Patent application number | Description | Published |
20090148396 | BIOCOMPATIBLE BIODEGRADABLE FUMAGILLIN ANALOG CONJUGATES - Fumagillin analog polymer conjugates, methods of making fumagillin analog polymer conjugates, compositions comprising a polymer conjugate of a fumagillin analog, and methods for treating cancer, or treating angiogenic diseases comprising administering to a subject in need thereof an effective amount of a polymer conjugate of a fumagillin analog, are described. Also described are novel fumagillin analogs, methods of making fumagillin analogs, compositions comprising at least one fumagillin analog, and methods for treating cancer, or treating angiogenic diseases comprising administering to a subject in need thereof an effective amount of a fumagillin analog. | 06-11-2009 |
20100305149 | Polyal Drug Conjugates Comprising Variable Rate-Releasing Linkers - Polyal-Drug conjugates comprising a variable rate-releasing linker are described along with methods of making such conjugates. Uses for such Polyal-Drug conjugates is also described. | 12-02-2010 |
20110243880 | MODIFIED POLYMERS FOR DELIVERY OF POLYNUCLEOTIDES, METHOD OF MANUFACTURE, AND METHODS OF USE THEREOF - A polynucleotide delivery vehicle comprising a modified polymer is provided herein, the modified polymer having the following formula: | 10-06-2011 |
20120321583 | Protein-Polymer-Drug Conjugates - A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L | 12-20-2012 |
20130101546 | Protein-Polymer-Drug Conjugates - A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L | 04-25-2013 |
20130109817 | Modified Polymers for Delivery of Polynucleotides, Method of Manufacture, and Methods of Use Thereof | 05-02-2013 |
20130158046 | BIOCOMPATIBLE BIODEGRADABLE FUMAGILLIN ANALOG CONJUGATES - Fumagillin analog polymer conjugates, methods of making fumagillin analog polymer conjugates, compositions comprising a polymer conjugate of a fumagillin analog, and methods for treating cancer, or treating angiogenic diseases comprising administering to a subject in need thereof an effective amount of a polymer conjugate of a fumagillin analog, are described. Also described are novel fumagillin analogs, methods of making fumagillin analogs, compositions comprising at least one fumagillin analog, and methods for treating cancer, or treating angiogenic diseases comprising administering to a subject in need thereof an effective amount of a fumagillin analog. | 06-20-2013 |
20130309192 | Auristatin Compounds and Conjugates Thereof - Auristatin compounds and conjugates thereof are provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L | 11-21-2013 |
20140134127 | Protein-Polymer-Drug Conjugates - A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L | 05-15-2014 |
20150044160 | PROTEIN-POLYMER-DRUG CONJUGATES - A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L | 02-12-2015 |
20150064130 | PROTEIN-POLYMER-DRUG CONJUGATES - Auristatin compounds and conjugates thereof are provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L | 03-05-2015 |
Patent application number | Description | Published |
20080311177 | Self Assembled Films for Protein and Drug Delivery Applications - Provided are systems for controlled release of proteins from decomposable thin films constructed by layer-by-layer deposition. Such films generally comprise alternating layers of polymers and proteins, and may further comprise additional layers of polyions. In some embodiments, decomposable thin films and methods of using such films allow proteins to be released over an extended period of time and/or retention of as much as 100% of function of released protein. | 12-18-2008 |
20090197138 | Highly Conducting Solid State Ionics for Electrochemical Systems and Methods of Fabricating Them Using Layer-by-Layer Technology - Herein are disclosed methods, and compositions produced using them, to assemble highly conducting, hydrolytically stable polymer electrolyte films from commercially-available, water-soluble polymers using layer-by-layer assembly technology. In certain embodiments, these films can be used for electrochemical device applications which require an ion-conducting material to operate. For example, the power efficiency of any electrochemical device with a solid polymer electrolyte layer can be increased by this technology by virtue of the low ionic resistance of these layer-by-layer assembled thin film electrolytes. Specifically, direct-methanol operated fuel cells (DMFCs) should benefit remarkably, as the described technology offers very high conductivity values at fully hydrated conditions with low fuel (methanol) crossover. | 08-06-2009 |
