Handley, US
Daniel A. Handley, Genoa City, WI US
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20130228241 | Apparatus, Systems and Methods for Managing Fluids - Apparatuses manage the flow of fluids, such as, for example, water, through pipes. Specifically, the apparatuses of the present invention creates a backward pressure in fluid traversing a pipe, wherein the backward pressure within the pipe provides compression to the fluid effectively compressing entrapped gas bubbles within the fluid, allowing more accurate water meter measurements. Moreover, the apparatuses of the present invention provide backflow prevention. Systems and methods for managing fluids are further provided. | 09-05-2013 |
David W. Handley, Waterford, WI US
Dean A. Handley, Shrewsbury, MA US
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20080293823 | Methods and Compositions For Treating Sleep-Related Breathing Disorders - Provided herein are methods of treating a sleep-related breathing disorder, such as obstructive sleep apnea, comprising the administration of O-desmethylvenlafaxine or duloxetine. | 11-27-2008 |
20120238616 | METHODS AND COMPOSITIONS FOR TREATING SLEEP-RELATED BREATHING DISORDERS - Provided herein are methods of treating a sleep-related breathing disorder, such as obstructive sleep apnea, comprising the administration of O-desmethylvenlafaxine or duloxetine. | 09-20-2012 |
20150196531 | Methods and Compositions For Treating Sleep-Related Breathing Disorders - Provided herein are methods of treating a sleep-related breathing disorder, such as obstructive sleep apnea, comprising the administration of O-desmethylvenlafaxine or duloxetine. | 07-16-2015 |
Harold H. Handley, Encinitas, CA US
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20110009796 | METHOD AND APPARATUS FOR INCREASING CONTAMINANT CLEARANCE RATES DURING EXTRACORPOREAL FLUID TREATMENT - An extracorporeal fluid treatment apparatus includes a separator comprising a cartridge surrounding a porous separation membrane. The membrane separates a main flow path of a cellular component of the blood from a plasma flow path. An affinity medium is disposed within the plasma flow path to bind contaminants such as viral pathogens or toxins contained within the plasma. A pump pumps the plasma through the affinity medium at an assisted flow rate preferably between 10% and 40% of the whole blood flow rate. The assisted flow rate is selected to reduce a T90% of the apparatus by at least 50% as compared to a T90% of the apparatus without the plasma pump. A method of treating blood containing contaminants includes supplying infected blood to a separator and pumping the plasma component through an affinity medium at an assisted flow rate to increase contaminant clearance. | 01-13-2011 |
20120037564 | METHODS AND SYSTEMS FOR REDUCING VIRAL LOAD OF HEPATITIS C VIRUS IN HEMODIALYSIS PATIENTS - The present technology relates to methods and systems for the removal of pathogens and fragments thereof in hemodialysis patients. In particular, methods and systems are described where lectins can be used to remove the Hepatitis C virus and fragments thereof in hemodialysis patients, and to provide a sustained reduction in viral load. | 02-16-2012 |
20130023849 | METHODS AND SYSTEMS FOR REDUCING VIRAL LOAD OF HEPATITIS C VIRUS IN HEMODIALYSIS PATIENTS - The present technology relates to methods and systems for the removal of pathogens and fragments thereof in hemodialysis patients. In particular, methods and systems are described where lectins can be used to remove the Hepatitis C virus and fragments thereof in hemodialysis patients, and to provide a sustained reduction in viral load. | 01-24-2013 |
20160000987 | DEVICE AND METHOD FOR PURIFYING VIRALLY INFECTED BLOOD - The present invention relates to a method for using lectins that bind to pathogens having surface glycoproteins or fragments thereof which contain glycoproteins, to remove them from infected blood or plasma or other fluids in an extracorporeal setting. Accordingly, the present invention provides a methods and devices for reducing viral load or plaque forming units in blood or plasma from one or more infected individuals. A preferred embodiment of the method comprises passing the blood or plasma through a porous hollow fiber membrane wherein lectin molecules are disposed proximate to the membrane, collecting pass-through blood or plasma and optionally reinfusing the pass-through blood or plasma into the individual. Additionally, the present invention provides a methods and devices for the reduction of plaque forming units, cleared more rapidly and more efficiently than overall viral load. | 01-07-2016 |
Harold H. Handley, Encintas, CA US
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20110284463 | DEVICE AND METHOD FOR PURIFYING VIRALLY INFECTED BLOOD - The present invention relates to a method for using lectins that bind to pathogens having surface glycoproteins or fragments thereof which contain glycoproteins, to remove them from infected blood or plasma or other fluids in an extracorporeal setting. Accordingly, the present invention provides a methods and devices for reducing viral load or plaque forming units in blood or plasma from one or more infected individuals. A preferred embodiment of the method comprises passing the blood or plasma through a porous hollow fiber membrane wherein lectin molecules are disposed proximate to the membrane, collecting pass-through blood or plasma and optionally reinfusing the pass-through blood or plasma into the individual. Additionally, the present invention provides a methods and devices for the reduction of plaque forming units, cleared more rapidly and more efficiently than overall viral load. | 11-24-2011 |
Ian Handley, Mountain View, CA US
