Patent application number | Description | Published |
20120095697 | METHODS FOR ESTIMATING GENOME-WIDE COPY NUMBER VARIATIONS - Methods for determining the copy number of a genomic region at a detection position of a target sequence in a sample are disclosed. Genomic regions of a target sequence in a sample are sequenced and measurement data for sequence coverage is obtained. Sequence coverage bias is corrected and may be normalized against a baseline sample. Hidden Markov Model (HMM) segmentation, scoring, and output are performed, and in some embodiments population-based no-calling and identification of low-confidence regions may also be performed. A total copy number value and region-specific copy number value for a plurality of regions are then estimated. | 04-19-2012 |
20130110407 | DETERMINING VARIANTS IN GENOME OF A HETEROGENEOUS SAMPLE | 05-02-2013 |
20130316915 | METHODS FOR DETERMINING ABSOLUTE GENOME-WIDE COPY NUMBER VARIATIONS OF COMPLEX TUMORS - Methods for interpreting absolute copy number of complex tumors and for determining the copy number of a genomic region at a detection position of a target sequence in a sample are disclosed. In certain aspects, genomic regions of a target sequence in a sample are sequenced and measurement data for sequence coverage is obtained. Sequence coverage bias is corrected and may be normalized against a baseline sample. Hidden Markov Model (HMM) segmentation, scoring, and output are performed, and in some embodiments population-based no-calling and identification of low-confidence regions may also be performed. A total copy number value and region-specific copy number value for a plurality of regions are then estimated. | 11-28-2013 |
20140188396 | OLIGOMER SEQUENCES MAPPING - Mapping oligomer sequences includes receiving a set of related oligomer sequences, applying one or more key patterns derived from a set of oligomer sequence relationships to obtain one or more keys that are consistent with the set of related oligomer sequences, and locating the one or more keys in an index configured to map a plurality of possible keys to their respective candidate and/or validated locations in a reference. | 07-03-2014 |
Patent application number | Description | Published |
20100286925 | OLIGOMER SEQUENCES MAPPING - Mapping oligomer sequences includes receiving a set of related oligomer sequences, applying one or more key patterns derived from a set of oligomer sequence relationships to obtain one or more keys that are consistent with the set of related oligomer sequences, and locating the one or more keys in an index configured to map a plurality of possible keys to their respective candidate and/or validated locations in a reference. | 11-11-2010 |
20100287165 | INDEXING A REFERENCE SEQUENCE FOR OLIGOMER SEQUENCE MAPPING - Generating an index includes receiving a reference sequence and applying one or more key patterns to the reference sequence to obtain a plurality of keys in the index. Each of the one or more key patterns is derived based on a corresponding set of oligomer sequence relationships of a plurality of oligomer sequences that are expected to be generated from the reference, and the keys correspond to a plurality of candidate and/or validated locations in the reference sequence. | 11-11-2010 |
20110004413 | METHOD AND SYSTEM FOR CALLING VARIATIONS IN A SAMPLE POLYNUCLEOTIDE SEQUENCE WITH RESPECT TO A REFERENCE POLYNUCLEOTIDE SEQUENCE - Embodiments for calling variations in a sample polynucleotide sequence compared to a reference polynucleotide sequence are provided. Aspects of the embodiments include executing an application on at least one computer that locates local areas in the reference polynucleotide sequence where a likelihood exists that one or more bases of the sample polynucleotide sequence are changed from corresponding bases in the reference polynucleotide sequence, where the likelihood is determined at least in part based on mapped mated reads of the sample polynucleotide sequence; generating at least one sequence hypothesis for each of the local areas, and optimizing the at least one sequence hypothesis for at least a portion of the local areas to find one or more optimized sequence hypotheses of high probability for the local areas; and analyzing the optimized sequence hypotheses to identify a series of variation calls in the sample polynucleotide sequence. | 01-06-2011 |
20110015864 | OLIGOMER SEQUENCES MAPPING - Mapping oligomer sequences includes receiving a set of related oligomer sequences, applying one or more key patterns derived from a set of oligomer sequence relationships to obtain one or more keys that are consistent with the set of related oligomer sequences, modifying positions within these keys, and locating the one or more keys in an index configured to map a plurality of candidate and/or validated keys to their respective possible and/or validated locations in a reference. | 01-20-2011 |