20100003499 | Automated layer by layer spray technology - The present invention comprises an automated apparatus capable of spray depositing polyelectrolytes via the LbL mechanism with minimal or no human interaction. In certain embodiments, the apparatus sprays atomized polyelectrolytes onto a vertically oriented substrate. To counteract the effects of irregular spray patterns, the substrate is preferably slowly rotated about a central axis. In certain embodiments, the apparatus also includes a forced pathway for the droplets, such as a pathway created by using a vacuum. In this way, a thicker or three-dimensional substrate can be coated. In certain embodiments, the apparatus is designed so as to be scalable. Thus, through the use of multiple instantiations of the apparatus, a large or irregularly shaped substrate can be coated. Rolls of textile can therefore be coated using the apparatus. Additionally, the present invention includes a method to uniformly coat a substrate, such as a hydrophobic textile material, using aqueous solutions of polyelectrolytes. | 01-07-2010 |
20100130082 | Highly Reactive Multilayer Assembled Coating of Metal Oxides on Organic and Inorganic Substrates - One aspect of the invention relates to a method of preparing metal oxide coated substrates for various potential applications, and the coated substrate formed thereby. | 05-27-2010 |
20110097419 | Poly(Propargyl-L-Glutamate) and Derivatives Thereof - A process of the present invention is directed toward conducting highly selective, high yield post-polymerization reactions on polypeptides to prepare functionalized polypeptides. In certain embodiments, the polypeptides can be prepared by ring opening polymerization of N-carboxyanhydrides. In certain embodiments, the post-polymerization reaction is a “click chemistry” reaction. In certain embodiment, the “click chemistry” reaction is a triazole-forming reaction involving an alkyne on the polypeptide and an azide. | 04-28-2011 |
20120027837 | MULTILAYER COATING COMPOSITIONS, COATED SUBSTRATES AND METHODS THEREOF - The present invention provides, among other things, multilayer film coating compositions, coated substrates and methods thereof In some embodiments, a structure, comprising a substrate and a multilayer film on the substrate, wherein the multilayer film comprises a first plurality of first units, each first unit comprising a protamine polypeptide. In some embodiments, a structure comprising a microneedle substrate and a multilayer film coated on at least portion of the microneedle substrate, wherein the multilayer film comprises an agent for release and a first plurality of first unit; each first unit comprising a first layer and a second layer, wherein the first layer and the second layer are associated with one another. | 02-02-2012 |
20120227800 | Biologically Self-Assembled Nanotubes - A method of a general biological approach to synthesizing compact nanotubes using a biological template is described. | 09-13-2012 |
20120269973 | Automated Layer By Layer Spray Technology - The present invention comprises an automated apparatus capable of spray depositing polyelectrolytes via the LbL mechanism with minimal or no human interaction. In certain embodiments, the apparatus sprays atomized polyelectrolytes onto a vertically oriented substrate. To counteract the effects of irregular spray patterns, the substrate is preferably slowly rotated about a central axis. In certain embodiments, the apparatus also includes a forced pathway for the droplets, such as a pathway created by using a vacuum. In this way, a thicker or three-dimensional substrate can be coated. In certain embodiments, the apparatus is designed so as to be scalable. Thus, through the use of multiple instantiations of the apparatus, a large or irregularly shaped substrate can be coated. Rolls of textile can therefore be coated using the apparatus. Additionally, the present invention includes a method to uniformly coat a substrate, such as a hydrophobic textile material, using aqueous solutions of polyelectrolytes. | 10-25-2012 |