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20110093006 | BIOCOMPATIBLE PHASE INVERTIBLE PROTEINACEOUS COMPOSITIONS AND METHODS FOR MAKING AND USING THE SAME - Biocompatible phase invertible proteinaceous compositions and methods for making and using the same are provided. The subject phase invertible compositions are prepared by combining a crosslinker and a proteinaceous substrate. The proteinaceous substrate includes one or more proteins and a polyamine, where the polyamine and a proteinaceous substrate are present in synergistic viscosity enhancing amounts, and may also include one or more of: a carbohydrate, a tackifying agent, a plasticizer, or other modification agent. In certain embodiments, the crosslinker is a heat-treated dialdehyde, e.g., heat-treated glutaraldehyde. Also provided are kits for use in preparing the subject compositions. The subject compositions, kits and systems find use in a variety of different applications. | 04-21-2011 |
Ian J. Handley, Mountain View, CA US
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20090143500 | BIOCOMPATIBLE PHASE INVERTIBLE PROTEINACEOUS COMPOSITIONS AND METHODS FOR MAKING AND USING THE SAME - Biocompatible phase invertible proteinaceous compositions and methods for making and using the same are provided. Phase invertible compositions in accordance with the invention are prepared by combining a liquid proteinaceous substrate and a liquid crosslinking composition, where the liquid crosslinking composition includes a macromolecular crosslinking agent. Also provided are kits for use in preparing the subject compositions. The subject compositions, kits and systems find use in a variety of different applications. | 06-04-2009 |
20120222584 | BIOCOMPATIBLE PHASE INVERTIBLE PROTEINACEOUS COMPOSITIONS AND METHODS FOR MAKING AND USING THE SAME - Biocompatible phase invertible proteinaceous compositions and methods for making and using the same are provided. Phase invertible compositions in accordance with the invention are prepared by combining a liquid proteinaceous substrate and a liquid crosslinking composition, where the liquid crosslinking composition includes a macromolecular crosslinking agent. Also provided are kits for use in preparing the subject compositions. The subject compositions, kits and systems find use in a variety of different applications. | 09-06-2012 |
20140041547 | BIOCOMPATIBLE PHASE INVERTIBLE PROTEINACEOUS COMPOSITIONS AND METHODS FOR MAKING AND USING THE SAME - Biocompatible phase invertible proteinaceous compositions and methods for making and using the same are provided. Phase invertible compositions in accordance with the invention are prepared by combining a liquid proteinaceous substrate and a liquid crosslinking composition, where the liquid crosslinking composition includes a macromolecular crosslinking agent. Also provided are kits for use in preparing the subject compositions. The subject compositions, kits and systems find use in a variety of different applications. | 02-13-2014 |
20140161761 | BIOCOMPATIBLE PHASE INVERTIBLE PROTEINACEOUS COMPOSITIONS AND METHODS FOR MAKING AND USING THE SAME - Biocompatible phase invertible proteinaceous compositions and methods for making and using the same are provided. The subject phase invertible compositions are prepared by combining a crosslinker and a proteinaceous substrate. The proteinaceous substrate includes one or more proteins and a polyamine, where the polyamine and a proteinaceous substrate are present in synergistic viscosity enhancing amounts, and may also include one or more of: a carbohydrate, a tackifying agent, a plasticizer, or other modification agent. In certain embodiments, the crosslinker is a heat-treated dialdehyde, e.g., heat-treated glutaraldehyde. Also provided are kits for use in preparing the subject compositions. The subject compositions, kits and systems find use in a variety of different applications. | 06-12-2014 |
20140235825 | BIOCOMPATIBLE PHASE INVERTIBLE PROTEINACEOUS COMPOSITIONS AND METHODS FOR MAKING AND USING THE SAME - Biocompatible phase invertible proteinaceous compositions and methods for making and using the same are provided. Phase invertible compositions in accordance with the invention are prepared by combining a liquid proteinaceous substrate and a liquid crosslinking composition, where the liquid crosslinking composition includes a macromolecular crosslinking agent. Also provided are kits for use in preparing the subject compositions. The subject compositions, kits and systems find use in a variety of different applications. | 08-21-2014 |
Ian Matthew Handley, Wisconsin Dells, WI US
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20140299029 | EXPANDABLE PONTOON SYSTEM - An extendable pontoon system is provided. The extendable pontoon system may include a center pontoon, two side pontoons, an adjustable frame and a plurality of actuator arms. The adjustable frame may include a plurality of fixed frame elements and a plurality of slidable elements. The plurality of fixed frame elements may be supported in a traverse relationship to and along the length of the center pontoon. Each elongated slidable element may have a received end and a hinged end. Each fixed frame element may be tubular having two opposing ends, wherein each opposing end may be adapted to slidably receive one received end. The plurality of hinged ends may be pivotably connected to either one of the two side pontoons. Each actuator arm has a fixed end and an extendable end, wherein the plurality of fixed ends are connected to one fixed frame element, and wherein the plurality of extendable ends are connected to the two side pontoons so that the two side pontoons are extendable relative to the center pontoon by shifting the two side pontoons between a contracted position to an expanded position. | 10-09-2014 |
James R. Handley, East Amherst, NY US