20120197533 | IDENTIFYING REARRANGEMENTS IN A SEQUENCED GENOME - Methods, apparatuses, and systems for identification of junctions (e.g., resulting from large-scale rearrangements) of a sequenced genome with respect to a human genome reference sequence is provided. For example, false positives can be distinguished from actual junctions. Such false positives can result from many sources, including mismapping, chimeric reactions among the DNA of a sample, and problems with the reference genome. As part of the filtering processes, a base pair resolution (or near base pair resolution) of a junction can be provided. In various implementations, junctions can be identified using discordant mate pairs and/or using a statistical analysis of the length distributions of fragments for local regions of the sample genome. Clinically significant junctions can also be identified so that further analysis can be focused on genomic regions that may have more of an impact on the health of a patient. | 08-02-2012 |
Patent application number | Description | Published |
20080300572 | WIRELESS MONITOR FOR A PERSONAL MEDICAL DEVICE SYSTEM - A monitor device for a fluid infusion system and its operating, display, and data processing characteristics are described herein. One embodiment of the monitor device is used in an insulin infusion system having an insulin infusion pump and a continuous glucose sensor transmitter. The monitor device is configured as a wireless bedside monitor that wirelessly receives status data from a device in the fluid infusion system, such as the infusion pump or the sensor transmitter. The monitor device supports a number of user interface features, alarm/alert features, and graphical display features, where such features enhance the overall operation and user-friendliness of the monitor device. For example, the monitor device can generate status icons that graphically indicate the time remaining for an exhaustible operating quantity of a device in the infusion system (e.g., a battery charge, a fluid reservoir volume, or a calibration or replacement period). The monitor device can also estimate future measurements of a physiological characteristic of a monitored patient, based upon empirical measurement data received by the monitor device. | 12-04-2008 |
20090112626 | REMOTE WIRELESS MONITORING, PROCESSING, AND COMMUNICATION OF PATIENT DATA - A remote wireless monitoring system for patient data, and an ambulatory system for processing and transmitting physiological characteristic data are provided. An embodiment of a system for remote wireless monitoring of data for a patient includes an ambulatory sensor/transmitter subsystem that wirelessly transmits measured values of a physiological characteristic of the patient, a base station that wirelessly receives signals from the sensor/transmitter subsystem, and a remote monitor that wirelessly receives signals from the base station. The remote monitor is configured to generate audio and/or visual indicia (representing alarms, the measured values, device or system status information, etc.) in response to the base station signals. An embodiment of an ambulatory system includes a physiological characteristic sensor, a self-contained sensor processor module coupled to the ambulatory physiological characteristic sensor, and an ambulatory data receiver device coupled to the self-contained sensor processor module. | 04-30-2009 |
20090113295 | GRAPHICAL DISPLAY FOR PHYSIOLOGICAL PATIENT DATA - An intuitive graphical display as described herein can be rendered by a host device that obtains physiological patient data (such as blood glucose values) in real time or substantially real time. The graphical display includes a calibrated bar graph having a desired measurement range for the monitored parameter. The graphical display also includes a dynamic measurement value indicator that moves along the bar graph in a manner that tracks the current value of the monitored physiological characteristic. The graphical display may also incorporate easy-to-interpret display elements that allow the user to quickly determine whether the current value of the monitored physiological characteristic is within or outside a normal range, whether the monitored physiological characteristic is rising or falling, and the approximate rate of change of the monitored physiological characteristic. | 04-30-2009 |
20100010330 | WIRELESS MONITOR FOR A PERSONAL MEDICAL DEVICE SYSTEM - A monitor device for a fluid infusion system and its operating, display, and data processing characteristics are described herein. One embodiment of the monitor device is used in an insulin infusion system having an insulin infusion pump and a continuous glucose sensor transmitter. The monitor device is configured as a wireless bedside monitor that wirelessly receives status data from a device in the fluid infusion system, such as the infusion pump or the sensor transmitter. The monitor device supports a number of user interface features, alarm/alert features, and graphical display features, where such features enhance the overall operation and user-friendliness of the monitor device. For example, the monitor device can generate status icons that graphically indicate the time remaining for an exhaustible operating quantity of a device in the infusion system (e.g., a battery charge, a fluid reservoir volume, or a calibration or replacement period). The monitor device can also estimate future measurements of a physiological characteristic of a monitored patient, based upon empirical measurement data received by the monitor device. | 01-14-2010 |