20120277719 | COATING COMPOSITIONS, METHODS AND COATED DEVICES - The present disclosure provides, am ng other things, a coated device comprising: a porous substrate; a film coating at least part of the substrate, which film comprises a multilayer unit comprising a first layer and a second layer adjacent to the first layer, wherein the first layer comprises a first polymeric material and at least first interacting moiety, wherein the second layer comprises a second polymeric material and at least second interacting moiety, and wherein the interacting moieties on adjacent layers interact with one another so that the adjacent layers are associated with each other into the film; and an agent for delivery associated with the coated device, such that decomposition of one or more layers of the film results in release of the agent. | 11-01-2012 |
20120277852 | COATING COMPOSITIONS, METHODS AND COATED DEVICES - In various embodiments, a coated device comprises: a substrate; a film coating at least part of the substrate, which film comprises a multilayer unit comprising a first layer and a second layer associated with one another via a hydrogen bond, wherein the first layer comprises a first natural polymeric material and a hydrogen bond donor and wherein the second layer comprises a second natural polymeric material and a hydrogen bond acceptor; and an agent for delivery associated with the coated device. In various embodiments, a coated device comprises: a substrate; a film coating at least part of the substrate, which film comprises a multilayer unit comprising a tetralayer with alternating layers of opposite charge; and an agent for delivery associated with the coated device. | 11-01-2012 |
20130190890 | COMPOSITION AND METHODS FOR COATING - The present invention provides, among other things, multilayer film coating compositions, coated substrates and methods thereof. In some embodiments, a structure includes a first and second layer-by-layer film disposes on a substrate, the structure being characterized in that layer-by-layer removal of at least the second film releases at least one polypeptide, and also may permit release of ions from the ceramic material so that a synergetic effect of the osteoinduction and osteoconduction of the structure is achieved. | 07-25-2013 |
20130273137 | DRUG DELIVERY COATING AND DEVICES - In various embodiments, the present invention provides certain systems comprising a multi-layer decomposable film coating composition on a substrate, where the coating composition includes one or more releasable agents in at least one of its layers, and decomposes layer-by-layer to release such agent(s) over time. In some embodiments, an intra-ocular lens (IOL) system comprising an IOL coated with a multi-layer decomposable film coating composition is disclosed. | 10-17-2013 |
20130341277 | Porous Film - A reverse osmosis (RO) membrane can include a porous substrate, a multilayer film arranged on the substrate, which includes a first layer including a polyelectrolyte and a second layer including a plurality of clay particles, where the first layer is arranged adjacent to the second layer. The multilayer film can be prepared by a spray-LbL process. The resulting RO membrane can provide high water permeability combined with high salt rejection. | 12-26-2013 |
20140000688 | Biologically Self-Assembled Nanotubes | 01-02-2014 |
20140048126 | VIRUS FILM AS TEMPLATE FOR POROUS INORGANIC SCAFFOLDS - Virus multilayers can be used as templates for growth of inorganic nanomaterials. For example, layer-by-layer construction of virus multilayers on functionalized surfaces form nanoporous structures onto which metal particles or metal oxide nanoparticles can be nucleated to result in an interconnected network of nanowires. | 02-20-2014 |
20140093575 | STABLE LAYER-BY-LAYER COATED PARTICLES - Systems and methods for coating a particle core with a layer-by-layer film are disclosed. | 04-03-2014 |
20140186724 | MULTI-LAYER STRUCTURES PREPARED BY LAYER-BY-LAYER ASSEMBLY - A protective layer can be deposited on a surface of an porous polymer separator placing on a Li-metal electrode to protect against adverse electrochemical activity in a battery. The protective layer can be a multilayered structure including graphene oxide. | 07-03-2014 |
20140302116 | COMPOSITIONS AND METHODS FOR NUCLEIC ACID DELIVERY - The present invention provides, among other things, multilayer film coating compositions, coated substrates and methods thereof. In some embodiments, a structure includes a substrate; and a multilayer film coated on the substrate, wherein adjacent layers of the multilayer film are associated with one another via one or more non-covalent interactions, wherein the multilayer film comprises a first nucleic acid agent present at a loading density, and further wherein the multilayer film is characterized in that, when the structure is placed on a subject so that the multilayer film contacts cells, the first nucleic acid agent is released with a profile characterized by a feature selected from the group consisting of 1) being a burst-free release; 2) being a sustained release; and 3) exhibiting in vitro and/or in vivo biological effectiveness. | 10-09-2014 |