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20140245782 | ARGON PRODUCTION METHOD AND APPARATUS - A method and apparatus for producing a purified liquid argon product in which liquid argon having oxygen impurities is produced in a cryogenic air separation plant by separating argon from oxygen within an argon column. An impure liquid argon stream, composed of part of the liquid argon, is purified in an adsorbent bed by adsorbing the oxygen impurities in an adsorbent to produce a purified liquid argon stream that constitutes the purified liquid argon product. During adsorption, the adsorbent bed is maintained at a reduced temperature with a coolant to prevent vaporization of the liquid argon. The bed is then regenerated by draining residual liquid argon from the adsorbent bed, introducing the residual liquid argon back into the air separation plant and then desorbing the oxygen impurities with a regeneration gas. After regeneration, the adsorbent bed is refilled with purified liquid argon prior to being brought back on-line. | 09-04-2014 |
20160003539 | ARGON CONDENSATION SYSTEM AND METHOD - An argon reflux condensation system and method in which a plurality of once-through condensers are connected to an argon column of an air separation plant to condense argon-rich vapor streams for production of reflux to the argon column. Condensation of the argon-rich vapor streams is brought about through indirect heat exchange with crude liquid oxygen streams that partially vaporize and are introduced into a lower pressure column of the plant for further refinement. The flow rate of the crude liquid oxygen streams are sensed and controlled at locations in the air separation plant where the crude liquid oxygen is in a liquid state and in proportion to the size of the once-through heat exchangers. Prior to flowing into the once-through condensers, the partially vaporized crude oxygen stream enters a phase separator which separates the crude oxygen vapor from the crude liquid oxygen. The separated crude oxygen vapor bypasses the once-through condensers and is mixed with the vaporized oxygen stream that exits the one-through condensers. Feed stream flow rate to the argon column is controlled in response to air flow rate to the plant and product flow rate is controlled in response to the feed stream flow rate to the argon column. | 01-07-2016 |
James Richard Handley, East Amherst, NY US
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20120125044 | FEED COMPRESSION METHOD AND APPARATUS FOR AIR SEPARATION PROCESS - A method and apparatus for separating air to produce a gaseous oxygen product in which the air is separated in an air separation plant to conduct a cryogenic rectification process that utilizes higher and lower pressure compressed air streams. The higher and lower pressure compressed air streams are generated in two multistage compressors linked together so that the lower pressure compressed air stream is produced from intermediate stages and the higher pressure compressed air stream is produced from higher pressure compression stages. During turn-down operational conditions, one of the two multistage compressors can be shut down to decrease the flow of air and therefore, the production of the oxygen product. | 05-24-2012 |
Jason Handley, Waxhaw, NC US
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20150180282 | COMMUNICATION NODES AND SENSOR DEVICES CONFIGURED TO USE POWER LINE COMMUNICATION SIGNALS, AND RELATED METHODS OF OPERATION - Methods of operating a communication node are provided. A method of operating a communication node may include transmitting a first power line communication signal from the communication node to a sensor device that is at or adjacent an electric grid device. The method may include receiving from the sensor device a second power line communication signal that is responsive to the first power line communication signal, at the communication node. Moreover, the method may include determining a distance between the communication node and the electric grid device by measuring an electrical parameter of the second power line communication signal, at the communication node. Related communication nodes are also described. | 06-25-2015 |
20150180538 | COMMUNICATION NODES AND SENSOR DEVICES CONFIGURED TO USE POWER LINE COMMUNICATION SIGNALS, AND RELATED METHODS OF OPERATION - Methods of operating a communication node are provided. A method of operating a communication node may include transmitting a first power line communication signal from the communication node to a sensor device that is at or adjacent an electric grid device. The method may include receiving from the sensor device a second power line communication signal that is responsive to the first power line communication signal, at the communication node. Moreover, the method may include determining a distance between the communication node and the electric grid device by measuring an electrical parameter of the second power line communication signal, at the communication node. Related communication nodes are also described. | 06-25-2015 |
Jeremy Handley, Boaz, AL US
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20140286716 | Portable Materials Transportation System - A transport and storage apparatus for loose or bulk goods, aggregate material, and liquids is disclosed herein. The apparatus is a container designed for shipping by rail, truck, or barge. Furthermore, the apparatus is of a modular shape such that multiple apparatuses may be stacked and stored together efficiently. The apparatus further includes an evacuation and vibration assembly for pneumatically disposing of stored goods in the storage compartment. | 09-25-2014 |
John Handley, Chicago, IL US