20120001920 | GRAPHICAL DISPLAY FOR PHYSIOLOGICAL PATIENT DATA - An intuitive graphical display as described herein can be rendered by a host device that obtains physiological patient data (such as blood glucose values) in real time or substantially real time. The graphical display includes a calibrated bar graph having a desired measurement range for the monitored parameter. The graphical display also includes a dynamic measurement value indicator that moves along the bar graph in a manner that tracks the current value of the monitored physiological characteristic. The graphical display may also incorporate easy-to-interpret display elements that allow the user to quickly determine whether the current value of the monitored physiological characteristic is within or outside a normal range, whether the monitored physiological characteristic is rising or falling, and the approximate rate of change of the monitored physiological characteristic. | 01-05-2012 |
Patent application number | Description | Published |
20080215918 | METHOD FOR MONITORING SERVER SUB-SYSTEM HEALTH - A server self health monitor (SHM) system monitors the health of the server it resides on. The health of a server is determined by the health of all of a server's sub-systems and deployed applications. The SHM may make health check inquiries to server sub-systems periodically or based on external trigger events. The sub-systems perform self health checks on themselves and provide sub-system health information to requesting entities such as the SHM. Sub-systems self health updates may be based on internal events such as counters or changes in status or based on external entity requests. Corrective action may be performed upon sub-systems by the SHM depending on their health status or the health status of the server. Corrective action may also be performed by a sub-system upon itself. | 09-04-2008 |
20080215924 | METHOD FOR PERFORMING A CORRECTIVE ACTION UPON A SUB-SYSTEM - A server self health monitor (SHM) system monitors the health of the server it resides on. The health of a server is determined by the health of all of a server's sub-systems and deployed applications. The SHM may make health check inquiries to server sub-systems periodically or based on external trigger events. The sub-systems perform self health checks on themselves and provide sub-system health information to requesting entities such as the SHM. Sub-systems self health updates may be based on internal events such as counters or changes in status or based on external entity requests. Corrective action may be performed upon sub-systems by the SHM depending on their health status or the health status of the server. Corrective action may also be performed by a sub-system upon itself. | 09-04-2008 |
20080313293 | SYSTEM AND METHOD FOR EXACTLY ONCE MESSAGE STORE COMMUNICATION - A system for managing a message store in a network includes an object acting as a message store. In one embodiment, the message store is for Java Message Service. A lead server is selected from several servers. The lead server uses a distributed consensus algorithm to select a host server. The selected host server hosts the message store, providing sole access to the message store. The other servers are notified of the new host by messaging. In one embodiment, servers can send messages to the message store on the host and pick up any messages from the message store. | 12-18-2008 |
20090037925 | SMART STUB OR ENTERPRISE JAVA BEAN IN A DISTRIBUTED PROCESSING SYSTEM - A clustered enterprise distributed processing system. The distributed processing system includes a first and a second computer coupled to a communication medium. The first computer includes a virtual machine (JVM) and kernel software layer for transferring messages, including a remote virtual machine (RJVM). The second computer includes a JVM and a kernel software layer having a RJVM. Messages are passed from a RJVM to the JVM in one computer to the JVM and RJVM in the second computer. Messages may be forwarded through an intermediate server or rerouted after a network reconfiguration. Each computer includes a Smart stub having a replica handler, including a load balancing software component and a failover software component. Each computer includes a duplicated service naming tree for storing a pool of Smart stubs at a node. | 02-05-2009 |