20140328931 | NUCLEIC ACID PARTICLES, METHODS AND USE THEREOF - The present invention provides, among other things, a particle which includes a core comprised of self-assembled one or more nucleic acid molecules, the core being characterized by an ability to adopt at least two configurations: a first configuration having a first greatest dimension greater than 2 μm and; a second configuration having a second greatest dimension less than 500 nm, wherein addition of a film coating converts the core from its first configuration to its second configuration. Methods of making and using of provided particles are also disclosed. | 11-06-2014 |
20140377670 | LITHIUM ION CONDUCTING PROTECTIVE FILM AND METHOD OF USE - A lithium ion conducting protective film produced using a layer-by-layer assembly process. The lithium ion conducting protective film is assembled on a substrate by a sequential exposure of the substrate to a first poly(ethylene oxide) (PEO) layer including a cross-linking silane component on the first side of the substrate, a graphene oxide (GO) layer on the first PEO layer, a second poly(ethylene oxide) (PEO) layer including a cross-linking silane component on the GO layer and a poly(acrylic acid) (PAA) layer on the second PEO layer. The film functions as a lithium ion conducting protective film that isolates the lithium anode from the positive electrochemistry of the cathode in a lithium-air battery, thereby preventing undesirable lithium dendrite growth | 12-25-2014 |
20150086599 | Self Assembled Films for Protein and Drug Delivery Applications - Provided are systems for controlled release of proteins from decomposable thin films constructed by layer-by-layer deposition. Such films generally comprise alternating layers of polymers and proteins, and may further comprise additional layers of polyions. In some embodiments, decomposable thin films and methods of using such films allow proteins to be released over an extended period of time and/or retention of as much as 100% of function of released protein. | 03-26-2015 |
20150250739 | Multilayer Compositions, Coated Devices And Use Thereof - The present invention provides, among other things, multilayer film coating compositions, coated substrates and methods thereof. In some embodiments, a structure, comprising a substrate and a multilayer film on the substrate, wherein the multilayer film comprises a release layer and one or more layer-by-layer films. In some embodiments, a structure comprising a microneedle substrate and a multilayer film coated on at least portion of the microneedle substrate, wherein the multilayer film comprises an agent for delivery. | 09-10-2015 |
20150262760 | PLASMON-ENHANCED DYE-SENSITIZED SOLAR CELLS - A dye-sensitized solar cell can include a plurality of a plasmon-forming nanostructures. The plasmon-forming nanostructures can include an oxide core, an inner metallic shell on a surface of the oxide core, and an outer oxide shell on a surface of the inner metallic shell. | 09-17-2015 |
20150290669 | Devices and Methods for Layer-by-Layer Assembly - Devices and associated methods are provided herein for creating arrays of thin films on a substrate utilizing a capillary force layer-by-layer assembly. Such devices and methods can be configured for forming one or more channels when the device is in operable contact with the substrate, each channel having an inlet reservoir at one end by which the coating material is introduced into the channel, wherein each channel is a lengthwise enclosure defined by a surface of the substrate on one side and one or more adjacent structures of the assembly surrounding the channel along its length. Provided devices and methods facilitate automated, precise manufacture of arrays of customized thin films for lab-on-a-chip biological and/or chemical assay products, for example. Additionally, provided devices and methods significantly reduce material waste, improves quality control, and expands the potential applications of LBL into new research space. | 10-15-2015 |