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20100138334 | EXCHANGE ORDER PRIORITY RETENTION FOR ELECTRONIC TRADING USING AUTOMATIC BOOK UPDATES - The present invention involves providing a computer based platform for allowing a user to establish a target trading book; evaluating the user's unmatched exchange trades to determine an actual trading book at a point in time; determining a differential between the target trading book and the actual trading book; and identifying at least one exchange trade action to transition from the actual trading book to the target trading book, wherein the exchange trade action is based on preserving at least one unmatched order with the oldest possible entry time stamp. | 06-03-2010 |
20120191591 | EXCHANGE ORDER PRIORITY RETENTION FOR ELECTRONIC TRADING USING AUTOMATIC BOOK UPDATES - The present invention involves providing a computer based platform for allowing a user to establish a target trading book; evaluating the user's unmatched exchange trades to determine an actual trading book at a point in time; determining a differential between the target trading book and the actual trading book; and identifying at least one exchange trade action to transition from the actual trading book to the target trading book, wherein the exchange trade action is based on preserving at least one unmatched order with the oldest possible entry time stamp. | 07-26-2012 |
20130304627 | EXCHANGE ORDER PRIORITY RETENTION FOR ELECTRONIC TRADING USING AUTOMATIC BOOK UPDATES - The present invention involves providing a computer based platform for allowing a user to establish a target trading book; evaluating the user's unmatched exchange trades to determine an actual trading book at a point in time; determining a differential between the target trading book and the actual trading book; and identifying at least one exchange trade action to transition from the actual trading book to the target trading book, wherein the exchange trade action is based on preserving at least one unmatched order with the oldest possible entry time stamp. | 11-14-2013 |
20150317731 | EXCHANGE ORDER PRIORITY RETENTION FOR ELECTRONIC TRADING USING AUTOMATIC BOOK UPDATES - The present invention involves providing a computer based platform for allowing a user to establish a target trading book; evaluating the user's unmatched exchange trades to determine an actual trading book at a point in time; determining a differential between the target trading book and the actual trading book; and identifying at least one exchange trade action to transition from the actual trading book to the target trading book, wherein the exchange trade action is based on preserving at least one unmatched order with the oldest possible entry time stamp. | 11-05-2015 |
John Handley, Duluth, MN US
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20110046315 | Method for Preparing Conjugates Using Polymer Maleimides - Methods for preparing conjugates using polymeric reagents bearing a maleimide are provided. Also provided are compositions comprising the conjugates. | 02-24-2011 |
20120022220 | Method for Preparing Polymer Maleimides - Methods for preparing polymeric reagents bearing a maleimide are provided. Also provided are related compositions. | 01-26-2012 |
20120271000 | COMPOSITIONS COMPRISING CONJUGATES AND MALEAMIC ACID-TERMINATED, WATER-SOLUBLE POLYMERS - Methods for preparing conjugates using polymeric reagents bearing a maleimide are provided. Also provided are compositions comprising the conjugates. | 10-25-2012 |
John C. Handley, Roselawn, NY US
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20130138481 | DETECTING PARKING ENFORCEMENT OPPORTUNITIES - Methods and systems automatically analyze different types of historical automobile parking violations within a predetermined geographic region to produce parking violation trends. Such methods and systems automatically predict the numbers of parking violations that potentially could be issued during a plurality of predetermined work periods based on the parking violation trends. The methods and systems automatically compare the actual number of parking violations issued during the predetermined work periods to the number of parking violations that potentially could be issued during the predetermined work periods to produce a parking violation issuance variance. The methods and systems also automatically identify ones of the predetermined work periods in which parking violation citations could be increased to produce an opportunity report, and output the opportunity report. | 05-30-2013 |
John R. Handley, Duluth, MN US
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20130041134 | METHODS FOR PREPARING POLYETHYLENE GLYCOL MALEIMIDE USING N-(2-HYDROXYETHYL) MALEIMIDE AS A STARTING MATERIAL - The present invention relates generally to methods for preparing polyethylene glycol maleimide (“PEG-Mal”). More specifically, the present invention relates to methods for synthesizing desired molecular weight PEG-Mal by direct ethoxylation of N-(2-hydroxyethyl)maleimide under specific reaction conditions. | 02-14-2013 |
20130143909 | Acid Salt Forms of Polymer-Drug Conjugates and Alkoxylation Methods - Among other aspects, provided herein is a mixed-acid salt of a water-soluble polymer-drug conjugate, along with related methods of making and using the same. The mixed-salt acid salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding predominantly pure acid salt or free base forms of the polymer-drug conjugate. The mixed acid salt is reproducibly prepared and recovered, and provides surprising advantages over non-mixed acid salt forms of the water-soluble polymer drug conjugate. | 06-06-2013 |
20130231359 | Salt Form of a Multi-Arm Polymer-Drug Conjugate - Among other aspects, provided herein is a hydrohalide salt of a multi-arm water-soluble polyethylene glycol-drug conjugate, along with related methods of making and using the same. The hydrohalide salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding free base form of the conjugate. | 09-05-2013 |