Patent application number | Description | Published |
20090145437 | VOLUME ADJUSTABLE MANUAL VENTILATION DEVICE - Disclosed is a manually operable volume-adjustable ventilation device. The device includes a reservoir with an inlet mechanism, an outlet mechanism, and a volume adjuster configured to move a volume adjustment limit of the reservoir and change an expressed maximum volume of the reservoir. The reservoir has a body having a plurality of movable walls defining an enclosed volume. The reservoir has an uncompressed state and a compressed state. The walls of the reservoir are movable with respect to each other, such that moving the walls expresses the volume adjustment limit of the reservoir. The walls can be operably connected by movable structures configured such that two adjacent walls are configured to rotate around substantially orthogonal axes with respect to each other when the reservoir moves from an uncompressed to a compressed state. In some embodiments, the movable structures can be hinges, such as snap-fit assembly hinges. Methods of ventilating a patient that involve the device are also disclosed. | 06-11-2009 |
20100132709 | VOLUME-ADJUSTABLE MANUAL VENTILATION DEVICE - Disclosed is a manually operable volume-adjustable ventilation device. The device includes a reservoir with an inlet mechanism, an outlet mechanism, and a volume adjuster configured to move a volume adjustment limit of the reservoir and change an expressed maximum volume of the reservoir. The reservoir has a body having a plurality of movable walls defining an enclosed volume. The reservoir has an uncompressed state and a compressed state. The walls of the reservoir are movable with respect to each other, such that moving the walls expresses the volume adjustment limit of the reservoir. The walls can be operably connected by movable structures configured such that two adjacent walls are configured to rotate around substantially orthogonal axes with respect to each other when the reservoir moves from an uncompressed to a compressed state. In some embodiments, the movable structures can be hinges, such as snap-fit assembly hinges. Methods of ventilating a patient that involve the device are also disclosed. | 06-03-2010 |
20120272965 | VOLUME-ADJUSTABLE MANUAL VENTILATION DEVICE - Disclosed is a manually operable volume-adjustable ventilation device. The device includes a reservoir with an inlet mechanism, an outlet mechanism, and a volume adjuster configured to move a volume adjustment limit of the reservoir and change an expressed maximum volume of the reservoir. The reservoir has a body having a plurality of movable walls defining an enclosed volume. The reservoir has an uncompressed state and a compressed state. The walls of the reservoir are movable with respect to each other, such that moving the walls expresses the volume adjustment limit of the reservoir. | 11-01-2012 |
Patent application number | Description | Published |
20130125894 | VOLUME-ADJUSTABLE MANUAL VENTILATION DEVICE - Disclosed is a manually operable volume-adjustable ventilation device. The device includes a reservoir with an inlet mechanism, an outlet mechanism, and a volume adjuster configured to move a volume adjustment limit of the reservoir and change an expressed maximum volume of the reservoir. The reservoir has a body having a plurality of movable walls defining an enclosed volume. The reservoir has an uncompressed state and a compressed state. The walls of the reservoir are movable with respect to each other, such that moving the walls expresses the volume adjustment limit of the reservoir. The walls can be operably connected by movable structures configured such that two adjacent walls are configured to rotate around substantially orthogonal axes with respect to each other when the reservoir moves from an uncompressed to a compressed state. In some embodiments, the movable structures can be hinges, such as snap-fit assembly hinges. Methods of ventilating a patient that involve the device are also disclosed. | 05-23-2013 |
20130172717 | NEURAL INTERFACE DEVICE AND INSERTION TOOLS - An implanted neural micro interface device is provided. The device comprises microfilaments of various materials and forms embedded within a body. The microfilaments form interaction sites with surrounding neural tissue at their exit points from the implantable body. The body and filaments are configurable in a multitude of positions to provide increased engagement of a given neural tissue section as well as interaction and closed loop feedback between the microfilament sites. Such configurations allow for a range of recording, stimulating, and treatment modalities for the device within research and clinical settings. | 07-04-2013 |
