parking determination process configured to determine a recommended spot for the vehicle based upon the indication of the at least one estimated dimension.10-22-2015
20160089073AUTOMATIC VISUAL REMOTE ASSESSMENT OF MOVEMENT SYMPTOMS IN PEOPLE WITH PARKINSON'S DISEASE FOR MDS-UPDRS FINGER TAPPING TASK - A system and method for assessing patient movement for Parkinson's disease includes capturing a video of a subject performing a finger tapping sequence comprising a predetermined number of open and close periods. According to an exemplary embodiment, a system and method includes extracting a region of interest for each frame of the video and generating a projection of the region of interest for each frame of the video using perpendicular vector projections in a direction or plurality of directions.03-31-2016
20160092733SYSTEM AND METHOD FOR SEAT OCCUPANCY DETECTION FROM CEILING MOUNTED CAMERA USING ROBUST ADAPTIVE THRESHOLD CRITERIA - A method for detecting sitting behavior includes acquiring a sequence of frames capturing a scene-of-interest at an overhead view. The method includes detecting at least one empty seat within the scene-of-interest and associating the seat as being unoccupied and the frame as a reference frame. The method includes extracting reference features describing a region of the unoccupied seat in the reference frame and quantifying the reference features to form a reference feature vector. The method includes extracting features describing the region in a given frame and quantifying the features to form a current feature vector. The method includes measuring a change in a feature vector over time using the reference feature vector and the current feature vector. The method includes and determining a status of the seat in the given frame as being one of occupied and unoccupied based on the change in the feature vector.03-31-2016
20160092734SYSTEM AND METHOD FOR DETECTING SETTLE DOWN TIME USING COMPUTER VISION TECHNIQUES - A method for detecting settle-down time in a space includes acquiring a sequence of frames capturing a select space from a first camera. The method includes determining an initial time for computing a duration it takes for an associated occupant to settle into a seat in the select space. The method includes determining one or more candidate frames from the sequence of frames where one or both of a sitting behavior and seat occupancy is observed at the seat. The method includes determining a final frame and a final time associated with the final frame from the one or more candidate frames. The method includes computing the settle-down time using the initial and the final times.03-31-2016
20160093214VISION-BASED ON-STREET PARKED VEHICLE DETECTION VIA NORMALIZED-VIEW CLASSIFIERS AND TEMPORAL FILTERING - A system for estimating parking occupancy includes a vehicle-detection device including an adjustable mast supporting an image capture device at a select height. The image capture device acquires video of a current parking area. A computer processor in communication with the image capture device is configured to receive the video data and define a region of interest in the video data. The processor is further configured to perform a spatial transform on the ROI to transform the ROI to a normalized geometric space. The processor is further configured to apply features of a detected object in the normalized geometric space to a vehicle classifier—previously trained with samples acquired from a normalized camera perspective similar to the normalized geometric space—and determine the occupancy of the current parking area using an output of the classifier.03-31-2016

Hao Wu US

Patent application numberDescriptionPublished
20150353565BTK INHIBITORS - The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or pharmaceutically acceptable salts thereof. Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders.12-10-2015
20150353570BTK INHIBITORS - The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders.12-10-2015
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