20150105519 | ACID SALT FORMS OF POLYMER-DRUG CONJUGATES AND ALKOXYLATION METHODS - Among other aspects, provided herein is a mixed-acid salt of a water-soluble polymer-drug conjugate, along with related methods of making and using the same. The mixed-salt acid salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding predominantly pure acid salt or free base forms of the polymer-drug conjugate. The mixed acid salt is reproducibly prepared and recovered, and provides surprising advantages over non-mixed acid salt forms of the water-soluble polymer drug conjugate. | 04-16-2015 |
Joshua Handley, Cambridge, MA US
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20090027411 | APPARATUS AND METHODS FOR STENCILING AN IMAGE - The invention provides methods of protecting selected regions of an image from subsequent modification during the operation of a graphics application. The methods allow a user to select a region of an image to protect, and to assign a level of protection to the selected region. Subsequent brush strokes in the region are then attenuated according to the assigned level of protection and blended into the image without artifacts caused by overlapping strokes. The invention also provides a method of blending individual strokes into a texture without segmentation artifacts. | 01-29-2009 |
20090033660 | APPARATUS AND METHODS FOR TEXTURE MAPPING - The invention provides texture mapping techniques that facilitate interactive painting of a three-dimensional virtual surface by a user in object space, without requiring global parameterization. The texture mapping techniques feature rendering texture for a given virtual object using a plurality of composite textures, each formed by blending collapsible texture layers. Texture coordinates in texture space are derived using information determined at the time of surface mesh generation. The invention features dynamic texture allocation and deallocation, allowing a user to interactively modify the shape of a painted, three-dimensional model. Finally, the invention features an architecture for combined graphical rendering and haptic rendering of a virtual object, allowing a user to experience force feedback during the painting of the object in object space. | 02-05-2009 |
Joshua Handley, Silver Spring, MD US
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20110202856 | Systems and methods for interfacing with a virtual object in a haptic virtual environment - A user of a modeling application modifies an initial virtual object using a sketch drawn on one or more construction planes. Typically, construction planes are connected by an axis that intersects the virtual object. The user can draw a sketch on each construction plane, and the modeling application interpolates a shape along the axis between the sketches to determine what material in the virtual object is to be removed from it. In this manner, material may be removed to create a recess or hole in the virtual object or otherwise to slice away material from the object. A user can use two or more axes and construction planes to produce complex shapes from the initial virtual object. A user can also select a portion of a virtual object and mirror the selected portion. Modifications that the user makes in the selected portion are made correspondingly in the mirrored portion. | 08-18-2011 |
Joshua E. Handley, Silver Spring, MD US
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20140333625 | Apparatus and Methods for Haptic Rendering Using a Haptic Camera View - The invention provides systems and methods for using a “haptic camera” within a virtual environment and for using graphical data from the haptic camera to produce touch feedback. The haptic camera obtains graphical data pertaining to virtual objects within the vicinity and along the trajectory of a user-controlled haptic interface device. The graphical data from the camera is interpreted haptically, thereby allowing touch feedback corresponding to the virtual environment to be provided to the user. | 11-13-2014 |
Joyce A. Handley, Atlanta, GA US
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20100000019 | MATTRESS WITH REMOVABLE TOP - A mattress is constructed from a mattress body having an upper and a lower deck, which is preferably pervious to moisture and air. A removable panel, which includes a top layer of breathable fabric, a bottom layer of a fabric that forms a moisture barrier, and a batting layer, is placed on at least the upper deck of the mattress body. The removable panel is removably attached along the perimeter of the deck or decks by a fastener, such as a zipper. The panel can be removed from the deck for cleaning and folded and secured by the fastener in an inverted configuration, with the top layer facing outward. | 01-07-2010 |
Karen Handley, Londonderry, NH US
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20140371225 | PYRIDAZINONE COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS - The invention relates to a compound of Formula I and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective amount of a compound of Formula I to a patient in need thereof: | 12-18-2014 |
Maynard Handley, Cupertino, CA US
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20080232475 | VIDEO ENCODING AND DECODING - A method for encoding video with a two-dimensional (2D) transform separable to two one-dimensional ( | 09-25-2008 |