20150174351 | VOLUME-ADJUSTABLE MANUAL VENTILATION DEVICE - Disclosed is a manually operable volume-adjustable ventilation device. The device includes a reservoir with an inlet mechanism, an outlet mechanism, and a volume adjuster configured to move a volume adjustment limit of the reservoir and change an expressed maximum volume of the reservoir. The reservoir has a body having a plurality of movable walls defining an enclosed volume. The reservoir has an uncompressed state and a compressed state. The walls of the reservoir are movable with respect to each other, such that moving the walls expresses the volume adjustment limit of the reservoir. The walls can be operably connected by movable structures configured such that two adjacent walls are configured to rotate around substantially orthogonal axes with respect to each other when the reservoir moves from an uncompressed to a compressed state. In some embodiments, the movable structures can be hinges, such as snap-fit assembly hinges. Methods of ventilating a patient that involve the device are also disclosed. | 06-25-2015 |
20150335883 | NEURAL INTERFACE DEVICE AND INSERTION TOOLS - An implanted neural micro interface device is provided. The device comprises microfilaments of various materials and forms embedded within a body. The microfilaments form interaction sites with surrounding neural tissue at their exit points from the implantable body. The body and filaments are configurable in a multitude of positions to provide increased engagement of a given neural tissue section as well as interaction and closed loop feedback between the microfilament sites. Such configurations allow for a range of recording, stimulating, and treatment modalities for the device within research and clinical settings. | 11-26-2015 |
Patent application number | Description | Published |
20100332723 | Memory Device and Method for Embedding Host-Identification Information into Content - A memory device and method for embedding host-identification information into content are disclosed. In one embodiment, a memory device is provided comprising a memory operative to store content and a controller in communication with the memory. The controller is operative to receive a credential comprising host-identification information from a host in communication with the memory device, authenticate the host using the credential, receive a request from the host to play content stored in the memory, embed the host-identification information into the content, and send the content with the embedded host-identification information to the host. | 12-30-2010 |
20110158606 | Storage Device and Method for Resuming Playback of Content - A storage device and method for resuming playback of content are provided. In one embodiment, a storage device comprises a memory operative to store a plurality of versions of content. The storage device receives a request for one of the versions of the content from a host, provides the requested version of the content to the host, and provides bookmark information from which the host can determine a location where to resume playback of the content, wherein the bookmark information indicates where playback ended for a different version of the content. | 06-30-2011 |
20130156196 | Storage Device and Method for Super-Distribution of Content Protected with a Localized Content Encyrption Key - In one embodiment, a storage device stores a content encryption key, content encrypted with the content encryption key, and a super-distribution key. To re-distribute the content, the storage device creates a super-distribution token by encrypting the content encryption key with the super-distribution key and provides the encrypted content and the super-distribution token to a host device for storage in a target storage device. To access the encrypted content on the target storage device, the target storage device provides the super-distribution token to a server via the host device. The server generates an activation token from the super-distribution token, wherein the activation token contains the content encryption key. The target storage device receives the activation token from the server via the host device, retrieves the content encryption key from the activation token, and decrypts the encrypted content using the retrieved content encryption key. | 06-20-2013 |
20130159707 | Host Device and Method for Super-Distribution of Content Protected with a Localized Content Encryption Key - In one embodiment, a host device creates a super-distribution token by encrypting a content encryption key with a super-distribution key and stores the super-distribution token and encrypted content retrieved from a source storage device in a target storage device. In another embodiment, a host device provides a super-distribution token to a server, wherein the server is configured to generate an activation token from the super-distribution token, receive the activation token from the server, retrieve a content encryption key from the activation token, and decrypt encrypted content received from a storage device using the content encryption key retrieved from the activation token. | 06-20-2013 |