20080240600 | ADAPTIVELY POST FILTERING ENCODED VIDEO - Some embodiments of the invention provide a method of decoding an encoded video signal that includes a plurality of successive encoded images. The method initially receives an encoded image of the video signal. It then decodes the encoded image. The method next examines the decoded image to determine whether the decoded image satisfies at least one criterion for performing a post-filter operation on the decoded image. Only if the decoded image satisfies the criterion, the method performs the post-filter operation on the decoded image. The criterion in some embodiments is whether the amount of time for applying the post-filter operation exceeds the remaining amount of time that the method has to process the received image. Some embodiments of the invention provide a method of post-filtering a current image that was decoded from an encoded video signal, which includes a plurality of successive encoded images. The current image has several sub-sections. The method selects a sub-section of the current image. It then determines whether the selected sub-section satisfies at least one condition for performing a post-filter operation on the selected sub-section. The method next performs the post-filter operation on the selected sub-section only if the selected sub-section satisfies the criterion. | 10-02-2008 |
Michael Handley, Farmington, MN US
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20110067368 | FILTER ARRANGEMENT AND METHODS - A filter element includes a single seamless media pack having first and second opposite ends and first and second lateral sides extending between the first and second ends. The media pack also has pleats extending between the first and second ends and a first cross-section defined between the first and second lateral sides. The first cross-section having at least one outward projection that defines an internal radius of at least ¼ inch wherein a plurality of pleats of the media pack are fanned around the internal radius. A first end cap is secured to the first end of the media pack while a second end cap secured to the second end of the media pack. Additionally, a frame member is secured to the first end cap, second end cap, the first lateral side, and the second lateral side. A pre-filter is usable with described filter arrangements. | 03-24-2011 |
20140033664 | FILTER ARRANGEMENT AND METHODS - A filter element includes a single seamless media pack having first and second opposite ends and first and second lateral sides extending between the first and second ends. The media pack also has pleats extending between the first and second ends and a first cross-section defined between the first and second lateral sides. The first cross-section having at least one outward projection that defines an internal radius of at least ¼ inch wherein a plurality of pleats of the media pack are fanned around the internal radius. A first end cap is secured to the first end of the media pack while a second end cap secured to the second end of the media pack. Additionally, a frame member is secured to the first end cap, second end cap, the first lateral side, and the second lateral side. A pre-filter is usable with described filter arrangements. | 02-06-2014 |
20150266145 | AIR INTAKE SEPARATOR SYSTEMS AND METHODS - An air intake separator system includes a plurality of vanes adapted to remove fluid or precipitation from an air stream, wherein the vanes are operably coupled to tubular rods with an interference fit. Applying an elevated temperature heat transfer fluid to the plurality of vanes removes fluid or precipitation from an air stream in order to prevent ice formation. Likewise, applying a lower temperature heat transfer fluid can cool the vanes. | 09-24-2015 |
Michael Handley, Greenbrae, CA US
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20120065185 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE - Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. | 03-15-2012 |
Michael J. Handley, Windsor, CO US
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20150025083 | PROCASPASE COMBINATION THERAPY FOR GLIOBLASTOMA - The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods of use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other compounds and combinations of compounds. | 01-22-2015 |
Michael K. Handley, Windsor, CO US
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20130330397 | Wound Care Products with Peracid Compositions - Methods have been developed for incorporation of a peracid compound into or on wound application matrices, such as bandages or dressings, and other matrices which will favorably impact wound healing and help eliminate microbial infection. The peracid compound comprises a base compound that is metabolically pertinent to wound healing, the oxidized form of the base compound (a peracid), and an appropriate oxidizer, such as hydrogen peroxide. In addition, other excipients with wound healing potential, such as esters of the base compound, may be added to the peracid compound. The combination peracid-wound application matrices can be used to disinfect and heal various wound types with designed time release of the peracid compound. | 12-12-2013 |
20140113967 | Stable Peracid-Containing Compositions - Methods have been developed for incorporation of peracid compounds and related compositions into a non-aqueous medium. The peracid incorporated into the non-aqueous medium is stable and keeps its chemical and antimicrobial activity for extended durations. The non-aqueous medium may be removed just prior to or during application of the peracid. | 04-24-2014 |
20140243881 | CATHETER-BASED APPARATUSES AND METHODS - Blood flow into vascular tissue is filtered in a manner that can also be useful for trapping particulates while allowing the flow of blood. Consistent with one or more embodiments, a filter apparatus includes a filter, an outer delivery sheath such as a catheter, and one or more shafts that are operable to manipulate the shape of the filter for positioning within vascular tissue. The filter conforms to various types of vascular tissue, and filters blood flow passing through openings in the vascular tissue. In some implementations, the filter is used to trap particulates that have been collected on the filter, and collapses to trap and draw the particulates into the outer delivery sheath. | 08-28-2014 |
20150017264 | PROCASPASE 3 ACTIVATION BY COMBINATION THERAPY - The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods of use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other compounds and combinations of compounds. | 01-15-2015 |
20150099759 | POTENT ANTICANCER ACTIVITY VIA DUAL COMPOUND ACTIVATION - The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods the use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other compounds and combinations of compounds. | 04-09-2015 |
20150306064 | Wound Care Products with Peracid Compositions - Methods have been developed for incorporation of a peracid compound into or on wound application matrices, such as bandages or dressings, and other matrices which will favorably impact wound healing and help eliminate microbial infection. The peracid compound comprises a base compound that is metabolically pertinent to wound healing, the oxidized form of the base compound (a peracid), and an appropriate oxidizer, such as hydrogen peroxide. In addition, other excipients with wound healing potential, such as esters of the base compound, may be added to the peracid compound. The combination peracid-wound application matrices can be used to disinfect and heal various wound types with designed time release of the peracid compound. | 10-29-2015 |
20160100928 | CATHETER-BASED APPARATUSES AND METHODS - Blood flow into vascular tissue is filtered in a manner that can also be useful for trapping particulates while allowing the flow of blood. Consistent with one or more embodiments, a filter apparatus includes a filter, an outer delivery sheath such as a catheter, and one or more shafts that are operable to manipulate the shape of the filter for positioning within vascular tissue. The filter conforms to various types of vascular tissue, and filters blood flow passing through openings in the vascular tissue. In some implementations, the filter is used to trap particulates that have been collected on the filter, and collapses to trap and draw the particulates into the outer delivery sheath. | 04-14-2016 |
Michael K. Handley, Greenbrae, CA US
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20130273004 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE - Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. | 10-17-2013 |
Michael W. Handley, Farmington, MN US
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20090064860 | Z-filter media with reverse-flow cleaning systems and methods - A method for cleaning a filter having Z-media includes providing a filter having Z-media and cleaning the media construction by directing a pulse of compressed gas into the media construction through the downstream flow face. Filter elements useable with such methods include elements made of Z-media. An example system utilizing the method includes a gas turbine air intake system. | 03-12-2009 |
20110048228 | FILTER CONSTRUCTION FOR USE WITH AIR IN-TAKE FOR GAS TURBINE AND METHODS - The filter of the invention is a cartridge filter comprising a structure that can maintain a filter medium in an air stream to filter particulates to protect a gas turbine power system. The filter combines a mechanically adequate filter structure and an effective filter medium for to obtain a useful system. | 03-03-2011 |
20130008313 | FILTER CONSTRUCTION FOR USE WITH AIR IN-TAKE FOR GAS TURBINE AND METHODS - The filter of the invention is a cartridge filter comprising a structure that can maintain a filter medium in an air stream to filter particulates to protect a gas turbine power system. The filter combines a mechanically adequate filter structure and an effective filter medium for to obtain a useful system. | 01-10-2013 |
Mont Andrew Handley, Pittsburgh, PA US
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20160096779 | MATERIALS SUITABLE AS SUBSTITUTES FOR PEAT MOSSES AND PROCESSES AND APPARATUS THEREFOR - Processes capable of producing bulk materials suitable for use by the horticulture industry, resulting bulk materials produced thereby, and applications for these processes and materials. Preferred bulk materials have physical properties similar to peat moss and comprise individual materials, each at least partially having a twisted, curled, clumped and rolled structure. The individual materials may further comprise small granular particles dispersed throughout the twisted, curled, clumped and rolled structure. The individual materials may be rolled fibers such that the bulk material has physical properties similar to | 04-07-2016 |
Richard A. Handley, Loon Lake, WA US
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20090053785 | METHODS AND COMPOSITIONS FOR OPTIMIZING FERMENTATION - Embodiments described include methods for maintaining the pH and alkalinity during industrial fermentation processes are described that foster optimal microorganism activities throughout the duration of the fermentation process. Magnesium based buffering agents having sufficient buffering capacity and applied at sufficient concentration levels required to neutralize the acidic content of fermentation fluids during the fermentation process cycle are detailed. These magnesium based buffering agents control fermenter processes without causing extreme pH swings to maximize the production of desired fermentation products. | 02-26-2009 |
20110024360 | COMPOSITIONS AND METHODS FOR WASTEWATER TREATMENT - Methods and compositions utilizing aluminum, magnesium, and calcium-based additives for the treatment and neutralization of wastewater are described for removing contaminants from wastewater, including reducing phosphorous-containing compounds, total suspended solids (TSS), biological oxygen demand (BOD), fats, oils, and greases (FOG), and total Kjedahl nitrogen (TKN) are described. Methods and compositions to control pH, sulfur and sodium loads present in wastewater and precipitatable solids are described. Concentrations of aluminum, magnesium, and calcium-based additives are maintained at mass action concentrations to the wastewater component levels present in the wastewater and bracketed approximately +/−0.5 pH units about the pK value of the soluble, buffering species. | 02-03-2011 |
Richard S. Handley, Canton, MI US
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20080261318 | Signalling Compounds For Use In Methods Of Detecting Hydrogen Peroxide - Methods and compound useful for detecting a source of hydrogen peroxide are disclosed wherein a signalling compound of the formula: | 10-23-2008 |
20100055800 | Compositions for Chemiluminescent Detection of Hydrogen Peroxide - Methods and compound useful for detecting a source of hydrogen peroxide are disclosed wherein a signalling compound of the formula: | 03-04-2010 |
20130084652 | Homogeneous Chemiluminescence Assay Methods with Increased Sensitivity - Methods are disclosed for determining an analyte in a medium suspected of containing the analyte. One method comprises treating a medium suspected of containing an analyte under conditions such that the analyte, if present, causes a photosensitizer and a chemiluminescent compound to come into close proximity. The photosensitizer generates singlet oxygen and activates the chemiluminescent compound when it is in close proximity. Non-specific signal generated by singlet oxygen not in proximity is reduced or suppressed using a singlet oxygen quencher (SOQ). The activated chemiluminescent compound subsequently produces light. The amount of light produced is related to the amount of analyte in the medium. Use of Noise Modulation Agents significantly improves signal-to-noise ratios and assay sensitivity. Compositions and kits are also disclosed. | 04-04-2013 |
Scott Handley, Saint Louis, MO US
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20150284814 | VIRUSES ASSOCIATED WITH IMMUNODEFICIENCY AND ENTEROPATHY AND METHODS USING SAME - The present invention relates to previously undescribed viruses that are associated with significant expansion of the virome, immunodeficiency, and enteropathy during lentiviral infection. The invention also provides methods to detect acquired immune deficiency syndrome (AIDS) or AIDS progression in a subject, methods to diagnose immunodeficiency or enteropathy in a subject, and methods to identify a therapeutic agent to treat the same. | 10-08-2015 |
Sheryll H. Handley, Fort Worth, TX US
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20080305514 | METHOD FOR DETECTING MICROBES - The present invention relates to methods for detecting microbes in a sample comprising filtering the sample through a fluid-permeable surface, contacting the surface with a viability stain, scanning the surface for viability stain to form a first scan, contacting the surface with a nucleic acid stain, scanning the surface for nucleic acid stain to form a second scan, and comparing said first scan and said second scan. | 12-11-2008 |
Simon Handley, Palo Alto, CA US
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20080249876 | METHOD AND SYSTEM USING DISTRIBUTIONS FOR MAKING AND OPTIMIZING OFFER SELECTIONS - A method and system for making and optimizing offer selections targeted to particular recipients or groups improves selection quality by combining and aggregating quantitative and qualitative data to capture recipient needs and provider expectations and intentions. Offer descriptions are first received. Distribution variables for application to offer descriptions and recipients are then selected. Distributions are then assigned to offer descriptions, and distributions appropriate to the recipient are determined and assigned to the recipient. Distributions can incorporate demographic, psychographic and behavioral variables. Offer description distributions and recipient distributions are combined for each offer description, resulting in a ranking for each offer description. Offer descriptions are automatically selected based on the rankings, using, for example, simple ordering or roulette wheel selection. Offer descriptions are instantiated as offers, and finally offers are output to the recipient. | 10-09-2008 |
Simon G. Handley, Palo Alto, CA US
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20130013645 | SEMANTIC MATCHING - In a method, system, and computer-readable medium having instructions for semantic matching, a configuration for one or more ontologies is determined with an ontology that has one or more concepts and a representation for the one or more concepts, and the configuration has an assignment of concepts to positions and one or more relationships between concepts in accordance with the representation. The configuration is optimized in accordance with one or more constraints, and a constraint has a relationship defined in a representation for an ontology and a judgment on a similarity of a plurality of concepts from the one or more ontologies, and an estimate is calculated for a similarity between a first concept and a second concept using the configuration. | 01-10-2013 |
William Handley, Chandler, AZ US
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20080217764 | Piezoelectric cooling of a semiconductor package - In one embodiment, the present invention includes a semiconductor package having a plurality of fan blades embedded within a first surface of the package, where a first group of the fan blades extend from a first side of the package and a second group of the fan blades extend from a second side of semiconductor package. The fan blades may be powered by piezoelectric devices to cause motion of the fan blades. Other embodiments are described and claimed. | 09-11-2008 |